Neoplasms

Inclusion Criteria

- Age greater than/equal to 18 years old
 - ECOG Performance Status of 0 - 1
 - Life expectancy of at least 12 weeks
 - Patients with advanced, histologically or cytologically confirmed solid tumors, refractory to any standard therapy or have no standard therapy available
 - LVEF (left ventricular ejection fraction) > or = to the lower limit of normal for the institution
 - Radiographically or clinically evaluable tumor
 - Adequate bone marrow, liver and renal function as assessed by the following laboratory requirements to be conducted within 14 days prior to start of first dose:
 -- Hemoglobin > 9.0 g/dL
 -- Absolute neutrophil count (ANC) > or = 1500/mm3
 -- Platelet count > or = 100,000 /mm3
 -- Total bilirubin < or = 1.5 times the upper limit of normal
 -- ALT (alanine aminotransferase) and AST (aspartate aminotransferase) < or = 2.5 x upper limit of normal (< or =  5 x upper limit of normal for patients with liver involvement)
 -- PT-INR (prothrombin-international normalized ratio) and PTT (partial thromboplastin time) < or = 1.5 times the upper limit of normal
 -- Serum creatinine < or = 1.5 times the upper limit of normal

Exclusion Criteria

- History of impaired cardiac function or clinically significant cardiac disease (i.e. congestive heart failure (CHF) NYHA (New York Heart Association) Class III or IV); active coronary artery disease, myocardial infarction within 6 months of study entry; new onset or unstable angina within 3 months of study entry, or cardiac arrhythmias requiring anti-arrhythmic therapy
 - Type 1 or type 2 diabetes mellitus or fasting glucose > 125 mg/dL or HgBA1c > or = 7.0
 - Use of systemic corticosteroids within 2 weeks of study entry
 - History of retinal vein occlusion
 - Known glucose-6-phosphate dehydrogenase (G6PD) deficiency
 - Active clinically serious infection
 - Uncontrolled hypertension
 - Positive for HIV, or chronic Hepatitis B or C
 - Subjects undergoing renal dialysis
 - Known bleeding diathesis
 - Ongoing substance abuse
 - Pregnant or breast-feeding women