Recruitment Complete

Non-diabetic chronic kidney disease

Bayer Identifier:

21177

ClinicalTrials.gov Identifier:

NCT05047263

EudraCT Number:

2021-000421-27

EU CT Number:

Not Available

A trial to learn how well finerenone works and how safe it is in adult participants with non-diabetic chronic kidney disease

Trial purpose

Researchers are looking for a better way to treat people who have non-diabetic chronic kidney disease (non-diabetic CKD). The trial treatment, finerenone, is being developed to help people who have long lasting kidney disease, also known as chronic kidney disease (CKD). It works by blocking a certain hormone called aldosterone that causes injury and inflammation in the heart and kidney which is known to play a role in CKD.
In this trial, the researchers want to learn if finerenone helps to slow down the worsening of the participants’ non-diabetic CKD compared to a placebo. A placebo looks like a trial treatment but does not have any medicine in it. The trial will include about 1,580 men and women who are at least 18 years old.
The participants will take finerenone or a placebo once a day as tablets by mouth. All of the participants will also continue to take their current medicine for their CKD. The participants will be in the trial for up to about 50 months.
During the trial, the doctors will collect blood and urine samples and check the participants’ health. The participants will also answer questions about how they are feeling and what adverse events they are having. An adverse event is a medical problem that happens during the trial. Doctors keep track of all adverse events that happen in trials, even if they do not think the adverse events might be related to the trial treatments.

Key Participants Requirements

Sex

All

Age

18 - N/A

Trial summary

Enrollment Goal

1584

Trial Dates

September 2021 - February 2026

Phase

Phase 3

Could I Receive a placebo

Yes

Products

Finerenone (BAY94-8862)

Accepts Healthy Volunteer

Where to participate

Status	Institution	Location
Completed	Shalby Hospital	Ahmedabad, 380054, India
Active, not recruiting	P. D. Hinduja Hospital and Medical Research Centre	Mumbai, 400016, India
Active, not recruiting	Osmania General Hospital	Telangana, 500012, India
Active, not recruiting	Providence Medical Research Center	Spokane Valley, 99204, United States
Active, not recruiting	Northwest Louisiana Nephrology	Shreveport, 71101, United States
Active, not recruiting	Johns Hopkins Hospital - Nephrology	Baltimore, 21287, United States
Active, not recruiting	Vanderbilt University Medical Center	Nashville, 37232, United States
Active, not recruiting	Geisinger Medical Center - Nephrology	Danville, 17822-9800, United States
Completed	Research by Design, LLC \| Chicago, IL	Chicago, 60643, United States
Withdrawn	W. G. (Bill) Hefner VA Medical Center	Salisbury, 28144, United States
Active, not recruiting	Balboa Research SMO+ - Chula Vista - West	Chula Vista, 91911, United States
Active, not recruiting	Nephrology Associates of Northern Virginia \| Fairfax, VA	Fairfax, 22033, United States
Completed	University of North Carolina at Chapel Hill \| Nephrology Department	Chapel Hill, 27514, United States
Completed	South Carolina Nephrology and Hypertension Center \| South Carolina Clinical Research LLC	Orangeburg, 29118, United States
Active, not recruiting	Central Georgia Kidney Specialists - Macon	Macon, 31201, United States
Completed	Temple University \| Nephrology	Philadelphia, 19140, United States
Active, not recruiting	University of California, Los Angeles \| UCLA Health Division of Nephrology	Los Angeles, 90095, United States
Not yet recruiting	Northwestern University \| Division of Nephrology and Hypertension	Chicago, 60611, United States
Active, not recruiting	Yale University \| Nephrology Clinical Research	New Haven, 06520, United States
Active, not recruiting	Grady Memorial Hospital - Endocrinology	Atlanta, 30303, United States
Active, not recruiting	DaVita Clinical Research \| North Houston, TX	Shenandoah, 77384, United States
Active, not recruiting	Rigshospitalet, Copenhagen University Hospital \| Department of Nefrology	Copenhagen, 2100, Denmark
Active, not recruiting	Region Midtjylland \| Regionshospitalet Godstrup - Nephrology Department	Herning, DK-7400, Denmark
Active, not recruiting	Region Sjælland \| Holbaek Sygehus - Cardiology department	Holbæk, 4300, Denmark
Active, not recruiting	Odense University Hospital \| Department of Kidney Medicine	Odense C, 5000, Denmark
Active, not recruiting	Hospital of South West Jutland \| Department of Endocrinology Research	Esbjerg, 6700, Denmark
Active, not recruiting	General Hospital of Athens LAIKO	Athens, 11527, Greece
Active, not recruiting	General Hospital of Thessaloniki Papageorgiou	Thessaloniki, 56403, Greece
Active, not recruiting	University General Hospital of Patras \| Nephrology Clinic	Patra, 26504, Greece
Active, not recruiting	PAPANIKOLAOU General Hospital Thessaloniki	Pilea Chortiatis, 57010, Greece
Active, not recruiting	HIPPOKRATION General Hospital of Athens	Athens, 115 27, Greece
Active, not recruiting	General Hospital of Arta \| Nephrology Department	Arta, 47100, Greece
Active, not recruiting	Istituto Di Ricerche Farmacologiche Mario Negri	Bergamo, 24020, Italy
Active, not recruiting	Istituti Clinici Scientifici Maugeri S.p.A._Pavia - Nefrologia	Pavia, 27100, Italy
Active, not recruiting	A.O.U. Universita' Degli Studi Della Campania Luigi Vanvitelli - Nefrologia	Napoli, 80131, Italy
Active, not recruiting	Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Nefrologia, Dialisi e Trapianto	Bologna, 40138, Italy
Active, not recruiting	Azienda Socio Sanitaria Territoriale Della Brianza_Ospedale Pio XI - Nefrologia e Dialisi	Desio, 20832, Italy
Withdrawn	Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli	Reggio Calabria, Italy
Not yet recruiting	A.O. Cannizzaro	Catania, MISSING, Italy
Active, not recruiting	Azienda USL IRCCS di Reggio Emilia_Arcispedale Santa Maria Nuova - S.C. Nefrologia e Dialisi	Reggio Emilia, 42123, Italy
Active, not recruiting	A.O.U. di Modena - Policlinico	Modena, 41100, Italy
Active, not recruiting	Azienda Ospedaliero Universitaria Parma - SC Nefrologia	Parma, 43126, Italy
Active, not recruiting	Hallym University Sacred Heart Hospital	Anyang-si, 14068, Korea,_republic_of
Active, not recruiting	Chung Nam National University Hospital	Daejeon, 35015, Korea,_republic_of
Active, not recruiting	The Catholic University of Korea, Incheon St.Mary's Hospital	Incheon, 21431, Korea,_republic_of
Active, not recruiting	Yonsei University Wonju Christian Hospital	Wonju, 26426, Korea,_republic_of
Active, not recruiting	Dongguk University Ilsan Hospital	Goyang-si, 10326, Korea,_republic_of
Active, not recruiting	Seoul National University Hospital	Seoul, 3080, Korea,_republic_of
Active, not recruiting	Všeobecná fakultní nemocnice v Praze	Praha 2, 12808, Czech Republic
Active, not recruiting	Nefrologicka ambulance	Praha 4, 140 00, Czech Republic
Active, not recruiting	MUDr.Petr Bucek s.r.o.	Frydek-Mistek, 738 01, Czech Republic
Completed	Vestra Clinics s.r.o.	Rychnov nad Kneznou, 516 01, Czech Republic
Active, not recruiting	Hospital Seri Manjung	Perak, 32040, Malaysia
Active, not recruiting	Hospital Raja Permaisuri Bainun	Perak, 30450, Malaysia
Active, not recruiting	Hospital Selayang	Shah Alam, 68100, Malaysia
Active, not recruiting	Hospital Tengku Ampuan Afzan	Pahang, 25100, Malaysia
Active, not recruiting	Hospital Sultan Abdul Halim	Kedah, 8000, Malaysia
Active, not recruiting	University Malaya Medical Centre	Kuala Lumpur, 59100, Malaysia
Completed	Hospital Pulau Pinang	Pulau Pinang, 10450, Malaysia
Active, not recruiting	Hospital Universitario 12 de Octubre \| Department of Nephrology	Madrid, 28041, Spain
Active, not recruiting	La Fe University and Polytechnic Hospital \| Nephrology Department	Valencia, 46026, Spain
Active, not recruiting	Complexo HU Ferrol \| Nefrología	Ferrol, 15405, Spain
Active, not recruiting	Hospital Principe de Asturias	Alcalá de Henares, 28805, Spain
Active, not recruiting	Hospital Universitario Ramon y Cajal \| Departamento de Medicina Interna	Madrid, 28034, Spain
Active, not recruiting	Ciutat Sanitaria i Universitaria de la Vall d'Hebron	Barcelona, 08035, Spain
Active, not recruiting	Hospital Clinico Universitario de Valencia \| Nephrology Department	MISSING, 46010, Spain
Active, not recruiting	Hospital Universitario Dr. Peset	Valencia, 46017, Spain
Active, not recruiting	Hospital Universitari de Bellvitge \| Bellvitge Biomedical Research Institute - Nephrology Department	L'Hospitalet de Llobregat, 8907, Spain
Active, not recruiting	Melbourne Renal Research Group	Reservoir, 3073, Australia
Active, not recruiting	Inje University Ilsan Paik Hospital	Goyang-si, 411-706, Korea,_republic_of
Active, not recruiting	Samsung Medical Center	Seoul, 06351, Korea,_republic_of
Active, not recruiting	Seoul National University Boramae Medical Center	Seoul, 7061, Korea,_republic_of
Active, not recruiting	Kyung Hee University Hospital at Gangdong	Seoul, 5278, Korea,_republic_of
Active, not recruiting	Taipei Medical University \| Clinical Research Center	Taipei, 110, Taiwan
Active, not recruiting	Barzilai Medical Center \| Department of Nephrology and Hypertension	Ashkelon, 7830604, Israel
Active, not recruiting	Meir Medical Center	Kfar Saba, 4428164, Israel
Active, not recruiting	Centro de Rehabilitacion Cardiovascular \| San Luis, Argentina	San Luis, D5700CGR, Argentina
Active, not recruiting	CEDIC Centro de Investigación Clínica \| Buenos Aires, Argentina	CABA, C1018DES, Argentina
Active, not recruiting	Herlev Hospital \| Nephrology Department	Herlev, 2730, Denmark
Completed	CTC Hodonín, s.r.o.	Hodonin, 695 01, Czech Republic
Withdrawn	Vseobecna fakultni nemocnice v Praze	Praha 2, 12808, Czechia
Active, not recruiting	Utah Kidney Research Institute \| Salt Lake City, UT	South Salt Lake, 84115, United States
Withdrawn	Louis Stokes Cleveland VA Medical Center	Cleveland, 44106, United States
Withdrawn	Renal and Transplant Associates of New England, PC	Springfield, 01107, United States
Active, not recruiting	Northeast Clinical Research Center \| Bethlehem, PA	Bethlehem, 18017, United States
Active, not recruiting	Florida Kidney Physicians - Boca Raton	Boca Raton, 33431, United States
Active, not recruiting	Clinical Advancement Center, PLLC	San Antonio, 78212, United States
Withdrawn	Office of Dr. James E. Race, MD	Dallas, 75224, United States
Completed	DaVita Clinical Research \| Middlebury, CT	Middlebury, 55404, United States
Active, not recruiting	DaVita Clinical Research \| Houston, TX	Houston, 77054, United States
Completed	SHATC Sveti Georgi - Pernik \| Pernik, Bulgaria	Pernik, 2300, Bulgaria
Active, not recruiting	Medical Center Hera \| Montana Branch	Montana, 3400, Bulgaria
Active, not recruiting	Diagnostic-Consultative Center XX \| Nephrology Department	Sofia, 1618, Bulgaria
Active, not recruiting	Medical Center ’’Nevromedics’’	Veliko Tarnovo, 5600, Bulgaria
Active, not recruiting	Medical Center ’’4Life’’	Burgas, 8000, Bulgaria
Active, not recruiting	Multiprofile Hospital for Active Treatment St. Ivan Rilski - Gorna Oryahovitsa \| Nephrology Department	Gorna Oryahovitsa, 5100, Bulgaria
Withdrawn	Center for Medical Research, LLC	Providence, 02908, United States
Active, not recruiting	Clinical Research Consultants	Kansas City, 64111, United States
Active, not recruiting	University of Texas Health Science Center at San Antonio \| Department of Medicine - Division of Nephrology	San Antonio, 78207, United States
Completed	University of Utah School of Medicine \| Kidney Research Clinic	Salt Lake City, 84132, United States
Completed	Balboa Research SMO+ - El Centro	El Centro, 92243, United States
Completed	Balboa Nephrology Medical Group - Poway	Poway, 92064, United States
Active, not recruiting	East Carolina University \| Nephrology & Hypertension	Greenville, 27834, United States
Completed	University of Iowa Hospitals & Clinics	Iowa City, 52242, United States
Active, not recruiting	University of Kansas	Kansas City, 66160, United States
Active, not recruiting	El Paso Medical Research Institute (MedResearch Inc) \| El Paso, TX	El Paso, 79902-4672, United States
Active, not recruiting	North America Research Institute \| NARI San Dimas, CA - Dr. Jamal	San Dimas, 91773, United States
Active, not recruiting	Eastern Nephrology Associates \| Wilmington	Wilmington, 28401, United States
Withdrawn	Univ of Chicago \| Hypertension Center	Chicago, 60637, United States
Active, not recruiting	Mendez Center For Clinical Research \| Woodbridge, VA	Woodbridge, 22192, United States
Active, not recruiting	Knoxville Kidney Center, PLLC	Knoxville, 37923-3624, United States
Active, not recruiting	University Hospitals \| UH Cleveland Medical Center - Division of Nephrology & Hypertension Research	Cleveland, 44106, United States
Completed	Research Management, Inc. \| Kansas Nephrology Research Institute, LLC	Wichita, 67214, United States
Active, not recruiting	Nephrology Associates, PC \| Southeastern Clinical Research Institute, LLC.	Augusta, 30904, United States
Completed	Chase Medical Research, LLC	Waterbury, 06708, United States
Active, not recruiting	Mountain Kidney & Hypertension Associates	Asheville, 28801, United States
Completed	Tufts Medical Center \| Nephrology Department	Boston, 02111, United States
Active, not recruiting	UNM Clinical and Translational Science Center	Albuquerque, 87131, United States
Withdrawn	Tidewater Kidney Specialists- Norfolk	Norfolk, 23510, United States
Active, not recruiting	Cleveland Clinic \| Urological and Kidney Department	Cleveland, 44195, United States
Active, not recruiting	DaVita Clinical Research \| Edina, MN	Edina, 55435, United States
Completed	University of Mississippi Medical Center \| Shafi Group	Jackson, 39216, United States
Active, not recruiting	University of Colorado \| Renal Research Office	Aurora, 80045, United States
Active, not recruiting	Iwate Prefectural Central Hospital	Morioka, 020-0066, Japan
Active, not recruiting	JA Toride Medical Center	Toride, 302-0022, Japan
Active, not recruiting	Tsuchiura Kyodo General Hospital	Tsuchiura, 300-0028, Japan
Active, not recruiting	Saitama Medical University Hospital	Irima-gun, 350-0495, Japan
Active, not recruiting	Japanese Red Cross Saitama Hospital	Saitama, 330-8553, Japan
Active, not recruiting	Juntendo University Urayasu Hospital	Urayasu, 279-0021, Japan
Active, not recruiting	Nihon University Itabashi Hospital	Itabashi-ku, 173-8610, Japan
Active, not recruiting	The University of Tokyo Hospital	Bunkyo-ku, 113-8655, Japan
Active, not recruiting	Tokyo Medical University Hospital	Shinjuku-ku, 160-0023, Japan
Completed	Tokyo Metropolitan Tama Medical Center	Fuchu, 183-8524, Japan
Active, not recruiting	Juntendo University Hospital	Bunkyo-ku, 113-8431, Japan
Active, not recruiting	Hiratsuka Kyosai Hospital	Hiratsuka, 254-8502, Japan
Active, not recruiting	Yokohama Sakae Kyosai Hospital	Yokohama, 247-8581, Japan
Active, not recruiting	Tokai University Hospital	Isehara, 259-1193, Japan
Active, not recruiting	Yokohama City University Hospital	Yokohama, 236-0004, Japan
Active, not recruiting	St. Marianna University Hospital	Kawasaki, 216-8511, Japan
Active, not recruiting	Saiseikai Yokohamashi Nanbu Hospital	Yokohama, 234-0054, Japan
Active, not recruiting	National Hospital Organization Kanazawa Medical Center \| Clinical Trial Management Office	Kanazawa, 920-8650, Japan
Active, not recruiting	University of Yamanashi Hospital	Chuo, 409-3898, Japan
Withdrawn	Japanese Red Cross Society Suwa Hospital	Suwa, 392-8510, Japan
Active, not recruiting	Shinshu University Hospital	Matsumoto, 390-8621, Japan
Active, not recruiting	Matsumoto City Hospital	Matsumoto, 390-1401, Japan
Active, not recruiting	Central Japan International Medical Center	Minokamo, 505-8510, Japan
Active, not recruiting	Seirei Hamamatsu General Hospital	Hamamatsu, 430-8558, Japan
Active, not recruiting	Kainan Hospital	Yatomi, 498-8502, Japan
Active, not recruiting	Daido Clinic	Nagoya, 457-8511, Japan
Active, not recruiting	Chubu Rosai Hospital	Nagoya, 455-8530, Japan
Active, not recruiting	Nagoya City University Hospital	Nagoya, 467-8602, Japan
Active, not recruiting	Osaka Rosai Hospital	Sakai, 591-8025, Japan
Active, not recruiting	Kobe University Hospital	Kobe, 650-0017, Japan
Active, not recruiting	Hyogo Prefectural Nishinomiya Hospital	Nishinomiya, 662-0918, Japan
Active, not recruiting	Nara Prefecture General Medical Center	Nara, 630-8581, Japan
Active, not recruiting	Kawasaki Medical School Hospital	Kurashiki, 701-0192, Japan
Active, not recruiting	Kokura Memorial Hospital	Kitakyushu, 802-8555, Japan
Completed	JCHO Kyushu Hospital	Kitakyushu, 806-8501, Japan
Active, not recruiting	Fukuoka University Hospital	Fukuoka, 814-0180, Japan
Active, not recruiting	Aso Iizuka Hospital	Iizuka, 820-8505, Japan
Active, not recruiting	Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro Hospital	Fukuoka, 811-0213, Japan
Active, not recruiting	Saga-Ken Medical Centre Koseikan	Saga, 840-8571, Japan
Active, not recruiting	Japanese Red Cross Kumamoto Hospital	Kumamoto, 861-8520, Japan
Active, not recruiting	SINACOR \| Culiacan, Mexico	Culiacán, 80230, Mexico
Active, not recruiting	Sitio Alfredo Chew Wong \| Aguascalientes, Mexico	Aguascalientes, 20124, Mexico
Active, not recruiting	Sociedad de Metabolismo y Corazon S.C. \| Veracruz, Mexico	Puerto de Veracruz, 91900, Mexico
Active, not recruiting	Fundacion Cardiovascular de Aguascalientes \| Aguascalientes, Mexico	MISSING, 20230, Mexico
Completed	Nefromed s.r.o.	Praha 6, 160 00, Czech Republic
Active, not recruiting	Nemocnice Znojmo	Znojmo, 669 02, Czech Republic
Active, not recruiting	Rabin Medical Center \| Beilinson Hospital - Internal Medicine C Department	Petach Tikva, 4941492, Israel
Active, not recruiting	Health Corporation of Galilee Medical Center	Nahariya, 2210001, Israel
Active, not recruiting	Clalit Health \| Soroka Medical Center - Internal Medicine Department	Beer Sheva, 8410101, Israel
Active, not recruiting	Chaim Sheba Medical Center	Ramat Gan, 5262000, Israel
Active, not recruiting	Assuta Ashdod Public Hospital (R.A)	Ashdod, 7747629, Israel
Active, not recruiting	Kaplan Medical Center	Rehovot, 7610001, Israel
Active, not recruiting	Shamir Medical Center (Assaf Harofeh)	Zerifin, 7030000, Israel
Active, not recruiting	Rambam Health Corporation	Haifa, 3109601, Israel
Active, not recruiting	Poria Medical Center \| Nephrology and Hypertension Department	Tiberias, 1528001, Israel
Active, not recruiting	Eastern Health Integrated Renal Service	Box Hill, 3128, Australia
Active, not recruiting	Sunshine Hospital	St. Albans, 3021, Australia
Active, not recruiting	Concord Repatriation General Hospital	Concord, 2139, Australia
Active, not recruiting	St George Hospital	Kogarah, 2217, Australia
Active, not recruiting	Illawarra Shoalhaven Local Health District	Wollongong, 2500, Australia
Active, not recruiting	Instituto de Investigaciones Clinicas de Mar del Plata \| Mar del Plata, Argentina	Mar del Plata, B7600FZ0, Argentina
Active, not recruiting	Centro de Investigaciones Clinicas del Litoral \| Santa Fe, Argentina	Santa Fe, S3000FWO, Argentina
Active, not recruiting	Asociacion de Fomento y Sala de Primeros Auxilios Alberto Mignaburu \| Berazategui, Argentina	Berazategui, B1837, Argentina
Active, not recruiting	Centro de Investigaciones Metabolicas \| Ciudad de Autonoma de Buenos Aires, Argentina	Ciudad Autónoma de Buenos Aire, C1056ABI, Argentina
Recruiting	Clinica de Nefrologia Urologia y Enfermedades Cardiovascular	Santa Fe, 3000, Argentina
Recruiting	Clinica Privada Velez Sarsfield	Córdoba, X5016KET, Argentina
Active, not recruiting	Saratov City Clinical Hospital #9	Saratov, 410030, Russia
Active, not recruiting	City Clinical Hospital of Emergency Care #1	Omsk, 644112, Russia
Active, not recruiting	Regional Clinical Hospital Yaroslavl	Yaroslavl, 150062, Russia
Completed	City Hospital #52	Moscow, 123182, Russia
Not yet recruiting	City clinical hospital #40 Sestroretsk	Sestroretsk, 197706, Russia
Not yet recruiting	City clinical hospital n.a. V.V. Vinogradov	Moscow, 117292, Russia
Completed	Kemerovo Regional Clinical Hospital	Kemerovo, 650066, Russia
Withdrawn	Perm Regional Hospital for War Veterans	Perm, 614097, Russian Federation
Withdrawn	1st Moscow State Medical University n.a. I.M.Sechenov	Moscow, 119991, Russian Federation
Active, not recruiting	Voronezh Regional Clinical Consultancy-Diagnostic Center	Voronezh, 394018, Russia
Active, not recruiting	Izhevsk City Clinical Hospital #9	Izhevsk, 426063, Russia
Not yet recruiting	First City Clinical Hospital n.a. E.E. Volosevich	Arkhangelsk, 163001, Russia
Completed	Rostov State Medical University	Rostov-on-Don, 344022, Russia
Completed	Limited liability company "MK-Med"	Saint-Petersburg, 197082, Russia
Withdrawn	Chelyabinsk City Clinical Hospital ¿6	Chelyabinsk, 454017, Russian Federation
Active, not recruiting	Chinese PLA General Hospital	Beijing, 100853, China
Active, not recruiting	The First Affiliated Hospital of Guangzhou University of TCM	Guangzhou, 510405, China
Active, not recruiting	Central Hospital of Minhang District, Shanghai	Shanghai, 201199, China
Active, not recruiting	Zhongda Hospital Southeast University	Nanjing, 210009, China
Active, not recruiting	Jiangsu Province Hospital of Chinese Medicine	Nanjing, 210029, China
Active, not recruiting	Daping Hospital, 3rd Affil Hosp. 3rd Military Med Univ PLA	Chongqing, 400042, China
Active, not recruiting	Sichuan University West China Hospital	Chengdu, MISSING, China
Active, not recruiting	The First Affiliated Hospital of Baotou Medical College	Baotou, 14010, China
Active, not recruiting	Huai'an First People's Hospital, Nanjing Medical University	Huai'An, 223300, China
Active, not recruiting	Shanghai Fifth People's Hospital,Fudan University	Shanghai, 200240, China
Active, not recruiting	The Second Hospital of Anhui medical university	Hefei, 230601, China
Active, not recruiting	The Second Hospital of Jilin University	Changchun, 130000, China
Active, not recruiting	Siping Central Hospital	Siping, MISSING, China
Active, not recruiting	Xinhua Hos Affiliated to SH Jiaotong Uni School of Medicine	Shanghai, 200092, China
Active, not recruiting	Hwa Mei Hospital, University of Chinese Academy Sciences	Ningbo, 31510, China
Active, not recruiting	SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos	Chengdu, 610072, China
Active, not recruiting	General Hospital of Ningxia Medical University	Yinchuan, 750004, China
Active, not recruiting	The First Affiliated Hospital of Dalian Medical University	Dalian, 116011, China
Completed	The First Affiliated Hospital of Xinjiang Medical University	Urumqi, 830011, China
Active, not recruiting	The Affiliated Hospital of Guizhou Medical University	Guiyang, 550004, China
Active, not recruiting	The First Affiliated Hospital of Xiamen University	Xiamen, 361003, China
Active, not recruiting	The First Affiliated Hospital of NanChang University	Nanchang, 330006, China
Active, not recruiting	Puai Hospital,Tongji Medical College, Huazhong Univ Sci&Tech	Wuhan, 430034, China
Active, not recruiting	Wuhan Hospital Of Traditional Chinese And Western Medicine	Wuhan, 430022, China
Recruiting	Zhujiang Hospital of Southern Medical University	Guangzhou, 510280, China
Active, not recruiting	Beijing Anzhen Hospital, Capital Medical University	Beijing, 100029, China
Active, not recruiting	Beijing Tsinghua Changgung Hospital	Beijing, 102218, China
Active, not recruiting	Renmin Hosp., Wuhan Univ.	Wuhan, 430040, China
Active, not recruiting	The First Affiliated Hospital of Jinan University	Guangzhou, 510630, China
Active, not recruiting	Jiangxi PingXiang people's Hospital	Pingxiang, 337055, China
Active, not recruiting	The First Affiliated Hospital of Xi'an Jiaotong University	Xi'an, 710061, China
Active, not recruiting	The First Affiliated Hospital of Wenzhou Medical Univ (New)	Wenzhou, 325000, China
Active, not recruiting	Lanzhou University Second Hospital	Lanzhou, 730030, China
Active, not recruiting	The First Affiliated Hospital of Bengbu Medical College	Bengbu, MISSING, China
Completed	Zhongshan Hospital, Fudan University	Shanghai, 200032, China
Withdrawn	Taizhou People's Hospital	Taizhou, 225317, China
Active, not recruiting	1st Peopl's Hosp of Changzhou 3rd Affil Hosp of Soochow Univ	Changzhou, 213003, China
Active, not recruiting	Tianjin Union Medicine Centre (People's Hospital of Tianjin)	Tianjin, 300121, China
Active, not recruiting	China-Japan Friendship Hospital	Beijing, 100029, China
Active, not recruiting	Severance Hospital, Yonsei University Health System	Seoul, 03722, Korea,_republic_of
Active, not recruiting	Korea University Ansan Hospital	Gyeonggi-do, 425-707, Korea,_republic_of
Active, not recruiting	BUNDANG CHA HOSPITAL	Seongnam-si, 13496, Korea,_republic_of
Active, not recruiting	Kangnam Sacred Heart Hospital	Seoul, 7441, Korea,_republic_of
Active, not recruiting	Far Eastern Memorial Hospital \| Nephrology Department	New Taipei City, 220, Taiwan
Active, not recruiting	Chang Gung Memorial Hospital at Linkou	Taoyuan, 33305, Taiwan
Active, not recruiting	National Taiwan University Hospital	Taipei, 100, Taiwan
Active, not recruiting	Chang Gung Memorial Hospital Kaohsiung	Kaohsiung, 833, Taiwan
Active, not recruiting	Taichung Veterans General Hospital	Taichung, 40705, Taiwan
Active, not recruiting	Changhua Christian Hospital	Changhua, 50006, Taiwan
Active, not recruiting	China Medical University Hospital	Taichung, 404327, Taiwan
Active, not recruiting	Queen Mary Hospital	Hong Kong, MISSING, Hong Kong
Active, not recruiting	Prince of Wales Hospital	Hong Kong, MISSING, Hong Kong
Active, not recruiting	Princess Margaret Hospital	Hong Kong, MISSING, Hong Kong
Active, not recruiting	Kanazawa University Hospital	Kanazawa, 920-8641, Japan
Withdrawn	Foshan First People's Hospital	Foshan, 528000, China
Active, not recruiting	Tung Wah Hospital	Sheung Wan, Hong Kong
Active, not recruiting	Hospital Kuala Lumpur	Kuala Lumpur, 50586, Malaysia
Active, not recruiting	Noble Hospital	Hadapsar, 411013, India
Active, not recruiting	All India Institute of Medical Sciences	Bhubaneswar, 751019, India
Active, not recruiting	Max Super Speciality Hospital, Saket	New Delhi, 110017, India
Active, not recruiting	Institute of Post-Graduate Medical Education and Research	Kolkata, 700020, India
Active, not recruiting	Azienda Socio Sanitaria Territoriale Ovest Milanese_Legnano - Nefrologia e Dialisi	Legnano, 20025, Italy
Active, not recruiting	Huizhou Central People's Hospital	Huizhou, 516001, China
Recruiting	Kangdong Sacred Heart Hospital	Teugbyeolsi, 134-701, Korea, Republic Of
Not yet recruiting	Fakultni nemocnice Ostrava	Ostrava, 708 52, Czech Republic
Active, not recruiting	Inje University Busan Paik Hospital	Busan, 47392, Korea,_republic_of
Active, not recruiting	The Catholic Univ. of Korea Eunpyeong St. Mary's Hospital	Seoul, 03312, Korea,_republic_of
Active, not recruiting	Singapore General Hospital	Singapore, 169608, Singapore
Active, not recruiting	Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit'	Thessaloniki, 54642, Greece
Active, not recruiting	Khoo Teck Puat Hospital	Singapore, 768828, Singapore
Active, not recruiting	Tan Tock Seng Hospital	Singapore, 308433, Singapore
Active, not recruiting	National University Hospital Medical Centre	Singapore, 119074, Singapore
Withdrawn	People's Friendship University of Russia	Moscow, 129327, Russian Federation
Withdrawn	Kazan State Medical University	Kazan, 420029, Russian Federation
Withdrawn	Pandy Kalman Korhaz	Gyula, 5700, Hungary
Active, not recruiting	Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz	Szombathely, 9700, Hungary
Active, not recruiting	Nagykanizsai Kanizsai Dorottya Korhaz	Nagykanizsa, 8800, Hungary
Not yet recruiting	Del-pesti Centrumkorhaz – Orszagos Hematologiai és Infektologiai Intezet	Budapest, 1097, Hungary
Completed	Pecsi Tudomanyegyetem Klinikai Kozpont	Pecs, 7624, Hungary
Active, not recruiting	Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.	Nyiregyhaza, 4400, Hungary
Active, not recruiting	Somogy Varmegyei Kaposi Mor Oktato Korhaz	Kaposvar, 7400, Hungary
Active, not recruiting	Tel-Aviv Sourasky Medical Center	Tel Aviv, 6423906, Israel
Active, not recruiting	Princess Alexandra Hospital Australia	Woolloongabba, 4102, Australia
Active, not recruiting	University General Hospital of Heraklion - Department of Paediatrics	Heraklion, 711 10, Greece
Active, not recruiting	Univ. General Hospital of Ioannina - Department of Paediatrics, Nephrology Unit	Ioannina, 45500, Greece
Active, not recruiting	SingHealth Polyclinics - Pasir Ris	Singapore, 519457, Singapore
Completed	Shree Siddhivinayak Maternity & Nursing Home	Nashik, 422002, India
Active, not recruiting	Hospital Tuanku Jaafar \| Nephrology Department	Negeri Sembilan, 70300, Malaysia
Recruiting	Centro de Investigación y Prevención Cardiovascular	Buenos Aires, C1061AAS, Argentina
Withdrawn	Core Research Group Pty Ltd \| Brisbane, Australia	Taringa QLD, 4068, Australia
Active, not recruiting	Centro de Investigaciones Medicas Lanus \| Buenos Aires, Argentina	Lanus, B1824, Argentina
Completed	Medical Center Zara-Med EOOD \| Nephrology Department	Stara Zagora, 6010, Bulgaria
Active, not recruiting	Viva Phoenix Medical Center \| Clinical Trials Department	Dobrich, 9300, Bulgaria
Active, not recruiting	Sunshine Coast University Hospital	Birtinya, 4575, Australia
Active, not recruiting	Centro Hospitalar de Lisboa Ocidental \| Clinical Research Department	Carnaxide, 2790-134, Portugal
Active, not recruiting	Hospital Garcia de Orta \| Research Department	Almada, 2805-267, Portugal
Active, not recruiting	Centro Hospitalar de Leiria \| Santo Andre Hospital - Research Center	Leiria, 2410-197, Portugal
Active, not recruiting	Centro Hospitalar do Medio Tejo \| Unidade de Torres Novas - Nephrology Department	Torres Novas, 2350-754, Portugal
Active, not recruiting	Centro Hospitalar Universitario de Lisboa Central \| Hospital Curry Cabral - Nephrology Department	Lisboa, 1069-166, Portugal
Active, not recruiting	Azienda Socio Sanitaria Territoriale Rhodense	Rho, 20017, Italy
Active, not recruiting	Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Nefrologia	Roma, 00168, Italy
Active, not recruiting	Royal London Hospital	London, E1 1BB, United Kingdom
Active, not recruiting	University Hospital of Wales	Cardiff, CF14 4XW, United Kingdom
Active, not recruiting	King’s College Hospital NHS Foundation Trust \| King's College Hospital - Neurology Department	London, SE5 9RS, United Kingdom
Active, not recruiting	Kent and Canterbury Hospital \| Renal Research Delivery Team	Canterbury, CT1 3NG, United Kingdom
Active, not recruiting	Gloucestershire Hospitals NHS Foundation Trust \| Gloucestershire Royal Hospital - Gloucestershire Retinal Research Group	Gloucester, GL1 3NN, United Kingdom
Completed	The First affiliated Hospital of Hebei North University	Zhangjiakou, 075000, China
Active, not recruiting	Qilu Hosp., Shandong Univ.	Jinan, 250000, China
Active, not recruiting	Northern General Hospital	Sheffield, S5 7AU, United Kingdom
Active, not recruiting	UZ Gent	GENT, 9000, Belgium
Active, not recruiting	CU Saint-Luc/UZ St-Luc	BRUXELLES - BRUSSEL, 1200, Belgium
Withdrawn	UZ Antwerpen - Nephrology	Edegem, 2650, Belgium
Active, not recruiting	AZ Groeninge Campus Kennedylaan \| Nephrology	Kortrijk, 8500, Belgium
Active, not recruiting	AZ Delta / Nephrology	Roeselare, 8800, Belgium
Active, not recruiting	UZ Leuven Gasthuisberg	LEUVEN, 3000, Belgium
Active, not recruiting	CHU de Liège	LIEGE, 4000, Belgium
Active, not recruiting	Jiangmen Wuyi Hospital of traditional Chinese Medicine	Jiangmen, 529099, China
Not yet recruiting	The People's Hospital of Guangxi Zhuang Autonomous Region	Nanning, 530021, China
Active, not recruiting	Nephrology Consultants, LLC	Huntsville, 35805-4104, United States
Active, not recruiting	Nephrology Associates of Northern Illinois and Indiana (NANI) - Hinsdale	Hinsdale, 60521, United States
Not yet recruiting	Frenova Renal Research \| Boise Kidney and Hypertension	Meridian, 83642, United States
Active, not recruiting	Hospital Kajang	Selangor, 43000, Malaysia
Active, not recruiting	Gamma Medical Research, Inc.	McAllen, 78503, United States
Terminated	St. Louis Heart & Vascular, PC	Saint Louis, 63136, United States
Completed	Research Physicians Network Alliance	Boca Raton, 33431, United States
Completed	Dallas Renal Group - Medical City	Dallas, 75230, United States
Active, not recruiting	Hospital del Mar \| Nephrology Department	Barcelona, 08003, Spain
Completed	Servicio Galego de Saude \| Hospital Publico da Marina - Department of Nephrology	Burela, 27880, Spain
Active, not recruiting	United Clinical Research & Innovations	South Gate, 90280, United States
Active, not recruiting	Wichita Nephrology Group, PA	Wichita, 67214, United States
Active, not recruiting	People's Hospital of Liuzhou City	Liuzhou, 545006, China
Active, not recruiting	Liuzhou Worker's Hospital	Liuzhou, 545005, China
Active, not recruiting	Privamed s.r.o.	Plzen, 323 33, Czech Republic
Active, not recruiting	Koshigaya Municipal Hospital	Koshigaya, 343-8577, Japan
Active, not recruiting	Kistarcsai Flor Ferenc Korhaz	Kistarcsa, 2143, Hungary
Active, not recruiting	Hospital Pakar Sultanah Fatimah	Muar, 84000, Malaysia
Active, not recruiting	AdventHealth Translational Research Institute	Orlando, 32804, United States
Active, not recruiting	Madras Medical College	Chennai, 600003, India
Active, not recruiting	Government Medical College Thiruvananthapuram	Thiruvananthapuram, 695011, India
Active, not recruiting	National Taiwan University Hospital, Hsin-Chu Branch	Hsin-Chu, 300, Taiwan
Active, not recruiting	Fakultní nemocnice Brno - Interní gastroenterologická klinika	Brno, 625 00, Czech Republic
Active, not recruiting	Mavani Research Center	Ahmedabad, 380052, India

Primary Outcome

Mean rate of change as measured by the total slope of eGFR from baseline to Month-32.
eGFR: Estimated glomerular filtration rate
Time Frame:
From baseline to month 32

Secondary Outcome

Time to the composite of kidney failure, sustained eGFR decline of >= 57%, heart failure hospitalization or Cardiovascular (CV) death
Time Frame:
Up to end of study visit (up to approximately 49 months)
Time to the composite of kidney failure or sustained eGFR decline of >= 57%
Time Frame:
Up to end of study visit (up to approximately 49 months)
Time to the composite to heart failure hospitalization or CV death
Time Frame:
Up to end of study visit (up to approximately 49 months)
Number of participants with Treatment-emergent adverse events (TEAEs), Treatment-emergent serious adverse events (TESAEs) and Adverse events of special interest (AESI)
Time Frame:
Up to approximately 50 months

Trial design

A randomized, double-blind, placebo-controlled, parallel-group, multicenter Phase 3 study to investigate the efficacy and safety of FInerenone, in addition to standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease

Trial Type

Interventional

Intervention Type

Drug

Trial Purpose

Treatment

Allocation

Randomized

Blinding

N/A

Assignment

Parallel Assignment

Trial Arms

Additional Information

Click here to find further information and, after study completion, the study results according to Bayer's transparency standards