Ovarian Neoplasms

Inclusion Criteria

- Females aged 18 or over  - Cancer of any of the following types:              -- epithelial ovarian cancer      -- peritoneal cavity cancer      -- fallopian tube cancer  - Up to 2 previous chemotherapies; the most recent must have been a platinum- containing therapy  - Progression of disease or symptomatic relapse during, or within 6 months of previous therapy  - 4 weeks or more since prior radiotherapy or chemotherapy  - 3 weeks or more since prior immunotherapy  - Adequate recovery from previous surgery, radiotherapy, and chemotherapy ( excluding alopecia)  - Survival expectation of 3 months or more

Exclusion Criteria

- More than 2 previous chemotherapies   - Previous treatment with epothilones  - Use of any investigational drug within 4 weeks of start of study treatment or inadequate recovery from any toxic effects of such therapy  - Previous radiation to the whole pelvis  - Symptomatic brain metastases requiring whole-brain irradiation  - Active infection  - Any other malignancy except:      -- Non-melanoma skin cancer      -- Carcinoma in situ of cervix      -- Malignancy with treatment 5 or more years ago without relapse  - Mixed mesodermal tumor  - Prior hormone therapy for any malignancy in the previous month  - Women of childbearing potential