Ibuprofen, and placebo in the treatment of pain secondary to dental impaction surgery
This was a single-dose, randomized, parallel, double-blind design
requiring 175 evaluable subjects at a single center. Subjects were
randomly assigned to one of the 3 groups in 2:2:1 ratio to receive a
single dose of naproxen (187.5 mg), ibuprofen (200 mg), or placebo.
After dosing with study medication, the subjects had to remain at the
study site for 2 hours. Analgesic response was evaluated on
categorical scales by subjects’ ratings of their pain intensity and pain
relief. Pain intensity was evaluated immediately prior to study drug
administration, and both pain intensity and pain relief were evaluated
hourly thereafter for 12 hours following study drug administration.
: - Generally healthy subjects, at least 15 years of age, with at least moderate pain following surgical extraction of one or 2 third molars with at least one being a mandibular partial or complete bony impaction were enrolled in the study.
No Exclusion Criteria Available
Single dose efficacy comparison of naproxen, ibuprofen, and placebo in the treatment of pain secondary to dental impaction surgery