stop_circleTerminated/Withdrawn

Prevention of stroke or systemic embolism, Atrial fibrillation

A study to learn how well the study treatment asundexian works and how safe it is compared to apixaban to prevent stroke or systemic embolism in people with irregular and often rapid heartbeat (atrial fibrillation), and at risk for stroke

Trial purpose

Researchers are looking for a better way to treat people with atrial fibrillation (AF) and prevent stroke or systemic embolism (blood clots travelling through the blood stream to plug another vessel).
Atrial fibrillation is a condition of having irregular and often rapid heartbeat. It can lead to the formation of blood clots in the heart which can travel through the blood stream to plug another vessel, and like this lead to serious and life-threatening conditions, such as a stroke. A stroke occurs because the brain tissue beyond the blockage no longer receives nutrients and oxygen so that brain cells die. As strokes arising from atrial fibrillation can involve extensive areas of the brain, it is important to prevent them.
Blood clots are formed in a process known as coagulation. Medications are already available to prevent the formation of blood clots. When taken by mouth (orally), they are known as oral anticoagulants (OACs) including apixaban. OACs decrease the risk of the above-mentioned serious and life-threatening conditions. The main side effect of OACs is an increase of the risk of bleeding.
The study treatment asundexian is a new type of anticoagulant currently under development to provide further treatment options. Asundexian aims to further improve the standard of care with regard to the risk of bleeding.
The main purpose of this study is to collect more data about how well asundexian works to prevent stroke and systemic embolism and how safe it is compared to apixaban in people with atrial fibrillation and at high risk for stroke.
To see how well the study treatment asundexian works researchers compare:
•   how long asundexian works well and
•   how long apixaban works well
after the start of the treatment. Working well means that the treatments can prevent the following from happening:
•   stroke and/or
•   systemic embolism.
The study will keep collecting data until a certain number of strokes or embolisms happen in the study.

To see how safe asundexian is, the researchers will compare how often major bleedings occur after taking the study treatments asundexian and apixaban, respectively. Major bleedings are bleedings that have a serious or even life-threatening impact on a person’s health.
The study participants will be randomly (by chance) assigned to 1 of 2 treatment groups, A and B. Dependent on the treatment group, the participants will either take the study treatment asundexian by mouth once a day or apixaban by mouth twice a day for approximately 9 - 33 months.
Each participant will be in the study for approximately 9 - 34 months. There will be visits to the study site every 3 to 6 months and up to 7 phone calls. Those participants who do not want or are unable to have visits to the study site may join the study remotely in selected locations. The location name contains the abbreviation - DCT in such cases.

During the study, the study team will:
•   take blood samples
•   do physical examinations
•   examine heart health using an electrocardiogram (ECG)
•   check vital signs such as blood pressure and heart rate
•   do pregnancy tests
•   ask the participants questions about their quality of life
•   ask the participants questions about how they are feeling and what adverse events they are having.
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.

Key Participants Requirements

Sex

All

Age

18 - N/A
  • - 18 years of age or older
    - The patient willing and able to understand the Patient information Sheet and provide written informed consent
    - Atrial fibrillation with an indication for indefinite treatment with an oral anticoagulant
    - CHA2DS2-VASc score ≥ 3 if male or ≥ 4 if female,
    OR
    CHA2DS2-VASc score of 2 if male or 3 if female and
    at least one of the following enrichment criteria:
     -- age ≥ 70
     -- previous stroke, transient ischemic attack, or systemic embolism
     -- renal dysfunction with eGFR < 50 ml/min within 14 days prior to randomization
     -- prior episode of non-traumatic major bleeding
     -- current single agent antiplatelet therapy planned to continue for at least 6 months after randomization
     -- ≤ 6 consecutive weeks of treatment with oral anticoagulant prior to randomization.
  • - Mechanical heart valve prosthesis
    - Moderate-to-severe mitral stenosis at the time of study inclusion.
    - Atrial fibrillation only due to reversible cause.
    - Participants after successful ablation therapy without documented recurrent AF or participants after left atrial appendage occlusion / exclusion or plan for ablation or Left atrial appendage (LAA) occlusion / exclusion within the next 6 months.
    - Recent ischemic stroke (within 7 days prior to randomization).
    - Active non-trivial bleeding; known chronic bleeding disorder ; history of non-traumatic intracranial hemorrhage.
    - Known significant liver disease or known hepatic insufficiency classified as Child-Pugh B or C at randomization.
    - Estimated glomerular filtration rate (eGFR) < 25 mL/min/1.73 m2 within 14 days prior to randomization or on dialysis or expected to be started on dialysis within the next 12 months starting from randomization.
    - Major surgery during the last 30 days prior to randomization.
    - Known allergy, intolerance or hypersensitivity to either of the study interventions.
    - Any contraindication for the use of an anticoagulant or listed in the local labelling for apixaban.
    - Requirement for chronic anticoagulation for a different indication than AF, e.g. mechanical heart valve or left ventricular cardiac thrombus (atrial thrombus is allowed), or dual antiplatelet therapy (single agent therapy is allowed).
    - Treatment with Vitamin K antagonist (VKA) in the 10 days prior to randomization.
    - Concomitant use of or anticipated need for:
     -- daily or near daily (> 5 days per week) therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) for more than 4 weeks during the study
     -- herbal or traditional medicine, and / or supplements with known anticoagulant and / or antiplatelet effect
     -- combined P-glycoprotein (P-gp) and strong cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors
     -- combined P-gp and strong / moderate CYP3A4 inducers
    Respective substances (apart from NSAIDs) must be stopped – in case of combined inhibitors / inducers of CYP3A4 and P-gp for at least 14 days before randomization.
    - Previous (within 30 days or 5 half-lives of the investigational drug, whichever is longer) or concomitant participation in another clinical study with investigational medicinal product(s) or device(s). Registries and observational studies are allowed.
    - Known current alcohol and / or illicit drug abuse.
    - Close affiliation with the investigational site.
    - Any other history, condition or therapy, or uncontrolled intercurrent illness which would make the participant unsuitable for the study vulnerable or life expectancy < 12 months.

Trial summary

Enrollment Goal
14830
Trial Dates
December 2022 - January 2024
Phase
Phase 3
Could I Receive a placebo
No
Products
Asundexian (BAY2433334)
Accepts Healthy Volunteer
No

Where to participate

StatusInstitutionLocation
Completed
OUS Ullevål CardiologyOslo, 450, Norway
Completed
Diakonhjemmets sykehusOslo, 319, Norway
Completed
Skedsmo Medisinske SenterSkedsmokorset, 2020, Norway
Completed
South Oklahoma Heart Research, LLCOklahoma City, 73135, United States
Completed
Mt. Olympus Medical ResearchSugar Land, 77479, United States
Completed
Styde Research LLC | Plano, TXPlano, 75093, United States
Completed
North Dallas Research Associate | McKinney, TXMcKinney, 75069-1780, United States
Completed
LifeBridge Health | Sinai Hospital - Platelet and Thrombosis Research DepartmentBaltimore, 21215, United States
Completed
Spectrum Clinical Research | Maryland Cardiovascular SpecialistsBaltimore, 21229, United States
Completed
Stavanger UHospital CardiologyStavanger, 4011, Norway
Completed
AA Medical Research Center | Flint, MIFlint, 48504, United States
Completed
Johns Hopkins Hospital/Health SystemBaltimore, 21287, United States
Completed
Uniwersytecki Szpital Kliniczny w BialymstokuBialystok, 15-276, Poland
Completed
Tyler Cardiovascular Consultants | Tyler, TXTyler, 75701, United States
Completed
Mayo Clinic - RochesterRochester, 55905, United States
Withdrawn
Cozy Research | Zephyrhills, FLZephyrhills, 33541, United States
Completed
Cardiovascular Research of KnoxvillePowell, 37849, United States
Completed
Northwest Houston Clinical Research, PLLC - Houston Heart Center | Tomball, TXTomball, 77375, United States
Completed
Southwest Family Medicine Associates | Dallas, TXDallas, 75235, United States
Completed
Johns Hopkins University School of Medicine | CAPRESColumbia, 21044, United States
Completed
Medication Management | Greensboro - CardiologyGreensboro, 27408, United States
Completed
Clearwater Cardiovascular Associates | Clearwater, FLClearwater, 33756, United States
Completed
Clinical Advancement Center, PLLCSan Antonio, 78212-4740, United States
Completed
Cardiovascular Associates Research, LLCCovington, 70433, United States
Withdrawn
Colorado Springs CardiologyColorado Springs, 80923, United States
Completed
NYU Langone Health | NYU Langone Medical Associates Chelsea - Cardiovascular ResearchNew York, 10001, United States
Completed
Mobile Heart Specialists, PCMobile, 36608, United States
Completed
Houston Methodist HospitalHouston, 77030, United States
Completed
M Health FairviewMaplewood, 55109, United States
Completed
Reid Physician Associates | Cardiology DepartmentRichmond, 47374, United States
Completed
CHI Health Clinic Heart Institute - Grand IslandGrand Island, 68803, United States
Completed
Advanced Heart Care, LLC | Bridgewater, NJBridgewater, 08807, United States
Completed
Prime Revival Reserach Institute, LLC | Denton, TXDenton, 76201, United States
Completed
Adventist HealthCare | White Oak Medical CenterSilver Spring, 20904, United States
Not yet recruiting
The Valley Hospital, Inc.Ridgewood, 07450, United States
Completed
Accellacare | Mt. Pleasant, SCLadson, 29456, United States
Completed
Interventional Cardiology Medical Group | West Hills, CAWest Hills, 91307, United States
Completed
North Texas Research AssociatesMcKinney, 75071, United States
Completed
Cardiovascular Research of Northwest Indiana, LLC. | Munster, INHammond, 46320, United States
Completed
PharmaTex Research, LLCAmarillo, 79109, United States
Completed
Holston Medical Group - BristolBristol, 37620, United States
Completed
Blue Coast Research Center, LLCVista, 92081, United States
Not yet recruiting
Lifespan | The Miriam Hospital - Cardiovascular ResearchProvidence, 02906, United States
Completed
Virginia HeartFalls Church, 22042, United States
Completed
Kettering Health Network | Research InstituteKettering, 45429, United States
Completed
Apex Research Foundation, LLC. | Jackson, TNJackson, 38301, United States
Completed
Great Lakes Medical Research | Westfield, NYWestfield, 14787, United States
Completed
Cardiology Associates of Fairfield County, P.C. | Stamford, CTNorwalk,, 06851, United States
Withdrawn
Methodist Physicians ClinicOmaha, 68114, United States
Completed
Life Spring Research | Miami, FLMiami, 33130, United States
Completed
Research Integrity, LLCOwensboro, 42303, United States
Completed
Sparrow Clinical Research Institute | Sparrow Hospital - Clinical Research DepartmentLansing, 48912, United States
Completed
CHRISTUS Trinity | Mother Frances Louis and Peaches Owen Heart Hospital - Electrophysiology ClinicTyler, 75702, United States
Completed
North Florida Foundation For Research And Education | Veterans Benefits AdministrationGainesville, 32608, United States
Not yet recruiting
Inova Fairfax Hospital - FairfaxFairfax, 22031, United States
Completed
Thomas Jefferson University HospitalPhiladelphia, 19107, United States
Completed
Amicis Research Center | Northridge, CANorthridge, 91324, United States
Not yet recruiting
Carolina Heart Specialists | Lancaster, SCLancaster, 29720, United States
Completed
Cottage Health | Santa Barbara Cottage Hospital - Cardiology DepartmentSanta Barbara, 93102, United States
Completed
Region Midtjylland | Aarhus University Hospital - Heart Diseases - Clinical ResearchÅrhus N, 8200, Denmark
Completed
Region Midtjylland | Viborg Regional Hospital - Cardiology - Heart ResearchViborg, 8800, Denmark
Completed
Region Midtjylland | Regionshospitalet Godstrup - Clinic for Heart ResearchHerning, 7400, Denmark
Recruiting
Sydvestjysk Sygehus Esbjerg | Kardiologisk ForskningsenhedESBJERG, 6700, Denmark
Completed
Sygehus Lillebaelt | Kolding Sygehus - Medicinske SygdommeKolding, 6000, Denmark
Completed
Region Sjælland | Holbaek Sygehus - Cardiology departmentHolbæk, 4300, Denmark
Completed
Sjællands Universitetshospital Roskilde - Hormon og stofskiftesygdommeRoskilde, 4000, Denmark
Not yet recruiting
University of California, IrvineIrvine, 92697, United States
Completed
MedUni Wien | Innere Medizin II, KardiologieVienna, 1090, Austria
Completed
Elisabethinen Linz | Kardiologie, Angiologie & Intensiv MedLinz, 4020, Austria
Completed
MedUni Innsbruck | Kardiologie und AngiologieInnsbruck, 6020, Austria
Completed
Uniklinikum Salzburg|Innere Medizin II, KardiologieSalzburg, 5020, Austria
Completed
MedUni Graz | KardiologieGraz, 8036, Austria
Completed
Klinik Floridsdorf | Herz-, Gefaess- u. Kardio AmbulazVienna, 1210, Austria
Completed
LKH Feldkirch | Innere Medizin I mit KardiologieFeldkirch, 6800, Austria
Completed
Krankenhaus St. Josef Braunau | Innere Medizin IBraunau, 5280, Austria
Completed
UK St. Poelten | Innere Med IIISt. Poelten, 3100, Austria
Completed
Kepler UK Linz | Kardiologie & Intensivmedizin Campus IIILinz, 4021, Austria
Completed
Imed19-privatWien, 1190, Austria
Completed
Landesklinikum Mistelbach|Kardiologie u. Internistische MedMistelbach, 2130, Austria
Completed
Heart Vein & Vascular | Longwood, FLLongwood, 32779, United States
Completed
Northeast Cardiology AssociatesBangor, 04401, United States
Completed
York Clinical Research, LLC | Norfolk, VANorfolk, 23504, United States
Withdrawn
Salem VA Medical CenterSalem, 24153, United States
Completed
Akershus University Hospital Cardiology DepartmentNordbyhagen, 1478, Norway
Completed
Nordlandssykehuset Bodø CardioBodø, 8092, Norway
Completed
Vestre Viken HF - Drammen Sykehus CardiologyDrammen, 3004, Norway
Completed
UNN Tromsø Cardiology Dep.Tromsø, 9038, Norway
Completed
Sykehus Østfold Kalnes CardioFredrikstad, NO-1603, Norway
Completed
Sykehuset i Gjøvik MedisinskGjøvik, 2819, Norway
Completed
Minneapolis Heart InstituteSt. Paul, 55102, United States
Completed
VA Long Beach Healthcare SystemLong Beach, 90822, United States
Completed
Cardiology Associates Research, LLCTupelo, 38801, United States
Completed
Region Nordjylland | Hjoerring - Cardiology DepartmentHjørring, DK-9800, Denmark
Completed
Region Nordjylland | Aalborg University Hospital - Cardiology DepartmentAalborg, 9000, Denmark
Completed
UNN Harstad Medisinsk avdelingHarstad, 9406, Norway
Completed
Turun yliopistollinen keskussairaalaTurku, 20520, Finland
Completed
Tays SydänsairaalaTampere, 33520, Finland
Completed
HUS Jorvin sairaalaEspoo, 2740, Finland
Not yet recruiting
University of South Alabama Medical CenterMobile, 36617, United States
Completed
Cardiology Associates Research CompanyDaytona Beach, 32117, United States
Completed
Cambridge Medical TrialsAlexandria, 71301, United States
Completed
IU Health Physicians CardiologyIndianapolis, 46202, United States
Not yet recruiting
St. Mary's Medical Center | West Palm Beach - Neurology DepartmentWest Palm Beach, 33407-2495, United States
Recruiting
Garden State Heart CareManalapan, 07726, United States
Completed
Samsung Medical CenterSeoul, 6351, Korea,_republic_of
Completed
National University HospitalSingapore, 119074, Singapore
Completed
National Heart Centre SingaporeSingapore, 169609, Singapore
Completed
NorthBay Clinical Research, LLC | Santa Rosa, CASanta Rosa, 95405, United States
Completed
Aultman | Aultman Hospital Main Campus - Clinical TrialsCanton, 44710, United States
Completed
Cardiology Consultants, PADaytona Beach, 32114, United States
Completed
Division of Cardiovascular Research at Peconic Bay Med CtrRiverhead, 11901, United States
Completed
IMA Clinical Research | Warren, NJWarren, 07059, United States
Completed
Advanced Research for Health Improvement, LLC | Naples, FLNaples, 34102, United States
Completed
Oregon Health and Science UniversityPortland, 97239, United States
Completed
The Lundquist Institute | Cardiology DepartmentTorrance, 90502-2004, United States
Completed
Clinical Trials of America, Inc.Mt. Airy, 27030, United States
Completed
Odense University Hospital | Svendborg Hospital - Cardiovascular Research UnitSvendborg, 5700, Denmark
Completed
Capital Region | Gentofte Hospital - Cardiology ResearchHellerup, 2900, Denmark
Recruiting
Capital Region | Herlev Hospital - Department of Heart DiseaseHERLEV, 2730, Denmark
Completed
Capital Region | Frederiksberg Hospital - Department of Cardiology ResearchFrederiksberg, 2000, Denmark
Completed
Capital Region | Hvidovre Hospital - Department of CardiologyHvidovre, 2650, Denmark
Completed
Capital Region | Amager Hospital - Cardiology Outpatient ClinicCopenhagen, 2300, Denmark
Completed
Rikshospitalet CardiologyOslo, 27, Norway
Completed
Sykehuset Lillehammer MedicineLillehammer, 2609, Norway
Completed
Sykehuset Innlandet HF ElverumElverum, 2409, Norway
Completed
Vestre Viken HF - Bærum Sykehus CardiologyGjettum, 1346, Norway
Completed
Seoul National University Bundang HospitalSeongnam-si, 13620, Korea,_republic_of
Completed
Chonnam National University HospitalGwangju, 501-757, Korea,_republic_of
Completed
Severance Hospital, Yonsei University Health SystemSeoul, 03722, Korea,_republic_of
Completed
Seoul National University HospitalSeoul, 3080, Korea,_republic_of
Completed
Keimyung University Dongsan Medical CenterDaegu, 42601, Korea,_republic_of
Completed
Asan Medical CenterSeoul, 138-736, Korea,_republic_of
Completed
Gachon University Gil Medical CenterIncheon, 21565, Korea,_republic_of
Completed
The Catholic Univ. of Korea Eunpyeong St. Mary's HospitalSeoul, 03312, Korea,_republic_of
Completed
StudyCor OyJyvaskyla, 40620, Finland
Completed
Tan Tock Seng HospitalSingapore, 308433, Singapore
Completed
Changi General HospitalSingapore, 529889, Singapore
Completed
Ng Teng Fong General HospitalSingapore, 609606, Singapore
Completed
Sengkang General HospitalSingapore, 544886, Singapore
Completed
Rapid City Regional HospitalRapid City, 57701, United States
Completed
Zaans Medisch Centrum | HartvaatcentrumZAANDAM, 1502 DV, Netherlands
Completed
Amphia Breda | Department of Cardiology, BMC ResearchBREDA, 4818 CK, Netherlands
Completed
Rijnstate | Arnhem - Cardiology Department - Cardio ResearchARNHEM, 6815 AD, Netherlands
Completed
Spaarne Gasthuis | Haarlem Zuid - CardiologyHAARLEM, 2035 RC, Netherlands
Withdrawn
Mercy ResearchChesterfield, 63017, United States
Withdrawn
ClinRx Research, LLCPlano, 75024, United States
Completed
Rama Research LLC | Marion, OHMarion, 43302-6774, United States
Completed
Accellacare | Ames, IAAmes, 50010, United States
Completed
Molde Sjukehus MedisinskMolde, 6407, Norway
Completed
McLaren Health Care | McLaren Bay Region - Research DepartmentBay City, 48708, United States
Completed
Louisiana Heart Center Research - SlidellSlidell, 70458, United States
Not yet recruiting
University of Texas Medical Branch at GalvestonGalveston, 77555-0587, United States
Completed
Integrity Clinical Research | Heller Heart HealthDelray Beach, 33446, United States
Completed
Henry Ford Health SystemDetroit, 48202, United States
Completed
Hunter Holmes McGuire Veterans Affairs Medical CenterRichmond, 23249-0001, United States
Not yet recruiting
Einstein Healthcare NetworkPhiladelphia, 19141, United States
Completed
Midwest Cardiovascular Research and Education Foundation | Elkhart, INElkhart, 46514, United States
Completed
TCR InstituteKingwood, 77339, United States
Completed
Stern Cardiovascular CenterGermantown, 38138, United States
Completed
Valley Clinical Trials, Inc. | Covina, CACovina, 91723, United States
Completed
University of North Carolina at Chapel Hill | Cardiology DepartmentChapel Hill, 27514, United States
Completed
Main Line HealthWynnewood, 19096, United States
Recruiting
Centro de Investigación y Prevención CardiovascularGeneral Arenales, C1061AAS, Argentina
Completed
Tolna Varmegyei Balassa Janos KorhazSzekszárd, 7100, Hungary
Completed
Nagykanizsai Kanizsai Dorottya KorhazNagykanizsa, 8800, Hungary
Completed
Pecsi Tudomanyegyetem Klinikai KozpontPecs, 7624, Hungary
Completed
Cardiomobile Egeszsegugyi Szolgaltato Kft.Balatonfured, 8230, Hungary
Completed
Somogy Varmegyei Kaposi Mor Oktato KorhazKaposvar, 7400, Hungary
Completed
Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.Nyiregyhaza, 4400, Hungary
Completed
Budapesti Jahn Ferenc Del-pesti Korhaz es RendelointezetBudapest, 1024, Hungary
Completed
Belinus Bt.Debrecen, 4025, Hungary
Completed
Borbanya Praxis Bt.Nyiregyhaza, 4405, Hungary
Completed
Vas Varmegyei Markusovszky Egyetemi OktatokorhazSzombathely, 9700, Hungary
Completed
COROMED SMO KFTPecs, 7623, Hungary
Completed
Dr. Nagy Laszlo Egyeni Egeszsegugyi VallalkozoOroshaza, 5900, Hungary
Completed
Cardiovascular Center of Sarasota Foundation for Research and Education | Sarasota, FLSarasota, 34239, United States
Completed
Virginia Commonwealth UniversityRichmond, 23284, United States
Withdrawn
Medicor CardiologyBridgewater, 08807, United States
Completed
Cardiology Consultants of Philadelphia | YardleyYardley, 19067, United States
Completed
Eastern Shore Research Institute, LLC | Fairhope, ALFairhope, 36532, United States
Completed
Northshore Medical CenterGlenview, 60026, United States
Completed
Texas Health Physicians Group - Fort WorthForth Worth, 76107, United States
Not yet recruiting
South Texas Cardiovascular Consultants, PLLCSan Antonio, 78201, United States
Withdrawn
Cardiac Study Center, Inc.Tacoma, 98405, United States
Not yet recruiting
Sanford USD Medical CenterSioux Falls, 57117, United States
Completed
Cardiology Partners Clinical Research Institute | Palm Beach Gardens OfficePalm Beach Gardens, 33410, United States
Completed
CardioAlem Investigaciones | San Isidro, ArgentinaSan Isidro, B1642DCD, Argentina
Completed
The Catholic University of Korea Seoul St. Mary's HospitalSeoul, 137-701, Korea,_republic_of
Completed
Hallym University Sacred Heart HospitalAnyang-si, 14068, Korea,_republic_of
Completed
Pusan National University HospitalBusan, 49241, Korea,_republic_of
Completed
Ajou University HospitalSuwon, 443-721, Korea,_republic_of
Completed
BUNDANG CHA HOSPITALSeongnam-si, 13496, Korea,_republic_of
Completed
Chung-Ang University HospitalSeoul, 156-755, Korea,_republic_of
Completed
Uniklinikum Hamburg-Eppendorf|Klinik für KardiologieHamburg, 20246, Germany
Completed
Ev. Krankenhaus Hagen-Haspe|Kardiologie und RhythmologieHagen, 58135, Germany
Completed
Universitätsmedizin der Johannes Gutenberg Universität MainzMainz, 55101, Germany
Completed
Cardio Centrum LudwigsburgLudwigsburg, 71634, Germany
Completed
Sana-Klinikum Remscheid|Kardio, Angio, Pneumo u. IntensivmedRemscheid, 42859, Germany
Completed
Forschungszentrum Ruhr KliFoCenter GmbHWitten, 58455, Germany
Completed
Universitaets Herzzentrum Bad KrozingenBad Krozingen, 79189, Germany
Completed
Klinikum Lüdenscheid - Märkische Kliniken GmbHLüdenscheid, 58515, Germany
Completed
Cardiologicum HamburgHamburg, 22041, Germany
Completed
Hegau-Bodensee-Klinikum Singen|I. Medizinische KlinikSingen, 78224, Germany
Completed
Kliniken Maria Hilf GmbHMönchengladbach, 41063, Germany
Completed
Klinikum Worms gGmbH|Kardiologie und AngiologieWorms, 67550, Germany
Completed
Praxisklinik Herz und Gefaesse|Kardiologische AmbulanzDresden, 1099, Germany
Completed
Krankenhaus Dresden-FriedrichstadtDresden, 1067, Germany
Completed
St. Vinzenz-Hospital|Innere Medizin III, KardiologieKoeln, 50733, Germany
Withdrawn
Klinikum Frankfurt Hoechst|Kardiologisches StudienzentrumFrankfurt am Main, 65929, Germany
Completed
Kardiologische Praxis Hr. Dr. A. Al-ZoebiWermsdorf, 4779, Germany
Completed
MEDICLIN Herzzentrum Lahr|KardiologieLahr, 77933, Germany
Not yet recruiting
Klinikum Fulda gAG|Medizinische Klinik IFulda, 36043, Germany
Withdrawn
Universitaetsmedizin Rostock|Abteilung KardiologieRostock, 18057, Germany
Completed
Medizinische Hochschule Hannover|Kardiologie und AngiologieHannover, 30625, Germany
Completed
UniKlinikum Aachen|Kardio, Angio, IntensivmedizinAachen, 52074, Germany
Completed
Siteworks Pruefzentrum VoelklingenVoelklingen, 66333, Germany
Completed
St.Johannes-Hospital|Klinik fuer Innere Medizin IDortmund, 44137, Germany
Completed
Josephs-Hospital|Kardiologie, Rhythmologie und AngiologieWarendorf, 48231, Germany
Completed
Klinische Forschung Dresden | Dresden, GermanyDresden, 01069, Germany
Completed
Klinische Forschung Hamburg GmbHHamburg, 20253, Germany
Completed
Uni-Klinikum Heidelberg | Kardiologie Angiologie PneumologieHeidelberg, 69120, Germany
Completed
University of Florida - JacksonvilleJacksonville, 32209, United States
Completed
Cardiology Partners Clinical Research Institute | Wellington OfficeWellington, 33449, United States
Completed
NJ Heart | Linden, NJLinden, 07036, United States
Completed
Cardiovascular & Vein Center of Florida | Bradenton, FLBradenton, 34209, United States
Completed
St. Louis Heart & Vascular, PCSaint Louis, 63136, United States
Completed
Southwest Florida Research | Naples, FLNaples, 34102-8143, United States
Not yet recruiting
University of Pittsburgh Medical Center, Hamot | Clinical Trials and ResearchErie, 16507, United States
Completed
Integrity Clinical Research | Florida Premier CardiologyBoyton Beach, 33437, United States
Not yet recruiting
Intermountain Healthcare | Cardiovascular Research DepartmentMurray, 84107, United States
Completed
Ochsner Medical Center - New OrleansNew Orleans, 70121, United States
Terminated
University of Colorado Hospital - CardiologyAurora, 80045, United States
Completed
Hospital Universitario Virgen de la Victoria | Cardiology DepartmentMalaga, 29010, Spain
Completed
Vall d'Hebron Barcelona Hospital Campus | Vall d'Hebron Hospital Universitario - Cardiology DepartmentBarcelona, 08035, Spain
Completed
Hospital Universitario 12 de Octubre | Cardiology DepartmentMadrid, 28041, Spain
Completed
Hospital de la Santa Creu i Sant Pau | Cardiology DepartmentBarcelona, 08025, Spain
Completed
Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Cardiology - AF, Stroke PreventionL'Hospitalet de Llobregat, 08907, Spain
Completed
Hospital Clinico Universitario Virgen de la Arrixaca | Cardiology DepartmentMurcia, 30120, Spain
Completed
La Fe University and Polytechnic Hospital | Cardiology DepartmentValencia, 46026, Spain
Completed
Hospital Universitario La Paz | IdiPAZ - Neurology DepartmentMadrid, 28046, Spain
Completed
Hospital Universitario Central de Asturias | Servicio de CardiologiaOviedo, 33006, Spain
Completed
Hospital Alta Resolucion de Utrera | Cardiology Service DepartmentUtrera, 41710, Spain
Completed
Hospital Quironsalud Barcelona | Internal Medicine DepartmentBarcelona, 8023, Spain
Completed
Jose Manuel Pascual Pascual S.A. | Hospital Virgen de las Montanas - Internal Medicine DepartmentVillamartin, 11650, Spain
Completed
Jose Manuel Pascual Pascual S.A. | Hospital Virgen del Camino - Internal Medicine DepartmentSanlucar de Barrameda, 11540, Spain
Completed
Hospital General Universitario de Valencia | Cardiology DepartmentValencia, 46014, Spain
Completed
Complejo Hospitalario Universitario de Ferrol | Hospital Naval - Unidad de Hipertensión ArterialFerrol, 15405, Spain
Completed
University Hospital of A Coruna | Cardiology departmentA Coruña, 15006, Spain
Completed
Hospital Universitario Virgen del Rocio | Hospital General - Departamento de Cardiologia y Cirugia CardiovascularSevilla, 41013, Spain
Completed
Hospital Universitario de La Princesa | Internal Medicine DepartmentMadrid, 28006, Spain
Completed
Hospital Universitario Ramon y Cajal | Departamento de Medicina InternaMadrid, 28034, Spain
Completed
Hospital Alta Resolucion de Lebrija | Cardiology Service DepartmentLebrija, 41740, Spain
Completed
Hospital General Universitario Doctor Balmis de Alicante | Cardiology DepartmentAlicante, 03010, Spain
Completed
Hospital Clinico Universitario de Santiago de Compostela | Cardiology DepartmentSantiago de Compostela, 15706, Spain
Completed
Amsterdam UMC | Heart Centre - Curius Research DepartmentAMSTERDAM, 1105 AZ, Netherlands
Completed
Martini Ziekenhuis, Locatie van SwietenGRONINGEN, 9728 NT, Netherlands
Completed
Albert Schweitzer Ziekenhuis | Dordwijk - Cardiology DepartmentDORDRECHT, 3318 AT, Netherlands
Completed
Medisch Spectrum Twente | Thorax Centrum Twente - Foundation Cardiovascular Research and Education EnschedeENSCHEDE, 7611 JH, Netherlands
Completed
Universitetssjukhuset ÖrebroÖrebro, 701 85, Sweden
Completed
SU/ÖstraGöteborg, 416 85, Sweden
Completed
Clemenstorget HjärtmottagningLund, 222 21, Sweden
Completed
Danderyds sjukhusStockholm, 182 88, Sweden
Completed
Södersjukhuset ABStockholm, 118 83, Sweden
Completed
Skellefteå LasarettSkellefteå, 931 86, Sweden
Completed
Falu LasarettFalun, 791 82, Sweden
Completed
Karolinska UniversitetssjukhusetStockholm, 171 76, Sweden
Completed
Skånes UniversitetssjukhusLund, 222 42, Sweden
Completed
SU/MölndalMölndal, 431 80, Sweden
Completed
Akademiska SjukhusetUppsala, TBC, Sweden
Completed
Norrlands Universitetssjukhus, UmeaUmea, 901 85, Sweden
Completed
Västmanlands Sjukhus VästeråsVästerås, 721 89, Sweden
Completed
Södra Älvsborgs SjukhusBorås, 501 82, Sweden
Completed
Karolinska Universitetssjukhuset Huddinge StockholmStockholm, 141 86, Sweden
Completed
Helsingborgs LasarettHelsingborg, TBC, Sweden
Completed
Rabin Medical Center | Clinical Trials Unit - Cardiology DepartmentPetah Tikva, 4941492, Israel
Completed
Shamir Medical Center | Cardiology DepartmentRishon LeZion, 6093000, Israel
Completed
Tel Aviv Sourasky Medical Center | Ichilov General Hospital - Cardiology DepartmentTel Aviv, 6423906, Israel
Completed
Hadassah Hebrew University Hospital Ein KeremJerusalem, 9112001, Israel
Completed
Clalit Health | Meir Medical Center - Division of Cardiology - Electrophysiology and Arrhythmias UnitJerusalem, 9112001, Israel
Completed
Clalit Health | Soroka Medical Center - Cardiology DepartmentBeer Sheva, 8410101, Israel
Completed
Galilee Medical Center | Cardiology DepartmentNahariya, 2210001, Israel
Completed
Barzilai Ashkelon University Medical Center | Cardiology DepartmentAshkelon, 7830604, Israel
Completed
Rambam Health Care Campus | Cardiology Department - Cardiology Research UnitHaifa, 3109601, Israel
Completed
Kaplan Medical Center | Cardiology Department - Heart Institute ResearchRehovot, 7610001, Israel
Completed
Poria Medical Center | Cardiovascular DepartmentLower Galilee, 15208, Israel
Completed
Ziv Medical Center | Cardiology DepartmentZefat, 1311001, Israel
Withdrawn
Chaim Sheba Medical CenterRamat Gan, 5262000, Israel
Completed
Assuta Hospital Be'er Sheva | Heart Institute - ClinicsBeer Sheva, 8489507, Israel
Completed
Carmel Medical Center | Cardiology Department - Cardiac Catheterization UnitHaifa, 3436212, Israel
Completed
Hillel Yaffe Medical Center | Cardiology DepartmentHadera, 3810101, Israel
Completed
Clalit Health | Soroka Medical Center - Internal Medicine DepartmentBeer Sheva, 8410101, Israel
Not yet recruiting
Tel-Aviv Sourasky Medical CenterTel Aviv, 6423906, Israel
Completed
Shaare Zedek Medical Center | The Jesselson Integrated Heart Center - Cardiology DepartmentJerusalem, 9103102, Israel
Completed
HaEmek Medical Center | Internal Medicine C Department - Research UnitAfula, 1834111, Israel
Completed
Samson Assuta Ashdod University Hospital | Cardiology DepartmentAshdod, 7747629, Israel
Completed
Bnai Zion Medical Center | Cardiology DepartmentHaifa, 3339419, Israel
Completed
University Hospital for Active Treatment Tsaritsa Joanna - ISUL | Cardiology ClinicSofia, 1527, Bulgaria
Completed
Second Medical Center Sofia EOODSofia, 1202, Bulgaria
Completed
Multiprofile Hospital for Active Treatment Knyaginya Klementina Sofia EAD | Cardiology DepartmentSofia, 1233, Bulgaria
Completed
Multiprofile Hospital for Active Treatment Medline | Cardiology DepartmentPlovdiv, 4000, Bulgaria
Completed
SHATC Sveti Georgi - Pernik | Pernik, BulgariaPernik, 2300, Bulgaria
Completed
Multiprofile Hospital for Active Treatment Dr. Stefan Cherkezov | Cardiology DepartmentVeliko Tarnovo, 5000, Bulgaria
Completed
Cardiohelp Medical Centre | Sofia, BulgariaSofia, 1142, Bulgaria
Completed
Medical centre Hipokrat - N EOODPlovdiv, 4000, Bulgaria
Completed
Multiprofile Hospital for Active Treatment Sveta Sofia | Internal Diseases DepartmentSofia, 1618, Bulgaria
Completed
Multiprofile Hospital for Active Treatment | Shumen - First Department of Internal MedicineShumen, 9700, Bulgaria
Completed
Multiprofile Hospital for Active Treatment Sveta Karidad | Cardiology DepartmentPlovdiv, 4004, Bulgaria
Completed
Multiprofile Hospital for Active Treatment Puls | Clinical Trial CenterBlagoevgrad, 2700, Bulgaria
Completed
Medical Center Avitsena Kardzhali | Cardiology ClinicKardzhali, 6600, Bulgaria
Completed
Multiprofile Hospital for Active Treatment National Cardiology Hospital | Cardiology DepartmentSofia, 1309, Bulgaria
Completed
The University General Hospital for Active Care and Emergency Medicine Pirogov | Cardiology DepartmentSofia, 1606, Bulgaria
Completed
Diagnostic Consultative Center Ascendent | Sofia, BulgariaSofia, 1202, Bulgaria
Completed
Medical Center Zara-Med EOOD | Cardiology DepartmentStara Zagora, 6010, Bulgaria
Completed
Medical Center Rusemed EOOD | Ruse, BulgariaRuse, 7000, Bulgaria
Completed
Laboratorio de Hemostasia y Trombosis | Rosario, ARRosario, S2000DTB, Argentina
Completed
Centro de Investigaciones Medicas Temperley | Buenos Aires, ArgentinaTemperley, B1834GUK, Argentina
Completed
Instituto De Investigaciones Clinicas Zarate | Zarate, ArgentinaZárate, B2800DGH, Argentina
Completed
Hospital Italiano de La Plata | Clinical Research DepartmentLa Plata, B1900, Argentina
Withdrawn
Grupo Orono | Instituto Cardiovascular de Rosario - Insuficiencia Cardiaca y Trasplante DepartmentRosario, 2000, Argentina
Completed
Consultorios Integrados Rosario | Instituto Medico de la Fundacion de Estudios ClinicosRosario, S2000DEJ, Argentina
Completed
Centro de Especialidades Medicas (Cemedic) | Cardiology DepartmentVilla Luro, C1440CFD, Argentina
Completed
Medical Group Kosice s.r.o. | Kosice, SlovakiaKosice, 04001, Slovakia
Completed
Nemocnica s poliklinikou Brezno, n.o.Brezno, 977 01, Slovakia
Completed
Interna SK s.r.o.Svidnik, 08901, Slovakia
Completed
Kardiosanus | Bratislava, SlovakiaBratislava, 84107, Slovakia
Completed
KARDIO-ANGIO s.r.o.Levice, 93401, Slovakia
Completed
Kardiocentrum Nitra | Cardiology Clinic - Outpatient DepartmentNitra, 949 01, Slovakia
Completed
KardioMed | Outpatient Cardiology and Internal Medicine II ClinicLucenec, 984 01, Slovakia
Completed
Medikard | Department of Internal MedicinePresov, 08001, Slovakia
Completed
Internal and Diabetes Clinic - IN-DIA s.r.o. | Lucenec, SlovakiaLucenec, 984 01, Slovakia
Completed
Medivasa s.r.o.Zilina, 01001, Slovakia
Completed
ALIAN s.r.o.Bardejov, 085 01, Slovakia
Completed
GALENUM s.r.o.Bratislava, 821 07, Slovakia
Completed
KaCH, s.r.o.Nove Zamky, 940 02, Slovakia
Completed
KARDIO 1 | Lucenec, SlovakiaLucenec, 98401, Slovakia
Completed
Kardiologicka ambulancia Trnava, MUDr. Vladimir MacekTrnava, 91701, Slovakia
Completed
BENIMED s.r.o.Piestany, 92101, Slovakia
Completed
KardioLEV s.r.o.Levoca, 05401, Slovakia
Completed
Specializovana nemocnica sv. Svorada Zobor, n.o.Nitra, 949 88, Slovakia
Completed
KARDIO R s.r.o.Kosice, 040 11, Slovakia
Completed
Kuopion yliopistollinen sairaalaKuopio, FIN- 70029, Finland
Completed
Oulun yliopistollinen sairaalaOulu, 90220, Finland
Completed
Health Step Finland OyKuopio, 70210, Finland
Not yet recruiting
Keski-Pohjanmaan keskussairaalaKokkola, 67200, Finland
Not yet recruiting
Päijät-Hämeen keskussairaalaLahti, 15850, Finland
Completed
P. Stradins Clinical University HospitalRiga, LV-1002, Latvia
Completed
Liepaja Regional HospitalLiepaja, LV-3414, Latvia
Completed
1st Riga Clinical HospitalRiga, LV-1001, Latvia
Completed
P. Stradins Clinical University HospitalRiga, LV-1002, Latvia
Completed
Daugavpils Regional HospitalDaugavpils, LV-5417, Latvia
Completed
Lija Mora physician practiceOgre, LV-5001, Latvia
Completed
Doctor's Practice in CardiologyDaugavpils, LV-5401, Latvia
Completed
Riga East Clinical University Hospital "Gailezers"Riga, LV-1038, Latvia
Completed
Gita Rancane - cardiology private practiceVentspils, LV-3601, Latvia
Completed
Health Center 4Riga, LV-1012, Latvia
Completed
SIA ARI MedDaugavpils, LV-5401, Latvia
Completed
Health Center AdoriaRiga, LV-1011, Latvia
Not yet recruiting
Ospedale San Raffaele s.r.l. - Cardiologia ClinicaMilano, 20132, Italy
Completed
Antwerp University Hospital | Cardiology DepartmentEDEGEM, 2650, Belgium
Completed
UZ Leuven GasthuisbergLEUVEN, 3000, Belgium
Completed
Jessa ZiekenhuisHasselt, 3500, Belgium
Completed
AZ Delta | Clinical Trial Center - CardiologyRoeselare, 8800, Belgium
Completed
Imelda Vzw | Study CardiologyBonheiden, 2820, Belgium
Completed
AZ Sint-MaartenDuffel, 2570, Belgium
Completed
Algemeen Ziekenhuis Klina | Cardiology DepartmentBrasschaat, 2930, Belgium
Completed
Maria Middelares General Hospital | Cardiology DepartmentGENT, 9000, Belgium
Completed
Groeninge Algemeen Ziekenhuis | Campus Kennedylaan - Cardiology DepartementKortrijk, 8500, Belgium
Completed
Ziekenhuis Oost-Limburg | Genk, Sint-Jan campus - Cardiology DepartmentGenk, 3600, Belgium
Completed
ZNA MiddelheimAntwerp, 2020, Belgium
Completed
Grand Hôpital de CharleroiGILLY, 6060, Belgium
Completed
Citadelle Hospital | Cardiology DepartmentLIEGE, 4000, Belgium
Completed
CHC MontLégia Neurology DepartmentLiège, 4000, Belgium
Completed
OL Vrouwziekenhuis - Campus AalstAalst, 9300, Belgium
Completed
Algemeen Stedelijk Ziekenhuis Campus AalstAalst, 9300, Belgium
Completed
University Hospital Louvain Namur | Godinne - Cardiology DepartmentYvoir, 5530, Belgium
Completed
Centro Hospitalar Universitario de Lisboa Norte | Heart and Vessels DepartmentLisbon, 1649-035, Portugal
Completed
Centro Hospitalar de Leiria | Santo Andre Hospital - Research CenterLeiria, 2410-197, Portugal
Completed
Hospital Garcia de Orta | Research DepartmentAlmada, 2805-267, Portugal
Completed
Centro Hospitalar Universitario Cova de Beira | Clinical Research DepartmentCovilha, 6200-251, Portugal
Completed
Centro Clinico Academico Braga | Braga, PortugalBraga, 4710-243, Portugal
Completed
Ucardio | Cardiology DepartmentRiachos, 2350-325, Portugal
Completed
Lusiadas | Hospital Lusiadas Lisboa - Lusiadas Knowledge CenterLisboa, 1500-458, Portugal
Completed
Hospital de Vila Franca de Xira | Centro de Desenvolvimento e InvestigacaoVila Franca de Xira, 2600-009, Portugal
Completed
Instituto de Investigaciones Clinicas Bahia Blanca | Bahia Blanca, ArgentinaBahía Blanca, 8000, Argentina
Completed
Centro de Investigaciones Metabolicas | Ciudad de Autonoma de Buenos Aires, ArgentinaBuenos Aires, C1056ABJ, Argentina
Completed
CEDIC Centro de Investigación Clínica | Buenos Aires, ArgentinaCABA, C1018DES, Argentina
Completed
Instituto de Cardiologia de Corrientes Juana F. Cabral | Corrientes, ArgentinaCorrientes, 3400, Argentina
Completed
Instituto de Investigaciones Clínicas (IIC) San Nicolas | San Nicolas de los Arroyos, ArgentinaSan Nicolás, B2900DMH, Argentina
Completed
Centro de Investigaciones Clinicas del Litoral | Santa Fe, ArgentinaSanta Fe, S3000FWO, Argentina
Completed
Investigaciones Clinicas Tucuman | San Miguel de Tucuman, ArgentinaSan Miguel de Tucumán, T4000ICL, Argentina
Completed
Budapesti Uzsoki Utcai KorhazBudapest, 1145, Hungary
Completed
Semmelweis UniversityBudapest, 1088, Hungary
Completed
Komaromi Selye Janos KorhazKomarom, 2900, Hungary
Completed
Borsod-Abauj-Zemplen Varmegyei Korhaz es Egyetemi OktatokorhazMiskolc, 3526, Hungary
Completed
Belvarosi Egeszseghaz Kft.Zalaegerszeg, 8900, Hungary
Withdrawn
Orszagos Mentalis, Ideggyogyaszati es Idegsebeszeti IntezetBudapest, 1135, Hungary
Completed
Beijing Anzhen Hospital, Capital Medical UniversityBeijing, 100029, China
Completed
Hainan Provincial People's HospitalHaikou, 570311, China
Completed
The Second Affiliated Hospital of Nanjing Medical universitynanjing, 210000, China
Completed
Zhongda Hospital Southeast UniversityNanjing, 210009, China
Completed
The Central Hospital of Wuhan, Tongji Medl Collg Huazhong...Wuhan, 430014, China
Completed
Puai Hospital,Tongji Medical College, Huazhong Univ Sci&TechWuhan, 430034, China
Completed
Beijing Tsinghua Changgung HospitalBeijing, MISSING, China
Completed
The First Affiliated Hospital of NanChang UniversityNanchang, 330006, China
Completed
Huai'an First People's Hospital, Nanjing Medical UniversityHuai'An, 223300, China
Completed
Taizhou People's HospitalTaizhou, MISSING, China
Completed
Affiliated Hospital of Jiangsu UniversityJiangSu, 212001, China
Completed
Qilu Hosp., Shandong Univ.Jinan, TBC, China
Completed
Taizhou Hospital of Zhejiang ProvinceTaizhou, 317099, China
Completed
Hwa Mei Hospital, University of Chinese Academy SciencesNingbo, 31510, China
Completed
Huashan Hospital, Fudan UniversityShanghai, 200040, China
Completed
The Third Hospital of ChangshaChangsha, 410011, China
Completed
Affiliated Hangzhou First People's Hospital, Zhejiang UnivHangzhou, 310006, China
Completed
The 2nd Affiliated Hospital of Guangzhou Medical UniversityGuangzhou, TBC, China
Completed
Tonghua Central HospitalTonghua, 134001, China
Completed
The Third Xiangya Hospital of Central South Universitychangsha, 410000, China
Completed
Shaanxi Provincial People's HospitalXi'an, 710068, China
Completed
The 1st Affiliated Hospital Fujian Medical UniversityFuzhou, TBC, China
Completed
Lanzhou University Second HospitalLanzhou, 730030, China
Completed
Panjin Liaohe Oilfield Gem Flower HospitalPanjin, 124010, China
Completed
Tianjin People's HospitalTianjin, 300000, China
Completed
Xinxiang Central HospitalXinxiang, 453000, China
Completed
Jinan Central HospitalJinan, 250013, China
Completed
The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou, 325000, China
Completed
The First Affiliated Hospital of Guangzhou University of TCMGuangzhou, 510405, China
Completed
Guangdong Provincial People's HospitalGuangzhou, 510000, China
Completed
China-Japan Union Hospital of Jilin UniversityChangchun, 130031, China
Completed
Daqing Oilfield General HospitalDaqing, 163311, China
Completed
Affiliated Hospital of Yangzhou University (Yangzhou First People's Hospital)Yangzhou, 225012, China
Completed
Nanjing Jiangning HospitalNanjing, 211103, China
Completed
Northern Jiangsu People's HospitalYangzhou, 225001, China
Completed
General Hospital of Ningxia Medical UniversityYinchuan, 750004, China
Completed
Peking Union Medical College Hospital CAMSBeijing, 100730, China
Completed
Hainan Third People's Hospital (Province Nongken Sanya Hopt)Sanya, 572000, China
Completed
Nanjing First HospitalNanjing, 210006, China
Completed
East Coast Institute for Research | St. Augustine, FLSt. Augustine, 32086, United States
Completed
Integrity Clinical Research | Cardiology Associates of South FloridaBoynton Beach, 33472, United States
Completed
EMED Centrum Uslug MedycznychRzeszow, 35-205, Poland
Completed
Unicardia Specjalistyczne Centrum Leczenia Ch.Serca i NaczynKrakow, 31-271, Poland
Completed
MICS Centrum Medyczne BydgoszczBydgoszcz, 85-065, Poland
Completed
NZOZ "Twoja Przychodnia" Sp. z o.o.Lublin, 20-857, Poland
Completed
Centrum Medyczne KerMedBydgoszcz, 85-231, Poland
Completed
Uniwersyteckie Centrum KliniczneGdansk, 80-214, Poland
Completed
Futuremeds sp. z o. o.Olsztyn, 10-010, Poland
Completed
Samodzielny Publiczny Specjalistyczny Szpital ZachodniGrodzisk Mazowiecki, 05 825, Poland
Completed
CM MED-GASTR Sp. z o.o.Lodz, 91-034, Poland
Completed
"NOWE ZDROWIE-CK" KIELTUCKI I WSPOLNICY SPOLKA JAWNAStaszow, 28-200, Poland
Completed
Velocity PulawyPulawy, 24-100, Poland
Completed
KO-MED Centra Kliniczne ZamoscZamosc, 22-400, Poland
Completed
1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ w LublinieLublin, 20-049, Poland
Completed
KLIMED Marek KlimkiewiczBialystok, 15-704, Poland
Completed
Narodowy Instytut Geriatrii, Reumatologii i RehabilitacjiWarszawa, 02-637, Poland
Completed
NZOZ HeurekaPiaseczno, 05-500, Poland
Completed
Irmed Klimkiewicz, Rudziewicz-Kowalska Sp.j.Piotrkow Trybunalski, 97-300, Poland
Completed
Humanitas Mirasole S.p.A. - Centro Trombosi e Malattie EmorragicheRozzano, 20089, Italy
Completed
ASUR Marche - Area Vasta 5Ascoli Piceno, 63074, Italy
Completed
AUSL Toscana Sud-EstArezzo, 52044, Italy
Completed
A.O.U. Policlinico Umberto IRoma, 161, Italy
Completed
A.O. di PerugiaPerugia, 6129, Italy
Completed
A.O.U. PisanaPisa, 56126, Italy
Completed
A.O.U. CareggiFirenze, 50134, Italy
Completed
Azienda Unita Sanitaria Locale Di Bologna_Ospedale Maggiore Pizzardi - CardiologiaBologna, 40133, Italy
Completed
A.O.U. Policlinico Umberto IRoma, 161, Italy
Completed
ASL2 Lanciano-Vasto-ChietiChieti, 66013, Italy
Completed
A.O.U. Maggiore della CaritàNovara, 28100, Italy
Not yet recruiting
A.O.U. Policlinico G. MartinoMessina, 98124, Italy
Completed
A.O.U. di Modena - PoliclinicoModena, 41100, Italy
Completed
ULSS3 SerenissimaVenezia, 30174, Italy
Completed
Ente Ecclesiastico Ospedale Generale Regionale MiulliBari, 70021, Italy
Completed
ASST Papa Giovanni XXIIIBergamo, 24127, Italy
Completed
IRCCS Centro Cardiologico MonzinoMilano, 20138, Italy
Completed
A.O.U. Ospedali Riuniti FoggiaFoggia, 71122, Italy
Completed
A.O.R.N. Ospedali dei Colli (Monaldi-Cotugno-CTO)Napoli, 80131, Italy
Completed
ASST Sette LaghiVarese, 21049, Italy
Completed
A.O.U. di FerraraFerrara, 44124, Italy
Completed
A.O.U. di PadovaPadova, 35128, Italy
Completed
A.O.U. di ParmaParma, 43126, Italy
Completed
Cambridge Cardiac Care CenterCambridge, N1R 6V6, Canada
Completed
Hospital da Senhora da Oliveira | Clinical Research DepartmentGuimaraes, Braga, 4835-044, Portugal
Completed
Instituto de Investigaciones Clinicas de Mar del Plata | Mar del Plata, ArgentinaMar del Plata, B7600FZ0, Argentina
Withdrawn
Hospital Privado de Comunidad | Clinical Research DepartmentMar del Plata, B7602CBM, Argentina
Withdrawn
Instituto Cardiovascular de Buenos Aires | Buenos Aires, ArgentinaBuenos Aires, C1428ART, Argentina
Completed
Centro de Investigaciones Medicas Lanus | Buenos Aires, ArgentinaLanus, B1824, Argentina
Completed
Institut universitaire de cardiologie et de pneumologie de QQuébec, G1V 4G5, Canada
Completed
Centre intégré de santé et de services sociaux de Laval, HôpLaval, H7M 3L9, Canada
Completed
QEII Health Sciences CentreHalifax, B3H 3A7, Canada
Completed
Hamilton Health SciencesHamilton, L8L 2X2, Canada
Completed
St. Michael's HospitalToronto, M5B 1W8, Canada
Completed
Victoria Heart Institute FoundationVictoria, V8R 1B2, Canada
Completed
Fraser Clinical Trials, Inc.New Westminster, V3L 3W4, Canada
Completed
Dr. James ChaOshawa, L1J2K1, Canada
Completed
Sunnybrook Health Sciences CentreToronto, M4N 3M5, Canada
Completed
Oakville Cardiovascular ResearchOakville, L6K 3W7, Canada
Completed
Hamilton Medical Research GroupHamilton, L8M 1K7, Canada
Completed
Viacar Recherches Cliniques Inc.Brossard, J4Z 2K9, Canada
Completed
CIUSSS NÎM Hôpital Sacré-CoeurMontreal, H4J 1C5, Canada
Completed
CHUM - Centre hospitalier de l'Université de MontréalMontreal, H2X 0C1, Canada
Completed
Centricity Research Mirabel MultispecialtyMirabel, J7J 2K8, Canada
Withdrawn
Jewish General HospitalMontreal, H3T 1E2, Canada
Completed
Eskisehir Osmangazi Universitesi Tip FakultesiEskisehir, 26480, Turkey
Completed
Ataturk Universitesi Tip FakultesiErzurum, 25240, Turkey
Withdrawn
Kartal Kosuyolu Yuksek Ihtisas Education and Research HospitIstanbul, 34846, Turkey
Completed
Dokuz Eylul Universitesi Tip FakultesiIzmir, 35100, Turkey
Completed
Erciyes Universitesi Tip FakultesiKayseri, 38039, Turkey
Completed
Kocaeli Universitesi Tip FakultesiKocaeli, 41380, Turkey
Completed
Afyonkarahisar Saglik Bilimleri UniversitesiAfyonkarahisar, 3218, Turkey
Completed
Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H.Istanbul, TBC, Turkey
Completed
Kutahya Saglik Bilimleri Uni. Evliya Celebi Egitim ve ArastiKutahya, 43040, Turkey
Completed
Akdeniz Universitesi Tip Fakultesi HastanesiAntalya, 7059, Turkey
Completed
Istanbul Universitesi Cerrahpasa – Kardiyoloji Anabilim DaliIstanbul, 34098, Turkey
Completed
Marmara Uni. Tip Fak. Pendik EAH KardiyolojiIstanbul, 34899, Turkey
Withdrawn
Cukurova Universitesi Tip Fakultesi HastanesiAdana, Turkey
Withdrawn
Istanbul Universitesi Kardiyoloji EnstitusuIstanbul, 34304, Turkey
Completed
Health Ministry Of Türkiye Republic Ankara Bilkent City HospitalAnkara, 6800, Turkey
Completed
Izmir Ekonomi Universitesi Medikal Point HastanesiIzmir, 35575, Turkey
Completed
Baskent Universitesi Tip Fakultesi HastanesiAnkara, 6490, Turkey
Completed
Adana Sehir Egitim ve Arastirma HastanesiYüregir, 1370, Turkey
Completed
Hitit Universitesi Tip FakultesiCorum, 19030, Turkey
Completed
Saglik Bilimleri Univ. Samsun EAH Kardiyoloji DepartmaniSamsun, 55090, Turkey
Completed
CardioBlu | Unidade SabinBlumenau, 89010-500, Brazil
Completed
Irmandade da Santa Casa de Misericordia de Porto Alegre | Hospital Sao Francisco - Centro Medico Pesquisa Clinica CardiologiaPorto Alegre, 90020-090, Brazil
Completed
Campinas Clinical Research Institute (IPECC) | Campinas, BrazilCampinas, 13060-080, Brazil
Completed
FZ Pesquisa e Servicos em Cardiologia | Porto Alegre, BrazilPorto Alegre, 91350-200, Brazil
Completed
Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research CenterPorto Alegre, 90035-903, Brazil
Completed
Instituto do Coração de Marilia | Marilia, BrasilMarília, 17515-000, Brazil
Completed
Hospital e Maternidade Sao LuizSão Paulo, 04321-150, Brazil
Completed
Sociedade Hospitalar Angelina Caron | Departamento de Ensino e PesquisaParaná, 83430-000, Brazil
Completed
Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao LucasSão Paulo, 13034-685, Brazil
Completed
Cardresearch Cardiologia Assistencial e de Pesquisa | Belo Horizonte, BrazilBelo Horizonte, 30150-240, Brazil
Completed
Centro de Pesquisa Clinica do Coração | Aracaju, BrasilAracaju, 49055-530, Brazil
Completed
Hospital das Clinicas da Universidade Federal de Goias | Centro de Pesquisa em CardiologiaGoiânia, 74605-020, Brazil
Completed
Instituto Dante Pazzanese de Cardiologia | Divisao de PesquisaSão Paulo, 04012-909, Brazil
Completed
Hospital Samaritano Paulista | Clinical Research DepartmentSão Paulo, 01317-002, Brazil
Completed
Centro Medico Sao Francisco | Curitiba, BrazilCuritiba, 80810-050, Brazil
Not yet recruiting
Geisinger Community Medical CenterScranton, 18510, United States
Not yet recruiting
Geisinger Wyoming Valley Medical CenterWilkes-Barre, 18711, United States
Completed
Capital Area Research | Camp Hill, PACamp Hill, 17011, United States
Completed
Inspira Medical Centers | Clinical Research OfficeMullica Hill, 08062, United States
Completed
Indago Research and Health Center | Hialeah, FLHialeah, 33012, United States
Not yet recruiting
University of Pittsburgh Medical Center Health SystemPittsburgh, 15219, United States
Completed
Kardio Egeszseghaz - Dr Amer Sayour Egyeni VallakozoGyor, 9024, Hungary
Withdrawn
Vasarhelyi Sarkanyfu Kft. (Porcika Klinika)Hodmezovasarhely, 6800, Hungary
Completed
Cardiocentro TicinoLugano, 6900, Switzerland
Not yet recruiting
Universitätsspital BaselBasel, 4056, Switzerland
Completed
UniversitätsSpital ZürichZürich, 8091, Switzerland
Completed
Kantonsspital AarauAarau, 5001, Switzerland
Completed
Inselspital Universitätsspital BernBern, 3010, Switzerland
Completed
Kantonsspital BadenBaden, 5404, Switzerland
Completed
Kantonsspital St. GallenSaint Gallen, 1009, Switzerland
Completed
Doylestown HospitalDoylestown, 18901, United States
Completed
Atlanta Heart Specialists, LLCTucker, 30084, United States
Not yet recruiting
University of IowaIowa City, 52242, United States
Withdrawn
Accel Research Sites | Atlanta Clinical Research Center - Atlanta, GAAtlanta, 30342, United States
Completed
Harbor - UCLA Medical CenterTorrance, 90502, United States
Completed
Hospital Alemao Oswaldo Cruz | Centro Internacional de PesquisaSao Paulo, 01321-001, Brazil
Completed
Hospital Cardio Pulmonar | Salvador, BrazilSalvador, 40170-130, Brazil
Completed
Luz Saude | Hospital da Luz Setubal - Clinical Research DepartmentSetúbal, 2900-722, Portugal
Completed
Hôpital Henri MondorCreteil, 94010, France
Completed
Centre Hospitalier Régional - Saint BrieucSAINT BRIEUC, 22000, France
Completed
Centre Hospitalier Départemental VendéeLA ROCHE SUR YON cedex, 85925, France
Completed
Centre Hospitalier Louis PasteurLE COUDRAY, 28630, France
Completed
Centre Hospitalier - Valenciennes CedexValenciennes, 59322, France
Completed
Hôpital de Rangueil - ToulouseTOULOUSE cedex, 31059, France
Completed
Hôpital Trousseau - ToursChambray-lès-Tours, 37170, France
Completed
Hôpital Pasteur - NiceNICE, 6002, France
Completed
Clinique Pasteur - ToulouseToulouse, 31076, France
Completed
CHU GRENOBLE - Hopital MichallonGRENOBLE Cedex 09, 38043, France
Completed
Hopital Européen Georges Pompidou - ParisPARIS CEDEX 15, 75908, France
Completed
Hôpital Cardiologique - PessacPESSAC, 33604, France
Completed
Hôpital Louis Pradel - BronBRON CEDEX, 69677, France
Completed
Centre Hospitalier Intercommunal de la Côte Basque-BayonneBAYONNE, 64100, France
Terminated
Centre de Cardiologie Nord - Saint DenisSAINT DENIS, 93207, France
Completed
Hôpital La Cavale Blanche - CHU de BrestBREST, 29200, France
Completed
Centre Hospitalier Universitaire - AngersAngers, 49933, France
Completed
Centre Hospitalier Universitaire de NancyVANDOEUVRE-LES-NANCY, 54500, France
Completed
Hôpital Civil - StrasbourgSTRASBOURG, 67091, France
Completed
Hôpital DupuytrenLIMOGES CEDEX, 87042, France
Completed
Nouvelles Cliniques Nantaises - NantesNANTES cedex 2, 44277, France
Completed
Institut Mutualiste MontsourisParis, 75014, France
Completed
Hôpital Guillaume et René Laennec - NantesNantes, 44035, France
Completed
Centre Hospitalier - CholetCHOLET, 49325, France
Completed
Hôpital de la Pitié-SalpétrièrePARIS, 75651, France
Completed
Hopital Carémeau - NîmesNîmes, 30029, France
Terminated
Hôpital Arnaud de Villeneuve - MontpellierMONTPELLIER, 34059, France
Completed
CHU de Caen - Hôpital Côte de NacreCAEN cedex 9, 14033, France
Completed
Centre Hospitalier du Docteur Schnaffer - LensLENS, 62307, France
Completed
Kansas Nephrology Physicians, PAWichita, 67226, United States
Completed
Alta Pharmaceutical Research Center, LLCPeachtree Corners, 30092, United States
Completed
Nova Clinical Research | Brandenton, FLBrandenton, 34209, United States
Completed
Pennsylvania State University College of MedicineHershey, 17033, United States
Not yet recruiting
Morehouse School of Medicine | Clinical Research CentreAtlanta, 30303-3031, United States
Completed
Universitair Medisch Centrum GroningenGRONINGEN, 9713 GZ, Netherlands
Completed
Treant locatie ScheperEmmen, 7824 AA, Netherlands
Completed
Spitatul Universitar de Urgenta BucarestiBucuresti, 50098, Romania
Completed
S.C. CARDIO MED S.R.L.Targu Mures, 540124, Romania
Completed
Sp. Judetean de Urgenta Dr. Constantin Opris Baia MareBaia Mare, 430031, Romania
Completed
S.C. Sal Med SRLPitesti, TBC, Romania
Completed
CMI. Dr. Podoleanu CristianTargu Mures, TBC, Romania
Not yet recruiting
S.C. CARDIOMED S.R.L. IasiIasi, 700732, Romania
Completed
S.C Thera Card S.R.LBrasov, 500102, Romania
Completed
Timisoara Institute of Cardiovascular DiseasesTimisoara, 300310, Romania
Withdrawn
Spitalul Clinic Judetean de Urgenta OradeaOradea, 410159, Romania
Completed
Spitalul Clinic de Urgenta Sf. IoanBucharest, 42122, Romania
Completed
Niculae Stancioiu Heart Institute Cluj-NapocaCluj Napoca, 400001, Romania
Completed
Emergency County Hospital, BrailaBraila, 810318, Romania
Completed
Municipal Clinical Emergency Hospital of TimisoaraTimisoara, 300254, Romania
Completed
Spitalul Clinic ColentinaBucuresti, 20125, Romania
Completed
Emergency Institute for Cardiovascular DiseasesBucharest, 22322, Romania
Completed
Emergency Institute of Cardiovascular Diseases & TransplantTargu Mures, 540136, Romania
Not yet recruiting
Sfantul Spiridon Emergency Clinical County HospitalIasi, 700111, Romania
Completed
Cardiomed S.R.LCluj-Napoca, 400015, Romania
Completed
Spitalul Clinic de Recuperare Cluj-NapocaCluj Napoca, 400300, Romania
Completed
S.C. Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRLBrasov, 500283, Romania
Not yet recruiting
Medical University of South Carolina - CardiologyCharleston, 29425, United States
Completed
Catharina Hospital | Cardiology DepartmentEINDHOVEN, 5623 EJ, Netherlands
Completed
Staploe Medical CentreEly, CB7 5SQ, United Kingdom
Completed
King's College Hospital - NHS Foundation TrustLondon, SE5 9RS, United Kingdom
Completed
Charing Cross HospitalLondon, W6 8RF, United Kingdom
Completed
Northwick Park HospitalHarrow, HA1 3UJ, United Kingdom
Completed
VieCuri - Medisch Centrum voor Noord-Limburg locatie VenloVENLO, 5912 BL, Netherlands
Completed
University General Hospital of Athens "ATTIKON"Chaidari, 12462, Greece
Completed
Lister HospitalStevenage, SG1 4AB, United Kingdom
Completed
St Richard's HospitalChichester, PO19 6SE, United Kingdom
Completed
North Hampshire HospitalBasingstoke, RG24 9NA, United Kingdom
Completed
Poole Hospital NHS TrustPoole, BH15 2JB, United Kingdom
Withdrawn
HUS, Meilahden sairaalaHelsinki, FIN-00260, Finland
Not yet recruiting
Terveystalo PulssiTurku, 20100, Finland
Completed
The Van Weel-Bethesda Hospital | Research DepartmentDirksland, 3247 BW, Netherlands
Completed
Freeman HospitalNewcastle, NE7 7DN, United Kingdom
Completed
G. GENNIMATAS General State Hospital of AthensAthens, 11527, Greece
Completed
Konstantopoulio General Hospital of Nea Ionia - AGIA OLGANea Ionia, 14233, Greece
Completed
KAT General Hospital of AthensKifisia, 14561, Greece
Completed
University General Hospital of LarissaLarissa, 41110, Greece
Completed
Hippokration General Hospital of ThessalonikiThessaloniki, 54642, Greece
Completed
AHEPA University General Hospital of ThessalonikiThessaloniki, 54636, Greece
Completed
Naval Hospital of AthensAthens, 11521, Greece
Withdrawn
General Hosp of Athens "Korgialenio-Benakeio" RCHAmpelokipi - Athens, 11526, Greece
Completed
University General Hospital of AlexandroupolisAlexandroupolis, 68100, Greece
Completed
University General Hospital of PatraPatra, 26504, Greece
Completed
HIPPOKRATION General Hospital of AthensAthens, 115 27, Greece
Completed
Thriassio General Hospital of ElefsinaElefsina, 19018, Greece
Withdrawn
Tzaneio General Hospital of PiraeusPiraeus, 18536, Greece
Completed
Univ. General Hospital of LarissaLarissa, 41110, Greece
Completed
University General Hospital of IoanninaIoannina, 45500, Greece
Completed
University General Hospital of Athens "ATTIKON"Chaidari, 12462, Greece
Completed
AHEPA University General Hospital of ThessalonikiThessaloniki, 54636, Greece
Completed
MITERA HospitalMarousi, 15123, Greece
Completed
General Hospital ASKLEPIEIO VOULASVoula, 16673, Greece
Completed
Univ. General Hospital of IoanninaIoannina, 45500, Greece
Completed
Craigavon Area HospitalCraigavon, BT63 5QQ, United Kingdom
Completed
Montreal Heart InstituteMontréal,, H1T 1C8, Canada
Completed
Interior Health - Royal Inland HospitalKamloops,, V2C 2T1, Canada
Completed
G.A. Research Associates, Ltd.Moncton, E1G 1A7, Canada
Completed
Heart Health InstituteScarborough, M1B 4Z8, Canada
Completed
Dr. Louis YaoYork, M9N 1W4, Canada
Completed
Women's College Hospital | WCH Main Site - Women's College Research Institute - Cardiology DepartmentToronto, M5S 1B2, Canada
Completed
Kawartha Cardiology Clinical TrialsPeterborough, K9J 0B2, Canada
Completed
Milestone ResearchLondon, N5W 6A2, Canada
Completed
London Health Sciences Centre | University Hospital - London Heart Rhythm Program - CardiologyLondon, N6A5A5, Canada
Completed
Niagara Health - St. Catharines SiteSt. Catharines, L2S 0A9, Canada
Completed
CISSSL - Hopital Pierre-Le GardeurTerrebonne, J6V 2H2, Canada
Completed
McGill University Health Centre – Glen SiteMontreal, H3G1A4, Canada
Completed
CIUSSS Saguenay Lac-St-JeanChicoutimi, G7H 5H6, Canada
Completed
CHU de Québec-Université LavalQuebec, G1R 2J6, Canada
Completed
CIUSSS de l’Estrie-CHUS, Hopital FleurimontSherbrooke, J1H 5N4, Canada
Completed
Diex Research Trois-Rivières Inc.Trois-Rivieres, G9A 4P3, Canada
Completed
Memorial University of NewfoundlandSt. John’s, A1B3V6, Canada
Completed
Ziekenhuis AmstellandAmstelveen, 1186 AM, Netherlands
Completed
Tergooiziekenhuizen-BlaricumBLARICUM, 1261 AN, Netherlands
Completed
Rode Kruis ZiekenhuisBeverwijk, 1942 LE, Netherlands
Completed
Gold Coast University HospitalSouthport, 4215, Australia
Completed
Fiona Stanley HospitalMurdoch, 6961, Australia
Completed
General Hospital of Athens "ALEXANDRA"Athens, 11528, Greece
Completed
General Hospital of Athens "Evangelismos"Athens, 10676, Greece
Completed
The 1st Affiliated Hospital of Zhejiang UniversityHangzhou, 310000, China
Completed
Teda International Cardiovascular HospitalTianjin, 300457, China
Completed
Beijing Tongren Hospital, Capital Medical University (West)Beijing, 100730, China
Withdrawn
Jiangsu Province Hospital of Chinese MedicineNanjing, 210029, China
Completed
The 4th Affiliated Hospital of Harbin Medical UniversityHarbin, 150001, China
Completed
The First Affiliated Hospital of Jinan UniversityGuangzhou, 510630, China
Completed
Veterans Benefits Administration | Minneapolis VA Medical Center - Cardiology DepartmentMinneapolis, 55417, United States
Completed
Erlanger Health, Inc.Chattanooga, 37403, United States
Completed
Duke Univ. Medical CenterDurham, 27710, United States
Completed
Peace River Cardiovascular Center | Port Charlotte, FLPort Charlotte, 33592, United States
Completed
South Denver Cardiology Associates, PCLittleton, 80120, United States
Withdrawn
Stanford UniversityStanford, 94305, United States
Withdrawn
Mercy Health ResearchSt. Louis, 63141, United States
Completed
Duke University | Duke Clinical Research Institute - Participant Research OperationsDurham, 27710-4000, United States
Completed
Saules family medicine centerKaunas, LT-49449, Lithuania
Completed
LUHS Kauno Hospital (Josvainiu str.)Kaunas, LT-47144, Lithuania
Completed
LUHS Kauno Hospital (Laisves ave.)Kaunas, LT-44320, Lithuania
Completed
Mariu klinika JSCKaunas, 45462, Lithuania
Completed
Klaipedos Jurininku LigonineKlaipeda, LT-92288, Lithuania
Completed
Sarawak Heart CentreSarawak, 94300, Malaysia
Completed
HagaZiekenhuis | Cardiology DepartmentDEN HAAG, 2545 AA, Netherlands
Completed
Saxenburgh Medisch Centrum | Cardiology DepartmentHardenberg, 7772 SE, Netherlands
Completed
Gelre Apeldoorn Ziekenhuizen | Cardiology DepartmentApeldoorn, 7334 DZ, Netherlands
Completed
Bravis Ziekenhuis | Roosendaal - Cardiology DepartmentROOSENDAAL, 4708 AE, Netherlands
Completed
Arkansas Cardiology | Little RockLittle Rock, 72205, United States
Completed
MaineHealth Maine Medical Center | Maine Medical Partners CardiologyScarborough, 04039, United States
Completed
Anderson Medical Group and Cardiology | Anderson Medical Research, LLCFort Washington, 20744, United States
Completed
Texas Health Research & Education InstituteFort Worth, 76104, United States
Completed
Fakultni nemocnice BrnoBrno, 625 00, Czech Republic
Completed
Fakultni Nemocnice OlomoucOlomouc, 77900, Czech Republic
Completed
Krajska Nemocnice LiberecLiberec, 460 63, Czech Republic
Completed
Nemocnice SlanySlany, 274 01, Czech Republic
Completed
Institut Klinicke a Experimentalni MedicinyPraha 4, 140 21, Czech Republic
Completed
Fakultni nemocnice v MotolePraha 5, 150 06, Czech Republic
Completed
Kardiologicka ambulance Brno s.r.o.Brno, 612 00, Czech Republic
Completed
Kardiologicka ambulance CormedicoBruntal, 792 01, Czech Republic
Completed
Medicon Poliklinika HolesovicePraha, 170 00, Czech Republic
Completed
MATMED s.r.o.Hodonin, 69501, Czech Republic
Completed
MUDr. Michalik s.r.o.Ostrava-Zabreh, 700 30, Czech Republic
Completed
Amkardia s.r.o.Brno, 639 00, Czech Republic
Completed
Cevni KulatakPraha, 160 00, Czech Republic
Completed
Cardio Research s.r.o.Zlin, 760 01, Czech Republic
Completed
Fakultni nemocnice Kralovske VinohradyPraha 10, 10034, Czech Republic
Completed
Edmonton Cardiology ConsultantsEdmonton, T5H 4B9, Canada
Completed
Vancouver General HospitalVancouver, V5Z 1M9, Canada
Completed
McMaster University Medical CentreHamilton, L8L 2X2, Canada
Withdrawn
KINGSTON HEALTH SCIENCES CENTREKingston, K7L 2 V7, Canada
Withdrawn
Uppsala Clinical Research CenterUppsala, 751 85, Sweden
Completed
Centro Hospitalar e Universitario de Coimbra, E.P.E. | Department of Cardiology, Research UnitCoimbra, 3004-561, Portugal
Completed
Centro Hospitalar Universitario de Sao Joao | Polo Porto - Centro de Investigacao e Ensaios ClinicosPorto, 4200-319, Portugal
Completed
Carient Heart and VascularManassas, 20109, United States
Completed
NSC Cardiology | Johns Creek, GACumming, 30041, United States
Completed
Siauliai Republican hospitalSiauliai, 76231, Lithuania
Completed
Vilnius University Hospital Santaros KlinikosVilnius, LT-08661, Lithuania
Completed
Vilnius University Hospital Santaros KlinikosVilnius, LT-08661, Lithuania
Completed
InMedica clinic ZaliakalnisKaunas, LT-50177, Lithuania
Completed
Kardiologijos ir reabilitacijos klinikaKlaipeda, LT-91131, Lithuania
Completed
Klaipeda Republican HospitalKlaipeda, LT-92231, Lithuania
Completed
Heart and Chest HospitalLiverpool, L14 3PE, United Kingdom
Completed
Countess of Chester HospitalChester, CH2 1UL, United Kingdom
Withdrawn
Carmel SurgeryDarlington, DL3 8SQ, United Kingdom
Completed
James Cook University Hospital South TeesMiddlesborough, TS43BW, United Kingdom
Completed
AZ St-Lucas Campus St-Lucas - CardiologyGent, 9000, Belgium
Completed
Wansbeck General HospitalAshington, NE63 9JJ, United Kingdom
Completed
Hospital of LT University of Health Sciences Kaunas ClinicsKaunas, LT-50161, Lithuania
Withdrawn
Healthy Medical Center S.A.SZipaquira, 250252, Colombia
Withdrawn
Fundación Centro de Obesidad y Metabolismo COMETAPästo, 520002, Colombia
Withdrawn
Promotora Médica Las Américas S.A.- Clinica Las AmericasMedellin, 050023, Colombia
Withdrawn
Centro de Diagnostico CardiológicoCartagena, 130001, Colombia
Withdrawn
Instituto del Corazón de BucaramangaBucaramanga, 680002, Colombia
Withdrawn
Hospital San Vicente FundaciónMedellin, 050010, Colombia
Completed
Lillestol Research LLC | Fargo, NDFargo, 58104, United States
Completed
National Hospital Organization Kyoto Medical CenterKyoto, 612-8555, Japan
Completed
Chiba Tokushukai Hospital | Clinical Trial CenterFunabashi-city, 274-8503, Japan
Completed
Tokyo Saiseikai Central Hospital | Clinical Research CenterMinato-ku, 108-0073, Japan
Completed
National Hospital Organization Kanazawa Medical Center | Clinical Trial Management OfficeKanazawa, 920-8650, Japan
Completed
Saiseikai Wakayama Hospital | Pharmaceutical departmentWakayama, 640-8158, Japan
Completed
Nakamura Cardiovascular ClinicItoshima, 819-1104, Japan
Completed
Oita Prefectural HospitalOita, 870-8511, Japan
Completed
Hakodate National HospitalHakodate, 041-8512, Japan
Completed
Tomakomai City HospitalTomakomai, 053-8567, Japan
Completed
National Hospital Organization Takasaki General Medical CenterTakasaki, 370-0829, Japan
Completed
Tokyo Angel Hospital | Clinical Trial DepartmentHachioji, 193-0811, Japan
Completed
Nihon University Itabashi HospitalItabashi-ku, 173-8610, Japan
Completed
Tokyo Medical and Dental University HospitalBunkyo-ku, 113-8519, Japan
Completed
Minamino Cardiovascular HospitalHachioji, 192-0918, Japan
Completed
Kanazawa Medical University HospitalKahoku-gun, 920-0293, Japan
Completed
Ishikawa Prefectural Central HospitalKanazawa, 920-8530, Japan
Completed
Public Central Hospital of Matto Ishikawa | Clinical Trial Management OfficeHakusan city, 924-8588, Japan
Completed
Japan Community Healthcare. Organization Chukyo HospitalNagoya, 457-8510, Japan
Completed
Sakurabashi Watanabe Future Medical Hospital | Department of CardiologyUmeda Kita-Ku, Osaka-shi, 5320001, Japan
Completed
Yao Tokushukai General Hospital | Clinical Research CenterYao-city, 581-0011, Japan
Completed
The Veritas HospitalKawanishi, 666-0125, Japan
Completed
Higashi Takarazuka Satoh HospitalTakarazuka, 665-0873, Japan
Completed
Akashi Medical Center | Hyogo, JapanAkashi-city, 674-0063, Japan
Completed
National Hospital Organization Hamada Medical CenterHamada, 697-8511, Japan
Completed
CMIC HealthCare Institute Co. Ltd. | Local IAA OCGMC - Okayama City Civic Hospital - Clinical Trial CentreOkayama, 7008557, Japan
Completed
CMIC HealthCare Institute Co. Ltd. | Okayama Rosai Hospital - Clinical Trial CentreOkayama, 7028055, Japan
Completed
Hiroshima City Hiroshima Citizens HospitalHiroshima, 730-8518, Japan
Completed
Mitoyo General Hospital | Kagawa, JapanToyohama-Cho,Kanonji-City, 769-1695, Japan
Completed
Kyushu Central HospitalFukuoka, 815-8588, Japan
Completed
Steel Memorial Yawata HospitalKitakyusyu, 805-8508, Japan
Completed
Munakata Suikokai General Hospital | Cardiology DepartmentFukutsu, 811-3298, Japan
Completed
Go Neurosurgical ClinicNakagawa, 811-1244, Japan
Completed
Kokura Memorial HospitalKitakyushu, 802-8555, Japan
Completed
Kumamoto Kinoh HospitalKumamoto, 860-8518, Japan
Completed
Miyazaki Medical Association HospitalMiyazaki, 880-2102, Japan
Completed
Klinikum Klagenfurt | Innere Medizin und KardiologieKlagenfurt, 9020, Austria
Withdrawn
Rodrigo Botero S.A.SMedellin, 050021, Colombia
Withdrawn
Clinica Cardio VIDMedellin, 050034, Colombia
Withdrawn
Centro Cardiovascular Arístides SotomayorCartagena, 130010, Colombia
Withdrawn
Fundación Oftalmológica de Santander Carlos Ardila LuleFlorida Blanca, 681004, Colombia
Withdrawn
IPS Centro Cientifico Asistencial S.A.SBarranquilla, 080020, Colombia
Withdrawn
Clínica Imbanaco S.A.SCali, 760042, Colombia
Withdrawn
Clínica de la Costa SASBaranquilla, 080020, Colombia
Withdrawn
Fundación Cardiovascular de ColombiaFloridablabca, 681011, Colombia
Withdrawn
Fundacio del Caribe para la Investigacio Bio-Medica (BIOS)Barranquilla, 080001, Colombia
Withdrawn
Hospital Pablo Tobón UribeMedellin, 050034, Colombia
Withdrawn
Julian Coronel Private PracticeCali, TBC, Colombia
Completed
Rabin Medical Center | Beilinson Hospital - Internal Medicine C DepartmentPetach Tikva, 4941492, Israel
Completed
Centro Hospitalar de Lisboa Ocidental | Clinical Research DepartmentLisboa, 1449-005, Portugal
Completed
Centre Hospitalier Gustave Dron - TourcoingTOURCOING, 59280, France
Completed
Universitetssjukhuset i LinköpingLinköping, 581 85, Sweden
Completed
University of Alberta HospitalEdmonton, T6G 2B7, Canada
Terminated
St. Joseph's Healthcare - HamiltonHamilton, L8N 4A6, Canada
Completed
Vanderbilt University Medical CenterNashville, 37232, United States
Not yet recruiting
Northwestern UniversityChicago, 60611, United States
Completed
Baptist Heart and Vascular/Cardiology ConsultantsPensacola, 32503, United States
Completed
Sound Medical Research | Sound Medical Research of Port OrchardPort Orchard, 98366, United States
Completed
Taipei Veterans General HospitalTaipei, 11217, Taiwan
Completed
National Cheng Kung University HospitalTainan, 704, Taiwan
Completed
Chang Gung Memorial Hospital KaohsiungKaohsiung, 833, Taiwan
Completed
Fakultni nemocnice PlzenPlzen, 301 00, Czech Republic
Completed
Benedor s.r.o.Ostrava - Poruba, 708 68, Czech Republic
Completed
Mrozek kardiologieFrydek-Mistek, 73801, Czech Republic
Completed
Sapporo Higashi Tokushukai HospitalSapporo, 065-0033, Japan
Completed
Miyanosawa Clinic of Internal Medicine and CardiologySapporo, 063-0826, Japan
Completed
Sainokuni Higashiomiya Medical CenterSaitama, 331-8577, Japan
Completed
Ageo Central General HospitalAgeo, 362-8588, Japan
Completed
CliniPro Co.,Ltd. | Tokyo-Eki Center-building Clinic - Tokyo, JapanChuo-ku, 103-0027, Japan
Completed
NewHeart Watanabe InstituteSuginami-ku, 168-0065, Japan
Completed
National Hospital Organization Tokyo Medical CenterMeguro-ku, 152-8902, Japan
Completed
Hayama Heart Center | Clinical Trial CenterMiura-gun, 240-0116, Japan
Completed
Asama Nanroku Komoro Medical Center | Komoro, JapanKomoro, 384-8588, Japan
Completed
Japan Red Cross Society Azumino HospitalAzumino, 399-8292, Japan
Completed
Gifu Heart CenterGifu, 500-8384, Japan
Completed
Omihachiman Community Medical CenterOmihachiman, 523-0082, Japan
Completed
Kishiwada Tokushukai HospitalKishiwada, 596-0042, Japan
Completed
Osaka Saiseikai Nakatsu HospitalOsaka, 530-0012, Japan
Completed
Japan Community Health Care Organization Osaka HospitalOsaka, 553-0003, Japan
Completed
Hyogo Prefectural HarimaHimeji General Medical CenterHimeji, 670-8560, Japan
Completed
JCHO Tokuyama Central HospitalShunan, 745-8522, Japan
Completed
Chikamori HospitalKochi, 780-8522, Japan
Completed
Yanagawa HospitalYanagawa-city, 832-0077, Japan
Completed
Tenyoukai Central ClinicKagoshima, 892-0822, Japan
Completed
Oosumikanoya HospitalKanoya, 893-0015, Japan
Completed
Yokohama City University Medical CenterYokohama, 232-0024, Japan
Completed
Centro Hospitalar de Tamega e Sousa | Hospital Padre Americo - Cardiology DepartmentGuilhufe, 4564-007, Portugal
Completed
National Taiwan University HospitalTaipei, 100, Taiwan
Completed
Taipei Medical University | Clinical Research CenterTaipei, 110, Taiwan
Completed
Chang Gung Memorial Hospital at LinkouTaoyuan, 33305, Taiwan
Completed
Taichung Veterans General HospitalTaichung, 40705, Taiwan
Completed
Changhua Christian HospitalChanghua, 50006, Taiwan
Completed
Kaohsiung Medical University Chung-Ho Memorial HospitalKaohsiung City, 807377, Taiwan
Completed
Mackay Memorial Hospital - Hsinchu BranchHsinchu, 300, Taiwan
Completed
Chi Mei Medical CenterTaikang, 71004, Taiwan
Completed
Mackay Memorial HospitalTaipei, 104, Taiwan
Completed
China Medical University HospitalTaichung, 404327, Taiwan
Completed
Taipei Municipal Wanfang HospitalTaipei, 116, Taiwan
Completed
National Yang Ming Chiao Tung University HospitalYilan, 260006, Taiwan
Completed
MacKay Memorial Hospital Tamsui BranchNew Taipei City, 25160, Taiwan
Completed
Chung Shan Medical University HospitalTaichung, 402306, Taiwan
Completed
Mita Internist and Cardiology Clinic | Hokkaido, JapanSapporo, 006-0852, Japan
Completed
Teine Keijinkai HospitalSapporo, 006-8555, Japan
Completed
Matsuda Cardiovascular clinicSapporo, 003-0026, Japan
Completed
Hanaoka Seishu Memorial HospitalSapporo, 062-0003, Japan
Completed
Asahikawa City HospitalAsahikawa, 070-8610, Japan
Completed
Iwate Prefectural Central HospitalMorioka, 020-0066, Japan
Completed
JA Toride Medical CenterToride, 302-0022, Japan
Completed
Ibaraki Prefectural Central HospitalKasama, 309-1793, Japan
Completed
Dokkyo Medical University HospitalShimotsuga-gun, 321-0293, Japan
Completed
Sanai hospitalSaitama, 338-0837, Japan
Completed
Toho University Sakura Medical CenterSakura, 285-8741, Japan
Completed
Fujisawa City HospitalFujisawa, 251-8550, Japan
Completed
Komatsu Municipal HospitalKomatsu, 923-8560, Japan
Completed
Shizuoka City Shizuoka HospitalShizuoka, 420-8630, Japan
Completed
Japan Culture and Welfare Federation of Agricultural Cooperatives | Toyota Kosei HospitalToyota-City, 470-0396, Japan
Completed
Osaka Saiseikai Senri HospitalSuita, 565-0862, Japan
Completed
Kobe City Medical Center General HospitalKobe, 650-0047, Japan
Completed
Mazda Motor Corporation Mazda HospitalAki-gun, 735-8585, Japan
Completed
Core Research Group Pty Ltd. | Brisbane, AustraliaTaringa QLD, 4068, Australia
Completed
University Malaya Medical CentreKuala Lumpur, 59100, Malaysia
Completed
Sarawak General HospitalSarawak, 93400, Malaysia
Completed
Hospital Universiti Sains MalaysiaKelantan, TBC, Malaysia
Completed
University Hospital Kebangsaan MalaysiaCheras, 56000, Malaysia
Completed
Hospital Al-Sultan Abdullah (UiTM Hospital)Selangor, 42300, Malaysia
Completed
Hospital Sultanah AminahJohor Bahru, 80100, Malaysia
Completed
Institute Jantung NegaraKuala Lumpur, 50400, Malaysia
Completed
Hospital Sultan Abdul Aziz ShahSelangor, 43400, Malaysia
Completed
Hospital Seberang JayaPulau Pinang, 13700, Malaysia
Completed
Hospital Sultanah BahiyahAlor Setar, 5460, Malaysia
Completed
Hakodate Municipal HospitalHakodate, 041-8680, Japan
Completed
The Sakakibara Heart Institute of OkayamaOkayama, 700-0804, Japan
Completed
Kagawa Prefectural Central HospitalTakamatsu, 760-8557, Japan
Completed
Kagoshima Medical CenterKagoshima, 892-0853, Japan
Completed
R.I.A.C Naha City HospitalNaha, 902-8511, Japan
Completed
Hospital Pedro Hispano | Clinical Research CenterMatosinhos, 4464-513, Portugal
Withdrawn
Hospital de Cascais Dr. Jose de Almeida | Clinical Investigation CenterAlcabideche, 2755-009, Portugal
Completed
Hospital Raja Perempuan Zainab IIKelantan, 15200, Malaysia
Completed
Seremban Hospital NeurologySeremban, 70300, Malaysia
Completed
Hospital Tengku Ampuan AfzanPahang, 25100, Malaysia
Completed
Rutas Eglites GP PracticeKuldiga, LV-3301, Latvia
Completed
Vidzemes HospitalValmiera, LV-4201, Latvia
Completed
National Hospital Organization Disaster Medical CenterTachikawa, 190-0014, Japan
Completed
North Alps Medical Center Azumi HospitalKitaazumi-gun, 399-8695, Japan
Completed
Fukuoka Shinmizumaki Hospital | Clinical Trial Management OfficeTateyashiki, Mizumakimachi, On, 807-0051, Japan
Completed
Urasoe General Hospital | Clinical Research Support CenterUrasoe, 901-2102, Japan
Completed
Yokohama Sakae Kyosai HospitalYokohama, 247-8581, Japan
Completed
Kimitsu Chuo HospitalKisarazu, 292-8535, Japan
Completed
Sendai Cardiovascular CenterSendai, 981-3133, Japan
Completed
Japan Culture and Welfare Federation of Agricultural Cooperatives | ShirakawaKosei General HospitalShirakawa-city, 105-0021, Japan
Completed
Iwatsuki-minami HospitalSaitama, 339-0033, Japan
Completed
Kawaguchi Cardiovascular and Respiratory HospitalKawaguchi, 333-0842, Japan
Completed
Nippon Medical School Chiba Hokusoh Hospital | Clinical Trial OfficeInzai, 270-1694, Japan
Completed
Tokyo Yamate Medical CenterShinjuku-ku, 169-0073, Japan
Completed
Fukui General ClinicFukui, 910-0067, Japan
Completed
Iida HospitalIida-city, 395-8505, Japan
Withdrawn
Cardio Colombia S.A.SBogota, 110221, Colombia
Withdrawn
Sociedad Médica Rionegro SOMER S.A.Rionegro, 054040, Colombia
Withdrawn
Fundación Hospital Universidad del NorteSoledad, TBC, Colombia
Withdrawn
IPS Centro de Investigaciones Clínicas Cardiomet PereiraPereira, 660003, Colombia
Withdrawn
Centro de Atencion e Investigation Medica S.A.S. - CAIMED CHChia, 250002, Colombia
Withdrawn
Corazón IPS S.A.S.Barranquilla, 080020, Colombia
Withdrawn
Hospital General de MedellinMedellin, 050015, Colombia
Withdrawn
Mediservis del Tolima IPS S.A.SIbague, 730006, Colombia
Completed
University General Hospital of HeraklionHeraklion, 711 10, Greece
Completed
LAIKO General Hospital of AthensAthens, 11527, Greece
Completed
University General Hospital of PatraPatra, 26504, Greece
Completed
Nucleo de Pesquisa Clinica | Curitiba, BrazilCuritiba, 80730-150, Brazil
Completed
Machida Municipal HospitalMachida, 194-0023, Japan
Completed
Hamilton Med.Research Group - DCTHamilton, L8M 1K7, Canada
Withdrawn
Toronto General Hospital UHN - DCTToronto, M5G 2C4, Canada
Withdrawn
University Medical Center (UMC) Utrecht | Heart and Lungs DivisionUTRECHT, 3584 CX, Netherlands
Not yet recruiting
Medisch Centrum Haaglanden, Locatie WesteindeDen Haag, 2512 VA, Netherlands
Withdrawn
Stanford University Medical CenterStanford, 94305, United States
Not yet recruiting
St. Luke's Health System | St. Luke's Clinic - Idaho Cardiology AssociatesMeridian, 83642, United States
Completed
Jackson Heart Clinic | Jackson, MSJackson, 39216, United States
Completed
Encore Research Group | Nature Coast Clinical Research – InvernessInverness, 34452, United States
Not yet recruiting
Confluence HealthWenatchee, 98801, United States
Completed
Encore Research Group | St. Johns Center for Clinical ResearchSt. Augustine, 32081, United States
Completed
ProMedica Toledo HospitalToledo, 43615, United States
Completed
Sunshine Coast University HospitalBirtinya, 4575, Australia
Completed
Illawarra Shoalhaven Local Health DistrictWollongong, 2500, Australia
Completed
The Prince Charles HospitalHerston, 4029, Australia
Completed
John Hunter HospitalNew Lambton, 2305, Australia
Completed
Grampians Health BallaratBallarat, 3350, Australia
Completed
Advara HealthCare LeabrookLeabrook, 5068, Australia
Completed
Concord Repatriation General HospitalConcord, 2139, Australia
Completed
Hospital SerdangSelangor, 43000, Malaysia
Completed
University Hospitals LeicesterLeicester, LE3 9QP, United Kingdom
Completed
Chesterfield Royal HospitalChesterfield, S44 5BL, United Kingdom
Completed
Glasgow Royal Infirmary | Stroke UnitGlasgow, G4 0SF, United Kingdom
Completed
Worcestershire Acute Hospital TrustWorcester, WR5 1DD, United Kingdom
Completed
Soho Health Centre, Future MedsBirmingham, B21 9RY, United Kingdom
Completed
Torbay HospitalTorbay, TQ2 7AA, United Kingdom
Completed
Future Meds - BromboroughWirral, CH62 6EE, United Kingdom
Completed
Ely Bridge Medical CentreCardiff, CF5 4AD, United Kingdom
Completed
Admiraal de RuyterziekenhuisGoes, 4462RA, Netherlands
Completed
Capital Region | Nordsjaellands Hospital - Hillerod - Cardiology DepartmentHilleroed, 3400, Denmark
Completed
Buddhist Tzu-Chi General Hospital, HualienHualien, 970, Taiwan
Completed
Klinikum Wels-Grieskirchen | Innere Medizin IIWels, 4600, Austria
Completed
Tri-Service General HospitalTaipei City, 114, Taiwan
Completed
Cathay General HospitalTaipei, 106, Taiwan
Withdrawn
Accellacare WarwickshireCoventry, CV3 4FJ, United Kingdom
Completed
Barwon HealthGeelong, 3220, Australia
Completed
Royal Adelaide HospitalAdelaide, 5000, Australia
Completed
South Western Sydney Local Health District | Liverpool Hospital - Stroke and Neurovascular DepartmentLiverpool, 2170, Australia
Completed
Blacktown HospitalBlacktownn, 2148, Australia
Completed
Royal Melbourne HospitalParkville, 3050, Australia
Completed
Eastern HealthBOX HILL, 3128, Australia
Completed
Flinders Medical CentreBedford Park, 5042, Australia
Completed
Royal Brisbane & Women's HospitalBrisbane, 4029, Australia
Completed
Advara HealthCare JoondalupPerth, 6150, Australia
Completed
The Canberra HospitalGarran, 2605, Australia
Completed
Nepean HospitalKingswood, 2747, Australia
Completed
The Alfred HospitalMelbourne, 3004, Australia
Withdrawn
Westmead HospitalWestmead, 2145, Australia
Withdrawn
University of AdelaideAdelaide, 5005, Australia
Completed
Nightingale ResearchAdelaide, 5000, Australia
Completed
Queen Elizabeth Hospital AUSWoodville South, 5011, Australia
Completed
Baker Heart and Diabetes InstituteHoppers Crossing, 3029, Australia
Completed
Queen Elizabeth the Queen Mother HospitalMargate, CT9 4AN, United Kingdom
Withdrawn
Circuit ClinicalOrchard Park, 14127, United States
Completed
SEC Clinical ResearchDothan, 36305, United States
Completed
Baptist Health Medical Group - Louisville CardiologyLouisville, 40207, United States
Completed
VrinnevisjukhusetNorrköping, 601 82, Sweden
Completed
David Turbay MD PLLCEl Paso, 79905, United States
Completed
VA Greater Los Angeles Healthcare System | West Los Angeles VA Medical Center - Cardiology DepartmentLos Angeles, 90073-1003, United States
Completed
ASL ROMA 2Roma, 157, Italy
Completed
A.O Sant'Anna-San SebastianoCaserta, 81100, Italy
Completed
ULSS2 Marca TrevigianaTreviso, 31015, Italy
Not yet recruiting
ULSS2 Marca TrevigianaTreviso, 31015, Italy
Withdrawn
A.O.U. Mater DominiCatanzaro, 88100, Italy
Completed
A.O.U. Ospedali Riuniti "Umberto I - G.M.Lancisi - G.Salesi"Ancona, 60126, Italy
Completed
ASST del GardaBrescia, 25085, Italy
Completed
A.O.U. Policlinico Federico II NapoliNaples, 80131, Italy
Completed
Hospital Universitario La Paz | Cardiology Department - AF, Stroke PreventionMadrid, 28046, Spain
Completed
Edith Wolfson Medical Center | Internal Medicine DepartmentHolon, 5822012, Israel
Completed
TaNa Med Kft.Mosonmagyarovar, 9200, Hungary
Completed
Dr. Laszlo Elek Korhaz es Rendelointezet, OroshazaOroshaza, 5900, Hungary
Completed
Complex Rendelo Med Zrt.Szekesfehervar, 8000, Hungary
Withdrawn
Nograd Varmegyei Szent Lazar Korhaz, II. Belgyogyaszat-KardiologiaSalgotarjan, 3100, Hungary
Completed
Trial Pharma Kft. GyulaGyula, 5700, Hungary
Withdrawn
Asociación IPS Médicos Internistas de CaldasManizales, 170004, Colombia
Withdrawn
Fundación Cardiomet CEQUIN Eje CafeteroArmenia, 630004, Colombia
Completed
InMedica Clinic SantariskesVilnius, LT-08431, Lithuania
Completed
Russells Hall HospitalDudley, DY1 2HQ, United Kingdom
Completed
Affinity Health Research Institute | Oak Brook, ILOak Brook, 60523, United States
Completed
NOVA Clinic Medical Center | Varna, BGVarna, 9020, Bulgaria
Completed
General Hospital Silistra | Department of Cardiology, Structure for Interventional CardiologySilistra, 7500, Bulgaria
Completed
Hanusch Krankenhaus | 2. Medizinische AbteilungWien, 1140, Austria
Completed
Landeskrankenhaus Hall | Abteilung fuer Innere MedizinHall in Tirol, 6060, Austria
Completed
Praxis Hr. Dr. med. Jens TaggeselleMarkkleeberg, 04416, Germany
Completed
Ochsner Clinic FoundationBaton Rouge, 70836, United States
Completed
Japan Culture and Welfare Federation of Agricultural Cooperatives | Hokushin General HospitalNakano-City, 383-8505, Japan
Completed
Japanese Red Cross Society Suwa HospitalSuwa, 392-8510, Japan
Completed
Nippon Life HospitalOsaka, 550-0006, Japan
Completed
Matsuyama Shimin HospitalMatsuyama, 790-0067, Japan
Completed
Fukui Prefectural HospitalFukui, 910-8526, Japan
Completed
Miyanomori Memorial HospitalSapporo, 064-8570, Japan
Completed
Tohoku Medical and Pharmaceutical University Hospital | Center for Clinical Research Promotion and DevelopmentSendai-city, 983-8512, Japan
Completed
Yamanashi Prefectural Central HospitalKofu, 400-8506, Japan
Completed
Saga Memorial HospitalSaga, 849-0917, Japan
Completed
GZA Ziekenhuizen | Saint Augustine Campus - Cardiology DepartmentWilrijk, 2610, Belgium
Completed
CU Saint-Luc/UZ St-LucBRUXELLES - BRUSSEL, 1200, Belgium
Completed
AZ Sint-Jan Brugge-Oostende | Sint-Jan - CardiologyBrugge, 8000, Belgium
Completed
AZ Sint Blasius, Cardiology, DendermondeDendermonde, 9200, Belgium
Completed
Vitaz | Sint-Niklaas Hospital - Cardiology DepartmentSint-Niklaas, 9100, Belgium
Completed
Ålesund Sykehus, Kardiologisk SeksjonÅlesund, 6026, Norway
Completed
Circuit Clinical/Crystal RunMiddletown, 10941, United States
Completed
Centrum Medyczne Ogrodowa G. i M. Kania Lekarze i Lekarze Dentysci Spólka Partnerska z siedziba w SkierniewicachLowicz, 99-400, Poland
Completed
CLINICAL MEDICAL RESEARCH Sp. z o. o.Katowice, 40-156, Poland
Completed
Vita Longa Sp. z o.o.Katowice, 40-748, Poland
Completed
ClinMedica Research Sp. z o.o.Skierniewice, 96-100, Poland
Completed
Centrum Terapii WspolczesnejLodz, 90-338, Poland
Completed
NBR Polska Tomasz KlodawskiWarszawa, 00-465, Poland
Completed
Etyka Osrodek Badan KlinicznychOlsztyn, 10-117, Poland
Completed
Solumed Centrum MedycznePoznan, 60-529, Poland
Completed
Rakuwakai Otowa HospitalKyoto, 607-8062, Japan
Completed
Fukuoka University Nishijin HospitalFukuoka, 814-8522, Japan
Completed
Japan Culture and Welfare Federation of Agricultural Cooperatives | Suzuka Chuo General HospitalSuzuka-shi, 513-8630, Japan
Completed
Oji General HospitalTomakomai, 053-8506, Japan
Completed
Onga Nakama Medical Association Onga HospitalOnga-gun, 811-4342, Japan
Completed
Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro HospitalFukuoka, 811-0213, Japan
Completed
Fukuoka University HospitalFukuoka, 814-0180, Japan
Completed
Centro Hospitalar Vila Nova de Gaia e Espinho | Unit 1 - Clinical Research CenterPorto, 4434-502, Portugal
Completed
Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao ClinicaLisboa, 1500-650, Portugal
Completed
MEDISPOL s.r.o.Presov, 08001, Slovakia
Completed
ORALEK, s.r.o.Namestovo, 02901, Slovakia
Completed
Huizhou Central People's HospitalHuizhou, 516001, China
Completed
Tsuchiura Kyodo General HospitalTsuchiura, 300-0028, Japan
Completed
Osaka Police Hospital | Clinical Research and Trial CenterOsaka, 543-0035, Japan
Completed
Hyogo Prefectural Amagasaki General Medical CenterAmagasaki, 660-8550, Japan
Completed
Japanese RedCross Aichi Medical Center Nagoya Daini HospitalNagoya, 466-8650, Japan
Completed
Hospital Sao Lucas Copacabana | Clinical Research DepartmentRio de Janeiro, 22.0080-040, Brazil
Completed
UNESP Faculdade de Medicina de Botucatu | UPECLINBotucatu, 18618-970, Brazil
Completed
Quanta Diagnostico Por Imagem | Research and Innovation DepartmentCuritiba, 80045-170, Brazil
Completed
Irmandade da Santa Casa de Misericordia de Sao Paulo | Hospital Central - Cardiology DepartmentSão Paulo, 01221-020, Brazil
Completed
Dong-A University HospitalBusan, 49201, Korea,_republic_of
Completed
Uijeongbu ST. Mary's HospitalUijeongbu-si, Gyeonggi-do, 11765, Korea,_republic_of
Completed
Kyungpook National University HospitalDaegu, 41944, Korea,_republic_of
Completed
Yonsei University Wonju Christian HospitalWonju, 26426, Korea,_republic_of
Completed
Eurolatino Pesquisas Medicas | Uberlandia, MGMinas Gerais, 38400-368, Brazil
Completed
Hospital Maternidade e Pronto Socorro Santa Lucia | Hospital do Coracao - Research CenterPoços de Caldas, 37706-106, Brazil
Completed
Kasugai Municipal HospitalKasugai, 486-8510, Japan
Completed
Multiprofile Hospital for Active Treatment Trakiya Park | Cardiology DepartmentStara Zagora, 6000, Bulgaria
Completed
Multidisciplinary Hospital for Active Treatment Heart and Brain Burgas | Cardiology DepartmentBurgas, 8000, Bulgaria
Completed
Kitada ClinicOsaka, 538-0044, Japan
Completed
Centro Hospitalar De Tras os Montes e Alto Douro | Hospital Sao Pedro - Centro de Investigacao ClinicaVila Real, 5000-508, Portugal
Completed
The First Affiliated Hospital of Harbin Medical UniversityHarbin, 150001, China
Completed
Beijing Chaoyang Hospital, Capital Medical UniversityBeijing, 100020, China
Completed
Inner Mongolia People's HospitalHohhot, 010017, China
Completed
Baotou Central HospitalBaotou, 14040, China
Completed
Xuanwu Hospital Capital Medical UniversityBeijing, 100053, China
Completed
Jiangxi Provincial People’s HospitalNanchang, 330006, China
Completed
Cangzhou Central HospitalCangzhou, 61000, China
Completed
Chengdu Second People's HospitalChengdu, 610021, China
Completed
People's Hospital of Deyang CityDeyang, 618000, China
Completed
The First Hospital of Hebei Medical UnivesityShijiazhuang, 50000, China
Completed
The First Affiliated Hospital of Baotou Medical CollegeBaotou, 14010, China
Completed
1st Affiliated Hospital of Henan Science and Technology UnivLuoyang, 471000, China
Completed
Luoyang Third People's HospitalLuoyang, 471002, China
Completed
Peking University First HospitalBeijing, 100034, China
Completed
Shanghai Putuo District Central HospitalShanghai, 200333, China
Completed
The 2nd Affiliated Hospital of Shandong UniversityJinan, 250033, China
Completed
Zibo Central HospitalZibo, 250036, China
Completed
Taian City Central HospitalTaian, 271099, China
Completed
Guangzhou First People HospitalGuangzhou, 510180, China
Completed
Jining No.1 People's HospitalJining, 272011, China
Completed
Affiliated Hospital of Jining Medical UniversityJining, 272007, China
Completed
Yinchuan No.1 People's HospitalYinchuan, 750001, China
Completed
Shanxi Bethune HospitalTaiyuan, 30032, China
Completed
Shanxi Candiovascular HospitalTaiyuan, 30024, China
Completed
The First affiliated Hospital of Hebei North UniversityZhangjiakou, 075000, China
Completed
China-Japan Friendship HospitalBeijing, 100029, China
Completed
The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou, 121001, China
Completed
The First Affiliated Hospital of Xinjiang Medical UniversityUrumchi, MISSING, China
Completed
Jiangxi PingXiang people's HospitalPingxiang, 337055, China
Completed
Xiamen Cardiovascular Hospital Xiamen UniversityXiamen, 361006, China
Completed
Korea University Anam Hospitalseoul, 02841, Korea,_republic_of
Completed
Mito Saiseikai General HospitalMito, 311-4198, Japan
Withdrawn
Universitätsklinikum CharitéBerlin, 13353, Germany
Completed
Uniklinik Jena / KardiologieJena, 7747, Germany
Completed
National hospital Organization Mito Medical CenterHigashiibaraki, 311-3193, Japan
Completed
Advara HealthCare WesleyAuchenflower, 4066, Australia
Completed
The Avenue Cardiovascular CentreSt Kilda East, 3183, Australia
Completed
Redcliffe District HospitalRedcliffe, 4020, Australia
Completed
Advara HeartCare MelbourneRingwood, 3135, Australia
Completed
Cabrini MalvernMalvern, 3144, Australia
Completed
Kardiolitos klinikos / BMPKaunas, LT-49287, Lithuania
Completed
Nemocnice Ceske Budejovice, a.s. Department of kardiologieCeske Budejovice, 370 01, Czech Republic
Completed
Vojenska nemocnice BrnoBrno, 63600, Czech Republic
Completed
Spitalul de urgenta Sf. Ioan Cel NouSuceava, 720237, Romania
Completed
Spitalul Judetean de Urgenta Satu MareSatu Mare, 440192, Romania
Withdrawn
Nightingale ResearchAdelaide, 5000, Australia
Completed
Zhongshan Hospital, Fudan UniversityShanghai, 200032, China
Completed
East Tallinn Central HospitalTallinn, 10138, Estonia
Completed
Dr Signe Alliksoo Family Doctors PracticeTallinn, 10138, Estonia
Completed
West Tallinn Central hospitalTallinn, EE-10617, Estonia
Completed
Office of Arvo RosenthalTallinn, 13419, Estonia
Completed
Pirita Family Doctors CentreTallinn, 11911, Estonia
Not yet recruiting
Rapla Family Doctors CentreRapla, 79515, Estonia
Completed
North Estonia Medical Centre FoundationTallinn, 13419, Estonia
Completed
Tartu University HospitalTartu, 50406, Estonia
Completed
West China Hospital,Sichuan UniversityChengdu, 610041, China
Completed
Guangzhou Panyu Central HospitalGuangzhou, 511400, China
Completed
Rivas | Beatrix Hospital Gorinchem - Cardiology DepartmentGORINCHEM, 4204 AA, Netherlands
Completed
Klaipeda Seamen's Hospital Cardiology Department IKlaipeda, LT-92288, Lithuania
Completed
APS ClinicRiga, LV-1050, Latvia
Withdrawn
Sir Run Run Shaw Hospital, Zhejiang Univ. School of MedicineHangzhou, 310016, China
Completed
CHI Toulon - H La Seyne - CardiologieToulon, 83000, France
Terminated
Hôpital de la Pitié-SalpétrièrePARIS, 75651, France
Completed
HOPITAL CHARLES NICOLLE CHU ROUENBois-Guillaume, 76320, France
Completed
CHU Rennes, H Pontchaillou, CardiologieRennes, 35033, France
Completed
Uniklinik Leipzig / KardiologieLeipzig, 4103, Germany
Completed
SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHosChengdu, 610072, China
Completed
Yuncheng Central HospitalYuncheng, 44099, China
Completed
Qinghai University Affiliated HospitalXining, 810001, China
Completed
Ningbo First HospitalNingbo, 315010, China
Completed
Liuzhou Worker's HospitalLiuzhou, 545005, China
Completed
Shanghai General HospitalShanghai, 200080, China
Completed
AnMed Clinical ResearchAnderson, 29621, United States
Completed
The Third Hospital of NanchangNanchang, 330009, China
Completed
Yan'an University Xianyang HospitalXianyang, 716000, China
Completed
Renmin Hosp., Wuhan Univ.Wuhan, 430040, China
Completed
Union Hospt Tongji Medical Colleg. Huazhong univ. Scien&TechWuhan, 430030, China
Completed
Shin Kong Wu Ho-Su Memorial HospitalTaipei, 111, Taiwan
Completed
E-Da HospitalKaohsiung, 82445, Taiwan
Completed
Veterans General HospitalKaohsiung City, 813414, Taiwan
Completed
Emergency Institute for Cardiovascular DiseasesBucharest, 22322, Romania
Completed
Hospital de Base | Integrated Research CenterSão José do Rio Preto, 15090-000, Brazil
Withdrawn
AZ Monica Campus Deurne - CardiologyDeurne, 2100, Belgium
Completed
Radin Cardiovascular Medical GroupNewport Beach, 92663, United States
Not yet recruiting
Baptist Health LexingtonLexington, 40503, United States
Completed
Cooper Specialty Care at VoorheesVoorhees, 08043, United States
Completed
Hospital e Maternidade Christovao da Gama | Santo Andre Medical Centre - Cardiology DepartmentSanto André, 09030-010, Brazil
Completed
Diagnostic-Consultative Center XX | Cardiology DepartmentSofia, 1618, Bulgaria
Completed
Science 37Culver City, 90230, United States
Completed
SingHealth Polyclinics - Pasir RisSingapore, 519457, Singapore
Completed
Toronto General Hospital UHNToronto, M5G 2C4, Canada
Completed
Ziekenhuis Rivierenland | Cardiology Research DepartmentTiel, 4002 WP, Netherlands
Not yet recruiting
Piedmont Research Partners LLCFort Mill, 29707, United States
Withdrawn
All India Institute of Medical Sciences (AIIMS) - New DelhiNew Delhi, 110 029, India
Completed
King Edward Memorial (KEM) Hospital - PunePune, 411 011, India
Withdrawn
Vardhman Mahavir Medical College & Safdarjung Hospital (VMMC-SJH)New Delhi, 110029, India
Completed
Vijan Cardiac & Critical Care CentreNashik, 422005, India
Withdrawn
Shri B.D. Mehta Mahavir Heart InstituteSurat, 395001, India
Completed
Lisie HospitalKochi, 682017, India
Withdrawn
The Institute of Post Graduate Medical Education & Research (IPGMER) (SSKM Hospital)Calcutta, 700020, India
Withdrawn
HFR - Fribourg | CardiologyFribourg, 1708, Switzerland
Withdrawn
Sir Gangaram Hospital, DelhiNew Delhi, 110060, India
Completed
Asian Institute of Gastroenterology (AIG Hospital)Hyderabad, 500032, India
Withdrawn
Zibo Municipal HospitalZibo, 255000, China
Withdrawn
Atyrau Regional Cardiology Center - Department of CardiologyAtyrau, 060005, Kazakhstan
Withdrawn
Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan - Cardiology Department No2Astana, 010017, Kazakhstan
Withdrawn
City cardiological center of AlmatyAlmaty, 50012, Kazakhstan
Withdrawn
Moscow Research Scient. Institute n.a. M.F. VladimirskyMoscow, 129110, Russia

Primary Outcome

  • Time to first occurrence of composite of stroke or systemic embolism
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of ISTH major bleeding
    ISTH = International Society on Thrombosis and Hemostasis
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of composite of stroke, systemic embolism, or ISTH major bleeding
    date_rangeTime Frame:
    Up to 34 months

Secondary Outcome

  • Time to first occurrence of composite of ischemic stroke or systemic embolism
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of all-cause mortality
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of ischemic stroke
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of CV death
    CV = cardiovascular
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of composite of CV death, stroke, or myocardial infarction
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of composite of ISTH major or clinically relevant non-major bleeding
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of clinically relevant non-major bleeding
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of hemorrhagic stroke
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of intracranial hemorrhage
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of fatal bleeding
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of minor bleeding
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of composite of stroke, systemic embolism, ISTH major bleeding, or all-cause mortality
    date_rangeTime Frame:
    Up to 34 months
  • Time to first occurrence of composite of disabling stroke (mRS ≥ 3), critical bleeding, or all-cause mortality
    mRS = modified Rankin Scale
    date_rangeTime Frame:
    Up to 34 months

Trial design

A multicenter, international, randomized, active comparator-controlled, double-blind, double-dummy, parallel-group, 2-arm, Phase 3 study to compare the efficacy and safety of the oral FXIa inhibitor asundexian (BAY 2433334) with apixaban for the prevention of stroke or systemic embolism in male and female participants aged 18 years and older with atrial fibrillation at risk for stroke
Trial Type
Interventional
Intervention Type
Drug
Trial Purpose
Treatment
Allocation
Randomized
Blinding
N/A
Assignment
Parallel Assignment
Trial Arms
2