Trial Condition(s):

Neoplasms

Phase I study of anetumab ravtansine in hepatic or renal impairment

Bayer Identifier:

18327

ClinicalTrials.gov Identifier:

NCT02696642

EudraCT Number:

2015-003897-33

Study Completed

Trial Purpose

To characterize the safety, tolerability, pharmacokinetics and immunogenicity of anetumab ravtansine in subjects with advanced solid cancers and with different degrees of hepatic or renal impairment

Inclusion Criteria
- Male or female subjects aged ≥18 years
 - Histologically or cytologically confirmed, locally advanced or metastatic solid cancers known to express mesothelin on the tumor cell surface (e.g. predominantly epithelial [>=50% tumor component] pleural or peritoneal mesothelioma, epithelial ovarian cancer [including the fallopian tube or primary peritoneal], adenocarcinoma of the pancreas, triple-negative adenocarcinoma of the breast, non-small-cell adenocarcinoma of the lung, endometrial cancer, serous uterine cancer, gastric cancer [including the gastro-esophageal junction], colon cancer, cholangiocarcinoma, thymic carcinoma, etc.). Subjects with resected primary cancers who have documented metastases or local recurrence are eligible.
 - Subjects must have no standard therapy available, or have actively refused standard therapy 
 - Subjects must meet the criteria for one of the 4 treatment groups:
 -- Group A:  Adequate hepatic and renal function (controls)
 -- Group B: Mild hepatic impairment, i.e. Grade A according to the Child-Pugh Classification (total score of 5 or 6) and adequate renal function
 -- Group C: Moderate hepatic impairment, i.e. Grade B according to the Child-Pugh Classification (total score of 7, 8 or 9) and adequate renal function
 -- Group D: Moderate renal impairment, i.e. eGFR (estimated glomerular filtration rate) <60 and ≥30 mL/min per 1.73 m*2 and hepatic function better than, or equal to mild impairment according to the Child-Pugh Classification (total score ≤6)
 - Adequate bone marrow function 
 - Life expectancy of at least 12 weeks
 - ECOG (Eastern Cooperative Oncology Group) performance status of 0 or 1 (control and mild hepatic impairment groups), or 0-2 (moderate hepatic impairment and moderate renal impairment groups)
Exclusion Criteria
- Subjects who have a previous or concurrent cancer that is distinct in primary site or histology from the cancer being evaluated in this study, except cervical carcinoma in situ, treated basal cell carcinoma, superficial noninvasive bladder tumors or any previous cancer curatively treated >3 years before the start of anetumab ravtansine
 - Subjects who have new or progressive brain or meningeal or spinal metastases
 - Subjects who have Gilbert’s syndrome or other benign congenital hyperbilirubinemia are not eligible for the mild or moderate hepatic impairment or moderate renal impairment groups.
 - Subjects who have a history or current evidence of bleeding disorder, i.e. any hemorrhage/bleeding event of CTCAE (Common Terminology Criteria for Adverse Events) Grade ≥2 bleeding within 4 weeks before the start of anetumab ravtansine
 - Subjects who have a history or current evidence of uncontrolled cardiovascular disease or hypertension.
 - Fridericia-corrected QT interval (QTcF) >480 ms, heart rate ≥100 beats per minute (bpm) or ≤45 bpm, LVEF (left ventricular ejection fraction) <50% 
 - Subjects with corneal epitheliopathy or any eye disorder that may predispose the subjects to drug-induced corneal epitheliopathy or may interfere with diagnosis of treatment-emergent corneal epitheliopathy at the investigator’s discretion in consultation with an ophthalmologist.
 - Subjects who have received systemic anticancer therapy (except pemetrexed, cisplatin, carboplatin and topical or intracavitary treatments with negligible absorption in systemic circulation ) within 4 weeks before the start of anetumab ravtansine, or within 5 half-lives of the anticancer agent before the start of anetumab ravtansine, whichever is longer. Mitomycin C or nitrosoureas must be excluded within 6 weeks before the start of anetumab ravtansine.
 - Subjects who have received radiotherapy within 4 weeks before the start of anetumab ravtansine
 - Use of drugs that, in the opinion of the investigator, have a strong potential for renal or hepatic toxicity within 2 weeks before the start of anetumab ravtansine until the EoT visit.
 - Use of strong cytochrome P450 3A4 (CYP3A4) inhibitors or strong CYP3A4 inducers within 2 weeks before the start of anetumab ravtansine until the EoT visit
 - Women who are pregnant or breast-feeding

Trial Summary

Enrollment Goal
54
Trial Dates
black-arrow
Phase
1
Could I receive a placebo?
No
Products
Anetumab ravtansine (BAY94-9343)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

Investigative Site

TOULOUSE CEDEX 9, France, 31059

Status
Completed
 
Locations

Investigative Site

LILLE CEDEX, France, 59020

Status
Completed
 
Locations

Investigative Site

Chisinau, Moldova, 2025

Status
Completed
 
Locations

Investigative Site

MARSEILLE CEDEX 5, France, 13385

Status
Completed
 
Locations

Investigative Site

SAINT HERBLAIN, France, 44805

Status
Completed
 
Locations

Investigative Site

DIJON, France, 21079

Status
Completed
 
Locations

Investigative Site

LYON CEDEX, France, 69008

Status
Completed
 
Locations

Investigative Site

CAEN, France, 14073

Status
Completed
 

Trial Design