Trial Condition(s):
Macular degeneration
Vascular endothelial growth factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration (AMD) (VIEW 2)
Bayer Identifier:
91689
ClinicalTrials.gov Identifier:
EudraCT Number:
EU CT Number:
Not Available
Trial Purpose
This study is a phase III, double-masked, randomized, study of the efficacy and safety of VEGF Trap-Eye in patients with neovascular age-related macular degeneration. Approximately 1200 patients will be randomized in Europe, Asia, Japan, Australia and South America.
Inclusion Criteria
- Signed informed consent. - Men and women >/=50 years of age. - Active primary or recurrent subfoveal CNV lesions secondary to AMD, including juxtafoveal lesions that affect the fovea as evidenced by Fluorescein angiography (FA) in the study eye. - ETDRS Best-Corrected Visual Acuity letter score of 73 to 25 (= Acuity of 20/40 to 20/320) in the study eye at 4 meters. - Willing, committed, and able to return for ALL clinic visits and complete all study-related procedures. - Able to read, (or, if unable to read due to visual impairment, be read to verbatim by the person administering the informed consent or a family member) understand and willing to sign the informed consent form.
Exclusion Criteria
- Any prior ocular (in the study eye) or systemic treatment or surgery for neovascular AMD, except dietary supplements or vitamins. - Any prior or concomitant therapy with another investigational agent to treat neovascular AMD in the study eye. - Any prior treatment with anti-VEGF agents in the study eye. - Total lesion size >12 disc areas (30.5 mm, including blood, scars and neovascularization) as assessed by FA in the study eye. - Subretinal hemorrhages that is either 50% or more of the total lesion area, or if the blood is under the fovea and is 1 or more disc areas in size in the study eye (if the blood is under the fovea, then the fovea must be surrounded by 270 degrees by visible CNV). - Scar or fibrosis making up >50% of the total lesion in the study eye. - Scar, fibrosis, or atrophy involving the center of the fovea in the study eye. - Presence of retinal pigment epithelial tears or rips involving the macula in the study eye. - History of any vitreous hemorrhage within 4 weeks prior to Visit 1 in the study eye. - Presence of other causes of CNV in the study eye. - Prior vitrectomy in the study eye. - History of retinal detachment or treatment or surgery for retinal detachment in the study eye. - Any history of macular hole of stage 2 and above in the study eye. - Any intraocular or periocular surgery within 3 months of Day 1 on the study eye, except lid surgery, which may not have taken place within 1 month of Day 1, as long as it is unlikely to interfere with the injection. - History or clinical evidence of diabetic retinopathy, diabetic macular edema or any retinal vascular disease other than AMD in either eye.
Trial Summary
Enrollment Goal
Trial Dates
Phase
Could I receive a placebo?
Products
Accepts Healthy Volunteers
Where to Participate
| Locations | |
|---|---|
Locations Klinikum der Eberhard-Karls-Universität Tübingen Tübingen, Germany, 72076 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Freiburg Freiburg, Germany, 79106 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations St. Franziskus-Hospital GmbH Münster, Germany, 48145 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Klinikum der Christian-Albrechts-Universität Kiel, Germany, 24105 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Charité Campus Benjamin Franklin Berlin, Germany, 12200 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Leipzig AöR Leipzig, Germany, 04103 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Klinikum rechts der Isar München, Germany, 81675 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Johannes-Gutenberg-Universität Mainz Mainz, Germany, 55131 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Aachen Aachen, Germany, 52074 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Essen Essen, Germany, 45122 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Heidelberg Heidelberg, Germany, 69120 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Medizinische Fakultät Carl Gustav Carus Dresden, Germany, 01307 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Hamburg Eppendorf (UKE) Hamburg, Germany, 20251 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Medizinische Einrichtungen der Universität Bonn Bonn, Germany, 53105 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Regensburg Regensburg, Germany, 93053 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Krankenhaus Dresden-Friedrichstadt Dresden, Germany, 06067 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Royal Liverpool University Hospital Liverpool, United Kingdom, L7 8XP | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Kings College Hospital London, United Kingdom, SE5 9RS | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Western Eye Hospital London, United Kingdom, NW1 5QH | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Aberdeen Royal Infirmary Aberdeen, United Kingdom, AB25 2ZN | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Queen's University Belfast, United Kingdom, BT12 6BA | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Plymouth Hospitals NHS Trust R&D Plymouth, United Kingdom, PL4 6PL | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Aston University Birmingham, United Kingdom, B4 7ET | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centre Hospitalier National d'Ophthalmologie Quinze-Vingt Paris, France, 75557 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centre Ophthalmologique Rabelais Lyon, France, 69003 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Köln Köln, Germany, 50924 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Schleswig-Holstein / AÖR Lübeck, Germany, 23538 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätskliniken des Saarlandes Homburg, Germany, 66421 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Klinikum Darmstadt Darmstadt, Germany, 64297 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Klinikum der Stadt Ludwigshafen am Rhein gGmbH Ludwigshafen, Germany, 67063 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Southampton General Hospital Southampton, United Kingdom, SO16 6YD | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Torbay Hospital Torquay, United Kingdom, TQ2 7AA | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Frimley Park Hospital NHS Camberley, United Kingdom, GU16 5UJ | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centre d'Ophtalmologie Monticelli Marseille, France, 13008 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hopital Lariboisiere Paris, France, 75010 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centre de Res en Ophthalmologie Lyon, France, 69006 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations C.H.U. Pellegrin Bordeaux, France, 33000 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hôpital Hôtel Dieu - Nantes Cedex Nantes, France, 44093 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centre hospitalier universitaire de Besancon Besancon, France, 25030 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations SMPK, SPSK im. Prof. W. Orlowskiego Warszawa, Poland, 00-416 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centre Ophthalmologie d'Imagerie et de Laser Paris, France, 75015 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centre Hospitalier Universitaire de Dijon Dijon, France, 21079 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Szpital Kliniczny Dzieciatka Jezus -Centrum Leczenia Obrazen Warszaa, Poland, 02-005 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Klinika Okulistyki Wroclaw, Poland, 50-368 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Gunma University Hospital Maebashi, Japan, 371-8511 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Shiga University of Medical Science Hospital Otsu, Japan, 520-2192 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Sapporo City General Hospital Sapporo, Japan, 060-8604 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Nagoya University Hospital Nagoya, Japan, 466-8560 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Kyoto University Hospital Kyoto, Japan, 606-8507 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Fukushima Medical University Hospital Fukushima, Japan, 960-1295 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Kagoshima University Medical and Dental Hospital Kagoshima, Japan, 890-8520 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Kagawa University Hospital Kita, Japan, 761-0793 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Osaka University Hospital Suita, Japan, 565-0871 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations ASL RM/A Roma - Lazio Roma, Italy, 00198 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. Santa Maria Misericordia UD Udine, Italy, 33100 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Szpiatal Kliniczny nr 1 Przemienienia Panskiego Poznan, Poland, 61-848 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Klinika Chorob Oczu Gdansk, Poland, 80-952 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Okregowy Szpital Kolejowy Katowice, Poland, 40-760 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations NZOZ "OFTALMIKA" Bydgoszcz, Poland, 85-631 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Keio University Hospital Shinjuku-ku, Japan, 160-8582 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Nagoya City University Hospital Nagoya, Japan, 467-8602 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Juntendo University Urayasu Hospital Urayasu, Japan, 279-0021 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Surugadai Nihon University Hospital Chiyoda-ku, Japan, 101-8309 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Kyushu University Hospital Fukuoka, Japan, 812-8582 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Kansai Medical University Hirakata Hospital Hirakata, Japan, 573-1191 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Università Cattolica del Sacro Cuore Roma, Italy, 00168 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. Policlinico Consorziale Bari, Italy, 70124 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations IRCCS A.O.U. San Martino – IST Ist. Nazionale Ricerca Cancro Genova, Italy, 16132 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. Ospedali Riuniti Umberto I - Lancisi - Salesi Ancona, Italy, 60126 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O. Sacco Polo Universitario Milano, Italy, 20157 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O. di Padova Padova, Italy, 35128 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O. Osp Circolo e Fond.Macchi Varese, Italy, 21100 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Ospedale Maggiore Borgo Trento Verona, Italy, 37121 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital Nuestra Senora de la Esperanza Santiago de Compostela, Spain, 15705 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Vissum Corporacion Alicante Alicante, Spain, 03016 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations VISSUM Madrid, Spain, 28002 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Instituto Oftalmológico de Barcelona Barcelona, Spain, 08017 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital General de Malaga Malaga, Spain, 29010 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Fundación Oftalmológica del Mediterraneo Valencia, Spain, 46015 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Leids Universitair Medisch Centrum Leiden, Netherlands, 2333 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Erasmus Medisch Centrum Rotterdam, Netherlands, 3000 CA | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Instituto de Oftalmología Mexico City, Mexico, 06800 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital Universitario "José Eleuterio González" Monterrey, Mexico, 64480 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centro Medico ISSEMYM Metepec, Mexico, 52140 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Fundacion Hospital Nuestra Señora de la Luz Mexico City, Mexico, 06030 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations IRCCS Fond. Ca' Granda Ospedale Maggiore Policlinico Milano, Italy, 20122 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations ASL TO/2 - Piemonte Torino, Italy, 10122 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations IRCCS Fondazione San Raffaele Milano, Italy, 20132 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. Policlinico - Vittorio Emanuele Catania, Italy, 95123 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. Policlinico Tor Vergata Roma, Italy, 00133 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital Clínic i Provincial de Barcelona Barcelona, Spain, 08036 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital Universitario "La Paz" Madrid, Spain, 28046 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Instituto Universitario de Oftalmobiología Aplicada Valladolid, Spain, 47005 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital General Universitario de Valencia Valencia, Spain, 46014 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital Universitario Virgen de la Macarena Sevilla, Spain, 41009 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Instituto Oftalmologico Fernandez Vega Oviedo, Spain, 33012 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Clínica Universitaria de Navarra Pamplona, Spain, 31008 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Ciutat Sanitària i Universitaria de la Vall d'Hebron Barcelona, Spain, 08035 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Clínica Piñero Sevilla, Spain, 41013 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centro Medico Teknon Barcelona, Spain, 08022 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Asociación para Evitar la Ceguera en México, I. A. P. México D.F., Mexico, 04030 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations St Eriks Eye Hospital Stockholm, Sweden, 11282 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Eye Clinic Örebro, Sweden, 70185 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Masaryk Hospital Usti n/L Usti nad Labem, Czech Republic, 401 13 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Chaim Sheba Medical Center Tel Hashomer, Israel | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Kaplan Medical Center Rehovot, Israel, 76100 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Haemek Medical Center Afula, Israel | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Marsden Eye Surgery Center Parramatta, Australia, 2150 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Royal Melbourne Hospital Parkville, Australia, 3050 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Save Sight Institute Sydney, Australia, 2000 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Lion Eye Institute Nedlands, Australia, 6009 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Eye Clinic Westmead Hospital Westmead, Australia, 2145 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Oftalmólogos especialistas Rosario, Argentina, S2000ANJ | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital Italiano Buenos Aires Buenos Aires, Argentina, C1181ACH | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations CHU de Liège Liege, Belgium, 4000 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations University Medical Center St. Radboud Nijmegen, Netherlands, 6525 EX | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Academic Medical Center Dept Ophthalmology Amsterdam, Netherlands, 1100 DD | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitair Medisch Centrum Groningen Groningen, Netherlands, 9713 GZ | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital CIMA Chihuahua Chihuahua, Mexico, 31238 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centro Oftalmologico de Guadalajara Zapopan, Mexico, 45060 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centro Médico Hidalgo Monterrey, Mexico, 64060 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Eye Clinic Linköping, Sweden, 58185 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Fakultni nemocnice Brno Brno, Czech Republic, 63400 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Vseobecna Fakultni Nemocnice Olomouc Olomouc, Czech Republic, 77520 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Ocni klinika Lexum Praha 4, Czech Republic, 14000 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Fakultni nemocnice Kralovske Vinohrady Praha 10, Czech Republic, 10034 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hebrew University - Hadassah Medical School Jerusalem, Israel, 91120 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Tel-Aviv Sourasky Medical Center Tel Aviv, Israel, 64239 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Organizacion Medica de Investigacion (OMI) Buenos Aires, Argentina, C1015ABO | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Csolnoky Ferenc Hospital Veszprem, Hungary, 8200 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Bajcsy Zsilinszky Hospital Budapest, Hungary, 1106 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Budapest Retina Associates Budapest, Hungary, 1133 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Clínica Oftalmológica San Diego Medellín, Colombia | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Fundación Oftalmológica Nacional Bogota, Colombia | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Instituto da Visao Minas Gerais, Brazil, 30150-270 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital Israelita Albert Einstein São Paulo, Brazil, 05651-901 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Seoul National University Bundang Hospital Seongnam, South Korea, 463 707 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Seoul St. Mary's Hospital Seoul, South Korea, 137 701 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Korea University Guro Hospital Seoul , South Korea, 152-703 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsspital Zürich Zürich, Switzerland, 8091 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hôpital Cantonal Universitaire de Genève Genève, Switzerland, 1211 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Inselspital Bern Bern, Switzerland, 3010 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations L.V. Prasad Eye Institute Orissa, India, 751 024 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Rabin Medical Center Petach Tikva, Israel, 49100 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Assaf Harofeh Medical Center Zrifin, Israel, 70300 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Meir Medical Center Kfar Saba, Israel | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Soroka University Medical Center Beer Sheva, Israel | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Lady Davis Carmel Medical Center Haifa, Israel, 34362 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Centre for Eye Research East Melbourne, Australia, 3002 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Vision Eye Institute Chatswood, Australia, 2067 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital de Sao Joao - Centro Hospitalar de Sao Joao, EPE Porto, Portugal, 4200-319 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations AIBILI Azinhaga de Santa Coimbra, Portugal, 3000-548 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Praxis Dr. Domingo Tacite Córdoba, Argentina, X5000IIT | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Fundación Zambrano Buenos Aires, Argentina, C1023AAQ | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Instituto de la Visión S.A. Buenos Aires, Argentina, C1122AAI | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsklinikum Innsbruck Innsbruck, Austria, 6020 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Allgemeines Krankenhaus der Stadt Wien Universitätskliniken Wien, Austria, 1090 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Konventhospital Barmherzige Brüder Linz Linz, Austria, 4021 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Dr.R.P. Center for Ophthalmic Sciences New Delhi, India, 110029 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Post Graduate Institute of Medical Education and Research Chandigarh, India, 160012 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Aravind Eye Hospital Madurai, India, 625 020 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Aravind Eye Hospital Coimbatore, India, 641014 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Retina Foundation Ahemedabad - 4, India, 380009 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Shroff Eye Hospital Mumbai, India, 400 050 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Alexandra Hospital Singapore, Singapore, 159964 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Tan Tock Seng Hospital Singapore, Singapore, 308433 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Dr. Solomatins Eye Riga, Latvia, 1050 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Latvijas-Amerikas acu centrs Riga, Latvia, 1009 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations University of Semmelweis Budapest, Hungary, 1083 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Clínica Oftalmológica de Cali Cali, Colombia | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Instituto Nacional de Investigación en Oftalmología Medellín, Colombia | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hosp Clínicas Facult. Med. de Ribeirão Preto / USP Ribeirão Preto, Brazil, 14048-900 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital Sao Paulo - UNIFESP Sao Paulo, Brazil, 04023-062 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Faculty Hospital F. D. Roosevelt Banska Bystrica, Slovakia, 97517 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Univerzitná nemocnica Bratislava, Nemocnica Stare Mesto Bratislava, Slovakia, 81369 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Asan Medical Center Seoul, South Korea, 138-736 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Seoul National University Hospital Seoul, South Korea, 110 744 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Gachon University Gil Medical Center Incheon, South Korea, 405-760 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Universitätsspital Basel Basel, Switzerland, 4031 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Regional Institute of Ophthalmology Kolkata, India, 700073 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations L.V. Prasad Eye Institute Hyderabad, India, 500 034 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Narayana Netralaya Bangalore, India, 560010 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Shankar Netralaya Chennai, India, 600 006 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Little Flower Hospital Kerala, India, 683572 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Aravind Eye Hospital Pondicherry, India, 600007 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Aditya Jyot Eye Hospital Pvt. Ltd. Wadala, Mumbai, India, 400031 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Dr. Shroff's Charity Eye Hospital New Delhi , India, 110002 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations National University Hospital Singapore, Singapore, 119074 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Paula Stradina Kliniskas Universitates slimnica Riga, Latvia, 1002 | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Singapore Eye Research Institution Singapore, Singapore, 168751 | Contact Us: E-mail: [email protected] Phone: Not Available |
Trial Design
A randomized, double masked, active controlled, phase 3 study of the efficacy, safety, and tolerability of repeated doses of intravitreal VEGF Trap in subjects with neovascular age-related macular degeneration (AMD)
Trial Type:
Interventional
Intervention Type:
Drug
Trial Purpose:
Treatment
Allocation:
Randomized
Blinding:
Double Blind
Assignment:
Parallel Assignment
Trial Arms:
4
Primary Outcome
- Percentage of Participants Who Maintained Vision at Week 52 - Last Observation Carried Forward (LOCF)Timeframe: At week 52
Secondary Outcome
- Mean Change From Baseline in Best Corrected Visual Acuity (BCVA) as Measured by ETDRS Letter Score at Week 52 - LOCFTimeframe: Baseline and at week 52
- Percentage of Participants Who Gained at Least 15 Letters of Vision in the ETDRS Letter Score in the Study Eye at Week 52 - LOCFTimeframe: At week 52
- Mean Change From Baseline in National Eye Institute 25-item Visual Function Questionnaire (NEI VFQ-25) Total Score at Week 52 - LOCFTimeframe: Baseline and at week 52
- Mean Change From Baseline in Choroidal Neovascularization (CNV) Area at Week 52 - LOCFTimeframe: Baseline and at week 52
Additional Information
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