Contraception, Premenstrual Syndrome, Acne

Inclusion Criteria

- Healthy female subjects 
 -- requesting contraception
 -- suggesting PMDD by Physician who are also requesting contraception
 -- with acne who are also requesting contraception
 - Age: 18 - 50 years
 - Women who is prescribed YAZ first, during study period

Exclusion Criteria

- Women who are contraindicated based on the label of YAZ
 -- Presence or a history of venous or arterial thrombotic/ thromboembolic events (e.g. deep venous thrombosis, pulmonary embolism, myocardial infarction) or of a cerebrovascular accident
 -- Presence or history of prodromi of a thrombosis (e.g. transient ischaemic attack, angina pectoris)
 --  History of migraine with focal neurological symptoms
 -- Diabetes mellitus with vascular involvement
 -- The presence of a severe or multiple risk factor(s) for venous or arterial thrombosis may also constitute a contraindication
 -- Pancreatitis or a history thereof if associated with severe hypertriglyceridemia
 -- Presence or history of severe hepatic disease as long as liver function values have not returned to normal
 -- Severe renal insufficiency or acute renal failure
 -- Presence or history of liver tumours (benign or malignant)
 -- Known or suspected sex-steroid influenced malignancies (e.g. of the genital organs or
the breasts)
 -- Undiagnosed vaginal bleeding
 --  Known or suspected pregnancy
 --  Hypersensitivity to the active substances or to any of the excipients