Trial Condition(s):
Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO) (GALILEO)
14130
Not Available
To determine the efficacy of vascular endothelial growth factor (VEGF) Trap-Eye injected into the eye on vision function in subjects with macular edema as a consequence of central retinal vein occlusion
- Center-involved macular edema secondary to central retinal vein occlusion (CRVO) for no longer than 9 months with mean central subfield thickness ≥ 250 μm on optical coherence tomography (OCT) - Adults ≥ 18 years - Early treatment diabetic retinopathy study (ETDRS) best corrected visual acuity (BCVA) of 20/40 to 20/320 (73 to 24 letters) in the study eye
- Any prior treatment with anti-VEGF agents in the study eye (Pegaptanib sodium, anecortave acetate, bevacizumab, ranibizumab, etc.) or previous administration of systemic anti-angiogenic medications - Prior panretinal laser photocoagulation or macular laser photocoagulation in the study eye - CRVO disease duration > 9 months from date of diagnosis - Previous use of intraocular corticosteroids in the study eye or use of periocular corticosteroids in the study eye within the 3 months prior to Day 1 - Iris neovascularization, vitreous hemorrhage, traction retinal detachment, or preretinal fibrosis involving the macula in either the study eye or fellow eye
Locations | |
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Locations Klinikum der Eberhard-Karls-Universität Tübingen Tübingen, Germany, 72076 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Freiburg Freiburg, Germany, 79106 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Klinikum rechts der Isar München, Germany, 81675 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Johannes-Gutenberg-Universität Mainz Mainz, Germany, 55131 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Heidelberg Heidelberg, Germany, 69120 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Schleswig-Holstein / AÖR Lübeck, Germany, 23538 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Klinikum Darmstadt Darmstadt, Germany, 64297 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Klinikum der Stadt Ludwigshafen am Rhein gGmbH Ludwigshafen, Germany, 67063 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Aachen Aachen, Germany, 52074 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Klinikum Chemnitz gGmbH Chemnitz, Germany, 09116 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Essen Essen, Germany, 45122 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Hamburg Eppendorf (UKE) Hamburg, Germany, 20251 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätskliniken des Saarlandes Homburg, Germany, 66421 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Medizinische Einrichtungen der Universität Bonn Bonn, Germany, 53105 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Klinikum der Christian-Albrechts-Universität Kiel, Germany, 24105 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Leipzig AöR Leipzig, Germany, 04103 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Medizinische Fakultät Carl Gustav Carus Dresden, Germany, 01307 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Köln Köln, Germany, 50924 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Krankenhaus Dresden-Friedrichstadt Dresden, Germany, 06067 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsmedizin der Georg-August-Universität Göttingen Göttingen, Germany, 37075 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Regensburg Regensburg, Germany, 93053 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centre Ophthalmologie d'Imagerie et de Laser Paris, France, 75015 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Nagoya University Hospital Nagoya, Japan, 466-8560 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Kyoto University Hospital Kyoto, Japan, 606-8507 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. Policlinico Consorziale Bari, Italy, 70124 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. Ospedali Riuniti Umberto I - Lancisi - Salesi Ancona, Italy, 60126 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations ASL RM/A Roma - Lazio Roma, Italy, 00198 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinik Gießen und Marburg GmbH Marburg, Germany, 35037 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations C.H.U. Pellegrin Bordeaux, France, 33000 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centre d'Ophtalmologie - Paradis-Monticelli MARSEILLE, France, 13008 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centre Hospitalier National d'Ophthalmologie Quinze-Vingt Paris, France, 75557 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hôpital Hôtel Dieu - Nantes Cedex Nantes, France, 44093 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centre Hospitalier Universitaire de Dijon Dijon, France, 21033 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Nagoya City University Hospital Nagoya, Japan, 467-8602 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Juntendo University Urayasu Hospital Urayasu, Japan, 279-0021 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Surugadai Nihon University Hospital Chiyoda-ku, Japan, 101-8309 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Osaka University Hospital Suita, Japan, 565-0871 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. Careggi Firenze, Italy, 50134 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. Policlinico Tor Vergata Roma, Italy, 00133 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico Milano, Italy, 20122 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations IRCCS Fondazione San Raffaele Milano, Italy, 20132 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. Policlinico Catania, Italy, 95123 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O. di Padova Padova, Italy, 35128 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O. Sacco Polo Universitario Milano, Italy, 20157 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations ASL TO/2 - Piemonte Torino, Italy, 10122 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Lion Eye Institute Nedlands, Australia, 6009 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Vision Eye Institute Chatswood, Australia, 2067 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Allgemeines Krankenhaus der Stadt Wien Universitätskliniken Wien, Austria, 1090 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations University of Semmelweis Budapest, Hungary, 1089 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Bajcsy Zsilinszky Hospital Budapest, Hungary, 1106 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations University of Debrecen Medical&Health Science Center Debrecen, Hungary, 4032 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Asan Medical Center Seoul, South Korea, 138-736 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Seoul St. Mary's Hospital Seoul, South Korea, 137-701 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Seoul National University Hospital Seoul, South Korea, 110 744 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Yonsei University College of Medicine Seoul, South Korea | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations National University Hospital Singapore, Singapore, 119074 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Latvijas-Amerikas acu centrs Riga, Latvia, 1050 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Paula Stradina Kliniskas Universitates slimnica Riga, Latvia, 1002 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Save Sight Institute Sydney, Australia, 2000 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Marsden Eye Surgery Center Parramatta, Australia, 2150 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Westmead Hospital Westmead, Australia, 2145 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centre for Eye Research East Melbourne, Australia, 3002 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Konventhospital Barmherzige Brüder Linz Linz, Austria, 4021 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Innsbruck Innsbruck, Austria, 6020 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.ö. Krankenhaus der Stadt Linz Linz, Austria, 4021 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Csolnoky Ferenc Hospital Veszprem, Hungary, 8200 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Budapest Retina Associates Budapest, Hungary, 1133 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Zala Megyei Korhaz Zalaegerszeg, Hungary, H-8900 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Gachon University Gil Medical Center Incheon , South Korea, 405-760 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Seoul National Univ. Bundang Hospital Seongnam-si, South Korea, 463-707 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Singapore National Eye Centre Singapore, Singapore, 168751 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Charité Campus Virchow-Klinikum (CVK) Berlin, Germany, 13353 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations St. Franziskus-Hospital GmbH Münster, Germany, 48145 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Klinikum der Johann Wolfgang Goethe Universität Frankfurt Frankfurt, Germany, 60596 | Contact Us: E-mail: [email protected] Phone: Not Available |
A randomized, double-masked, sham-controlled phase 3 study of the efficacy, safety and tolerability of repeated intravitreal administration of VEGF Trap-Eye in subjects with macular edema secondary to central retinal vein occlusion (CRVO)
Trial Type:
Interventional
Intervention Type:
Biological/Vaccine
Trial Purpose:
Treatment
Allocation:
Randomized
Blinding:
Double Blind
Assignment:
Parallel Assignment
Trial Arms:
2