stop_circleTerminated/Withdrawn
Prevention of stroke or systemic embolism, Atrial fibrillation
Bayer Identifier:
19767
ClinicalTrials.gov Identifier:
EudraCT Number:
EU CT Number:
2023-503794-38-00
A study to learn how well the study treatment asundexian works and how safe it is compared to apixaban to prevent stroke or systemic embolism in people with irregular and often rapid heartbeat (atrial fibrillation), and at risk for stroke
Trial purpose
Researchers are looking for a better way to treat people with atrial fibrillation (AF) and prevent stroke or systemic embolism (blood clots travelling through the blood stream to plug another vessel).
Atrial fibrillation is a condition of having irregular and often rapid heartbeat. It can lead to the formation of blood clots in the heart which can travel through the blood stream to plug another vessel, and like this lead to serious and life-threatening conditions, such as a stroke. A stroke occurs because the brain tissue beyond the blockage no longer receives nutrients and oxygen so that brain cells die. As strokes arising from atrial fibrillation can involve extensive areas of the brain, it is important to prevent them.
Blood clots are formed in a process known as coagulation. Medications are already available to prevent the formation of blood clots. When taken by mouth (orally), they are known as oral anticoagulants (OACs) including apixaban. OACs decrease the risk of the above-mentioned serious and life-threatening conditions. The main side effect of OACs is an increase of the risk of bleeding.
The study treatment asundexian is a new type of anticoagulant currently under development to provide further treatment options. Asundexian aims to further improve the standard of care with regard to the risk of bleeding.
The main purpose of this study is to collect more data about how well asundexian works to prevent stroke and systemic embolism and how safe it is compared to apixaban in people with atrial fibrillation and at high risk for stroke.
To see how well the study treatment asundexian works researchers compare:
• how long asundexian works well and
• how long apixaban works well
after the start of the treatment. Working well means that the treatments can prevent the following from happening:
• stroke and/or
• systemic embolism.
The study will keep collecting data until a certain number of strokes or embolisms happen in the study.
To see how safe asundexian is, the researchers will compare how often major bleedings occur after taking the study treatments asundexian and apixaban, respectively. Major bleedings are bleedings that have a serious or even life-threatening impact on a person’s health.
The study participants will be randomly (by chance) assigned to 1 of 2 treatment groups, A and B. Dependent on the treatment group, the participants will either take the study treatment asundexian by mouth once a day or apixaban by mouth twice a day for approximately 9 - 33 months.
Each participant will be in the study for approximately 9 - 34 months. There will be visits to the study site every 3 to 6 months and up to 7 phone calls. Those participants who do not want or are unable to have visits to the study site may join the study remotely in selected locations. The location name contains the abbreviation - DCT in such cases.
During the study, the study team will:
• take blood samples
• do physical examinations
• examine heart health using an electrocardiogram (ECG)
• check vital signs such as blood pressure and heart rate
• do pregnancy tests
• ask the participants questions about their quality of life
• ask the participants questions about how they are feeling and what adverse events they are having.
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.
Atrial fibrillation is a condition of having irregular and often rapid heartbeat. It can lead to the formation of blood clots in the heart which can travel through the blood stream to plug another vessel, and like this lead to serious and life-threatening conditions, such as a stroke. A stroke occurs because the brain tissue beyond the blockage no longer receives nutrients and oxygen so that brain cells die. As strokes arising from atrial fibrillation can involve extensive areas of the brain, it is important to prevent them.
Blood clots are formed in a process known as coagulation. Medications are already available to prevent the formation of blood clots. When taken by mouth (orally), they are known as oral anticoagulants (OACs) including apixaban. OACs decrease the risk of the above-mentioned serious and life-threatening conditions. The main side effect of OACs is an increase of the risk of bleeding.
The study treatment asundexian is a new type of anticoagulant currently under development to provide further treatment options. Asundexian aims to further improve the standard of care with regard to the risk of bleeding.
The main purpose of this study is to collect more data about how well asundexian works to prevent stroke and systemic embolism and how safe it is compared to apixaban in people with atrial fibrillation and at high risk for stroke.
To see how well the study treatment asundexian works researchers compare:
• how long asundexian works well and
• how long apixaban works well
after the start of the treatment. Working well means that the treatments can prevent the following from happening:
• stroke and/or
• systemic embolism.
The study will keep collecting data until a certain number of strokes or embolisms happen in the study.
To see how safe asundexian is, the researchers will compare how often major bleedings occur after taking the study treatments asundexian and apixaban, respectively. Major bleedings are bleedings that have a serious or even life-threatening impact on a person’s health.
The study participants will be randomly (by chance) assigned to 1 of 2 treatment groups, A and B. Dependent on the treatment group, the participants will either take the study treatment asundexian by mouth once a day or apixaban by mouth twice a day for approximately 9 - 33 months.
Each participant will be in the study for approximately 9 - 34 months. There will be visits to the study site every 3 to 6 months and up to 7 phone calls. Those participants who do not want or are unable to have visits to the study site may join the study remotely in selected locations. The location name contains the abbreviation - DCT in such cases.
During the study, the study team will:
• take blood samples
• do physical examinations
• examine heart health using an electrocardiogram (ECG)
• check vital signs such as blood pressure and heart rate
• do pregnancy tests
• ask the participants questions about their quality of life
• ask the participants questions about how they are feeling and what adverse events they are having.
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.
Key Participants Requirements
Sex
AllAge
18 - N/ATrial summary
Enrollment Goal
14830Trial Dates
December 2022 - January 2024Phase
Phase 3Could I Receive a placebo
NoProducts
Asundexian (BAY2433334)Accepts Healthy Volunteer
NoWhere to participate
Status | Institution | Location |
---|---|---|
Completed | OUS Ullevål Cardiology | Oslo, 450, Norway |
Completed | Diakonhjemmets sykehus | Oslo, 319, Norway |
Completed | Skedsmo Medisinske Senter | Skedsmokorset, 2020, Norway |
Completed | South Oklahoma Heart Research, LLC | Oklahoma City, 73135, United States |
Completed | Mt. Olympus Medical Research | Sugar Land, 77479, United States |
Completed | Styde Research LLC | Plano, TX | Plano, 75093, United States |
Completed | North Dallas Research Associate | McKinney, TX | McKinney, 75069-1780, United States |
Completed | LifeBridge Health | Sinai Hospital - Platelet and Thrombosis Research Department | Baltimore, 21215, United States |
Completed | Spectrum Clinical Research | Maryland Cardiovascular Specialists | Baltimore, 21229, United States |
Completed | Stavanger UHospital Cardiology | Stavanger, 4011, Norway |
Completed | AA Medical Research Center | Flint, MI | Flint, 48504, United States |
Completed | Johns Hopkins Hospital/Health System | Baltimore, 21287, United States |
Completed | Uniwersytecki Szpital Kliniczny w Bialymstoku | Bialystok, 15-276, Poland |
Completed | Tyler Cardiovascular Consultants | Tyler, TX | Tyler, 75701, United States |
Completed | Mayo Clinic - Rochester | Rochester, 55905, United States |
Withdrawn | Cozy Research | Zephyrhills, FL | Zephyrhills, 33541, United States |
Completed | Cardiovascular Research of Knoxville | Powell, 37849, United States |
Completed | Northwest Houston Clinical Research, PLLC - Houston Heart Center | Tomball, TX | Tomball, 77375, United States |
Completed | Southwest Family Medicine Associates | Dallas, TX | Dallas, 75235, United States |
Completed | Johns Hopkins University School of Medicine | CAPRES | Columbia, 21044, United States |
Completed | Medication Management | Greensboro - Cardiology | Greensboro, 27408, United States |
Completed | Clearwater Cardiovascular Associates | Clearwater, FL | Clearwater, 33756, United States |
Completed | Clinical Advancement Center, PLLC | San Antonio, 78212-4740, United States |
Completed | Cardiovascular Associates Research, LLC | Covington, 70433, United States |
Withdrawn | Colorado Springs Cardiology | Colorado Springs, 80923, United States |
Completed | NYU Langone Health | NYU Langone Medical Associates Chelsea - Cardiovascular Research | New York, 10001, United States |
Completed | Mobile Heart Specialists, PC | Mobile, 36608, United States |
Completed | Houston Methodist Hospital | Houston, 77030, United States |
Completed | M Health Fairview | Maplewood, 55109, United States |
Completed | Reid Physician Associates | Cardiology Department | Richmond, 47374, United States |
Completed | CHI Health Clinic Heart Institute - Grand Island | Grand Island, 68803, United States |
Completed | Advanced Heart Care, LLC | Bridgewater, NJ | Bridgewater, 08807, United States |
Completed | Prime Revival Reserach Institute, LLC | Denton, TX | Denton, 76201, United States |
Completed | Adventist HealthCare | White Oak Medical Center | Silver Spring, 20904, United States |
Not yet recruiting | The Valley Hospital, Inc. | Ridgewood, 07450, United States |
Completed | Accellacare | Mt. Pleasant, SC | Ladson, 29456, United States |
Completed | Interventional Cardiology Medical Group | West Hills, CA | West Hills, 91307, United States |
Completed | North Texas Research Associates | McKinney, 75071, United States |
Completed | Cardiovascular Research of Northwest Indiana, LLC. | Munster, IN | Hammond, 46320, United States |
Completed | PharmaTex Research, LLC | Amarillo, 79109, United States |
Completed | Holston Medical Group - Bristol | Bristol, 37620, United States |
Completed | Blue Coast Research Center, LLC | Vista, 92081, United States |
Not yet recruiting | Lifespan | The Miriam Hospital - Cardiovascular Research | Providence, 02906, United States |
Completed | Virginia Heart | Falls Church, 22042, United States |
Completed | Kettering Health Network | Research Institute | Kettering, 45429, United States |
Completed | Apex Research Foundation, LLC. | Jackson, TN | Jackson, 38301, United States |
Completed | Great Lakes Medical Research | Westfield, NY | Westfield, 14787, United States |
Completed | Cardiology Associates of Fairfield County, P.C. | Stamford, CT | Norwalk,, 06851, United States |
Withdrawn | Methodist Physicians Clinic | Omaha, 68114, United States |
Completed | Life Spring Research | Miami, FL | Miami, 33130, United States |
Completed | Research Integrity, LLC | Owensboro, 42303, United States |
Completed | Sparrow Clinical Research Institute | Sparrow Hospital - Clinical Research Department | Lansing, 48912, United States |
Completed | CHRISTUS Trinity | Mother Frances Louis and Peaches Owen Heart Hospital - Electrophysiology Clinic | Tyler, 75702, United States |
Completed | North Florida Foundation For Research And Education | Veterans Benefits Administration | Gainesville, 32608, United States |
Not yet recruiting | Inova Fairfax Hospital - Fairfax | Fairfax, 22031, United States |
Completed | Thomas Jefferson University Hospital | Philadelphia, 19107, United States |
Completed | Amicis Research Center | Northridge, CA | Northridge, 91324, United States |
Not yet recruiting | Carolina Heart Specialists | Lancaster, SC | Lancaster, 29720, United States |
Completed | Cottage Health | Santa Barbara Cottage Hospital - Cardiology Department | Santa Barbara, 93102, United States |
Completed | Region Midtjylland | Aarhus University Hospital - Heart Diseases - Clinical Research | Århus N, 8200, Denmark |
Completed | Region Midtjylland | Viborg Regional Hospital - Cardiology - Heart Research | Viborg, 8800, Denmark |
Completed | Region Midtjylland | Regionshospitalet Godstrup - Clinic for Heart Research | Herning, 7400, Denmark |
Recruiting | Sydvestjysk Sygehus Esbjerg | Kardiologisk Forskningsenhed | ESBJERG, 6700, Denmark |
Completed | Sygehus Lillebaelt | Kolding Sygehus - Medicinske Sygdomme | Kolding, 6000, Denmark |
Completed | Region Sjælland | Holbaek Sygehus - Cardiology department | Holbæk, 4300, Denmark |
Completed | Sjællands Universitetshospital Roskilde - Hormon og stofskiftesygdomme | Roskilde, 4000, Denmark |
Not yet recruiting | University of California, Irvine | Irvine, 92697, United States |
Completed | MedUni Wien | Innere Medizin II, Kardiologie | Vienna, 1090, Austria |
Completed | Elisabethinen Linz | Kardiologie, Angiologie & Intensiv Med | Linz, 4020, Austria |
Completed | MedUni Innsbruck | Kardiologie und Angiologie | Innsbruck, 6020, Austria |
Completed | Uniklinikum Salzburg|Innere Medizin II, Kardiologie | Salzburg, 5020, Austria |
Completed | MedUni Graz | Kardiologie | Graz, 8036, Austria |
Completed | Klinik Floridsdorf | Herz-, Gefaess- u. Kardio Ambulaz | Vienna, 1210, Austria |
Completed | LKH Feldkirch | Innere Medizin I mit Kardiologie | Feldkirch, 6800, Austria |
Completed | Krankenhaus St. Josef Braunau | Innere Medizin I | Braunau, 5280, Austria |
Completed | UK St. Poelten | Innere Med III | St. Poelten, 3100, Austria |
Completed | Kepler UK Linz | Kardiologie & Intensivmedizin Campus III | Linz, 4021, Austria |
Completed | Imed19-privat | Wien, 1190, Austria |
Completed | Landesklinikum Mistelbach|Kardiologie u. Internistische Med | Mistelbach, 2130, Austria |
Completed | Heart Vein & Vascular | Longwood, FL | Longwood, 32779, United States |
Completed | Northeast Cardiology Associates | Bangor, 04401, United States |
Completed | York Clinical Research, LLC | Norfolk, VA | Norfolk, 23504, United States |
Withdrawn | Salem VA Medical Center | Salem, 24153, United States |
Completed | Akershus University Hospital Cardiology Department | Nordbyhagen, 1478, Norway |
Completed | Nordlandssykehuset Bodø Cardio | Bodø, 8092, Norway |
Completed | Vestre Viken HF - Drammen Sykehus Cardiology | Drammen, 3004, Norway |
Completed | UNN Tromsø Cardiology Dep. | Tromsø, 9038, Norway |
Completed | Sykehus Østfold Kalnes Cardio | Fredrikstad, NO-1603, Norway |
Completed | Sykehuset i Gjøvik Medisinsk | Gjøvik, 2819, Norway |
Completed | Minneapolis Heart Institute | St. Paul, 55102, United States |
Completed | VA Long Beach Healthcare System | Long Beach, 90822, United States |
Completed | Cardiology Associates Research, LLC | Tupelo, 38801, United States |
Completed | Region Nordjylland | Hjoerring - Cardiology Department | Hjørring, DK-9800, Denmark |
Completed | Region Nordjylland | Aalborg University Hospital - Cardiology Department | Aalborg, 9000, Denmark |
Completed | UNN Harstad Medisinsk avdeling | Harstad, 9406, Norway |
Completed | Turun yliopistollinen keskussairaala | Turku, 20520, Finland |
Completed | Tays Sydänsairaala | Tampere, 33520, Finland |
Completed | HUS Jorvin sairaala | Espoo, 2740, Finland |
Not yet recruiting | University of South Alabama Medical Center | Mobile, 36617, United States |
Completed | Cardiology Associates Research Company | Daytona Beach, 32117, United States |
Completed | Cambridge Medical Trials | Alexandria, 71301, United States |
Completed | IU Health Physicians Cardiology | Indianapolis, 46202, United States |
Not yet recruiting | St. Mary's Medical Center | West Palm Beach - Neurology Department | West Palm Beach, 33407-2495, United States |
Recruiting | Garden State Heart Care | Manalapan, 07726, United States |
Completed | Samsung Medical Center | Seoul, 6351, Korea,_republic_of |
Completed | National University Hospital | Singapore, 119074, Singapore |
Completed | National Heart Centre Singapore | Singapore, 169609, Singapore |
Completed | NorthBay Clinical Research, LLC | Santa Rosa, CA | Santa Rosa, 95405, United States |
Completed | Aultman | Aultman Hospital Main Campus - Clinical Trials | Canton, 44710, United States |
Completed | Cardiology Consultants, PA | Daytona Beach, 32114, United States |
Completed | Division of Cardiovascular Research at Peconic Bay Med Ctr | Riverhead, 11901, United States |
Completed | IMA Clinical Research | Warren, NJ | Warren, 07059, United States |
Completed | Advanced Research for Health Improvement, LLC | Naples, FL | Naples, 34102, United States |
Completed | Oregon Health and Science University | Portland, 97239, United States |
Completed | The Lundquist Institute | Cardiology Department | Torrance, 90502-2004, United States |
Completed | Clinical Trials of America, Inc. | Mt. Airy, 27030, United States |
Completed | Odense University Hospital | Svendborg Hospital - Cardiovascular Research Unit | Svendborg, 5700, Denmark |
Completed | Capital Region | Gentofte Hospital - Cardiology Research | Hellerup, 2900, Denmark |
Recruiting | Capital Region | Herlev Hospital - Department of Heart Disease | HERLEV, 2730, Denmark |
Completed | Capital Region | Frederiksberg Hospital - Department of Cardiology Research | Frederiksberg, 2000, Denmark |
Completed | Capital Region | Hvidovre Hospital - Department of Cardiology | Hvidovre, 2650, Denmark |
Completed | Capital Region | Amager Hospital - Cardiology Outpatient Clinic | Copenhagen, 2300, Denmark |
Completed | Rikshospitalet Cardiology | Oslo, 27, Norway |
Completed | Sykehuset Lillehammer Medicine | Lillehammer, 2609, Norway |
Completed | Sykehuset Innlandet HF Elverum | Elverum, 2409, Norway |
Completed | Vestre Viken HF - Bærum Sykehus Cardiology | Gjettum, 1346, Norway |
Completed | Seoul National University Bundang Hospital | Seongnam-si, 13620, Korea,_republic_of |
Completed | Chonnam National University Hospital | Gwangju, 501-757, Korea,_republic_of |
Completed | Severance Hospital, Yonsei University Health System | Seoul, 03722, Korea,_republic_of |
Completed | Seoul National University Hospital | Seoul, 3080, Korea,_republic_of |
Completed | Keimyung University Dongsan Medical Center | Daegu, 42601, Korea,_republic_of |
Completed | Asan Medical Center | Seoul, 138-736, Korea,_republic_of |
Completed | Gachon University Gil Medical Center | Incheon, 21565, Korea,_republic_of |
Completed | The Catholic Univ. of Korea Eunpyeong St. Mary's Hospital | Seoul, 03312, Korea,_republic_of |
Completed | StudyCor Oy | Jyvaskyla, 40620, Finland |
Completed | Tan Tock Seng Hospital | Singapore, 308433, Singapore |
Completed | Changi General Hospital | Singapore, 529889, Singapore |
Completed | Ng Teng Fong General Hospital | Singapore, 609606, Singapore |
Completed | Sengkang General Hospital | Singapore, 544886, Singapore |
Completed | Rapid City Regional Hospital | Rapid City, 57701, United States |
Completed | Zaans Medisch Centrum | Hartvaatcentrum | ZAANDAM, 1502 DV, Netherlands |
Completed | Amphia Breda | Department of Cardiology, BMC Research | BREDA, 4818 CK, Netherlands |
Completed | Rijnstate | Arnhem - Cardiology Department - Cardio Research | ARNHEM, 6815 AD, Netherlands |
Completed | Spaarne Gasthuis | Haarlem Zuid - Cardiology | HAARLEM, 2035 RC, Netherlands |
Withdrawn | Mercy Research | Chesterfield, 63017, United States |
Withdrawn | ClinRx Research, LLC | Plano, 75024, United States |
Completed | Rama Research LLC | Marion, OH | Marion, 43302-6774, United States |
Completed | Accellacare | Ames, IA | Ames, 50010, United States |
Completed | Molde Sjukehus Medisinsk | Molde, 6407, Norway |
Completed | McLaren Health Care | McLaren Bay Region - Research Department | Bay City, 48708, United States |
Completed | Louisiana Heart Center Research - Slidell | Slidell, 70458, United States |
Not yet recruiting | University of Texas Medical Branch at Galveston | Galveston, 77555-0587, United States |
Completed | Integrity Clinical Research | Heller Heart Health | Delray Beach, 33446, United States |
Completed | Henry Ford Health System | Detroit, 48202, United States |
Completed | Hunter Holmes McGuire Veterans Affairs Medical Center | Richmond, 23249-0001, United States |
Not yet recruiting | Einstein Healthcare Network | Philadelphia, 19141, United States |
Completed | Midwest Cardiovascular Research and Education Foundation | Elkhart, IN | Elkhart, 46514, United States |
Completed | TCR Institute | Kingwood, 77339, United States |
Completed | Stern Cardiovascular Center | Germantown, 38138, United States |
Completed | Valley Clinical Trials, Inc. | Covina, CA | Covina, 91723, United States |
Completed | University of North Carolina at Chapel Hill | Cardiology Department | Chapel Hill, 27514, United States |
Completed | Main Line Health | Wynnewood, 19096, United States |
Recruiting | Centro de Investigación y Prevención Cardiovascular | General Arenales, C1061AAS, Argentina |
Completed | Tolna Varmegyei Balassa Janos Korhaz | Szekszárd, 7100, Hungary |
Completed | Nagykanizsai Kanizsai Dorottya Korhaz | Nagykanizsa, 8800, Hungary |
Completed | Pecsi Tudomanyegyetem Klinikai Kozpont | Pecs, 7624, Hungary |
Completed | Cardiomobile Egeszsegugyi Szolgaltato Kft. | Balatonfured, 8230, Hungary |
Completed | Somogy Varmegyei Kaposi Mor Oktato Korhaz | Kaposvar, 7400, Hungary |
Completed | Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft. | Nyiregyhaza, 4400, Hungary |
Completed | Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet | Budapest, 1024, Hungary |
Completed | Belinus Bt. | Debrecen, 4025, Hungary |
Completed | Borbanya Praxis Bt. | Nyiregyhaza, 4405, Hungary |
Completed | Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz | Szombathely, 9700, Hungary |
Completed | COROMED SMO KFT | Pecs, 7623, Hungary |
Completed | Dr. Nagy Laszlo Egyeni Egeszsegugyi Vallalkozo | Oroshaza, 5900, Hungary |
Completed | Cardiovascular Center of Sarasota Foundation for Research and Education | Sarasota, FL | Sarasota, 34239, United States |
Completed | Virginia Commonwealth University | Richmond, 23284, United States |
Withdrawn | Medicor Cardiology | Bridgewater, 08807, United States |
Completed | Cardiology Consultants of Philadelphia | Yardley | Yardley, 19067, United States |
Completed | Eastern Shore Research Institute, LLC | Fairhope, AL | Fairhope, 36532, United States |
Completed | Northshore Medical Center | Glenview, 60026, United States |
Completed | Texas Health Physicians Group - Fort Worth | Forth Worth, 76107, United States |
Not yet recruiting | South Texas Cardiovascular Consultants, PLLC | San Antonio, 78201, United States |
Withdrawn | Cardiac Study Center, Inc. | Tacoma, 98405, United States |
Not yet recruiting | Sanford USD Medical Center | Sioux Falls, 57117, United States |
Completed | Cardiology Partners Clinical Research Institute | Palm Beach Gardens Office | Palm Beach Gardens, 33410, United States |
Completed | CardioAlem Investigaciones | San Isidro, Argentina | San Isidro, B1642DCD, Argentina |
Completed | The Catholic University of Korea Seoul St. Mary's Hospital | Seoul, 137-701, Korea,_republic_of |
Completed | Hallym University Sacred Heart Hospital | Anyang-si, 14068, Korea,_republic_of |
Completed | Pusan National University Hospital | Busan, 49241, Korea,_republic_of |
Completed | Ajou University Hospital | Suwon, 443-721, Korea,_republic_of |
Completed | BUNDANG CHA HOSPITAL | Seongnam-si, 13496, Korea,_republic_of |
Completed | Chung-Ang University Hospital | Seoul, 156-755, Korea,_republic_of |
Completed | Uniklinikum Hamburg-Eppendorf|Klinik für Kardiologie | Hamburg, 20246, Germany |
Completed | Ev. Krankenhaus Hagen-Haspe|Kardiologie und Rhythmologie | Hagen, 58135, Germany |
Completed | Universitätsmedizin der Johannes Gutenberg Universität Mainz | Mainz, 55101, Germany |
Completed | Cardio Centrum Ludwigsburg | Ludwigsburg, 71634, Germany |
Completed | Sana-Klinikum Remscheid|Kardio, Angio, Pneumo u. Intensivmed | Remscheid, 42859, Germany |
Completed | Forschungszentrum Ruhr KliFoCenter GmbH | Witten, 58455, Germany |
Completed | Universitaets Herzzentrum Bad Krozingen | Bad Krozingen, 79189, Germany |
Completed | Klinikum Lüdenscheid - Märkische Kliniken GmbH | Lüdenscheid, 58515, Germany |
Completed | Cardiologicum Hamburg | Hamburg, 22041, Germany |
Completed | Hegau-Bodensee-Klinikum Singen|I. Medizinische Klinik | Singen, 78224, Germany |
Completed | Kliniken Maria Hilf GmbH | Mönchengladbach, 41063, Germany |
Completed | Klinikum Worms gGmbH|Kardiologie und Angiologie | Worms, 67550, Germany |
Completed | Praxisklinik Herz und Gefaesse|Kardiologische Ambulanz | Dresden, 1099, Germany |
Completed | Krankenhaus Dresden-Friedrichstadt | Dresden, 1067, Germany |
Completed | St. Vinzenz-Hospital|Innere Medizin III, Kardiologie | Koeln, 50733, Germany |
Withdrawn | Klinikum Frankfurt Hoechst|Kardiologisches Studienzentrum | Frankfurt am Main, 65929, Germany |
Completed | Kardiologische Praxis Hr. Dr. A. Al-Zoebi | Wermsdorf, 4779, Germany |
Completed | MEDICLIN Herzzentrum Lahr|Kardiologie | Lahr, 77933, Germany |
Not yet recruiting | Klinikum Fulda gAG|Medizinische Klinik I | Fulda, 36043, Germany |
Withdrawn | Universitaetsmedizin Rostock|Abteilung Kardiologie | Rostock, 18057, Germany |
Completed | Medizinische Hochschule Hannover|Kardiologie und Angiologie | Hannover, 30625, Germany |
Completed | UniKlinikum Aachen|Kardio, Angio, Intensivmedizin | Aachen, 52074, Germany |
Completed | Siteworks Pruefzentrum Voelklingen | Voelklingen, 66333, Germany |
Completed | St.Johannes-Hospital|Klinik fuer Innere Medizin I | Dortmund, 44137, Germany |
Completed | Josephs-Hospital|Kardiologie, Rhythmologie und Angiologie | Warendorf, 48231, Germany |
Completed | Klinische Forschung Dresden | Dresden, Germany | Dresden, 01069, Germany |
Completed | Klinische Forschung Hamburg GmbH | Hamburg, 20253, Germany |
Completed | Uni-Klinikum Heidelberg | Kardiologie Angiologie Pneumologie | Heidelberg, 69120, Germany |
Completed | University of Florida - Jacksonville | Jacksonville, 32209, United States |
Completed | Cardiology Partners Clinical Research Institute | Wellington Office | Wellington, 33449, United States |
Completed | NJ Heart | Linden, NJ | Linden, 07036, United States |
Completed | Cardiovascular & Vein Center of Florida | Bradenton, FL | Bradenton, 34209, United States |
Completed | St. Louis Heart & Vascular, PC | Saint Louis, 63136, United States |
Completed | Southwest Florida Research | Naples, FL | Naples, 34102-8143, United States |
Not yet recruiting | University of Pittsburgh Medical Center, Hamot | Clinical Trials and Research | Erie, 16507, United States |
Completed | Integrity Clinical Research | Florida Premier Cardiology | Boyton Beach, 33437, United States |
Not yet recruiting | Intermountain Healthcare | Cardiovascular Research Department | Murray, 84107, United States |
Completed | Ochsner Medical Center - New Orleans | New Orleans, 70121, United States |
Terminated | University of Colorado Hospital - Cardiology | Aurora, 80045, United States |
Completed | Hospital Universitario Virgen de la Victoria | Cardiology Department | Malaga, 29010, Spain |
Completed | Vall d'Hebron Barcelona Hospital Campus | Vall d'Hebron Hospital Universitario - Cardiology Department | Barcelona, 08035, Spain |
Completed | Hospital Universitario 12 de Octubre | Cardiology Department | Madrid, 28041, Spain |
Completed | Hospital de la Santa Creu i Sant Pau | Cardiology Department | Barcelona, 08025, Spain |
Completed | Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Cardiology - AF, Stroke Prevention | L'Hospitalet de Llobregat, 08907, Spain |
Completed | Hospital Clinico Universitario Virgen de la Arrixaca | Cardiology Department | Murcia, 30120, Spain |
Completed | La Fe University and Polytechnic Hospital | Cardiology Department | Valencia, 46026, Spain |
Completed | Hospital Universitario La Paz | IdiPAZ - Neurology Department | Madrid, 28046, Spain |
Completed | Hospital Universitario Central de Asturias | Servicio de Cardiologia | Oviedo, 33006, Spain |
Completed | Hospital Alta Resolucion de Utrera | Cardiology Service Department | Utrera, 41710, Spain |
Completed | Hospital Quironsalud Barcelona | Internal Medicine Department | Barcelona, 8023, Spain |
Completed | Jose Manuel Pascual Pascual S.A. | Hospital Virgen de las Montanas - Internal Medicine Department | Villamartin, 11650, Spain |
Completed | Jose Manuel Pascual Pascual S.A. | Hospital Virgen del Camino - Internal Medicine Department | Sanlucar de Barrameda, 11540, Spain |
Completed | Hospital General Universitario de Valencia | Cardiology Department | Valencia, 46014, Spain |
Completed | Complejo Hospitalario Universitario de Ferrol | Hospital Naval - Unidad de Hipertensión Arterial | Ferrol, 15405, Spain |
Completed | University Hospital of A Coruna | Cardiology department | A Coruña, 15006, Spain |
Completed | Hospital Universitario Virgen del Rocio | Hospital General - Departamento de Cardiologia y Cirugia Cardiovascular | Sevilla, 41013, Spain |
Completed | Hospital Universitario de La Princesa | Internal Medicine Department | Madrid, 28006, Spain |
Completed | Hospital Universitario Ramon y Cajal | Departamento de Medicina Interna | Madrid, 28034, Spain |
Completed | Hospital Alta Resolucion de Lebrija | Cardiology Service Department | Lebrija, 41740, Spain |
Completed | Hospital General Universitario Doctor Balmis de Alicante | Cardiology Department | Alicante, 03010, Spain |
Completed | Hospital Clinico Universitario de Santiago de Compostela | Cardiology Department | Santiago de Compostela, 15706, Spain |
Completed | Amsterdam UMC | Heart Centre - Curius Research Department | AMSTERDAM, 1105 AZ, Netherlands |
Completed | Martini Ziekenhuis, Locatie van Swieten | GRONINGEN, 9728 NT, Netherlands |
Completed | Albert Schweitzer Ziekenhuis | Dordwijk - Cardiology Department | DORDRECHT, 3318 AT, Netherlands |
Completed | Medisch Spectrum Twente | Thorax Centrum Twente - Foundation Cardiovascular Research and Education Enschede | ENSCHEDE, 7611 JH, Netherlands |
Completed | Universitetssjukhuset Örebro | Örebro, 701 85, Sweden |
Completed | SU/Östra | Göteborg, 416 85, Sweden |
Completed | Clemenstorget Hjärtmottagning | Lund, 222 21, Sweden |
Completed | Danderyds sjukhus | Stockholm, 182 88, Sweden |
Completed | Södersjukhuset AB | Stockholm, 118 83, Sweden |
Completed | Skellefteå Lasarett | Skellefteå, 931 86, Sweden |
Completed | Falu Lasarett | Falun, 791 82, Sweden |
Completed | Karolinska Universitetssjukhuset | Stockholm, 171 76, Sweden |
Completed | Skånes Universitetssjukhus | Lund, 222 42, Sweden |
Completed | SU/Mölndal | Mölndal, 431 80, Sweden |
Completed | Akademiska Sjukhuset | Uppsala, TBC, Sweden |
Completed | Norrlands Universitetssjukhus, Umea | Umea, 901 85, Sweden |
Completed | Västmanlands Sjukhus Västerås | Västerås, 721 89, Sweden |
Completed | Södra Älvsborgs Sjukhus | Borås, 501 82, Sweden |
Completed | Karolinska Universitetssjukhuset Huddinge Stockholm | Stockholm, 141 86, Sweden |
Completed | Helsingborgs Lasarett | Helsingborg, TBC, Sweden |
Completed | Rabin Medical Center | Clinical Trials Unit - Cardiology Department | Petah Tikva, 4941492, Israel |
Completed | Shamir Medical Center | Cardiology Department | Rishon LeZion, 6093000, Israel |
Completed | Tel Aviv Sourasky Medical Center | Ichilov General Hospital - Cardiology Department | Tel Aviv, 6423906, Israel |
Completed | Hadassah Hebrew University Hospital Ein Kerem | Jerusalem, 9112001, Israel |
Completed | Clalit Health | Meir Medical Center - Division of Cardiology - Electrophysiology and Arrhythmias Unit | Jerusalem, 9112001, Israel |
Completed | Clalit Health | Soroka Medical Center - Cardiology Department | Beer Sheva, 8410101, Israel |
Completed | Galilee Medical Center | Cardiology Department | Nahariya, 2210001, Israel |
Completed | Barzilai Ashkelon University Medical Center | Cardiology Department | Ashkelon, 7830604, Israel |
Completed | Rambam Health Care Campus | Cardiology Department - Cardiology Research Unit | Haifa, 3109601, Israel |
Completed | Kaplan Medical Center | Cardiology Department - Heart Institute Research | Rehovot, 7610001, Israel |
Completed | Poria Medical Center | Cardiovascular Department | Lower Galilee, 15208, Israel |
Completed | Ziv Medical Center | Cardiology Department | Zefat, 1311001, Israel |
Withdrawn | Chaim Sheba Medical Center | Ramat Gan, 5262000, Israel |
Completed | Assuta Hospital Be'er Sheva | Heart Institute - Clinics | Beer Sheva, 8489507, Israel |
Completed | Carmel Medical Center | Cardiology Department - Cardiac Catheterization Unit | Haifa, 3436212, Israel |
Completed | Hillel Yaffe Medical Center | Cardiology Department | Hadera, 3810101, Israel |
Completed | Clalit Health | Soroka Medical Center - Internal Medicine Department | Beer Sheva, 8410101, Israel |
Not yet recruiting | Tel-Aviv Sourasky Medical Center | Tel Aviv, 6423906, Israel |
Completed | Shaare Zedek Medical Center | The Jesselson Integrated Heart Center - Cardiology Department | Jerusalem, 9103102, Israel |
Completed | HaEmek Medical Center | Internal Medicine C Department - Research Unit | Afula, 1834111, Israel |
Completed | Samson Assuta Ashdod University Hospital | Cardiology Department | Ashdod, 7747629, Israel |
Completed | Bnai Zion Medical Center | Cardiology Department | Haifa, 3339419, Israel |
Completed | University Hospital for Active Treatment Tsaritsa Joanna - ISUL | Cardiology Clinic | Sofia, 1527, Bulgaria |
Completed | Second Medical Center Sofia EOOD | Sofia, 1202, Bulgaria |
Completed | Multiprofile Hospital for Active Treatment Knyaginya Klementina Sofia EAD | Cardiology Department | Sofia, 1233, Bulgaria |
Completed | Multiprofile Hospital for Active Treatment Medline | Cardiology Department | Plovdiv, 4000, Bulgaria |
Completed | SHATC Sveti Georgi - Pernik | Pernik, Bulgaria | Pernik, 2300, Bulgaria |
Completed | Multiprofile Hospital for Active Treatment Dr. Stefan Cherkezov | Cardiology Department | Veliko Tarnovo, 5000, Bulgaria |
Completed | Cardiohelp Medical Centre | Sofia, Bulgaria | Sofia, 1142, Bulgaria |
Completed | Medical centre Hipokrat - N EOOD | Plovdiv, 4000, Bulgaria |
Completed | Multiprofile Hospital for Active Treatment Sveta Sofia | Internal Diseases Department | Sofia, 1618, Bulgaria |
Completed | Multiprofile Hospital for Active Treatment | Shumen - First Department of Internal Medicine | Shumen, 9700, Bulgaria |
Completed | Multiprofile Hospital for Active Treatment Sveta Karidad | Cardiology Department | Plovdiv, 4004, Bulgaria |
Completed | Multiprofile Hospital for Active Treatment Puls | Clinical Trial Center | Blagoevgrad, 2700, Bulgaria |
Completed | Medical Center Avitsena Kardzhali | Cardiology Clinic | Kardzhali, 6600, Bulgaria |
Completed | Multiprofile Hospital for Active Treatment National Cardiology Hospital | Cardiology Department | Sofia, 1309, Bulgaria |
Completed | The University General Hospital for Active Care and Emergency Medicine Pirogov | Cardiology Department | Sofia, 1606, Bulgaria |
Completed | Diagnostic Consultative Center Ascendent | Sofia, Bulgaria | Sofia, 1202, Bulgaria |
Completed | Medical Center Zara-Med EOOD | Cardiology Department | Stara Zagora, 6010, Bulgaria |
Completed | Medical Center Rusemed EOOD | Ruse, Bulgaria | Ruse, 7000, Bulgaria |
Completed | Laboratorio de Hemostasia y Trombosis | Rosario, AR | Rosario, S2000DTB, Argentina |
Completed | Centro de Investigaciones Medicas Temperley | Buenos Aires, Argentina | Temperley, B1834GUK, Argentina |
Completed | Instituto De Investigaciones Clinicas Zarate | Zarate, Argentina | Zárate, B2800DGH, Argentina |
Completed | Hospital Italiano de La Plata | Clinical Research Department | La Plata, B1900, Argentina |
Withdrawn | Grupo Orono | Instituto Cardiovascular de Rosario - Insuficiencia Cardiaca y Trasplante Department | Rosario, 2000, Argentina |
Completed | Consultorios Integrados Rosario | Instituto Medico de la Fundacion de Estudios Clinicos | Rosario, S2000DEJ, Argentina |
Completed | Centro de Especialidades Medicas (Cemedic) | Cardiology Department | Villa Luro, C1440CFD, Argentina |
Completed | Medical Group Kosice s.r.o. | Kosice, Slovakia | Kosice, 04001, Slovakia |
Completed | Nemocnica s poliklinikou Brezno, n.o. | Brezno, 977 01, Slovakia |
Completed | Interna SK s.r.o. | Svidnik, 08901, Slovakia |
Completed | Kardiosanus | Bratislava, Slovakia | Bratislava, 84107, Slovakia |
Completed | KARDIO-ANGIO s.r.o. | Levice, 93401, Slovakia |
Completed | Kardiocentrum Nitra | Cardiology Clinic - Outpatient Department | Nitra, 949 01, Slovakia |
Completed | KardioMed | Outpatient Cardiology and Internal Medicine II Clinic | Lucenec, 984 01, Slovakia |
Completed | Medikard | Department of Internal Medicine | Presov, 08001, Slovakia |
Completed | Internal and Diabetes Clinic - IN-DIA s.r.o. | Lucenec, Slovakia | Lucenec, 984 01, Slovakia |
Completed | Medivasa s.r.o. | Zilina, 01001, Slovakia |
Completed | ALIAN s.r.o. | Bardejov, 085 01, Slovakia |
Completed | GALENUM s.r.o. | Bratislava, 821 07, Slovakia |
Completed | KaCH, s.r.o. | Nove Zamky, 940 02, Slovakia |
Completed | KARDIO 1 | Lucenec, Slovakia | Lucenec, 98401, Slovakia |
Completed | Kardiologicka ambulancia Trnava, MUDr. Vladimir Macek | Trnava, 91701, Slovakia |
Completed | BENIMED s.r.o. | Piestany, 92101, Slovakia |
Completed | KardioLEV s.r.o. | Levoca, 05401, Slovakia |
Completed | Specializovana nemocnica sv. Svorada Zobor, n.o. | Nitra, 949 88, Slovakia |
Completed | KARDIO R s.r.o. | Kosice, 040 11, Slovakia |
Completed | Kuopion yliopistollinen sairaala | Kuopio, FIN- 70029, Finland |
Completed | Oulun yliopistollinen sairaala | Oulu, 90220, Finland |
Completed | Health Step Finland Oy | Kuopio, 70210, Finland |
Not yet recruiting | Keski-Pohjanmaan keskussairaala | Kokkola, 67200, Finland |
Not yet recruiting | Päijät-Hämeen keskussairaala | Lahti, 15850, Finland |
Completed | P. Stradins Clinical University Hospital | Riga, LV-1002, Latvia |
Completed | Liepaja Regional Hospital | Liepaja, LV-3414, Latvia |
Completed | 1st Riga Clinical Hospital | Riga, LV-1001, Latvia |
Completed | P. Stradins Clinical University Hospital | Riga, LV-1002, Latvia |
Completed | Daugavpils Regional Hospital | Daugavpils, LV-5417, Latvia |
Completed | Lija Mora physician practice | Ogre, LV-5001, Latvia |
Completed | Doctor's Practice in Cardiology | Daugavpils, LV-5401, Latvia |
Completed | Riga East Clinical University Hospital "Gailezers" | Riga, LV-1038, Latvia |
Completed | Gita Rancane - cardiology private practice | Ventspils, LV-3601, Latvia |
Completed | Health Center 4 | Riga, LV-1012, Latvia |
Completed | SIA ARI Med | Daugavpils, LV-5401, Latvia |
Completed | Health Center Adoria | Riga, LV-1011, Latvia |
Not yet recruiting | Ospedale San Raffaele s.r.l. - Cardiologia Clinica | Milano, 20132, Italy |
Completed | Antwerp University Hospital | Cardiology Department | EDEGEM, 2650, Belgium |
Completed | UZ Leuven Gasthuisberg | LEUVEN, 3000, Belgium |
Completed | Jessa Ziekenhuis | Hasselt, 3500, Belgium |
Completed | AZ Delta | Clinical Trial Center - Cardiology | Roeselare, 8800, Belgium |
Completed | Imelda Vzw | Study Cardiology | Bonheiden, 2820, Belgium |
Completed | AZ Sint-Maarten | Duffel, 2570, Belgium |
Completed | Algemeen Ziekenhuis Klina | Cardiology Department | Brasschaat, 2930, Belgium |
Completed | Maria Middelares General Hospital | Cardiology Department | GENT, 9000, Belgium |
Completed | Groeninge Algemeen Ziekenhuis | Campus Kennedylaan - Cardiology Departement | Kortrijk, 8500, Belgium |
Completed | Ziekenhuis Oost-Limburg | Genk, Sint-Jan campus - Cardiology Department | Genk, 3600, Belgium |
Completed | ZNA Middelheim | Antwerp, 2020, Belgium |
Completed | Grand Hôpital de Charleroi | GILLY, 6060, Belgium |
Completed | Citadelle Hospital | Cardiology Department | LIEGE, 4000, Belgium |
Completed | CHC MontLégia Neurology Department | Liège, 4000, Belgium |
Completed | OL Vrouwziekenhuis - Campus Aalst | Aalst, 9300, Belgium |
Completed | Algemeen Stedelijk Ziekenhuis Campus Aalst | Aalst, 9300, Belgium |
Completed | University Hospital Louvain Namur | Godinne - Cardiology Department | Yvoir, 5530, Belgium |
Completed | Centro Hospitalar Universitario de Lisboa Norte | Heart and Vessels Department | Lisbon, 1649-035, Portugal |
Completed | Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center | Leiria, 2410-197, Portugal |
Completed | Hospital Garcia de Orta | Research Department | Almada, 2805-267, Portugal |
Completed | Centro Hospitalar Universitario Cova de Beira | Clinical Research Department | Covilha, 6200-251, Portugal |
Completed | Centro Clinico Academico Braga | Braga, Portugal | Braga, 4710-243, Portugal |
Completed | Ucardio | Cardiology Department | Riachos, 2350-325, Portugal |
Completed | Lusiadas | Hospital Lusiadas Lisboa - Lusiadas Knowledge Center | Lisboa, 1500-458, Portugal |
Completed | Hospital de Vila Franca de Xira | Centro de Desenvolvimento e Investigacao | Vila Franca de Xira, 2600-009, Portugal |
Completed | Instituto de Investigaciones Clinicas Bahia Blanca | Bahia Blanca, Argentina | Bahía Blanca, 8000, Argentina |
Completed | Centro de Investigaciones Metabolicas | Ciudad de Autonoma de Buenos Aires, Argentina | Buenos Aires, C1056ABJ, Argentina |
Completed | CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina | CABA, C1018DES, Argentina |
Completed | Instituto de Cardiologia de Corrientes Juana F. Cabral | Corrientes, Argentina | Corrientes, 3400, Argentina |
Completed | Instituto de Investigaciones Clínicas (IIC) San Nicolas | San Nicolas de los Arroyos, Argentina | San Nicolás, B2900DMH, Argentina |
Completed | Centro de Investigaciones Clinicas del Litoral | Santa Fe, Argentina | Santa Fe, S3000FWO, Argentina |
Completed | Investigaciones Clinicas Tucuman | San Miguel de Tucuman, Argentina | San Miguel de Tucumán, T4000ICL, Argentina |
Completed | Budapesti Uzsoki Utcai Korhaz | Budapest, 1145, Hungary |
Completed | Semmelweis University | Budapest, 1088, Hungary |
Completed | Komaromi Selye Janos Korhaz | Komarom, 2900, Hungary |
Completed | Borsod-Abauj-Zemplen Varmegyei Korhaz es Egyetemi Oktatokorhaz | Miskolc, 3526, Hungary |
Completed | Belvarosi Egeszseghaz Kft. | Zalaegerszeg, 8900, Hungary |
Withdrawn | Orszagos Mentalis, Ideggyogyaszati es Idegsebeszeti Intezet | Budapest, 1135, Hungary |
Completed | Beijing Anzhen Hospital, Capital Medical University | Beijing, 100029, China |
Completed | Hainan Provincial People's Hospital | Haikou, 570311, China |
Completed | The Second Affiliated Hospital of Nanjing Medical university | nanjing, 210000, China |
Completed | Zhongda Hospital Southeast University | Nanjing, 210009, China |
Completed | The Central Hospital of Wuhan, Tongji Medl Collg Huazhong... | Wuhan, 430014, China |
Completed | Puai Hospital,Tongji Medical College, Huazhong Univ Sci&Tech | Wuhan, 430034, China |
Completed | Beijing Tsinghua Changgung Hospital | Beijing, MISSING, China |
Completed | The First Affiliated Hospital of NanChang University | Nanchang, 330006, China |
Completed | Huai'an First People's Hospital, Nanjing Medical University | Huai'An, 223300, China |
Completed | Taizhou People's Hospital | Taizhou, MISSING, China |
Completed | Affiliated Hospital of Jiangsu University | JiangSu, 212001, China |
Completed | Qilu Hosp., Shandong Univ. | Jinan, TBC, China |
Completed | Taizhou Hospital of Zhejiang Province | Taizhou, 317099, China |
Completed | Hwa Mei Hospital, University of Chinese Academy Sciences | Ningbo, 31510, China |
Completed | Huashan Hospital, Fudan University | Shanghai, 200040, China |
Completed | The Third Hospital of Changsha | Changsha, 410011, China |
Completed | Affiliated Hangzhou First People's Hospital, Zhejiang Univ | Hangzhou, 310006, China |
Completed | The 2nd Affiliated Hospital of Guangzhou Medical University | Guangzhou, TBC, China |
Completed | Tonghua Central Hospital | Tonghua, 134001, China |
Completed | The Third Xiangya Hospital of Central South University | changsha, 410000, China |
Completed | Shaanxi Provincial People's Hospital | Xi'an, 710068, China |
Completed | The 1st Affiliated Hospital Fujian Medical University | Fuzhou, TBC, China |
Completed | Lanzhou University Second Hospital | Lanzhou, 730030, China |
Completed | Panjin Liaohe Oilfield Gem Flower Hospital | Panjin, 124010, China |
Completed | Tianjin People's Hospital | Tianjin, 300000, China |
Completed | Xinxiang Central Hospital | Xinxiang, 453000, China |
Completed | Jinan Central Hospital | Jinan, 250013, China |
Completed | The First Affiliated Hospital of Wenzhou Medical University | Wenzhou, 325000, China |
Completed | The First Affiliated Hospital of Guangzhou University of TCM | Guangzhou, 510405, China |
Completed | Guangdong Provincial People's Hospital | Guangzhou, 510000, China |
Completed | China-Japan Union Hospital of Jilin University | Changchun, 130031, China |
Completed | Daqing Oilfield General Hospital | Daqing, 163311, China |
Completed | Affiliated Hospital of Yangzhou University (Yangzhou First People's Hospital) | Yangzhou, 225012, China |
Completed | Nanjing Jiangning Hospital | Nanjing, 211103, China |
Completed | Northern Jiangsu People's Hospital | Yangzhou, 225001, China |
Completed | General Hospital of Ningxia Medical University | Yinchuan, 750004, China |
Completed | Peking Union Medical College Hospital CAMS | Beijing, 100730, China |
Completed | Hainan Third People's Hospital (Province Nongken Sanya Hopt) | Sanya, 572000, China |
Completed | Nanjing First Hospital | Nanjing, 210006, China |
Completed | East Coast Institute for Research | St. Augustine, FL | St. Augustine, 32086, United States |
Completed | Integrity Clinical Research | Cardiology Associates of South Florida | Boynton Beach, 33472, United States |
Completed | EMED Centrum Uslug Medycznych | Rzeszow, 35-205, Poland |
Completed | Unicardia Specjalistyczne Centrum Leczenia Ch.Serca i Naczyn | Krakow, 31-271, Poland |
Completed | MICS Centrum Medyczne Bydgoszcz | Bydgoszcz, 85-065, Poland |
Completed | NZOZ "Twoja Przychodnia" Sp. z o.o. | Lublin, 20-857, Poland |
Completed | Centrum Medyczne KerMed | Bydgoszcz, 85-231, Poland |
Completed | Uniwersyteckie Centrum Kliniczne | Gdansk, 80-214, Poland |
Completed | Futuremeds sp. z o. o. | Olsztyn, 10-010, Poland |
Completed | Samodzielny Publiczny Specjalistyczny Szpital Zachodni | Grodzisk Mazowiecki, 05 825, Poland |
Completed | CM MED-GASTR Sp. z o.o. | Lodz, 91-034, Poland |
Completed | "NOWE ZDROWIE-CK" KIELTUCKI I WSPOLNICY SPOLKA JAWNA | Staszow, 28-200, Poland |
Completed | Velocity Pulawy | Pulawy, 24-100, Poland |
Completed | KO-MED Centra Kliniczne Zamosc | Zamosc, 22-400, Poland |
Completed | 1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ w Lublinie | Lublin, 20-049, Poland |
Completed | KLIMED Marek Klimkiewicz | Bialystok, 15-704, Poland |
Completed | Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji | Warszawa, 02-637, Poland |
Completed | NZOZ Heureka | Piaseczno, 05-500, Poland |
Completed | Irmed Klimkiewicz, Rudziewicz-Kowalska Sp.j. | Piotrkow Trybunalski, 97-300, Poland |
Completed | Humanitas Mirasole S.p.A. - Centro Trombosi e Malattie Emorragiche | Rozzano, 20089, Italy |
Completed | ASUR Marche - Area Vasta 5 | Ascoli Piceno, 63074, Italy |
Completed | AUSL Toscana Sud-Est | Arezzo, 52044, Italy |
Completed | A.O.U. Policlinico Umberto I | Roma, 161, Italy |
Completed | A.O. di Perugia | Perugia, 6129, Italy |
Completed | A.O.U. Pisana | Pisa, 56126, Italy |
Completed | A.O.U. Careggi | Firenze, 50134, Italy |
Completed | Azienda Unita Sanitaria Locale Di Bologna_Ospedale Maggiore Pizzardi - Cardiologia | Bologna, 40133, Italy |
Completed | A.O.U. Policlinico Umberto I | Roma, 161, Italy |
Completed | ASL2 Lanciano-Vasto-Chieti | Chieti, 66013, Italy |
Completed | A.O.U. Maggiore della Carità | Novara, 28100, Italy |
Not yet recruiting | A.O.U. Policlinico G. Martino | Messina, 98124, Italy |
Completed | A.O.U. di Modena - Policlinico | Modena, 41100, Italy |
Completed | ULSS3 Serenissima | Venezia, 30174, Italy |
Completed | Ente Ecclesiastico Ospedale Generale Regionale Miulli | Bari, 70021, Italy |
Completed | ASST Papa Giovanni XXIII | Bergamo, 24127, Italy |
Completed | IRCCS Centro Cardiologico Monzino | Milano, 20138, Italy |
Completed | A.O.U. Ospedali Riuniti Foggia | Foggia, 71122, Italy |
Completed | A.O.R.N. Ospedali dei Colli (Monaldi-Cotugno-CTO) | Napoli, 80131, Italy |
Completed | ASST Sette Laghi | Varese, 21049, Italy |
Completed | A.O.U. di Ferrara | Ferrara, 44124, Italy |
Completed | A.O.U. di Padova | Padova, 35128, Italy |
Completed | A.O.U. di Parma | Parma, 43126, Italy |
Completed | Cambridge Cardiac Care Center | Cambridge, N1R 6V6, Canada |
Completed | Hospital da Senhora da Oliveira | Clinical Research Department | Guimaraes, Braga, 4835-044, Portugal |
Completed | Instituto de Investigaciones Clinicas de Mar del Plata | Mar del Plata, Argentina | Mar del Plata, B7600FZ0, Argentina |
Withdrawn | Hospital Privado de Comunidad | Clinical Research Department | Mar del Plata, B7602CBM, Argentina |
Withdrawn | Instituto Cardiovascular de Buenos Aires | Buenos Aires, Argentina | Buenos Aires, C1428ART, Argentina |
Completed | Centro de Investigaciones Medicas Lanus | Buenos Aires, Argentina | Lanus, B1824, Argentina |
Completed | Institut universitaire de cardiologie et de pneumologie de Q | Québec, G1V 4G5, Canada |
Completed | Centre intégré de santé et de services sociaux de Laval, Hôp | Laval, H7M 3L9, Canada |
Completed | QEII Health Sciences Centre | Halifax, B3H 3A7, Canada |
Completed | Hamilton Health Sciences | Hamilton, L8L 2X2, Canada |
Completed | St. Michael's Hospital | Toronto, M5B 1W8, Canada |
Completed | Victoria Heart Institute Foundation | Victoria, V8R 1B2, Canada |
Completed | Fraser Clinical Trials, Inc. | New Westminster, V3L 3W4, Canada |
Completed | Dr. James Cha | Oshawa, L1J2K1, Canada |
Completed | Sunnybrook Health Sciences Centre | Toronto, M4N 3M5, Canada |
Completed | Oakville Cardiovascular Research | Oakville, L6K 3W7, Canada |
Completed | Hamilton Medical Research Group | Hamilton, L8M 1K7, Canada |
Completed | Viacar Recherches Cliniques Inc. | Brossard, J4Z 2K9, Canada |
Completed | CIUSSS NÎM Hôpital Sacré-Coeur | Montreal, H4J 1C5, Canada |
Completed | CHUM - Centre hospitalier de l'Université de Montréal | Montreal, H2X 0C1, Canada |
Completed | Centricity Research Mirabel Multispecialty | Mirabel, J7J 2K8, Canada |
Withdrawn | Jewish General Hospital | Montreal, H3T 1E2, Canada |
Completed | Eskisehir Osmangazi Universitesi Tip Fakultesi | Eskisehir, 26480, Turkey |
Completed | Ataturk Universitesi Tip Fakultesi | Erzurum, 25240, Turkey |
Withdrawn | Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospit | Istanbul, 34846, Turkey |
Completed | Dokuz Eylul Universitesi Tip Fakultesi | Izmir, 35100, Turkey |
Completed | Erciyes Universitesi Tip Fakultesi | Kayseri, 38039, Turkey |
Completed | Kocaeli Universitesi Tip Fakultesi | Kocaeli, 41380, Turkey |
Completed | Afyonkarahisar Saglik Bilimleri Universitesi | Afyonkarahisar, 3218, Turkey |
Completed | Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H. | Istanbul, TBC, Turkey |
Completed | Kutahya Saglik Bilimleri Uni. Evliya Celebi Egitim ve Arasti | Kutahya, 43040, Turkey |
Completed | Akdeniz Universitesi Tip Fakultesi Hastanesi | Antalya, 7059, Turkey |
Completed | Istanbul Universitesi Cerrahpasa – Kardiyoloji Anabilim Dali | Istanbul, 34098, Turkey |
Completed | Marmara Uni. Tip Fak. Pendik EAH Kardiyoloji | Istanbul, 34899, Turkey |
Withdrawn | Cukurova Universitesi Tip Fakultesi Hastanesi | Adana, Turkey |
Withdrawn | Istanbul Universitesi Kardiyoloji Enstitusu | Istanbul, 34304, Turkey |
Completed | Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital | Ankara, 6800, Turkey |
Completed | Izmir Ekonomi Universitesi Medikal Point Hastanesi | Izmir, 35575, Turkey |
Completed | Baskent Universitesi Tip Fakultesi Hastanesi | Ankara, 6490, Turkey |
Completed | Adana Sehir Egitim ve Arastirma Hastanesi | Yüregir, 1370, Turkey |
Completed | Hitit Universitesi Tip Fakultesi | Corum, 19030, Turkey |
Completed | Saglik Bilimleri Univ. Samsun EAH Kardiyoloji Departmani | Samsun, 55090, Turkey |
Completed | CardioBlu | Unidade Sabin | Blumenau, 89010-500, Brazil |
Completed | Irmandade da Santa Casa de Misericordia de Porto Alegre | Hospital Sao Francisco - Centro Medico Pesquisa Clinica Cardiologia | Porto Alegre, 90020-090, Brazil |
Completed | Campinas Clinical Research Institute (IPECC) | Campinas, Brazil | Campinas, 13060-080, Brazil |
Completed | FZ Pesquisa e Servicos em Cardiologia | Porto Alegre, Brazil | Porto Alegre, 91350-200, Brazil |
Completed | Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research Center | Porto Alegre, 90035-903, Brazil |
Completed | Instituto do Coração de Marilia | Marilia, Brasil | Marília, 17515-000, Brazil |
Completed | Hospital e Maternidade Sao Luiz | São Paulo, 04321-150, Brazil |
Completed | Sociedade Hospitalar Angelina Caron | Departamento de Ensino e Pesquisa | Paraná, 83430-000, Brazil |
Completed | Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas | São Paulo, 13034-685, Brazil |
Completed | Cardresearch Cardiologia Assistencial e de Pesquisa | Belo Horizonte, Brazil | Belo Horizonte, 30150-240, Brazil |
Completed | Centro de Pesquisa Clinica do Coração | Aracaju, Brasil | Aracaju, 49055-530, Brazil |
Completed | Hospital das Clinicas da Universidade Federal de Goias | Centro de Pesquisa em Cardiologia | Goiânia, 74605-020, Brazil |
Completed | Instituto Dante Pazzanese de Cardiologia | Divisao de Pesquisa | São Paulo, 04012-909, Brazil |
Completed | Hospital Samaritano Paulista | Clinical Research Department | São Paulo, 01317-002, Brazil |
Completed | Centro Medico Sao Francisco | Curitiba, Brazil | Curitiba, 80810-050, Brazil |
Not yet recruiting | Geisinger Community Medical Center | Scranton, 18510, United States |
Not yet recruiting | Geisinger Wyoming Valley Medical Center | Wilkes-Barre, 18711, United States |
Completed | Capital Area Research | Camp Hill, PA | Camp Hill, 17011, United States |
Completed | Inspira Medical Centers | Clinical Research Office | Mullica Hill, 08062, United States |
Completed | Indago Research and Health Center | Hialeah, FL | Hialeah, 33012, United States |
Not yet recruiting | University of Pittsburgh Medical Center Health System | Pittsburgh, 15219, United States |
Completed | Kardio Egeszseghaz - Dr Amer Sayour Egyeni Vallakozo | Gyor, 9024, Hungary |
Withdrawn | Vasarhelyi Sarkanyfu Kft. (Porcika Klinika) | Hodmezovasarhely, 6800, Hungary |
Completed | Cardiocentro Ticino | Lugano, 6900, Switzerland |
Not yet recruiting | Universitätsspital Basel | Basel, 4056, Switzerland |
Completed | UniversitätsSpital Zürich | Zürich, 8091, Switzerland |
Completed | Kantonsspital Aarau | Aarau, 5001, Switzerland |
Completed | Inselspital Universitätsspital Bern | Bern, 3010, Switzerland |
Completed | Kantonsspital Baden | Baden, 5404, Switzerland |
Completed | Kantonsspital St. Gallen | Saint Gallen, 1009, Switzerland |
Completed | Doylestown Hospital | Doylestown, 18901, United States |
Completed | Atlanta Heart Specialists, LLC | Tucker, 30084, United States |
Not yet recruiting | University of Iowa | Iowa City, 52242, United States |
Withdrawn | Accel Research Sites | Atlanta Clinical Research Center - Atlanta, GA | Atlanta, 30342, United States |
Completed | Harbor - UCLA Medical Center | Torrance, 90502, United States |
Completed | Hospital Alemao Oswaldo Cruz | Centro Internacional de Pesquisa | Sao Paulo, 01321-001, Brazil |
Completed | Hospital Cardio Pulmonar | Salvador, Brazil | Salvador, 40170-130, Brazil |
Completed | Luz Saude | Hospital da Luz Setubal - Clinical Research Department | Setúbal, 2900-722, Portugal |
Completed | Hôpital Henri Mondor | Creteil, 94010, France |
Completed | Centre Hospitalier Régional - Saint Brieuc | SAINT BRIEUC, 22000, France |
Completed | Centre Hospitalier Départemental Vendée | LA ROCHE SUR YON cedex, 85925, France |
Completed | Centre Hospitalier Louis Pasteur | LE COUDRAY, 28630, France |
Completed | Centre Hospitalier - Valenciennes Cedex | Valenciennes, 59322, France |
Completed | Hôpital de Rangueil - Toulouse | TOULOUSE cedex, 31059, France |
Completed | Hôpital Trousseau - Tours | Chambray-lès-Tours, 37170, France |
Completed | Hôpital Pasteur - Nice | NICE, 6002, France |
Completed | Clinique Pasteur - Toulouse | Toulouse, 31076, France |
Completed | CHU GRENOBLE - Hopital Michallon | GRENOBLE Cedex 09, 38043, France |
Completed | Hopital Européen Georges Pompidou - Paris | PARIS CEDEX 15, 75908, France |
Completed | Hôpital Cardiologique - Pessac | PESSAC, 33604, France |
Completed | Hôpital Louis Pradel - Bron | BRON CEDEX, 69677, France |
Completed | Centre Hospitalier Intercommunal de la Côte Basque-Bayonne | BAYONNE, 64100, France |
Terminated | Centre de Cardiologie Nord - Saint Denis | SAINT DENIS, 93207, France |
Completed | Hôpital La Cavale Blanche - CHU de Brest | BREST, 29200, France |
Completed | Centre Hospitalier Universitaire - Angers | Angers, 49933, France |
Completed | Centre Hospitalier Universitaire de Nancy | VANDOEUVRE-LES-NANCY, 54500, France |
Completed | Hôpital Civil - Strasbourg | STRASBOURG, 67091, France |
Completed | Hôpital Dupuytren | LIMOGES CEDEX, 87042, France |
Completed | Nouvelles Cliniques Nantaises - Nantes | NANTES cedex 2, 44277, France |
Completed | Institut Mutualiste Montsouris | Paris, 75014, France |
Completed | Hôpital Guillaume et René Laennec - Nantes | Nantes, 44035, France |
Completed | Centre Hospitalier - Cholet | CHOLET, 49325, France |
Completed | Hôpital de la Pitié-Salpétrière | PARIS, 75651, France |
Completed | Hopital Carémeau - Nîmes | Nîmes, 30029, France |
Terminated | Hôpital Arnaud de Villeneuve - Montpellier | MONTPELLIER, 34059, France |
Completed | CHU de Caen - Hôpital Côte de Nacre | CAEN cedex 9, 14033, France |
Completed | Centre Hospitalier du Docteur Schnaffer - Lens | LENS, 62307, France |
Completed | Kansas Nephrology Physicians, PA | Wichita, 67226, United States |
Completed | Alta Pharmaceutical Research Center, LLC | Peachtree Corners, 30092, United States |
Completed | Nova Clinical Research | Brandenton, FL | Brandenton, 34209, United States |
Completed | Pennsylvania State University College of Medicine | Hershey, 17033, United States |
Not yet recruiting | Morehouse School of Medicine | Clinical Research Centre | Atlanta, 30303-3031, United States |
Completed | Universitair Medisch Centrum Groningen | GRONINGEN, 9713 GZ, Netherlands |
Completed | Treant locatie Scheper | Emmen, 7824 AA, Netherlands |
Completed | Spitatul Universitar de Urgenta Bucaresti | Bucuresti, 50098, Romania |
Completed | S.C. CARDIO MED S.R.L. | Targu Mures, 540124, Romania |
Completed | Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare | Baia Mare, 430031, Romania |
Completed | S.C. Sal Med SRL | Pitesti, TBC, Romania |
Completed | CMI. Dr. Podoleanu Cristian | Targu Mures, TBC, Romania |
Not yet recruiting | S.C. CARDIOMED S.R.L. Iasi | Iasi, 700732, Romania |
Completed | S.C Thera Card S.R.L | Brasov, 500102, Romania |
Completed | Timisoara Institute of Cardiovascular Diseases | Timisoara, 300310, Romania |
Withdrawn | Spitalul Clinic Judetean de Urgenta Oradea | Oradea, 410159, Romania |
Completed | Spitalul Clinic de Urgenta Sf. Ioan | Bucharest, 42122, Romania |
Completed | Niculae Stancioiu Heart Institute Cluj-Napoca | Cluj Napoca, 400001, Romania |
Completed | Emergency County Hospital, Braila | Braila, 810318, Romania |
Completed | Municipal Clinical Emergency Hospital of Timisoara | Timisoara, 300254, Romania |
Completed | Spitalul Clinic Colentina | Bucuresti, 20125, Romania |
Completed | Emergency Institute for Cardiovascular Diseases | Bucharest, 22322, Romania |
Completed | Emergency Institute of Cardiovascular Diseases & Transplant | Targu Mures, 540136, Romania |
Not yet recruiting | Sfantul Spiridon Emergency Clinical County Hospital | Iasi, 700111, Romania |
Completed | Cardiomed S.R.L | Cluj-Napoca, 400015, Romania |
Completed | Spitalul Clinic de Recuperare Cluj-Napoca | Cluj Napoca, 400300, Romania |
Completed | S.C. Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL | Brasov, 500283, Romania |
Not yet recruiting | Medical University of South Carolina - Cardiology | Charleston, 29425, United States |
Completed | Catharina Hospital | Cardiology Department | EINDHOVEN, 5623 EJ, Netherlands |
Completed | Staploe Medical Centre | Ely, CB7 5SQ, United Kingdom |
Completed | King's College Hospital - NHS Foundation Trust | London, SE5 9RS, United Kingdom |
Completed | Charing Cross Hospital | London, W6 8RF, United Kingdom |
Completed | Northwick Park Hospital | Harrow, HA1 3UJ, United Kingdom |
Completed | VieCuri - Medisch Centrum voor Noord-Limburg locatie Venlo | VENLO, 5912 BL, Netherlands |
Completed | University General Hospital of Athens "ATTIKON" | Chaidari, 12462, Greece |
Completed | Lister Hospital | Stevenage, SG1 4AB, United Kingdom |
Completed | St Richard's Hospital | Chichester, PO19 6SE, United Kingdom |
Completed | North Hampshire Hospital | Basingstoke, RG24 9NA, United Kingdom |
Completed | Poole Hospital NHS Trust | Poole, BH15 2JB, United Kingdom |
Withdrawn | HUS, Meilahden sairaala | Helsinki, FIN-00260, Finland |
Not yet recruiting | Terveystalo Pulssi | Turku, 20100, Finland |
Completed | The Van Weel-Bethesda Hospital | Research Department | Dirksland, 3247 BW, Netherlands |
Completed | Freeman Hospital | Newcastle, NE7 7DN, United Kingdom |
Completed | G. GENNIMATAS General State Hospital of Athens | Athens, 11527, Greece |
Completed | Konstantopoulio General Hospital of Nea Ionia - AGIA OLGA | Nea Ionia, 14233, Greece |
Completed | KAT General Hospital of Athens | Kifisia, 14561, Greece |
Completed | University General Hospital of Larissa | Larissa, 41110, Greece |
Completed | Hippokration General Hospital of Thessaloniki | Thessaloniki, 54642, Greece |
Completed | AHEPA University General Hospital of Thessaloniki | Thessaloniki, 54636, Greece |
Completed | Naval Hospital of Athens | Athens, 11521, Greece |
Withdrawn | General Hosp of Athens "Korgialenio-Benakeio" RCH | Ampelokipi - Athens, 11526, Greece |
Completed | University General Hospital of Alexandroupolis | Alexandroupolis, 68100, Greece |
Completed | University General Hospital of Patra | Patra, 26504, Greece |
Completed | HIPPOKRATION General Hospital of Athens | Athens, 115 27, Greece |
Completed | Thriassio General Hospital of Elefsina | Elefsina, 19018, Greece |
Withdrawn | Tzaneio General Hospital of Piraeus | Piraeus, 18536, Greece |
Completed | Univ. General Hospital of Larissa | Larissa, 41110, Greece |
Completed | University General Hospital of Ioannina | Ioannina, 45500, Greece |
Completed | University General Hospital of Athens "ATTIKON" | Chaidari, 12462, Greece |
Completed | AHEPA University General Hospital of Thessaloniki | Thessaloniki, 54636, Greece |
Completed | MITERA Hospital | Marousi, 15123, Greece |
Completed | General Hospital ASKLEPIEIO VOULAS | Voula, 16673, Greece |
Completed | Univ. General Hospital of Ioannina | Ioannina, 45500, Greece |
Completed | Craigavon Area Hospital | Craigavon, BT63 5QQ, United Kingdom |
Completed | Montreal Heart Institute | Montréal,, H1T 1C8, Canada |
Completed | Interior Health - Royal Inland Hospital | Kamloops,, V2C 2T1, Canada |
Completed | G.A. Research Associates, Ltd. | Moncton, E1G 1A7, Canada |
Completed | Heart Health Institute | Scarborough, M1B 4Z8, Canada |
Completed | Dr. Louis Yao | York, M9N 1W4, Canada |
Completed | Women's College Hospital | WCH Main Site - Women's College Research Institute - Cardiology Department | Toronto, M5S 1B2, Canada |
Completed | Kawartha Cardiology Clinical Trials | Peterborough, K9J 0B2, Canada |
Completed | Milestone Research | London, N5W 6A2, Canada |
Completed | London Health Sciences Centre | University Hospital - London Heart Rhythm Program - Cardiology | London, N6A5A5, Canada |
Completed | Niagara Health - St. Catharines Site | St. Catharines, L2S 0A9, Canada |
Completed | CISSSL - Hopital Pierre-Le Gardeur | Terrebonne, J6V 2H2, Canada |
Completed | McGill University Health Centre – Glen Site | Montreal, H3G1A4, Canada |
Completed | CIUSSS Saguenay Lac-St-Jean | Chicoutimi, G7H 5H6, Canada |
Completed | CHU de Québec-Université Laval | Quebec, G1R 2J6, Canada |
Completed | CIUSSS de l’Estrie-CHUS, Hopital Fleurimont | Sherbrooke, J1H 5N4, Canada |
Completed | Diex Research Trois-Rivières Inc. | Trois-Rivieres, G9A 4P3, Canada |
Completed | Memorial University of Newfoundland | St. John’s, A1B3V6, Canada |
Completed | Ziekenhuis Amstelland | Amstelveen, 1186 AM, Netherlands |
Completed | Tergooiziekenhuizen-Blaricum | BLARICUM, 1261 AN, Netherlands |
Completed | Rode Kruis Ziekenhuis | Beverwijk, 1942 LE, Netherlands |
Completed | Gold Coast University Hospital | Southport, 4215, Australia |
Completed | Fiona Stanley Hospital | Murdoch, 6961, Australia |
Completed | General Hospital of Athens "ALEXANDRA" | Athens, 11528, Greece |
Completed | General Hospital of Athens "Evangelismos" | Athens, 10676, Greece |
Completed | The 1st Affiliated Hospital of Zhejiang University | Hangzhou, 310000, China |
Completed | Teda International Cardiovascular Hospital | Tianjin, 300457, China |
Completed | Beijing Tongren Hospital, Capital Medical University (West) | Beijing, 100730, China |
Withdrawn | Jiangsu Province Hospital of Chinese Medicine | Nanjing, 210029, China |
Completed | The 4th Affiliated Hospital of Harbin Medical University | Harbin, 150001, China |
Completed | The First Affiliated Hospital of Jinan University | Guangzhou, 510630, China |
Completed | Veterans Benefits Administration | Minneapolis VA Medical Center - Cardiology Department | Minneapolis, 55417, United States |
Completed | Erlanger Health, Inc. | Chattanooga, 37403, United States |
Completed | Duke Univ. Medical Center | Durham, 27710, United States |
Completed | Peace River Cardiovascular Center | Port Charlotte, FL | Port Charlotte, 33592, United States |
Completed | South Denver Cardiology Associates, PC | Littleton, 80120, United States |
Withdrawn | Stanford University | Stanford, 94305, United States |
Withdrawn | Mercy Health Research | St. Louis, 63141, United States |
Completed | Duke University | Duke Clinical Research Institute - Participant Research Operations | Durham, 27710-4000, United States |
Completed | Saules family medicine center | Kaunas, LT-49449, Lithuania |
Completed | LUHS Kauno Hospital (Josvainiu str.) | Kaunas, LT-47144, Lithuania |
Completed | LUHS Kauno Hospital (Laisves ave.) | Kaunas, LT-44320, Lithuania |
Completed | Mariu klinika JSC | Kaunas, 45462, Lithuania |
Completed | Klaipedos Jurininku Ligonine | Klaipeda, LT-92288, Lithuania |
Completed | Sarawak Heart Centre | Sarawak, 94300, Malaysia |
Completed | HagaZiekenhuis | Cardiology Department | DEN HAAG, 2545 AA, Netherlands |
Completed | Saxenburgh Medisch Centrum | Cardiology Department | Hardenberg, 7772 SE, Netherlands |
Completed | Gelre Apeldoorn Ziekenhuizen | Cardiology Department | Apeldoorn, 7334 DZ, Netherlands |
Completed | Bravis Ziekenhuis | Roosendaal - Cardiology Department | ROOSENDAAL, 4708 AE, Netherlands |
Completed | Arkansas Cardiology | Little Rock | Little Rock, 72205, United States |
Completed | MaineHealth Maine Medical Center | Maine Medical Partners Cardiology | Scarborough, 04039, United States |
Completed | Anderson Medical Group and Cardiology | Anderson Medical Research, LLC | Fort Washington, 20744, United States |
Completed | Texas Health Research & Education Institute | Fort Worth, 76104, United States |
Completed | Fakultni nemocnice Brno | Brno, 625 00, Czech Republic |
Completed | Fakultni Nemocnice Olomouc | Olomouc, 77900, Czech Republic |
Completed | Krajska Nemocnice Liberec | Liberec, 460 63, Czech Republic |
Completed | Nemocnice Slany | Slany, 274 01, Czech Republic |
Completed | Institut Klinicke a Experimentalni Mediciny | Praha 4, 140 21, Czech Republic |
Completed | Fakultni nemocnice v Motole | Praha 5, 150 06, Czech Republic |
Completed | Kardiologicka ambulance Brno s.r.o. | Brno, 612 00, Czech Republic |
Completed | Kardiologicka ambulance Cormedico | Bruntal, 792 01, Czech Republic |
Completed | Medicon Poliklinika Holesovice | Praha, 170 00, Czech Republic |
Completed | MATMED s.r.o. | Hodonin, 69501, Czech Republic |
Completed | MUDr. Michalik s.r.o. | Ostrava-Zabreh, 700 30, Czech Republic |
Completed | Amkardia s.r.o. | Brno, 639 00, Czech Republic |
Completed | Cevni Kulatak | Praha, 160 00, Czech Republic |
Completed | Cardio Research s.r.o. | Zlin, 760 01, Czech Republic |
Completed | Fakultni nemocnice Kralovske Vinohrady | Praha 10, 10034, Czech Republic |
Completed | Edmonton Cardiology Consultants | Edmonton, T5H 4B9, Canada |
Completed | Vancouver General Hospital | Vancouver, V5Z 1M9, Canada |
Completed | McMaster University Medical Centre | Hamilton, L8L 2X2, Canada |
Withdrawn | KINGSTON HEALTH SCIENCES CENTRE | Kingston, K7L 2 V7, Canada |
Withdrawn | Uppsala Clinical Research Center | Uppsala, 751 85, Sweden |
Completed | Centro Hospitalar e Universitario de Coimbra, E.P.E. | Department of Cardiology, Research Unit | Coimbra, 3004-561, Portugal |
Completed | Centro Hospitalar Universitario de Sao Joao | Polo Porto - Centro de Investigacao e Ensaios Clinicos | Porto, 4200-319, Portugal |
Completed | Carient Heart and Vascular | Manassas, 20109, United States |
Completed | NSC Cardiology | Johns Creek, GA | Cumming, 30041, United States |
Completed | Siauliai Republican hospital | Siauliai, 76231, Lithuania |
Completed | Vilnius University Hospital Santaros Klinikos | Vilnius, LT-08661, Lithuania |
Completed | Vilnius University Hospital Santaros Klinikos | Vilnius, LT-08661, Lithuania |
Completed | InMedica clinic Zaliakalnis | Kaunas, LT-50177, Lithuania |
Completed | Kardiologijos ir reabilitacijos klinika | Klaipeda, LT-91131, Lithuania |
Completed | Klaipeda Republican Hospital | Klaipeda, LT-92231, Lithuania |
Completed | Heart and Chest Hospital | Liverpool, L14 3PE, United Kingdom |
Completed | Countess of Chester Hospital | Chester, CH2 1UL, United Kingdom |
Withdrawn | Carmel Surgery | Darlington, DL3 8SQ, United Kingdom |
Completed | James Cook University Hospital South Tees | Middlesborough, TS43BW, United Kingdom |
Completed | AZ St-Lucas Campus St-Lucas - Cardiology | Gent, 9000, Belgium |
Completed | Wansbeck General Hospital | Ashington, NE63 9JJ, United Kingdom |
Completed | Hospital of LT University of Health Sciences Kaunas Clinics | Kaunas, LT-50161, Lithuania |
Withdrawn | Healthy Medical Center S.A.S | Zipaquira, 250252, Colombia |
Withdrawn | Fundación Centro de Obesidad y Metabolismo COMETA | Pästo, 520002, Colombia |
Withdrawn | Promotora Médica Las Américas S.A.- Clinica Las Americas | Medellin, 050023, Colombia |
Withdrawn | Centro de Diagnostico Cardiológico | Cartagena, 130001, Colombia |
Withdrawn | Instituto del Corazón de Bucaramanga | Bucaramanga, 680002, Colombia |
Withdrawn | Hospital San Vicente Fundación | Medellin, 050010, Colombia |
Completed | Lillestol Research LLC | Fargo, ND | Fargo, 58104, United States |
Completed | National Hospital Organization Kyoto Medical Center | Kyoto, 612-8555, Japan |
Completed | Chiba Tokushukai Hospital | Clinical Trial Center | Funabashi-city, 274-8503, Japan |
Completed | Tokyo Saiseikai Central Hospital | Clinical Research Center | Minato-ku, 108-0073, Japan |
Completed | National Hospital Organization Kanazawa Medical Center | Clinical Trial Management Office | Kanazawa, 920-8650, Japan |
Completed | Saiseikai Wakayama Hospital | Pharmaceutical department | Wakayama, 640-8158, Japan |
Completed | Nakamura Cardiovascular Clinic | Itoshima, 819-1104, Japan |
Completed | Oita Prefectural Hospital | Oita, 870-8511, Japan |
Completed | Hakodate National Hospital | Hakodate, 041-8512, Japan |
Completed | Tomakomai City Hospital | Tomakomai, 053-8567, Japan |
Completed | National Hospital Organization Takasaki General Medical Center | Takasaki, 370-0829, Japan |
Completed | Tokyo Angel Hospital | Clinical Trial Department | Hachioji, 193-0811, Japan |
Completed | Nihon University Itabashi Hospital | Itabashi-ku, 173-8610, Japan |
Completed | Tokyo Medical and Dental University Hospital | Bunkyo-ku, 113-8519, Japan |
Completed | Minamino Cardiovascular Hospital | Hachioji, 192-0918, Japan |
Completed | Kanazawa Medical University Hospital | Kahoku-gun, 920-0293, Japan |
Completed | Ishikawa Prefectural Central Hospital | Kanazawa, 920-8530, Japan |
Completed | Public Central Hospital of Matto Ishikawa | Clinical Trial Management Office | Hakusan city, 924-8588, Japan |
Completed | Japan Community Healthcare. Organization Chukyo Hospital | Nagoya, 457-8510, Japan |
Completed | Sakurabashi Watanabe Future Medical Hospital | Department of Cardiology | Umeda Kita-Ku, Osaka-shi, 5320001, Japan |
Completed | Yao Tokushukai General Hospital | Clinical Research Center | Yao-city, 581-0011, Japan |
Completed | The Veritas Hospital | Kawanishi, 666-0125, Japan |
Completed | Higashi Takarazuka Satoh Hospital | Takarazuka, 665-0873, Japan |
Completed | Akashi Medical Center | Hyogo, Japan | Akashi-city, 674-0063, Japan |
Completed | National Hospital Organization Hamada Medical Center | Hamada, 697-8511, Japan |
Completed | CMIC HealthCare Institute Co. Ltd. | Local IAA OCGMC - Okayama City Civic Hospital - Clinical Trial Centre | Okayama, 7008557, Japan |
Completed | CMIC HealthCare Institute Co. Ltd. | Okayama Rosai Hospital - Clinical Trial Centre | Okayama, 7028055, Japan |
Completed | Hiroshima City Hiroshima Citizens Hospital | Hiroshima, 730-8518, Japan |
Completed | Mitoyo General Hospital | Kagawa, Japan | Toyohama-Cho,Kanonji-City, 769-1695, Japan |
Completed | Kyushu Central Hospital | Fukuoka, 815-8588, Japan |
Completed | Steel Memorial Yawata Hospital | Kitakyusyu, 805-8508, Japan |
Completed | Munakata Suikokai General Hospital | Cardiology Department | Fukutsu, 811-3298, Japan |
Completed | Go Neurosurgical Clinic | Nakagawa, 811-1244, Japan |
Completed | Kokura Memorial Hospital | Kitakyushu, 802-8555, Japan |
Completed | Kumamoto Kinoh Hospital | Kumamoto, 860-8518, Japan |
Completed | Miyazaki Medical Association Hospital | Miyazaki, 880-2102, Japan |
Completed | Klinikum Klagenfurt | Innere Medizin und Kardiologie | Klagenfurt, 9020, Austria |
Withdrawn | Rodrigo Botero S.A.S | Medellin, 050021, Colombia |
Withdrawn | Clinica Cardio VID | Medellin, 050034, Colombia |
Withdrawn | Centro Cardiovascular Arístides Sotomayor | Cartagena, 130010, Colombia |
Withdrawn | Fundación Oftalmológica de Santander Carlos Ardila Lule | Florida Blanca, 681004, Colombia |
Withdrawn | IPS Centro Cientifico Asistencial S.A.S | Barranquilla, 080020, Colombia |
Withdrawn | Clínica Imbanaco S.A.S | Cali, 760042, Colombia |
Withdrawn | Clínica de la Costa SAS | Baranquilla, 080020, Colombia |
Withdrawn | Fundación Cardiovascular de Colombia | Floridablabca, 681011, Colombia |
Withdrawn | Fundacio del Caribe para la Investigacio Bio-Medica (BIOS) | Barranquilla, 080001, Colombia |
Withdrawn | Hospital Pablo Tobón Uribe | Medellin, 050034, Colombia |
Withdrawn | Julian Coronel Private Practice | Cali, TBC, Colombia |
Completed | Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department | Petach Tikva, 4941492, Israel |
Completed | Centro Hospitalar de Lisboa Ocidental | Clinical Research Department | Lisboa, 1449-005, Portugal |
Completed | Centre Hospitalier Gustave Dron - Tourcoing | TOURCOING, 59280, France |
Completed | Universitetssjukhuset i Linköping | Linköping, 581 85, Sweden |
Completed | University of Alberta Hospital | Edmonton, T6G 2B7, Canada |
Terminated | St. Joseph's Healthcare - Hamilton | Hamilton, L8N 4A6, Canada |
Completed | Vanderbilt University Medical Center | Nashville, 37232, United States |
Not yet recruiting | Northwestern University | Chicago, 60611, United States |
Completed | Baptist Heart and Vascular/Cardiology Consultants | Pensacola, 32503, United States |
Completed | Sound Medical Research | Sound Medical Research of Port Orchard | Port Orchard, 98366, United States |
Completed | Taipei Veterans General Hospital | Taipei, 11217, Taiwan |
Completed | National Cheng Kung University Hospital | Tainan, 704, Taiwan |
Completed | Chang Gung Memorial Hospital Kaohsiung | Kaohsiung, 833, Taiwan |
Completed | Fakultni nemocnice Plzen | Plzen, 301 00, Czech Republic |
Completed | Benedor s.r.o. | Ostrava - Poruba, 708 68, Czech Republic |
Completed | Mrozek kardiologie | Frydek-Mistek, 73801, Czech Republic |
Completed | Sapporo Higashi Tokushukai Hospital | Sapporo, 065-0033, Japan |
Completed | Miyanosawa Clinic of Internal Medicine and Cardiology | Sapporo, 063-0826, Japan |
Completed | Sainokuni Higashiomiya Medical Center | Saitama, 331-8577, Japan |
Completed | Ageo Central General Hospital | Ageo, 362-8588, Japan |
Completed | CliniPro Co.,Ltd. | Tokyo-Eki Center-building Clinic - Tokyo, Japan | Chuo-ku, 103-0027, Japan |
Completed | NewHeart Watanabe Institute | Suginami-ku, 168-0065, Japan |
Completed | National Hospital Organization Tokyo Medical Center | Meguro-ku, 152-8902, Japan |
Completed | Hayama Heart Center | Clinical Trial Center | Miura-gun, 240-0116, Japan |
Completed | Asama Nanroku Komoro Medical Center | Komoro, Japan | Komoro, 384-8588, Japan |
Completed | Japan Red Cross Society Azumino Hospital | Azumino, 399-8292, Japan |
Completed | Gifu Heart Center | Gifu, 500-8384, Japan |
Completed | Omihachiman Community Medical Center | Omihachiman, 523-0082, Japan |
Completed | Kishiwada Tokushukai Hospital | Kishiwada, 596-0042, Japan |
Completed | Osaka Saiseikai Nakatsu Hospital | Osaka, 530-0012, Japan |
Completed | Japan Community Health Care Organization Osaka Hospital | Osaka, 553-0003, Japan |
Completed | Hyogo Prefectural HarimaHimeji General Medical Center | Himeji, 670-8560, Japan |
Completed | JCHO Tokuyama Central Hospital | Shunan, 745-8522, Japan |
Completed | Chikamori Hospital | Kochi, 780-8522, Japan |
Completed | Yanagawa Hospital | Yanagawa-city, 832-0077, Japan |
Completed | Tenyoukai Central Clinic | Kagoshima, 892-0822, Japan |
Completed | Oosumikanoya Hospital | Kanoya, 893-0015, Japan |
Completed | Yokohama City University Medical Center | Yokohama, 232-0024, Japan |
Completed | Centro Hospitalar de Tamega e Sousa | Hospital Padre Americo - Cardiology Department | Guilhufe, 4564-007, Portugal |
Completed | National Taiwan University Hospital | Taipei, 100, Taiwan |
Completed | Taipei Medical University | Clinical Research Center | Taipei, 110, Taiwan |
Completed | Chang Gung Memorial Hospital at Linkou | Taoyuan, 33305, Taiwan |
Completed | Taichung Veterans General Hospital | Taichung, 40705, Taiwan |
Completed | Changhua Christian Hospital | Changhua, 50006, Taiwan |
Completed | Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung City, 807377, Taiwan |
Completed | Mackay Memorial Hospital - Hsinchu Branch | Hsinchu, 300, Taiwan |
Completed | Chi Mei Medical Center | Taikang, 71004, Taiwan |
Completed | Mackay Memorial Hospital | Taipei, 104, Taiwan |
Completed | China Medical University Hospital | Taichung, 404327, Taiwan |
Completed | Taipei Municipal Wanfang Hospital | Taipei, 116, Taiwan |
Completed | National Yang Ming Chiao Tung University Hospital | Yilan, 260006, Taiwan |
Completed | MacKay Memorial Hospital Tamsui Branch | New Taipei City, 25160, Taiwan |
Completed | Chung Shan Medical University Hospital | Taichung, 402306, Taiwan |
Completed | Mita Internist and Cardiology Clinic | Hokkaido, Japan | Sapporo, 006-0852, Japan |
Completed | Teine Keijinkai Hospital | Sapporo, 006-8555, Japan |
Completed | Matsuda Cardiovascular clinic | Sapporo, 003-0026, Japan |
Completed | Hanaoka Seishu Memorial Hospital | Sapporo, 062-0003, Japan |
Completed | Asahikawa City Hospital | Asahikawa, 070-8610, Japan |
Completed | Iwate Prefectural Central Hospital | Morioka, 020-0066, Japan |
Completed | JA Toride Medical Center | Toride, 302-0022, Japan |
Completed | Ibaraki Prefectural Central Hospital | Kasama, 309-1793, Japan |
Completed | Dokkyo Medical University Hospital | Shimotsuga-gun, 321-0293, Japan |
Completed | Sanai hospital | Saitama, 338-0837, Japan |
Completed | Toho University Sakura Medical Center | Sakura, 285-8741, Japan |
Completed | Fujisawa City Hospital | Fujisawa, 251-8550, Japan |
Completed | Komatsu Municipal Hospital | Komatsu, 923-8560, Japan |
Completed | Shizuoka City Shizuoka Hospital | Shizuoka, 420-8630, Japan |
Completed | Japan Culture and Welfare Federation of Agricultural Cooperatives | Toyota Kosei Hospital | Toyota-City, 470-0396, Japan |
Completed | Osaka Saiseikai Senri Hospital | Suita, 565-0862, Japan |
Completed | Kobe City Medical Center General Hospital | Kobe, 650-0047, Japan |
Completed | Mazda Motor Corporation Mazda Hospital | Aki-gun, 735-8585, Japan |
Completed | Core Research Group Pty Ltd. | Brisbane, Australia | Taringa QLD, 4068, Australia |
Completed | University Malaya Medical Centre | Kuala Lumpur, 59100, Malaysia |
Completed | Sarawak General Hospital | Sarawak, 93400, Malaysia |
Completed | Hospital Universiti Sains Malaysia | Kelantan, TBC, Malaysia |
Completed | University Hospital Kebangsaan Malaysia | Cheras, 56000, Malaysia |
Completed | Hospital Al-Sultan Abdullah (UiTM Hospital) | Selangor, 42300, Malaysia |
Completed | Hospital Sultanah Aminah | Johor Bahru, 80100, Malaysia |
Completed | Institute Jantung Negara | Kuala Lumpur, 50400, Malaysia |
Completed | Hospital Sultan Abdul Aziz Shah | Selangor, 43400, Malaysia |
Completed | Hospital Seberang Jaya | Pulau Pinang, 13700, Malaysia |
Completed | Hospital Sultanah Bahiyah | Alor Setar, 5460, Malaysia |
Completed | Hakodate Municipal Hospital | Hakodate, 041-8680, Japan |
Completed | The Sakakibara Heart Institute of Okayama | Okayama, 700-0804, Japan |
Completed | Kagawa Prefectural Central Hospital | Takamatsu, 760-8557, Japan |
Completed | Kagoshima Medical Center | Kagoshima, 892-0853, Japan |
Completed | R.I.A.C Naha City Hospital | Naha, 902-8511, Japan |
Completed | Hospital Pedro Hispano | Clinical Research Center | Matosinhos, 4464-513, Portugal |
Withdrawn | Hospital de Cascais Dr. Jose de Almeida | Clinical Investigation Center | Alcabideche, 2755-009, Portugal |
Completed | Hospital Raja Perempuan Zainab II | Kelantan, 15200, Malaysia |
Completed | Seremban Hospital Neurology | Seremban, 70300, Malaysia |
Completed | Hospital Tengku Ampuan Afzan | Pahang, 25100, Malaysia |
Completed | Rutas Eglites GP Practice | Kuldiga, LV-3301, Latvia |
Completed | Vidzemes Hospital | Valmiera, LV-4201, Latvia |
Completed | National Hospital Organization Disaster Medical Center | Tachikawa, 190-0014, Japan |
Completed | North Alps Medical Center Azumi Hospital | Kitaazumi-gun, 399-8695, Japan |
Completed | Fukuoka Shinmizumaki Hospital | Clinical Trial Management Office | Tateyashiki, Mizumakimachi, On, 807-0051, Japan |
Completed | Urasoe General Hospital | Clinical Research Support Center | Urasoe, 901-2102, Japan |
Completed | Yokohama Sakae Kyosai Hospital | Yokohama, 247-8581, Japan |
Completed | Kimitsu Chuo Hospital | Kisarazu, 292-8535, Japan |
Completed | Sendai Cardiovascular Center | Sendai, 981-3133, Japan |
Completed | Japan Culture and Welfare Federation of Agricultural Cooperatives | ShirakawaKosei General Hospital | Shirakawa-city, 105-0021, Japan |
Completed | Iwatsuki-minami Hospital | Saitama, 339-0033, Japan |
Completed | Kawaguchi Cardiovascular and Respiratory Hospital | Kawaguchi, 333-0842, Japan |
Completed | Nippon Medical School Chiba Hokusoh Hospital | Clinical Trial Office | Inzai, 270-1694, Japan |
Completed | Tokyo Yamate Medical Center | Shinjuku-ku, 169-0073, Japan |
Completed | Fukui General Clinic | Fukui, 910-0067, Japan |
Completed | Iida Hospital | Iida-city, 395-8505, Japan |
Withdrawn | Cardio Colombia S.A.S | Bogota, 110221, Colombia |
Withdrawn | Sociedad Médica Rionegro SOMER S.A. | Rionegro, 054040, Colombia |
Withdrawn | Fundación Hospital Universidad del Norte | Soledad, TBC, Colombia |
Withdrawn | IPS Centro de Investigaciones Clínicas Cardiomet Pereira | Pereira, 660003, Colombia |
Withdrawn | Centro de Atencion e Investigation Medica S.A.S. - CAIMED CH | Chia, 250002, Colombia |
Withdrawn | Corazón IPS S.A.S. | Barranquilla, 080020, Colombia |
Withdrawn | Hospital General de Medellin | Medellin, 050015, Colombia |
Withdrawn | Mediservis del Tolima IPS S.A.S | Ibague, 730006, Colombia |
Completed | University General Hospital of Heraklion | Heraklion, 711 10, Greece |
Completed | LAIKO General Hospital of Athens | Athens, 11527, Greece |
Completed | University General Hospital of Patra | Patra, 26504, Greece |
Completed | Nucleo de Pesquisa Clinica | Curitiba, Brazil | Curitiba, 80730-150, Brazil |
Completed | Machida Municipal Hospital | Machida, 194-0023, Japan |
Completed | Hamilton Med.Research Group - DCT | Hamilton, L8M 1K7, Canada |
Withdrawn | Toronto General Hospital UHN - DCT | Toronto, M5G 2C4, Canada |
Withdrawn | University Medical Center (UMC) Utrecht | Heart and Lungs Division | UTRECHT, 3584 CX, Netherlands |
Not yet recruiting | Medisch Centrum Haaglanden, Locatie Westeinde | Den Haag, 2512 VA, Netherlands |
Withdrawn | Stanford University Medical Center | Stanford, 94305, United States |
Not yet recruiting | St. Luke's Health System | St. Luke's Clinic - Idaho Cardiology Associates | Meridian, 83642, United States |
Completed | Jackson Heart Clinic | Jackson, MS | Jackson, 39216, United States |
Completed | Encore Research Group | Nature Coast Clinical Research – Inverness | Inverness, 34452, United States |
Not yet recruiting | Confluence Health | Wenatchee, 98801, United States |
Completed | Encore Research Group | St. Johns Center for Clinical Research | St. Augustine, 32081, United States |
Completed | ProMedica Toledo Hospital | Toledo, 43615, United States |
Completed | Sunshine Coast University Hospital | Birtinya, 4575, Australia |
Completed | Illawarra Shoalhaven Local Health District | Wollongong, 2500, Australia |
Completed | The Prince Charles Hospital | Herston, 4029, Australia |
Completed | John Hunter Hospital | New Lambton, 2305, Australia |
Completed | Grampians Health Ballarat | Ballarat, 3350, Australia |
Completed | Advara HealthCare Leabrook | Leabrook, 5068, Australia |
Completed | Concord Repatriation General Hospital | Concord, 2139, Australia |
Completed | Hospital Serdang | Selangor, 43000, Malaysia |
Completed | University Hospitals Leicester | Leicester, LE3 9QP, United Kingdom |
Completed | Chesterfield Royal Hospital | Chesterfield, S44 5BL, United Kingdom |
Completed | Glasgow Royal Infirmary | Stroke Unit | Glasgow, G4 0SF, United Kingdom |
Completed | Worcestershire Acute Hospital Trust | Worcester, WR5 1DD, United Kingdom |
Completed | Soho Health Centre, Future Meds | Birmingham, B21 9RY, United Kingdom |
Completed | Torbay Hospital | Torbay, TQ2 7AA, United Kingdom |
Completed | Future Meds - Bromborough | Wirral, CH62 6EE, United Kingdom |
Completed | Ely Bridge Medical Centre | Cardiff, CF5 4AD, United Kingdom |
Completed | Admiraal de Ruyterziekenhuis | Goes, 4462RA, Netherlands |
Completed | Capital Region | Nordsjaellands Hospital - Hillerod - Cardiology Department | Hilleroed, 3400, Denmark |
Completed | Buddhist Tzu-Chi General Hospital, Hualien | Hualien, 970, Taiwan |
Completed | Klinikum Wels-Grieskirchen | Innere Medizin II | Wels, 4600, Austria |
Completed | Tri-Service General Hospital | Taipei City, 114, Taiwan |
Completed | Cathay General Hospital | Taipei, 106, Taiwan |
Withdrawn | Accellacare Warwickshire | Coventry, CV3 4FJ, United Kingdom |
Completed | Barwon Health | Geelong, 3220, Australia |
Completed | Royal Adelaide Hospital | Adelaide, 5000, Australia |
Completed | South Western Sydney Local Health District | Liverpool Hospital - Stroke and Neurovascular Department | Liverpool, 2170, Australia |
Completed | Blacktown Hospital | Blacktownn, 2148, Australia |
Completed | Royal Melbourne Hospital | Parkville, 3050, Australia |
Completed | Eastern Health | BOX HILL, 3128, Australia |
Completed | Flinders Medical Centre | Bedford Park, 5042, Australia |
Completed | Royal Brisbane & Women's Hospital | Brisbane, 4029, Australia |
Completed | Advara HealthCare Joondalup | Perth, 6150, Australia |
Completed | The Canberra Hospital | Garran, 2605, Australia |
Completed | Nepean Hospital | Kingswood, 2747, Australia |
Completed | The Alfred Hospital | Melbourne, 3004, Australia |
Withdrawn | Westmead Hospital | Westmead, 2145, Australia |
Withdrawn | University of Adelaide | Adelaide, 5005, Australia |
Completed | Nightingale Research | Adelaide, 5000, Australia |
Completed | Queen Elizabeth Hospital AUS | Woodville South, 5011, Australia |
Completed | Baker Heart and Diabetes Institute | Hoppers Crossing, 3029, Australia |
Completed | Queen Elizabeth the Queen Mother Hospital | Margate, CT9 4AN, United Kingdom |
Withdrawn | Circuit Clinical | Orchard Park, 14127, United States |
Completed | SEC Clinical Research | Dothan, 36305, United States |
Completed | Baptist Health Medical Group - Louisville Cardiology | Louisville, 40207, United States |
Completed | Vrinnevisjukhuset | Norrköping, 601 82, Sweden |
Completed | David Turbay MD PLLC | El Paso, 79905, United States |
Completed | VA Greater Los Angeles Healthcare System | West Los Angeles VA Medical Center - Cardiology Department | Los Angeles, 90073-1003, United States |
Completed | ASL ROMA 2 | Roma, 157, Italy |
Completed | A.O Sant'Anna-San Sebastiano | Caserta, 81100, Italy |
Completed | ULSS2 Marca Trevigiana | Treviso, 31015, Italy |
Not yet recruiting | ULSS2 Marca Trevigiana | Treviso, 31015, Italy |
Withdrawn | A.O.U. Mater Domini | Catanzaro, 88100, Italy |
Completed | A.O.U. Ospedali Riuniti "Umberto I - G.M.Lancisi - G.Salesi" | Ancona, 60126, Italy |
Completed | ASST del Garda | Brescia, 25085, Italy |
Completed | A.O.U. Policlinico Federico II Napoli | Naples, 80131, Italy |
Completed | Hospital Universitario La Paz | Cardiology Department - AF, Stroke Prevention | Madrid, 28046, Spain |
Completed | Edith Wolfson Medical Center | Internal Medicine Department | Holon, 5822012, Israel |
Completed | TaNa Med Kft. | Mosonmagyarovar, 9200, Hungary |
Completed | Dr. Laszlo Elek Korhaz es Rendelointezet, Oroshaza | Oroshaza, 5900, Hungary |
Completed | Complex Rendelo Med Zrt. | Szekesfehervar, 8000, Hungary |
Withdrawn | Nograd Varmegyei Szent Lazar Korhaz, II. Belgyogyaszat-Kardiologia | Salgotarjan, 3100, Hungary |
Completed | Trial Pharma Kft. Gyula | Gyula, 5700, Hungary |
Withdrawn | Asociación IPS Médicos Internistas de Caldas | Manizales, 170004, Colombia |
Withdrawn | Fundación Cardiomet CEQUIN Eje Cafetero | Armenia, 630004, Colombia |
Completed | InMedica Clinic Santariskes | Vilnius, LT-08431, Lithuania |
Completed | Russells Hall Hospital | Dudley, DY1 2HQ, United Kingdom |
Completed | Affinity Health Research Institute | Oak Brook, IL | Oak Brook, 60523, United States |
Completed | NOVA Clinic Medical Center | Varna, BG | Varna, 9020, Bulgaria |
Completed | General Hospital Silistra | Department of Cardiology, Structure for Interventional Cardiology | Silistra, 7500, Bulgaria |
Completed | Hanusch Krankenhaus | 2. Medizinische Abteilung | Wien, 1140, Austria |
Completed | Landeskrankenhaus Hall | Abteilung fuer Innere Medizin | Hall in Tirol, 6060, Austria |
Completed | Praxis Hr. Dr. med. Jens Taggeselle | Markkleeberg, 04416, Germany |
Completed | Ochsner Clinic Foundation | Baton Rouge, 70836, United States |
Completed | Japan Culture and Welfare Federation of Agricultural Cooperatives | Hokushin General Hospital | Nakano-City, 383-8505, Japan |
Completed | Japanese Red Cross Society Suwa Hospital | Suwa, 392-8510, Japan |
Completed | Nippon Life Hospital | Osaka, 550-0006, Japan |
Completed | Matsuyama Shimin Hospital | Matsuyama, 790-0067, Japan |
Completed | Fukui Prefectural Hospital | Fukui, 910-8526, Japan |
Completed | Miyanomori Memorial Hospital | Sapporo, 064-8570, Japan |
Completed | Tohoku Medical and Pharmaceutical University Hospital | Center for Clinical Research Promotion and Development | Sendai-city, 983-8512, Japan |
Completed | Yamanashi Prefectural Central Hospital | Kofu, 400-8506, Japan |
Completed | Saga Memorial Hospital | Saga, 849-0917, Japan |
Completed | GZA Ziekenhuizen | Saint Augustine Campus - Cardiology Department | Wilrijk, 2610, Belgium |
Completed | CU Saint-Luc/UZ St-Luc | BRUXELLES - BRUSSEL, 1200, Belgium |
Completed | AZ Sint-Jan Brugge-Oostende | Sint-Jan - Cardiology | Brugge, 8000, Belgium |
Completed | AZ Sint Blasius, Cardiology, Dendermonde | Dendermonde, 9200, Belgium |
Completed | Vitaz | Sint-Niklaas Hospital - Cardiology Department | Sint-Niklaas, 9100, Belgium |
Completed | Ålesund Sykehus, Kardiologisk Seksjon | Ålesund, 6026, Norway |
Completed | Circuit Clinical/Crystal Run | Middletown, 10941, United States |
Completed | Centrum Medyczne Ogrodowa G. i M. Kania Lekarze i Lekarze Dentysci Spólka Partnerska z siedziba w Skierniewicach | Lowicz, 99-400, Poland |
Completed | CLINICAL MEDICAL RESEARCH Sp. z o. o. | Katowice, 40-156, Poland |
Completed | Vita Longa Sp. z o.o. | Katowice, 40-748, Poland |
Completed | ClinMedica Research Sp. z o.o. | Skierniewice, 96-100, Poland |
Completed | Centrum Terapii Wspolczesnej | Lodz, 90-338, Poland |
Completed | NBR Polska Tomasz Klodawski | Warszawa, 00-465, Poland |
Completed | Etyka Osrodek Badan Klinicznych | Olsztyn, 10-117, Poland |
Completed | Solumed Centrum Medyczne | Poznan, 60-529, Poland |
Completed | Rakuwakai Otowa Hospital | Kyoto, 607-8062, Japan |
Completed | Fukuoka University Nishijin Hospital | Fukuoka, 814-8522, Japan |
Completed | Japan Culture and Welfare Federation of Agricultural Cooperatives | Suzuka Chuo General Hospital | Suzuka-shi, 513-8630, Japan |
Completed | Oji General Hospital | Tomakomai, 053-8506, Japan |
Completed | Onga Nakama Medical Association Onga Hospital | Onga-gun, 811-4342, Japan |
Completed | Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro Hospital | Fukuoka, 811-0213, Japan |
Completed | Fukuoka University Hospital | Fukuoka, 814-0180, Japan |
Completed | Centro Hospitalar Vila Nova de Gaia e Espinho | Unit 1 - Clinical Research Center | Porto, 4434-502, Portugal |
Completed | Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica | Lisboa, 1500-650, Portugal |
Completed | MEDISPOL s.r.o. | Presov, 08001, Slovakia |
Completed | ORALEK, s.r.o. | Namestovo, 02901, Slovakia |
Completed | Huizhou Central People's Hospital | Huizhou, 516001, China |
Completed | Tsuchiura Kyodo General Hospital | Tsuchiura, 300-0028, Japan |
Completed | Osaka Police Hospital | Clinical Research and Trial Center | Osaka, 543-0035, Japan |
Completed | Hyogo Prefectural Amagasaki General Medical Center | Amagasaki, 660-8550, Japan |
Completed | Japanese RedCross Aichi Medical Center Nagoya Daini Hospital | Nagoya, 466-8650, Japan |
Completed | Hospital Sao Lucas Copacabana | Clinical Research Department | Rio de Janeiro, 22.0080-040, Brazil |
Completed | UNESP Faculdade de Medicina de Botucatu | UPECLIN | Botucatu, 18618-970, Brazil |
Completed | Quanta Diagnostico Por Imagem | Research and Innovation Department | Curitiba, 80045-170, Brazil |
Completed | Irmandade da Santa Casa de Misericordia de Sao Paulo | Hospital Central - Cardiology Department | São Paulo, 01221-020, Brazil |
Completed | Dong-A University Hospital | Busan, 49201, Korea,_republic_of |
Completed | Uijeongbu ST. Mary's Hospital | Uijeongbu-si, Gyeonggi-do, 11765, Korea,_republic_of |
Completed | Kyungpook National University Hospital | Daegu, 41944, Korea,_republic_of |
Completed | Yonsei University Wonju Christian Hospital | Wonju, 26426, Korea,_republic_of |
Completed | Eurolatino Pesquisas Medicas | Uberlandia, MG | Minas Gerais, 38400-368, Brazil |
Completed | Hospital Maternidade e Pronto Socorro Santa Lucia | Hospital do Coracao - Research Center | Poços de Caldas, 37706-106, Brazil |
Completed | Kasugai Municipal Hospital | Kasugai, 486-8510, Japan |
Completed | Multiprofile Hospital for Active Treatment Trakiya Park | Cardiology Department | Stara Zagora, 6000, Bulgaria |
Completed | Multidisciplinary Hospital for Active Treatment Heart and Brain Burgas | Cardiology Department | Burgas, 8000, Bulgaria |
Completed | Kitada Clinic | Osaka, 538-0044, Japan |
Completed | Centro Hospitalar De Tras os Montes e Alto Douro | Hospital Sao Pedro - Centro de Investigacao Clinica | Vila Real, 5000-508, Portugal |
Completed | The First Affiliated Hospital of Harbin Medical University | Harbin, 150001, China |
Completed | Beijing Chaoyang Hospital, Capital Medical University | Beijing, 100020, China |
Completed | Inner Mongolia People's Hospital | Hohhot, 010017, China |
Completed | Baotou Central Hospital | Baotou, 14040, China |
Completed | Xuanwu Hospital Capital Medical University | Beijing, 100053, China |
Completed | Jiangxi Provincial People’s Hospital | Nanchang, 330006, China |
Completed | Cangzhou Central Hospital | Cangzhou, 61000, China |
Completed | Chengdu Second People's Hospital | Chengdu, 610021, China |
Completed | People's Hospital of Deyang City | Deyang, 618000, China |
Completed | The First Hospital of Hebei Medical Univesity | Shijiazhuang, 50000, China |
Completed | The First Affiliated Hospital of Baotou Medical College | Baotou, 14010, China |
Completed | 1st Affiliated Hospital of Henan Science and Technology Univ | Luoyang, 471000, China |
Completed | Luoyang Third People's Hospital | Luoyang, 471002, China |
Completed | Peking University First Hospital | Beijing, 100034, China |
Completed | Shanghai Putuo District Central Hospital | Shanghai, 200333, China |
Completed | The 2nd Affiliated Hospital of Shandong University | Jinan, 250033, China |
Completed | Zibo Central Hospital | Zibo, 250036, China |
Completed | Taian City Central Hospital | Taian, 271099, China |
Completed | Guangzhou First People Hospital | Guangzhou, 510180, China |
Completed | Jining No.1 People's Hospital | Jining, 272011, China |
Completed | Affiliated Hospital of Jining Medical University | Jining, 272007, China |
Completed | Yinchuan No.1 People's Hospital | Yinchuan, 750001, China |
Completed | Shanxi Bethune Hospital | Taiyuan, 30032, China |
Completed | Shanxi Candiovascular Hospital | Taiyuan, 30024, China |
Completed | The First affiliated Hospital of Hebei North University | Zhangjiakou, 075000, China |
Completed | China-Japan Friendship Hospital | Beijing, 100029, China |
Completed | The First Affiliated Hospital of Jinzhou Medical University | Jinzhou, 121001, China |
Completed | The First Affiliated Hospital of Xinjiang Medical University | Urumchi, MISSING, China |
Completed | Jiangxi PingXiang people's Hospital | Pingxiang, 337055, China |
Completed | Xiamen Cardiovascular Hospital Xiamen University | Xiamen, 361006, China |
Completed | Korea University Anam Hospital | seoul, 02841, Korea,_republic_of |
Completed | Mito Saiseikai General Hospital | Mito, 311-4198, Japan |
Withdrawn | Universitätsklinikum Charité | Berlin, 13353, Germany |
Completed | Uniklinik Jena / Kardiologie | Jena, 7747, Germany |
Completed | National hospital Organization Mito Medical Center | Higashiibaraki, 311-3193, Japan |
Completed | Advara HealthCare Wesley | Auchenflower, 4066, Australia |
Completed | The Avenue Cardiovascular Centre | St Kilda East, 3183, Australia |
Completed | Redcliffe District Hospital | Redcliffe, 4020, Australia |
Completed | Advara HeartCare Melbourne | Ringwood, 3135, Australia |
Completed | Cabrini Malvern | Malvern, 3144, Australia |
Completed | Kardiolitos klinikos / BMP | Kaunas, LT-49287, Lithuania |
Completed | Nemocnice Ceske Budejovice, a.s. Department of kardiologie | Ceske Budejovice, 370 01, Czech Republic |
Completed | Vojenska nemocnice Brno | Brno, 63600, Czech Republic |
Completed | Spitalul de urgenta Sf. Ioan Cel Nou | Suceava, 720237, Romania |
Completed | Spitalul Judetean de Urgenta Satu Mare | Satu Mare, 440192, Romania |
Withdrawn | Nightingale Research | Adelaide, 5000, Australia |
Completed | Zhongshan Hospital, Fudan University | Shanghai, 200032, China |
Completed | East Tallinn Central Hospital | Tallinn, 10138, Estonia |
Completed | Dr Signe Alliksoo Family Doctors Practice | Tallinn, 10138, Estonia |
Completed | West Tallinn Central hospital | Tallinn, EE-10617, Estonia |
Completed | Office of Arvo Rosenthal | Tallinn, 13419, Estonia |
Completed | Pirita Family Doctors Centre | Tallinn, 11911, Estonia |
Not yet recruiting | Rapla Family Doctors Centre | Rapla, 79515, Estonia |
Completed | North Estonia Medical Centre Foundation | Tallinn, 13419, Estonia |
Completed | Tartu University Hospital | Tartu, 50406, Estonia |
Completed | West China Hospital,Sichuan University | Chengdu, 610041, China |
Completed | Guangzhou Panyu Central Hospital | Guangzhou, 511400, China |
Completed | Rivas | Beatrix Hospital Gorinchem - Cardiology Department | GORINCHEM, 4204 AA, Netherlands |
Completed | Klaipeda Seamen's Hospital Cardiology Department I | Klaipeda, LT-92288, Lithuania |
Completed | APS Clinic | Riga, LV-1050, Latvia |
Withdrawn | Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine | Hangzhou, 310016, China |
Completed | CHI Toulon - H La Seyne - Cardiologie | Toulon, 83000, France |
Terminated | Hôpital de la Pitié-Salpétrière | PARIS, 75651, France |
Completed | HOPITAL CHARLES NICOLLE CHU ROUEN | Bois-Guillaume, 76320, France |
Completed | CHU Rennes, H Pontchaillou, Cardiologie | Rennes, 35033, France |
Completed | Uniklinik Leipzig / Kardiologie | Leipzig, 4103, Germany |
Completed | SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos | Chengdu, 610072, China |
Completed | Yuncheng Central Hospital | Yuncheng, 44099, China |
Completed | Qinghai University Affiliated Hospital | Xining, 810001, China |
Completed | Ningbo First Hospital | Ningbo, 315010, China |
Completed | Liuzhou Worker's Hospital | Liuzhou, 545005, China |
Completed | Shanghai General Hospital | Shanghai, 200080, China |
Completed | AnMed Clinical Research | Anderson, 29621, United States |
Completed | The Third Hospital of Nanchang | Nanchang, 330009, China |
Completed | Yan'an University Xianyang Hospital | Xianyang, 716000, China |
Completed | Renmin Hosp., Wuhan Univ. | Wuhan, 430040, China |
Completed | Union Hospt Tongji Medical Colleg. Huazhong univ. Scien&Tech | Wuhan, 430030, China |
Completed | Shin Kong Wu Ho-Su Memorial Hospital | Taipei, 111, Taiwan |
Completed | E-Da Hospital | Kaohsiung, 82445, Taiwan |
Completed | Veterans General Hospital | Kaohsiung City, 813414, Taiwan |
Completed | Emergency Institute for Cardiovascular Diseases | Bucharest, 22322, Romania |
Completed | Hospital de Base | Integrated Research Center | São José do Rio Preto, 15090-000, Brazil |
Withdrawn | AZ Monica Campus Deurne - Cardiology | Deurne, 2100, Belgium |
Completed | Radin Cardiovascular Medical Group | Newport Beach, 92663, United States |
Not yet recruiting | Baptist Health Lexington | Lexington, 40503, United States |
Completed | Cooper Specialty Care at Voorhees | Voorhees, 08043, United States |
Completed | Hospital e Maternidade Christovao da Gama | Santo Andre Medical Centre - Cardiology Department | Santo André, 09030-010, Brazil |
Completed | Diagnostic-Consultative Center XX | Cardiology Department | Sofia, 1618, Bulgaria |
Completed | Science 37 | Culver City, 90230, United States |
Completed | SingHealth Polyclinics - Pasir Ris | Singapore, 519457, Singapore |
Completed | Toronto General Hospital UHN | Toronto, M5G 2C4, Canada |
Completed | Ziekenhuis Rivierenland | Cardiology Research Department | Tiel, 4002 WP, Netherlands |
Not yet recruiting | Piedmont Research Partners LLC | Fort Mill, 29707, United States |
Withdrawn | All India Institute of Medical Sciences (AIIMS) - New Delhi | New Delhi, 110 029, India |
Completed | King Edward Memorial (KEM) Hospital - Pune | Pune, 411 011, India |
Withdrawn | Vardhman Mahavir Medical College & Safdarjung Hospital (VMMC-SJH) | New Delhi, 110029, India |
Completed | Vijan Cardiac & Critical Care Centre | Nashik, 422005, India |
Withdrawn | Shri B.D. Mehta Mahavir Heart Institute | Surat, 395001, India |
Completed | Lisie Hospital | Kochi, 682017, India |
Withdrawn | The Institute of Post Graduate Medical Education & Research (IPGMER) (SSKM Hospital) | Calcutta, 700020, India |
Withdrawn | HFR - Fribourg | Cardiology | Fribourg, 1708, Switzerland |
Withdrawn | Sir Gangaram Hospital, Delhi | New Delhi, 110060, India |
Completed | Asian Institute of Gastroenterology (AIG Hospital) | Hyderabad, 500032, India |
Withdrawn | Zibo Municipal Hospital | Zibo, 255000, China |
Withdrawn | Atyrau Regional Cardiology Center - Department of Cardiology | Atyrau, 060005, Kazakhstan |
Withdrawn | Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan - Cardiology Department No2 | Astana, 010017, Kazakhstan |
Withdrawn | City cardiological center of Almaty | Almaty, 50012, Kazakhstan |
Withdrawn | Moscow Research Scient. Institute n.a. M.F. Vladimirsky | Moscow, 129110, Russia |
Primary Outcome
- Time to first occurrence of composite of stroke or systemic embolismdate_rangeTime Frame:Up to 34 months
- Time to first occurrence of ISTH major bleedingISTH = International Society on Thrombosis and Hemostasisdate_rangeTime Frame:Up to 34 months
- Time to first occurrence of composite of stroke, systemic embolism, or ISTH major bleedingdate_rangeTime Frame:Up to 34 months
Secondary Outcome
- Time to first occurrence of composite of ischemic stroke or systemic embolismdate_rangeTime Frame:Up to 34 months
- Time to first occurrence of all-cause mortalitydate_rangeTime Frame:Up to 34 months
- Time to first occurrence of ischemic strokedate_rangeTime Frame:Up to 34 months
- Time to first occurrence of CV deathCV = cardiovasculardate_rangeTime Frame:Up to 34 months
- Time to first occurrence of composite of CV death, stroke, or myocardial infarctiondate_rangeTime Frame:Up to 34 months
- Time to first occurrence of composite of ISTH major or clinically relevant non-major bleedingdate_rangeTime Frame:Up to 34 months
- Time to first occurrence of clinically relevant non-major bleedingdate_rangeTime Frame:Up to 34 months
- Time to first occurrence of hemorrhagic strokedate_rangeTime Frame:Up to 34 months
- Time to first occurrence of intracranial hemorrhagedate_rangeTime Frame:Up to 34 months
- Time to first occurrence of fatal bleedingdate_rangeTime Frame:Up to 34 months
- Time to first occurrence of minor bleedingdate_rangeTime Frame:Up to 34 months
- Time to first occurrence of composite of stroke, systemic embolism, ISTH major bleeding, or all-cause mortalitydate_rangeTime Frame:Up to 34 months
- Time to first occurrence of composite of disabling stroke (mRS ≥ 3), critical bleeding, or all-cause mortalitymRS = modified Rankin Scaledate_rangeTime Frame:Up to 34 months
Trial design
Trial Type
InterventionalIntervention Type
DrugTrial Purpose
TreatmentAllocation
RandomizedBlinding
N/AAssignment
Parallel AssignmentTrial Arms
2