Heart failure

For all subjects:
- Aged between 18 and 79 years (inclusive) with body mass index 18 to 34 kg/m^2 (both inclusive)
- Women without childbearing potential; women of childbearing potential only if the pregnancy test was negative and a combination of condoms with a safe and highly effective contraception method was granted
For subjects with renal impairment:
- With an estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73m^2 determined from a serum creatinine control 2-14 days prior to dosing
- Stable renal disease, i.e. a serum creatinine value determined at least 3 months before the pre-study visit should not vary by more than 25% from the serum creatinine value determined at the pre-study visit
For healthy subjects:
- eGFR ≥ 90 mL/min/1.73m^2 determined from serum creatinine 2-14 days prior to dosing
- Healthy subjects with age-, weight- and gender- matched to renal impaired subjects

For all subjects:
- Febrile illness within 1 week before the start of the study
- History of severe allergies, non-allergic drug reactions, or multiple drug allergies
- Hypersensitivity to the investigational drug, the control agent and/ or to inactive constituents
- Regular daily consumption of more than 1/2 liter of usual beer or the equivalent quantity of approximately 20 g of alcohol in another form or more than 1 liter of xanthine-containing beverages or more than 10 cigarettes
- Positive testing in the drug screening
- Positive results for hepatitis B virus surface antigen (HBsAg), hepatitis C virus antibodies (anti-HCV), human immune deficiency virus antibodies (anti-HIV 1+2)
- Donation of more than 100 mL of blood in the preceding 4 weeks or 500 mL in the preceding 3 months
- Relevant deviation from the normal range in clinical chemistry, hematology, coagulation or urinalysis as judged by the investigator
For subjects with renal impairment
- Acute renal failure
- Acute nephritis
- Any organ transplant in the past 5 years
- Severe cerebrovascular or cardiac disorders, e.g. myocardial infarction less than 6 months prior to dosing, congestive heart failure of New York Heart Association grade III or IV, severe arrhythmia requiring anti-arrhythmic treatment
- Percutaneous transluminal coronary angioplasty or coronary artery bypass graft less than 6 months prior to dosing
- Diagnosed malignancy within the past 5 years
- Failure of any other major organ system other than the kidney
- Concomitant use of any medication except medications necessary for the treatment of diseases
- Diastolic BP >100 mmHg and/or systolic BP >180 mmHg
- Heart rate below 50 beats/min or above 100 beats/min at screening visit
- Significant uncorrected rhythm or conduction disturbances
For healthy subjects
- Subjects with conspicuous findings in medical history or pre-study examination
- A history of relevant diseases of vital organs, of the central nervous system or other organs
- Excluded therapies (e.g. physiotherapy, acupuncture, etc.) from 1 week before admission to the ward (-01d)
- Use of medication within the 2 weeks preceding the study which could interfere with the investigational product
- Systolic BP below 100 mmHg or above 145 mmHg and Diastolic BP below 55 mmHg or above 95 mmHg
- Heart rate below 50 beats/min or above 100 beats/min
- Clinically relevant findings in the electrocardiogram (ECG)