Hypertension, Pulmonary

Inclusion Criteria

- Patients with PAH or CTEPH undergoing medically indicated routine invasive diagnostics
- Men and women aged 18 to 80 years

Part A:
- Untreated patients: Therapy-naïve patients (defined as off
treatment with PDE-5 inhibitors, endothelin receptor antagonists,
prostanoids, or other sGC stimulators/activators) with PAH or
CTEPH or patients pre-treated with these medications who have to
undergo a drug specific wash-out period at the discretion of the
investigator for least 24 h prior to Day -1 if medically safe

Part B:
- Untreated patients with PAH or CTEPH:
-- Group 1 (total will be summed up with corresponding dosage group from Part A)
- Pre-treated patients with PAH or CTEPH:
-- Group 2: Pre-treated patients with any kind of monotherapy* for PAH/CTEPH
-- Group 3: Pre-treated patients with any kind of double
combination therapy* for PAH/CTEPH
* patients receiving inhaled Iloprost, and patients who are known
responders to iNO are excluded

Main

Exclusion Criteria

- Medical history indicating a different cause for PH than PAH or CTEPH according to the guidelines of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), such as significant left heart disease, valvular disease, or structural heart defects, as assessed by the investigator, significant pulmonary disease or clinical suspicion of pulmonary venoocclusive disease