Trial Condition(s):
Non-diabetic chronic kidney disease
A trial to learn how well finerenone works and how safe it is in adult participants with non-diabetic chronic kidney disease (FIND-CKD)
Bayer Identifier:
21177
ClinicalTrials.gov Identifier:
EudraCT Number:
EU CT Number:
Not Available
Trial Purpose
Researchers are looking for a better way to treat people who have non-diabetic chronic kidney disease (non-diabetic CKD). The trial treatment, finerenone, is being developed to help people who have long lasting kidney disease, also known as chronic kidney disease (CKD). It works by blocking a certain hormone called aldosterone that causes injury and inflammation in the heart and kidney which is known to play a role in CKD.
In this trial, the researchers want to learn if finerenone helps to slow down the worsening of the participants’ non-diabetic CKD compared to a placebo. A placebo looks like a trial treatment but does not have any medicine in it. The trial will include about 1,580 men and women who are at least 18 years old.
The participants will take finerenone or a placebo once a day as tablets by mouth. All of the participants will also continue to take their current medicine for their CKD. The participants will be in the trial for up to about 50 months.
During the trial, the doctors will collect blood and urine samples and check the participants’ health. The participants will also answer questions about how they are feeling and what adverse events they are having. An adverse event is a medical problem that happens during the trial. Doctors keep track of all adverse events that happen in trials, even if they do not think the adverse events might be related to the trial treatments.
Inclusion Criteria
- A clinical diagnosis of chronic kidney disease and: --Urine albumin/creatinine ratio (UACR) of ≥ 200 but ≤ 3500 mg/g and estimated glomerular filtration rate (eGFR) ≥ 25 but < 90 mL/min/1.73m^2 at screening, and --Documentation of albuminuria/proteinuria in the participant’s medical records at least 3 months prior to screening. - Stable and maximum tolerated labeled dose of an Angiotensin-converting enzyme inhibitor (ACEI) or Angiotensin receptor blocker (ARB) for at least 4 weeks prior to screening - K+ ≤ 4.8 mmol/L at screening
Exclusion Criteria
- Established diagnosis of Type 1 or 2 Diabetes mellitus, or HbA1c ≥ 6.5% (48 mmol/mol) - Autosomal dominant or autosomal recessive polycystic kidney disease - Lupus nephritis or anti-neutrophilic cytoplasmic autoantibody (ANCA) -associated vasculitis or any other primary or secondary kidney disease requiring immunosuppressive therapy within 6 months prior to screening - Symptomatic heart failure with reduced ejection fraction with class 1A indication for Mineralocorticoid receptor antagonists (MRAs)
Trial Summary
Enrollment Goal
Trial Dates
Phase
Could I receive a placebo?
Products
Accepts Healthy Volunteers
Where to Participate
| Locations | |
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Locations Shalby Hospital Ahmedabad, India, 380054 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations P. D. Hinduja Hospital and Medical Research Centre Mumbai, India, 400016 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Osmania General Hospital Telangana, India, 500012 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Providence Medical Research Center Spokane Valley, United States, 99204 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Northwest Louisiana Nephrology Shreveport, United States, 71101 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Johns Hopkins University School of Medicine | Johns Hopkins Hospital - Division of Nephrology Baltimore, United States, 21287 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Vanderbilt University Medical Center Nashville, United States, 37232 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Geisinger Medical Center Danville, United States, 17822 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Research by Design, LLC | Chicago, IL Chicago, United States, 60643 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations California Institute of Renal Research - Chula Vista Chula Vista, United States, 91910 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Nephrology Associates of Northern Virginia | Fairfax, VA Fairfax, United States, 22033 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of North Carolina at Chapel Hill | Nephrology Department Chapel Hill, United States, 27514 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations South Carolina Nephrology and Hypertension Center | South Carolina Clinical Research LLC Orangeburg, United States, 29118 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Central Georgia Kidney Specialist Macon, United States, 31201 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Temple University | Nephrology Philadelphia, United States, 19140 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of California, Los Angeles | UCLA Health Division of Nephrology Los Angeles, United States, 90095 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Northwestern University | Division of Nephrology and Hypertension Chicago, United States, 60611 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Yale University | Nephrology Clinical Research New Haven, United States, 06520 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Emory University | Endocrinology Research Atlanta, United States, 30303 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations DaVita Clinical Research | North Houston, TX Shenandoah, United States, 77384 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Rigshospitalet, Copenhagen University Hospital | Department of Nefrology Copenhagen, Denmark, 2100 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Region Midtjylland | Regionshospitalet Godstrup - Nephrology Department Herning, Denmark, DK-7400 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Region Sjælland | Holbaek Sygehus - Cardiology department Holbæk, Denmark, 4300 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Odense University Hospital | Department of Kidney Medicine Odense C, Denmark, 5000 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital of South West Jutland | Department of Endocrinology Research Esbjerg, Denmark, 6700 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations General Hospital of Athens LAIKO Athens, Greece, 11527 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations General Hospital of Thessaloniki Papageorgiou Thessaloniki, Greece, 56403 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University General Hospital of Patras | Nephrology Clinic Patra, Greece, 26504 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations PAPANIKOLAOU General Hospital Thessaloniki Pilea Chortiatis, Greece, 57010 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations HIPPOKRATION General Hospital of Athens Athens, Greece, 115 27 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations General Hospital of Arta | Nephrology Department Arta, Greece, 47100 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Istituto Ricerche Farmacologiche Mario Negri IRCCS Bergamo, Italy, 24020 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations IRCCS Istituti Clinici Scientifici Maugeri SpA SB Pavia, Italy, 27100 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations A.O.U. Luigi Vanvitelli Napoli, Italy, 80138 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Nefrologia, Dialisi e Trapianto Bologna, Italy, 40138 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations ASST di Monza Monza Brianza, Italy, 20832 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations A.O. Cannizzaro Catania, Italy, MISSING | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Azienda USL IRCCS di Reggio Emilia_Arcispedale Santa Maria Nuova - S.C. Nefrologia e Dialisi Reggio Emilia, Italy, 42123 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations A.O.U. di Modena - Policlinico Modena, Italy, 41100 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Azienda Ospedaliero Universitaria Parma - SC Nefrologia Parma, Italy, 43126 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hallym University Sacred Heart Hospital Anyang-si, Unmapped, 14068 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Chung Nam National University Hospital Daejeon, Unmapped, 35015 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations The Catholic University of Korea, Incheon St.Mary's Hospital Incheon, Unmapped, 21431 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Yonsei University Wonju Christian Hospital Wonju, Unmapped, 26426 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Dongguk University Ilsan Hospital Goyang-si, Unmapped, 10326 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Seoul National University Hospital Seoul, Unmapped, 3080 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Vseobecna fakultni nemocnice v Praze Praha 2, Czech Republic, 12808 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Nefrologicka ambulance Praha 4, Czech Republic, 140 00 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations MUDr.Petr Bucek s.r.o. Frydek-Mistek, Czech Republic, 738 01 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Vestra Clinics s.r.o. Rychnov nad Kneznou, Czech Republic, 516 01 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Seri Manjung Perak, Malaysia, 32040 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Raja Permaisuri Bainun Perak, Malaysia, 30450 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Selayang Shah Alam, Malaysia, 68100 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Tengku Ampuan Afzan Pahang, Malaysia, 25100 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Sultan Abdul Halim Kedah, Malaysia, 8000 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University Malaya Medical Centre Kuala Lumpur, Malaysia, 59100 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Pulau Pinang Pulau Pinang, Malaysia, 10450 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Universitario 12 de Octubre | Department of Nephrology Madrid, Spain, 28041 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations La Fe University and Polytechnic Hospital | Nephrology Department Valencia, Spain, 46026 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Complexo HU Ferrol | Nefrología Ferrol, Spain, 15405 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Principe de Asturias Alcalá de Henares, Spain, 28805 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Universitario Ramon y Cajal | Departamento de Medicina Interna Madrid, Spain, 28034 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Ciutat Sanitaria i Universitaria de la Vall d'Hebron Barcelona, Spain, 08035 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Clinico Universitario de Valencia | Nephrology Department MISSING, Spain, 46010 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Universitario Dr. Peset Valencia, Spain, 46017 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Nephrology Department L'Hospitalet de Llobregat, Spain, 8907 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Melbourne Renal Research Group Reservoir, Australia, 3073 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Inje University Ilsan Paik Hospital Goyang-si, Unmapped, 411-706 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Samsung Medical Center Seoul, Unmapped, 6351 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Seoul National University Boramae Medical Center Seoul, Unmapped, 7061 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Kyung Hee University Hospital at Gangdong Seoul, Unmapped, 5278 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Taipei Medical University | Clinical Research Center Taipei, Taiwan, China, 110 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Barzilai Medical Center | Department of Nephrology and Hypertension Ashkelon, Israel, 7830604 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Meir Medical Center Kfar Saba, Israel, 4428164 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Centro de Rehabilitacion Cardiovascular | San Luis, Argentina San Luis, Argentina, D5700CGR | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina CABA, Argentina, C1018DES | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Herlev Hospital | Nephrology Department Herlev, Denmark, 2730 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations CTC Hodonin sro Hodonin, Czech Republic, 69501 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Utah Kidney Research Institute | Salt Lake City, UT South Salt Lake, United States, 84115 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Northeast Clinical Research Center | Bethlehem, PA Bethlehem, United States, 18017 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Florida Kidney Physicians - Boca Raton Boca Raton, United States, 33431 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Clinical Advancement Center, PLLC San Antonio, United States, 78212-4740 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations DaVita Clinical Research | Middlebury, CT Middlebury, United States, 55404 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations DaVita Clinical Research | Houston, TX Houston, United States, 77054 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations SHATC Sveti Georgi - Pernik | Pernik, Bulgaria Pernik, Bulgaria, 2300 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Medical Center Hera | Montana Branch Montana, Bulgaria, 3400 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Diagnostic-Consultative Center XX | Nephrology Department Sofia, Bulgaria, 1618 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Medical Center ’’Nevromedics’’ Veliko Tarnovo, Bulgaria, 5600 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Medical Center ’’4Life’’ Burgas, Bulgaria, 8000 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Multiprofile Hospital for Active Treatment St. Ivan Rilski - Gorna Oryahovitsa | Nephrology Department Gorna Oryahovitsa, Bulgaria, 5100 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Clinical Research Consultants Kansas City, United States, 64111 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Texas Health Science Center at San Antonio | Department of Medicine - Division of Nephrology San Antonio, United States, 78207 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Utah School of Medicine | Kidney Research Clinic Salt Lake City, United States, 84132 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations California Institute of Renal Research, Inc. - El Centro El Centro, United States, 92243 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Balboa Nephrology Medical Group - Poway Poway, United States, 92064 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations East Carolina University | Nephrology & Hypertension Greenville, United States, 27834 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Iowa Hospitals & Clinics Iowa City, United States, 52242 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Kansas Kansas City, United States, 66160 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations El Paso Medical Research Institute (MedResearch Inc) | El Paso, TX El Paso, United States, 79902-4672 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations North America Research Institute | NARI San Dimas, CA - Dr. Jamal San Dimas, United States, 91773 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Eastern Nephrology Associates | Wilmington Wilmington, United States, 28401 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Mendez Center For Clinical Research | Woodbridge, VA Woodbridge, United States, 22192 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Knoxville Kidney Center Knoxville, United States, 37923 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University Hospitals | UH Cleveland Medical Center - Division of Nephrology & Hypertension Research Cleveland, United States, 44106 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Research Management, Inc. | Kansas Nephrology Research Institute, LLC Wichita, United States, 67214 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Nephrology Associates, PC | Southeastern Clinical Research Institute, LLC. Augusta, United States, 30904 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Chase Medical Research, LLC Waterbury, United States, 06708 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Mountain Kidney & Hypertension Associates Asheville, United States, 28801 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Tufts Medical Center | Nephrology Department Boston, United States, 02111 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of New Mexico Albuquerque, United States, 87131 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Cleveland Clinic | Urological and Kidney Department Cleveland, United States, 44195 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations DaVita Clinical Research | Edina, MN Edina, United States, 55435 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Mississippi Medical Center | Shafi Group Jackson, United States, 39216 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Colorado | Renal Research Office Aurora, United States, 80045 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Iwate Prefectural Central Hospital Morioka, Japan, 020-0066 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations JA Toride Medical Center Toride, Japan, 302-0022 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Tsuchiura Kyodo General Hospital Tsuchiura, Japan, 300-0028 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Saitama Medical University Hospital Irima-gun, Japan, 350-0495 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Japanese Red Cross Saitama Hospital Saitama, Japan, 330-8553 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Juntendo University Urayasu Hospital Urayasu, Japan, 279-0021 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Nihon University Itabashi Hospital Itabashi-ku, Japan, 173-8610 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations The University of Tokyo Hospital Bunkyo-ku, Japan, 113-8655 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Tokyo Medical University Hospital Shinjuku-ku, Japan, 160-0023 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Tokyo Metropolitan Tama Medical Center Fuchu, Japan, 183-8524 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Juntendo University Hospital Bunkyo-ku, Japan, 113-8431 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hiratsuka Kyosai Hospital Hiratsuka, Japan, 254-8502 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Yokohama Sakae Kyosai Hospital Yokohama, Japan, 247-8581 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Tokai University Hospital Isehara, Japan, 259-1193 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Yokohama City University Hospital Yokohama, Japan, 236-0004 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations St. Marianna University Hospital Kawasaki, Japan, 216-8511 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Saiseikai Yokohamashi Nanbu Hospital Yokohama, Japan, 234-0054 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations National Hospital Organization Kanazawa Medical Center | Clinical Trial Management Office Kanazawa, Japan, 920-8650 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations University of Yamanashi Hospital Chuo, Japan, 409-3898 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Shinshu University Hospital Matsumoto, Japan, 390-8621 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Matsumoto City Hospital Matsumoto, Japan, 390-1401 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Central Japan International Medical Center Minokamo, Japan, 505-8510 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Seirei Hamamatsu General Hospital Hamamatsu, Japan, 430-8558 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Kainan Hospital Yatomi, Japan, 498-8502 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Daido Clinic Nagoya, Japan, 457-8511 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Chubu Rosai Hospital Nagoya, Japan, 455-8530 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Nagoya City University Hospital Nagoya, Japan, 467-8602 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Osaka Rosai Hospital Sakai, Japan, 591-8025 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Kobe University Hospital Kobe, Japan, 650-0017 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Hyogo Prefectural Nishinomiya Hospital Nishinomiya, Japan, 662-0918 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Nara Prefecture General Medical Center Nara, Japan, 630-8581 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Kawasaki Medical School Hospital Kurashiki, Japan, 701-0192 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Kokura Memorial Hospital Kitakyushu, Japan, 802-8555 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations JCHO Kyushu Hospital Kitakyushu, Japan, 806-8501 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Fukuoka University Hospital Fukuoka, Japan, 814-0180 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Aso Iizuka Hospital Iizuka, Japan, 820-8505 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro Hospital Fukuoka, Japan, 811-0213 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Saga-Ken Medical Centre Koseikan Saga, Japan, 840-8571 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Japanese Red Cross Kumamoto Hospital Kumamoto, Japan, 861-8520 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations SINACOR | Culiacan, Mexico Culiacán, Mexico, 80230 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Sitio Alfredo Chew Wong | Aguascalientes, Mexico Aguascalientes, Mexico, 20124 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Sociedad de Metabolismo y Corazon S.C. | Veracruz, Mexico Puerto de Veracruz, Mexico, 91900 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Fundacion Cardiovascular de Aguascalientes | Aguascalientes, Mexico MISSING, Mexico, 20230 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Nefromed s.r.o. Praha 6, Czech Republic, 160 00 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Nemocnice Znojmo Znojmo, Czech Republic, 669 02 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department Petach Tikva, Israel, 4941492 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Health Corporation of Galilee Medical Center Nahariya, Israel, 2210001 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Clalit Health | Soroka Medical Center - Internal Medicine Department Beer Sheva, Israel, 8410101 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Locations Chaim Sheba Medical Center Ramat Gan, Israel, 5262000 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
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Locations AZ Groeninge Campus Kennedylaan | Nephrology Kortrijk, Belgium, 8500 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
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Locations NANI Research, LLC Hinsdale, United States, 60521 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
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Locations Mavani Research Center Ahmedabad, India, 380052 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Trial Design
A randomized, double-blind, placebo-controlled, parallel-group, multicenter Phase 3 study to investigate the efficacy and safety of FInerenone, in addition to standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease
Trial Type:
Interventional
Intervention Type:
Drug
Trial Purpose:
Treatment
Allocation:
Randomized
Blinding:
N/A
Assignment:
Parallel Assignment
Trial Arms:
2
Primary Outcome
- Mean rate of change as measured by the total slope of eGFR from baseline to Month-32.eGFR: Estimated glomerular filtration rateTimeframe: From baseline to month 32
Secondary Outcome
- Time to the composite of kidney failure, sustained eGFR decline of >= 57%, heart failure hospitalization or Cardiovascular (CV) deathTimeframe: Up to end of study visit (up to approximately 49 months)
- Time to the composite of kidney failure or sustained eGFR decline of >= 57%Timeframe: Up to end of study visit (up to approximately 49 months)
- Time to the composite to heart failure hospitalization or CV deathTimeframe: Up to end of study visit (up to approximately 49 months)
- Number of participants with Treatment-emergent adverse events (TEAEs), Treatment-emergent serious adverse events (TESAEs) and Adverse events of special interest (AESI)Timeframe: Up to approximately 50 months
Additional Information
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