Trial Condition(s):
Advanced Non-Small Cell Lung Cancer, HER2 mutation
A study to learn more about how well BAY 2927088 works and how safe it is compared with standard treatment, in participants who have advanced non-small cell lung cancer (NSCLC) with mutations in the genes of human epidermal growth factor receptor 2 (HER2) (SOHO-02)
Bayer Identifier:
22615
ClinicalTrials.gov Identifier:
EudraCT Number:
Not Available
EU CT Number:
2024-511319-91-00
Trial Purpose
Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called human epidermal growth factor receptor 2 (HER2) mutations.
Advanced NSCLC is a group of lung cancers that have spread to nearby tissues or to other parts of the body or that are unlikely to be cured or controlled with currently available treatments. HER2 is a protein that helps cells to grow and divide. A damage (also called mutation) to the building plans (genes) for this protein in cancer cells leads to a production of abnormal HER2 and therefore abnormal cell growth and division.
The study treatment, BAY 2927088, is expected to block the mutated HER2 protein which may stop the spread of NSCLC.
The main purpose of this study is to learn how well BAY 2927088 works and how safe it is compared with standard treatment, in participants who have advanced NSCLC with specific genetic changes called HER2 mutations.
The study participants will receive one of the study treatments:
• BAY 2927088 twice every day as a tablet by mouth, or
• Standard treatment in cycles of 21 days via infusion (“drip”) into the vein.
The treatment will continue for as long as participants benefit from it without any severe side effects or until they or their doctor decide to stop the treatment.
During the study, the doctors and their study team will:
• take imaging scans, including CT, PET, MRI, and X-rays, of different parts of the body to study the spread of cancer
• check the overall health of the participants by performing tests such as blood and urine tests, and checking
• heart health using an electrocardiogram (ECG)
• perform pregnancy tests for women
• ask the participants questions about how they are feeling and what adverse events they are having.
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events, irrespective if they think it is related or not to the study treatment.
Inclusion Criteria
- Participant must be ≥18 years of age or over the legal age of consent in countries where that is greater than 18 years at the time of signing the informed consent. - Documented histologically or cytologically confirmed locally advanced non-squamous NSCLC, not suitable for definitive therapy or metastatic non-squamous NSCLC at screening (small cell or mixed histologies are excluded) (Stage III-IV NSCLC). - Documented activating HER2 mutation in the tyrosine kinase domain (TKD) assessed by tissue molecular test in a CLIA-certified (US sites) or an equally accredited (outside of the US) local laboratory. However, participants may be included at the discretion of the investigator if the laboratory performing the assay is not CLIA or similar certified but the laboratory is locally accredited. - No prior systemic therapy for locally advanced or metastatic disease. No prior treatment with a HER2 ex20ins-targeted therapy (e.g. poziotinib, trastuzumab deruxtecan). Participants who received adjuvant or neoadjuvant therapy are eligible if the adjuvant/neoadjuvant therapy was completed at least 12 months prior to the start of screening. - Eligible to receive treatment with the selected platinum-based doublet-chemotherapy (i.e. cisplatin/pemetrexed or carboplatin/pemetrexed) and pembrolizumab in accordance with the SmPC/Product Information.
Exclusion Criteria
- Known history of prior malignancy except if the participant has undergone potentially curative therapy with no evidence of that disease recurrence for five years since initiation of that therapy. Exception: the following cancer types are acceptable within five years if curatively treated or under surveillance: -- a. in situ cancers of cervix, breast, or skin, -- b. superficial bladder cancer (Ta, Tis and T1), -- c. limited-stage prostate cancer, -- d. basal or squamous cancers of the skin. - Tumors with targetable alterations with approved available therapy, with the exception of HER2 mutation in the TKD. - Inability to discontinue treatment with chronic systemic corticosteroids. Participants who require intermittent use of bronchodilators, inhaled steroids, or local steroid injections would not be excluded from the study. Replacement therapy (e.g., physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is acceptable, provided that the dose is stable for >4 weeks prior to planned start of study intervention. - Pre-existing peripheral neuropathy that is Grade ≥2 by CTCAE (v5.0). - History of severe hypersensitivity reaction to treatment with a monoclonal antibody. - Prior radiotherapy outside of the brain within 21 days of planned start of study intervention. Participants must have recovered from all radiation-related toxicities and not require corticosteroids.
Trial Summary
Enrollment Goal
Trial Dates
Phase
Could I receive a placebo?
Products
Accepts Healthy Volunteers
Where to Participate
| Locations | Status | |
|---|---|---|
Locations Hôpital Emile Muller - Mulhouse MULHOUSE, France, 68051 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Centre Hospitalier Intercommunal Créteil - Service de pneumologie Créteil, France, 94010 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Institut Bergonié - Unicancer Nouvelle Aquitaine BORDEAUX CEDEX, France, 33076 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Institut Curie - Ulm - Paris PARIS cedex 5, France, 75248 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Institut de Cancérologie de l'Ouest - Saint Herblain Saint-Herblain, France, 44800 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Institut Gustave Roussy - Département de Médecine Oncologique VILLEJUIF CEDEX, France, 94805 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Sirio-Libanes (HSL) - Centro de Oncologia - Brasilia Brasilia, Brazil, 71635-610 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Pronutrir Fortaleza - CE Fortaleza, Brazil, 60810-180 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica Natal, Brazil, 59040-000 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Sirio Libanes Sao Paulo, Brazil, 01308-050 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations A Beneficencia Portuguesa de Sao Paulo - Hospital BP Mirante Sao Paulo, Brazil, 01323-030 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Fundacao Pio XII - Hospital de Cancer de Barretos Barretos, Brazil, 14784-400 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Centro de Pesquisa da Clínica de Oncologia Reichow Blumenau, Brazil, 89010-340 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Centro Paulista de Oncologia (CPO) - Sao Paulo - Faria Lima Sao Paulo, Brazil, 04538-132 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hôpital Foch - Oncologie digestive et thoracique Suresnes, France, 92150 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Institut Coeur Poumon - CHRU Lille - Pôle Cardio-vasculaire et pulmonaire Lille, France, 59000 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Rede DoR Recife - PE Recife, Brazil, 50070-480 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations NAIC - Instituto do Cancer Bauru, Brazil, 17033-490 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Irmandade Santa Casa de Misericordia de Porto Alegre | Oncology Porto Alegre, Brazil, 90020-090 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations UZ Leuven Gasthuisberg - Pneumology Department Leuven, Belgium, 3000 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations AZ Delta | Clinical Trial Center - Pneumology Roeselare, Belgium, 8800 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Antwerp University Hospital | Oncology Department Antwerpen, Belgium, 2650 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations IPO Porto Porto, Portugal, 4200-072 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Kansai Medical University Hospital Hirakata, Japan, 573-1191 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations National Hospital Organization Kyushu Medical Center Fukuoka, Japan, 810-8563 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations National Hospital Organization Himeji Medical Center Himeji, Japan, 670-8520 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hokkaido University Hospital Sapporo, Japan, 060-8648 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Tottori University Hospital Yonago, Japan, 683-8504 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Saitama Cancer Center Kitaadachi-gun, Japan, 362-0806 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations National Cancer Center Hospital East Kashiwa, Japan, 277-8577 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Osaka International Cancer Institute Osaka, Japan, 541-8567 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Tel-Aviv Sourasky Medical Center Tel Aviv, Israel, 6423906 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Sendai Kousei Hospital Sendai, Japan, 980-0873 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations CHU Limoges - Unité oncologie thoracique Limoges, France, 87042 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hôpital Arnaud de Villeneuve - Montpellier MONTPELLIER, France, 34059 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Chungbuk National University Hospital Cheongju-si, Unmapped, 28644 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Severance Hospital, Yonsei University Health System Seoul, Unmapped, 03722 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Chonnam National University Hwasun Hospital Hwasun Gun, Unmapped, 58128 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Samsung Medical Center Seoul, Unmapped, 6351 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Gyeongsang National University Hospital Jinju-si, Unmapped, 52727 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Pusan National University Yangsan Hospital Yangsan-si, Unmapped, 50612 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations The Oncology Institute of Hope and Innovation Whittier, United States, 90602 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Princess Margaret Cancer Centre – University Health Network - Department of Medical Oncology and Hematology Toronto, Canada, M5G 2C4 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Nederlands Kanker Instituut AMSTERDAM, Netherlands, 1066 CX | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Kindai University Hospital Osakasayama, Japan, 589-8511 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Curie Oncology | Farrer Singapore, Singapore, 329563 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Kobe University Hospital Kobe, Japan, 650-0017 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Seoul National University Hospital Seoul, Unmapped, 3080 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Centro Ricerche Cliniche Di Verona S.r.l. - Oncologia Verona, Italy, 37134 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Oncologia Medica Orbassano, Italy, 10043 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOSD Oncologia Toraco-Polmonare Roma, Italy, 00168 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Istituto Europeo di Oncologia s.r.l - Oncologia Toracica Milano, Italy, 20141 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia Rozzano, Italy, 20089 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1 Milano, Italy, 20133 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations I.F.O. Istituti Fisioterapici Ospitalieri_Ospedale Regina Elena -- Oncologia Medica 2 Roma, Italy, 00128 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l. - GDP Toracica Meldola, Italy, 47014 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations AORN San Giuseppe Moscati Avellino - U.O.C. Oncologia Medica Avellino, Italy, 83100 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Centro di Riferimento Oncologico di Aviano - Oncologia Medica e dei Tumori Immuno-Correlati Aviano, Italy, 33081 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Shaare Zedek Medical Center (SZMC) Jerusalem, Israel, 91031 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations National Hospital Organization-Yamaguchi-Ube Medical Center (Sanyo Hospital) Ube, Japan, 755-0241 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Jewish General Hospital - Department of Pulmonary Oncology Montreal, Canada, H3T 1E2 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations CHULN - Hospital Pulido Valente Lisboa, Portugal, 1769-001 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Fundacao Champalimaud | Centro Clinico Champalimaud - Unidade Investigacao Clinica Lisboa, Portugal, 1400-038 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Pedro Hispano | Clinical Research Center Matosinhos, Portugal, 4464-513 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations BC Cancer - The Vancouver Centre Vancouver, Canada, V5Z 4E6 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Soroka Medical Center- Legacy Heritage Cancer Center Be'er Sheva, Israel, 8410101 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations The Canberra Hospital (TCH) - Canberra Region Cancer Centre (CRCC) Garran, Australia, 2605 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Calvary Mater Hospital Newcastle Waratah, Australia, 2298 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations OncoCare Cancer Centre | Gleneagles Medical Centre Singapore, Singapore, 258499 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Belfast City Hospital Belfast, United Kingdom, BT12 7AB | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hôpital Lyon Sud - HCL - Service de pneumologie aiguë spécialisée et cancérologie thoracique Pierre Bénite, France, 69495 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations CHU Grenoble Alpes - Pneumologie La Tronche, France | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Ciutat Sanitaria i Universitaria de la Vall d'Hebron Barcelona, Spain, 08035 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Clinic de Barcelona (Hospital Clinic i Provincial) Barcelona, Spain, 08036 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Institut Catala d'Oncologia (ICO) - Hospital Universitari Germans Trias i Pujol (HUGTP) Location Badalona, Spain, 8916 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - UOC Oncologia Medica Bologna, Italy, 40138 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Quiron Dexeus Barcelona, Spain, 08028 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Complejo Hospitalario de Navarra Pamplona, Spain, 31008 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Universitari i Politecnic La Fe | Oncologia Valencia, Spain, 46026 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Complejo Hospitalario Universitario A Coruna (CHUAC) A Coruna, Spain, 15006 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Fundacion Instituto Valenciano de Oncologia (IVO Valencia, Spain, 46009 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Niigata Cancer Center Hospital Niigata, Japan, 951-8566 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Nippon Medical School - Nippon Medical School Hospital - Cancer Center Bunkyo-ku, Japan, 113-8603 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Rigshospitalet - Kræftbehandling Copenhagen OE, Denmark, 2100 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Istituto Oncologico Veneto_Padova - UOC Oncologia 2 Padova, Italy, 35128 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Beijing Cancer Hospital Beijing, China, 100142 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Beijing Hospital Beijing, China, 100730 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Shandong University - Shandong Cancer Hospital Jinan, China, 250117 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy w Otwocku Otwock, Poland, 05-400 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations National Hospital Organization Nagoya Medical Center Nagoya, Japan, 460-0001 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Kitasato University Hospital Sagamihara, Japan, 252-0375 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Uniklinikum Salzburg, Universitätsklinik für Pneumologie/ Lungenheilkunde Salzburg, Austria, 5020 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Maryland Baltimore, United States, 21201 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Torbay Hospital Torquay, United Kingdom, TQ2 7AA | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School Nanjing, China, 210008 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations CHU de Rouen - Pneumologie rouen, France, 76031 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai, China, 200030 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Kantonsspital Baden Baden, Switzerland, 5404 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University General Hospital ATTIKON, Department of Internal Medicine IV Chaidari, Greece, 12462 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations ONCARE Treatment Center San Pedro Garza García, Mexico, 66220 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Institut de Cancérologie et d'Imagerie brest, France, 29200 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Fundacion Jimenez Diaz (Clinica de la Concepcion) Madrid, Spain, 28040 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital General Universitario Gregorio Maranon | Oncologia Madrid, Spain, 28009 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Universitario Clinica Puerta de Hierro Majadahonda, Spain, 28222 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University General Hospital of Athens "ATTIKON" Chaidari, Greece, 12462 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Bioclinic Thessaloniki Thessaloniki, Greece, 54622 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations PAPANIKOLAOU General Hospital of Thessaloniki Thessaloniki, Greece, 57010 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University General Hospital of Larissa Larissa, Greece, 41110 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Athens Medical School- Alexandra General Hospital of Athens Athens, Greece, 11528 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Athens Medical School-Sotiria General Hospital - 3rd Dept of Medicine & Medical Oncology Athens, Greece, 11527 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Raffles Cancer Centre Singapore, Singapore, 188770 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Odense University Hospital - Oncology Department Odense C, Denmark, 5000 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Chi-Mei Medical Center, Liouyine Tainan, Taiwan, China, 73657 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Chung Shan Medical University Hospital Taichung, Taiwan, China, 402306 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations National Cheng Kung University Hospital Tainan, Taiwan, China, 704 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Taichung Veterans General Hospital Taichung, Taiwan, China, 40705 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung City, Taiwan, China, 807377 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Aalborg University hospital - oncology department Aalborg, Denmark, 9000 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Aarhus Universitetshospital Aarhus N, Denmark, 8200 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Klinik Floridsdorf, Pneumo-onkologische Ambulanz und Tagesklinik Wien, Austria, 1210 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Medizinische Universität Wien Universitätsklinik f. Innere Medizin I Klinische Abteilung für Onkologie Wien, Austria, 1090 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Profound Research LLC Farmington Hills, United States, 48334 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Assuta Ashdod Public Hospital (R.A) Ashdod, Israel, 7747629 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Lungenklinik Hemer, Thorakale Onkologie und onkologische Palliativmedizin Hemer, Germany, 58675 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Robert Bosch Krankenhaus - Haematologie, Onkologie und Palliativmedizin Stuttgart, Germany, 70376 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Kliniken der Stadt Köln gGmbH - Krankenhaus Merheim - Lungenklinik Köln, Germany, 51109 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Universitaetsklinikum Giessen und Marburg - Medizinische Klinik IV Organonkologie Giessen, Germany, 35392 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Providence Cancer Institute - Franz Clinic Portland, United States, 97213-2933 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Uniklinikum Salzburg, Universitätsklinik für Innere Medizin III Salzburg, Austria, 5020 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Royal Surrey County Hospital Guildford, United Kingdom, GU2 7XX | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations The U Chicago Medicine Comprehensive Cancer Center Chicago, United States, 60805 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hôpital Cochin - Cancérologie Paris, France, 75014 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Instituto Nacional de Cancerología México, Mexico, 14080 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Oncare Viaducto Nápoles CDMX, Mexico, 3810 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Oncología Integral Satélite Naucalpan, Mexico, 53100 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Skåne University Hospital Lund, Sweden, 221 85 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations MHAT "Heart and brain" Pleven Pleven, Bulgaria, 5804 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations MHAT Serdika Sofia, Bulgaria, 1632 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations MHAT Sofiamed Sofia, Bulgaria, 1797 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations MHAT Uni Hospital Panagyurishte, Bulgaria, 4500 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Specialized Hospital for Active Treatment of Oncology Sofia, Bulgaria, 1797 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations MHAT Sveta Marina EAD Varna, Bulgaria, 9010 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Multiprofile Hospital for Active Treatment "Sveta Sofia" Sofia, Bulgaria, 1404 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations MHAT Park Hospital EOOD Plovdiv, Bulgaria, 4109 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Complex Oncology Center - Plovdiv EOOD Plovdiv, Bulgaria, 4004 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Metropolitan Hospital- 4th Oncology Clinic Piraeus, Greece, 18547 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Docrates Cancer Center Helsinki, Finland, FIN-00180 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Turun yliopistollinen keskussairaala Turku, Finland, 20521 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations SP ZOZ USK im. WAM UM w Lodzi - Centralny Szpital Weteranow Lodz, Poland, 92-213 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Swietokrzyskie Centrum Onkologii Kielce, Poland, 25-734 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Wielkopolskie Centrum Pulmonologii i Torakochirurgii Poznan, Poland, 60-569 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii Wroclaw, Poland, 53-413 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Norrland University Hospital - Cancercentrum Umeå, Sweden, 90185 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Istanbul Medeniyet Üniversitesi Göztepe Süleyman Yalçin Sehir Hastanesi Kadikoy, Turkey, 34722 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Adana Sehir Egitim ve Arastirma Hastanesi Yüregir, Turkey, 1370 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Ankara Bilkent Sehir Hastanesi Bilkent ankara, Turkey, 6800 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Ankara Etlik Sehir Hastanesi Yenimahalle, Turkey, 6170 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations I.A.Ü. VM Medical Park Florya Hastanesi Kucukcekmece, Turkey, 34295 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Marmara University Hospital Istanbul, Turkey, 34899 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Ege Universitesi Tip Fakultesi Izmir, Turkey, 35100 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Sakarya Universitesi Egitim ve Arastirma Hastanesi Sakarya, Turkey, 54100 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Radiotherapy Center Cluj SRL Flore?ti, Romania, 407280 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Centrul de Oncologie Sfantul Nectarie Craiova, Romania, 200745 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Institutul Oncologic Prof. Dr. Alexandru Trestioreanu (IOB); Oncologie Medicala II Bucuresti, Romania, 22328 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Blacktown Cancer & Haematology Centre Blacktown, Australia, 2148 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations SC ONCOLAB SRL Craiova, Romania, 200385 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of California Los Angeles (UCLA) - Cancer Care - Santa Monica Santa Monica, United States, 90404-2023 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Budapesti Uzsoki Utcai Korhaz Budapest, Hungary, 1145 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Komarom-Esztergom Varmegyei Szent Borbala Korhaz Tatabanya, Hungary, 2800 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Fakultna nemocnica Trnava Trnava, Slovakia, 91775 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations POKO Poprad s.r.o. Poprad, Slovakia, 058 01 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Zhejiang University School of Medicine - Taizhou Hospital of Zhejiang Province Taizhou, China, 317000 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Prince of Wales Hospital Hong Kong, Hong Kong, China, MISSING | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Queen Mary Hospital Hong Kong, Hong Kong, China, MISSING | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hong Kong United Oncology Centre Kowloon, Hong Kong, China, 0 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Spitalul Clinic Coltea Bucuresti, Romania, 30171 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Krajská nemocnice T. Bati - Pneumoonkologická a klinická onkologie Zlin, Czech Republic, 762 75 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Masarykova Univerzita - Masarykuv Onkologicky Ustav (MOU) - Klinika Komplexni Onkologicke Pece (KKOP) Brno, Czech Republic, 602 00 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Nemocnice AGEL Nový Jicín a.s. - Oddelení radioterapie a onkologie Nový Jicín, Czech Republic, 741 01 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Vitkovicka nemocnice a.s. Ostrava, Czech Republic, 703 84 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine Hangzhou, China, 310016 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations West China Hospital Sichuan University Chengdu, China, 610041 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Universitaetsklinikum Essen - Innere Klinik (Tumorforschung) Essen, Germany, 45122 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Klinikum Nürnberg - Klinik für Innere Medizin 3, Schwerpunkt Pneumologie (Lungenheilkunde) Nürnberg, Germany, 90419 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Beijing chest hospital, Capital Medical University Beijing, China, 101149 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Cancer Hospital, Chinese Academy of Medical Sciences Beijing, China, 100000 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Electronic Science & Technology of China - Sichuan Cancer Hospital & Institute (Sichuan Provincial Tumor Hospital) chengdu, China, 610041 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Jilin Cancer Hospital Changchun, China, 130000 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Fudan University - Zhongshan Hospital Shanghai, China, 200032 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Queen Elizabeth Hospital Hong Kong Hong Kong, Hong Kong, China, NA | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Universitrio Dr. José Eleuterio González. Servicio de Oincología Nuevo León, Mexico, 64460 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Concord Repatriation General Hospital - Medical Oncology Clinical Trials Unit Concord, Australia, 2139 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Austin Hospital - Olivia Newton John Cancer Research Institute Heidelberg, Australia, 3084 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of the Sunshine Coast Buderim, Australia, 4556 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations MNCE "Uzhhorod City Multidisciplinary Clinical Hospital" -Oncology Department Uzhgorod, Ukraine, 88000 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations LLC "RDP Ukraine" - Medical Department Dnipro, Ukraine, 49102 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Yuri Semenyuk Rivne Regional Clinical Hospital Rivne, Ukraine, 33007 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Kyiv City Clinical Oncology Center - Department of Chemotherapy #1 Kyiv, Ukraine, 03115 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Private Enterprise Private Production Company "Acinus", Treatment and Diagnostic Center Kropyvnytskyi, Ukraine, 25006 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Medical Center LLC "Verum Expert Clinic" Kyiv, Ukraine, 3039 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Volyn Regional Oncology Center Lutsk, Ukraine, 43018 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Limited Liability Company "MedOffice Group Medical Center" Kyiv, Ukraine, 03189 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Fujian Cancer Hospital Fuzhou, China, 350014 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hunan Cancer Hospital Changsha, China, 410013 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Guangxi Medical University (GXMU) - Affiliated Tumor Hospital Nanning, China, 530021 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Harbin Medical University Cancer Hospital Harbin, China, 150000 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hubei Cancer Hospital Wuhan, China, 430079 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Jiangsu Provincial People's Hospital - The First Affiliated Hospital of Nanjing Medical University Nanjing, China, 210029 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations The People's Liberation Army General Hospital (Beijing 301 Hospital) Beijing, China, 100853 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Union Hospi, Tongji Med College, Huazhong Univ. Scien&Tech Wuhan, China, 430023 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Xiamen University - The First Affiliated Hospital Xiamen, China, 361003 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Zhejiang Cancer Hospital Hangzhou, China, 310022 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations LinYi Cancer Hospital (Linyi Tumor Hospital) Linyi, China, 276001 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Guangzhou Medical University - The First Affiliated Hospital Guangzhou, China, 510230 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Taipei Veterans General Hospital Taipei, Taiwan, China, 11217 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Beacon Hospital Petaling Jaya, Selangor, Malaysia, 46050 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Sunway Medical Centre Subang Jaya, Malaysia, 47500 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Sunway Medical Centre Penang Perai, Malaysia, 13700 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University Malaya Medical Centre Kuala Lumpur, Malaysia, 59100 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Tan Tock Seng Hospital Singapore, Singapore, 308433 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations National Taiwan University Hospital Taipei, Taiwan, China, 100 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations National Taiwan University Hospital (NTUH) - Cancer Research Center Taipei, Taiwan, China, 100225 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations UC San Diego Health - Moores Cancer Center San Diego, United States, 92093-1503 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca, Romania, 400015 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations CardioMed S.R.L. Cluj-Napoca, Romania, 400015 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Memorial Healthcare System Hollywood, United States, 33021 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Texas MD Anderson Cancer Center Houston, United States, 77030 | Status Recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Columbia Asia Hospital Bukit Rimau Shah Alam, Malaysia, 40460 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University Hospital Kebangsaan Malaysia Cheras, Malaysia, 56000 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Cincinnati Medical Center Cincinnati, United States, 45219-2316 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of California San Francisco (UCSF) - Thoracic Surgery and Oncology Clinic San Francisco, United States, 94115-3010 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Minnesota Medical Center Minneapolis, United States, 55455 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Ramón y Cajal | Oncología Madrid, Spain, 28034 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Careggi University Hospital - Oncologia Clinica Firenze, Italy, 50134 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Ospedale San Raffaele s.r.l. - Oncologia Medica Milano, Italy, 20132 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello - Oncologia Medica Palermo, Italy, 90146 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations ASST Sette Laghi_Ospedale Macchi - Oncologia Varese, Italy, 21100 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Ospedale Vito Fazzi Lecce - Oncologia Lecce, Italy, 73100 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations William Osler Health System- Brampton Civic Hospital Brampton, Canada, L6R 3J7 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Oncocenter Timisoara, Romania, 300166 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations S.C Ovidius Clinical Hospital SRL - Oncology Department Ovidiu, Romania, 905900 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej Warsaw, Poland, 02-781 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Charité Universitätsmedizin Berlin CBF - Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie Berlin, Germany, 12203 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations HFR Freiburg – Kantonsspital Fribourg, Switzerland, 1708 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Illinois at Chicago Chicago, United States, 60607 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations AdventHealth Cancer Institute Orlando, United States, 32804 | Status Not yet recruiting | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Trial Design
A Phase 3 open-label, randomized, active-controlled, multicenter trial to evaluate the efficacy and safety of orally administered BAY 2927088 compared with standard of care as a first-line therapy in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with HER2-activating mutations
Trial Type:
Interventional
Intervention Type:
Drug
Trial Purpose:
Treatment
Allocation:
Randomized
Blinding:
N/A
Assignment:
Parallel Assignment
Trial Arms:
2
Primary Outcome
- Progression free survival (PFS) per RECIST 1.1 as assessed by BICRRECIST 1.1 = Response Evaluation Criteria in Solid Tumors, version 1.1; BICR = blinded independent central review (BICR)Timeframe: Up to approximately 2 years
Secondary Outcome
- Overall survival (OS)Timeframe: Up to approximately 4 years.
- Objective response rate (ORR) per RECIST 1.1 as assessed by BICRRECIST 1.1 = Response Evaluation Criteria in Solid Tumors, version 1.1; BICR = blinded independent central review (BICR)Timeframe: Up to approximately 4 years
- Progression free survival (PFS) per RECIST 1.1 as assessed by the investigatorRECIST 1.1 = Response Evaluation Criteria in Solid Tumors, version 1.1Timeframe: Up to approximately 4 years
- Objective Response Rate (ORR) as assessed by the investigatorTimeframe: Up to approximately 4 years
- Disease control rate (DCR) per RECIST 1.1 as assessed by BICRRECIST 1.1 = Response Evaluation Criteria in Solid Tumors, version 1.1; BICR = blinded independent central review (BICR)Timeframe: Up to approximately 4 years
- Disease control rate (DCR) per RECIST 1.1 as assessed by the investigatorRECIST 1.1 = Response Evaluation Criteria in Solid Tumors, version 1.1Timeframe: Up to approximately 4 years
- Duration of response (DOR) as assessed by BICRBICR = blinded independent central review (BICR)Timeframe: Up to approximately 4 years
- Duration of response (DOR) as assessed by the investigatorTimeframe: Up to approximately 4 years
- Adverse events per CTCAE v 5.0 (eg. TEAEs, TESAEs) categorized by severityCTCAE = common terminology criteria for adverse events; TEAE = treatment-emergent adverse event; TESAE = treatment-emergent serious adverse eventTimeframe: Up to approximately 4 years
- Change from baseline in NSCLC-SAQ total scoreNSCLC-SAQ = Non-small cell lung cancer Symptom Assessment QuestionnaireTimeframe: Up to approximately 4 years
- Change from baseline in NSCLC-SAQ individual domain scoresNSCLC-SAQ = Non-small cell lung cancer Symptom Assessment Questionnaire; Domains: cough, pain, dyspnea, fatigue, appetiteTimeframe: Up to approximately 4 years
- Time to deterioration in NSCLC-SAQ total scoreNSCLC-SAQ = Non-small cell lung cancer Symptom Assessment QuestionnaireTimeframe: Up to approximately 4 years
- Time to deterioration in NSCLC-SAQ individual domain scoresNSCLC-SAQ = Non-small cell lung cancer Symptom Assessment Questionnaire; Domains: cough, pain, dyspnea, fatigue, appetiteTimeframe: Up to approximately 4 years
- Time to deterioration in EORTC QLQ-C30 physical functioning domain scoreEORTC QLQ-C30: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30Timeframe: Up to approximately 4 years
- Change from baseline in EORTC QLQ-C30 physical functioning domain scoreEORTC QLQ-C30: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30; QoL: quality of lifeTimeframe: Up to approximately 4 years
- Change from baseline in EORTC QLQ-C30 global health status/QoLEORTC QLQ-C30: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30; QoL: quality of lifeTimeframe: Up to approximately 4 years
Additional Information
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