Trial Condition(s):

Pulmonary Embolism, Thromboembolism, Thrombosis, Venous thrombosis, Venous Thromboembolism

Reduced-dosed rivaroxaban in the long-term prevention of recurrent symptomatic VTE(Venous thromboembolism) (EinsteinChoice)

Bayer Identifier:

16416

ClinicalTrials.gov Identifier:

NCT02064439

EudraCT Number:

2013-000619-26

Study Completed

Trial Purpose

This is a multicenter, randomized, double-blind, event-driven, superiority study for efficacy.
Patients with confirmed symptomatic DVT (Deep Vein Thrombosis) or PE (Pulmonary embolism) who completed 6 or 12 months of treatment of anticoagulation are eligible for this trial

Inclusion Criteria
- Patients with confirmed symptomatic PE and/or DVT who have been treated for 6 to 12 months and did not interrupt anticoagulation for longer than 1 week
Exclusion Criteria
- Legal lower age limitations (country specific)
Indication for therapeutic-dosed anticoagulants
Indication for antiplatelet therapy or a conventional non-steroid anti-inflammatory drug (NSAID)
Hepatic disease which is associated with coagulopathy leading to a clinically relevant bleeding risk
Calculated creatinine clearance < 30 mL/min

Trial Summary

Enrollment Goal
3365
Trial Dates
black-arrow
Phase
3
Could I receive a placebo?
No
Products
Xarelto (Rivaroxaban, BAY59-7939)
Accepts Healthy Volunteers
No

Where to Participate

Loading...
Locations
Status
LocationsStatus
Locations

Investigative Site

Svendborg, Denmark, 5700

Status
Completed
 
Locations

Investigative Site

Hellerup, Denmark, 2900

Status
Completed
 
Locations

Investigative Site

Christchurch, New Zealand, 8011

Status
Completed
 
Locations

Investigative Site

Columbus, United States, 31904

Status
Completed
 
Locations

Investigative Site

Butte, United States, 59701

Status
Completed
 
Locations

Investigative Site

Rockport, United States, 04856

Status
Completed
 
Locations

Investigative Site

SAINT ETIENNE, France, 42055

Status
Completed
 
Locations

Investigative Site

VERNON, France, 27200

Status
Completed
 
Locations

Investigative Site

ARRAS, France, 62000

Status
Completed
 
Locations

Investigative Site

DIJON, France, 21000

Status
Completed
 
Locations

Investigative Site

NICE, France, 06002

Status
Completed
 
Locations

Investigative Site

LIMOGES CEDEX, France, 87042

Status
Completed
 
Locations

Investigative Site

COLOMBES CEDEX, France, 92701

Status
Completed
 
Locations

Investigative Site

GRENOBLE, France, 38043

Status
Completed
 
Locations

Investigative Site

St. Jerome, Canada, J7Z 5T3

Status
Completed
 
Locations

Investigative Site

Montreal, Canada, H3T 1M5

Status
Completed
 
Locations

Investigative Site

AALST, Belgium, 9300

Status
Completed
 
Locations

Investigative Site

HASSELT, Belgium, 3500

Status
Completed
 
Locations

Investigative Site

Leuven, Belgium, 3000

Status
Completed
 
Locations

Investigative Site

AMSTERDAM, Netherlands, 1105 AZ

Status
Completed
 
Locations

Investigative Site

ZWOLLE, Netherlands, 8025 AB

Status
Completed
 
Locations

Investigative Site

HOOFDDORP, Netherlands, 2134 TM

Status
Completed
 
Locations

Investigative Site

SITTARD, Netherlands, 6131 BK

Status
Completed
 
Locations

Investigative Site

Göteborg, Sweden, 416 85

Status
Completed
 
Locations

Investigative Site

Kristianstad, Sweden, 29185

Status
Completed
 
Locations

Investigative Site

Herning, Denmark, 7400

Status
Completed
 
Locations

Investigative Site

København NV, Denmark, 2400

Status
Completed
 
Locations

Investigative Site

Aarhus N, Denmark, 8200

Status
Completed
 
Locations

Investigative Site

Palmerston North, New Zealand, 4414

Status
Completed
 
Locations

Investigative Site

Padova, Italy, 35128

Status
Completed
 
Locations

Investigative Site

Madrid, Spain, 28007

Status
Completed
 
Locations

Investigative Site

Reggio Emilia, Italy, 42100

Status
Completed
 
Locations

Investigative Site

Varese, Italy, 21100

Status
Completed
 
Locations

Investigative Site

ALKMAAR, Netherlands, 1815 JD

Status
Completed
 
Locations

Investigative Site

Holon, Israel, 5810001

Status
Completed
 
Locations

Investigative Site

RANDWICK, Australia, 2031

Status
Completed
 
Locations

Investigative Site

Redcliffe, Australia, 4020

Status
Completed
 
Locations

Investigative Site

Box Hill, Australia, 3128

Status
Completed
 
Locations

Investigative Site

Brisbane, Australia, 4029

Status
Terminated
 
Locations

Investigative Site

Debrecen, Hungary, 4032

Status
Completed
 
Locations

Investigative Site

Genève, Switzerland, 1205

Status
Completed
 
Locations

Investigative Site

Taipei, Taiwan, China, 11217

Status
Completed
 
Locations

Investigative Site

Bangkok, Thailand, 10400

Status
Completed
 
Locations

Investigative Site

Mainz, Germany, 55131

Status
Completed
 
Locations

Investigative Site

Dresden, Germany, 01067

Status
Completed
 
Locations

Investigative Site

Berlin, Germany, 10787

Status
Completed
 
Locations

Investigative Site

BESANCON, France, 25030

Status
Completed
 
Locations

Investigative Site

STRASBOURG CEDEX, France, 67091

Status
Completed
 
Locations

Investigative Site

Girona, Spain, 17007

Status
Completed
 
Locations

Investigative Site

London, Canada, N6A 4G5

Status
Completed
 
Locations

Investigative Site

Groningen, Netherlands, 9713 GZ

Status
Completed
 
Locations

Investigative Site

Fredrikstad, Norway, 1603

Status
Completed
 
Locations

Investigative Site

Tel-Aviv, Israel, 64239

Status
Terminated
 
Locations

Investigative Site

Wien, Austria, 1090

Status
Completed
 
Locations

Investigative Site

Graz, Austria, 8036

Status
Completed
 
Locations

Investigative Site

Budapest, Hungary, 1115

Status
Completed
 
Locations

Investigative Site

Kecskemet, Hungary, 6000

Status
Completed
 
Locations

Investigative Site

Lausanne, Switzerland, 1011

Status
Completed
 
Locations

Investigative Site

Taichung, Taiwan, China, 40447

Status
Completed
 
Locations

Investigative Site

Magdeburg, Germany, 39112

Status
Terminated
 
Locations

Investigative Site

PARIS CEDEX 15, France, 75908

Status
Completed
 
Locations

Investigative Site

PARIS, France, 75475

Status
Completed
 
Locations

Investigative Site

TOULOUSE, France, 31403

Status
Completed
 
Locations

Investigative Site

Warszawa, Poland, 01-138

Status
Completed
 
Locations

Investigative Site

Victoria, Canada, V8R 4R2

Status
Completed
 
Locations

Investigative Site

Montreal, Canada, H3T 1E2

Status
Completed
 
Locations

Investigative Site

BRUXELLES - BRUSSEL, Belgium, 1200

Status
Completed
 
Locations

Investigative Site

Copenhagen, Denmark, 2300

Status
Completed
 
Locations

Investigative Site

Oslo, Norway, 0450

Status
Completed
 
Locations

Investigative Site

Pretoria, South Africa, 0181

Status
Completed
 
Locations

Investigative Site

Litomysl, Czech Republic, 570 14

Status
Completed
 
Locations

Investigative Site

Kladno, Czech Republic, 27259

Status
Completed
 
Locations

Investigative Site

Praha 1, Czech Republic, 110 00

Status
Completed
 
Locations

Investigative Site

Praha 5, Czech Republic, 150 06

Status
Completed
 
Locations

Investigative Site

Liberec, Czech Republic, 46063

Status
Completed
 
Locations

Investigative Site

Garran, Australia, 2605

Status
Terminated
 
Locations

Investigative Site

Melbourne, Australia, 3004

Status
Completed
 
Locations

Investigative Site

St Leonards, Australia, 2065

Status
Completed
 
Locations

Investigative Site

LISMORE, Australia, 2480

Status
Completed
 
Locations

Investigative Site

Innsbruck, Austria, 6020

Status
Completed
 
Locations

Investigative Site

São Paulo, Brazil, 01323-001

Status
Completed
 
Locations

Investigative Site

São Paulo, Brazil, 04039-004

Status
Completed
 
Locations

Investigative Site

Porto Alegre, Brazil

Status
Completed
 
Locations

Investigative Site

Campinas, Brazil, 13083-970

Status
Completed
 
Locations

Investigative Site

Luzern, Switzerland, 6000

Status
Completed
 
Locations

Investigative Site

Auckland, New Zealand, 1023

Status
Completed
 
Locations

Investigative Site

Cosenza, Italy, 87100

Status
Completed
 
Locations

Investigative Site

Newcastle Upon Tyne, United Kingdom, NE1 4LP

Status
Completed
 
Locations

Investigative Site

BRUXELLES - BRUSSEL, Belgium, 1070

Status
Completed
 
Locations

Investigative Site

Ostrava, Czech Republic, 728 80

Status
Completed
 
Locations

Investigative Site

Santo André, Brazil, 09060-650

Status
Completed
 
Locations

Investigative Site

Sao Paulo, Brazil, 05403-900

Status
Completed
 
Locations

Investigative Site

Nanning, China, 530021

Status
Completed
 
Locations

Investigative Site

Yinchuan, China, 750004

Status
Completed
 
Locations

Investigative Site

Wellington, New Zealand, 6021

Status
Completed
 
Locations

Investigative Site

Nahariya, Israel, 2210001

Status
Completed
 
Locations

Investigative Site

Petah Tikva, Israel, 4941492

Status
Completed
 
Locations

Investigative Site

Haifa, Israel, 3339419

Status
Completed
 
Locations

Investigative Site

Zefat, Israel, 1311001

Status
Completed
 
Locations

Investigative Site

London, United Kingdom, SE1 7EH

Status
Terminated
 
Locations

Investigative Site

CASTELNAU LE LEZ, France, 34170

Status
Completed
 
Locations

Investigative Site

Afula, Israel, 1834111

Status
Completed
 
Locations

Investigative Site

Kfar Saba, Israel, 4428164

Status
Completed
 
Locations

Investigative Site

Quezon City, Philippines, NCR 1100

Status
Completed
 
Locations

Investigative Site

Witten, Germany, 58448

Status
Completed
 
Locations

Investigative Site

Dresden, Germany, 01307

Status
Completed
 
Locations

Investigative Site

Karlsbad, Germany, 76307

Status
Completed
 
Locations

Investigative Site

TOULON, France, 83056

Status
Completed
 
Locations

Investigative Site

ANGERS, France, 49933

Status
Completed
 
Locations

Investigative Site

Poznan, Poland, 60-631

Status
Completed
 
Locations

Investigative Site

Bydgoszcz, Poland, 85-681

Status
Completed
 
Locations

Investigative Site

Wroclaw, Poland, 51-124

Status
Completed
 
Locations

Investigative Site

Chieti, Italy, 66013

Status
Completed
 
Locations

Investigative Site

Torrevieja, Spain, 03186

Status
Completed
 
Locations

Investigative Site

L'Hospitalet de Llobregat, Spain, 08907

Status
Completed
 
Locations

Investigative Site

San Sebastián de los Reyes, Spain, 28702

Status
Completed
 
Locations

Investigative Site

Johannesburg, South Africa, 2191

Status
Completed
 
Locations

Investigative Site

Pretoria West, South Africa, 0082

Status
Completed
 
Locations

Investigative Site

Prague, Czech Republic, 118 33

Status
Completed
 
Locations

Investigative Site

Ostrava, Czech Republic, 708 52

Status
Completed
 
Locations

Investigative Site

Haifa, Israel, 3109601

Status
Completed
 
Locations

Investigative Site

Seoul, South Korea, 120-752

Status
Completed
 
Locations

Investigative Site

Genève, Switzerland, 1205

Status
Terminated
 
Locations

Investigative Site

Perugia, Italy, 06156

Status
Completed
 
Locations

Investigative Site

Treviso, Italy, 31029

Status
Completed
 
Locations

Investigative Site

MAASTRICHT, Netherlands, 6229 HX

Status
Completed
 
Locations

Investigative Site

Istanbul, Turkey, 34-300

Status
Completed
 
Locations

Investigative Site

Rio de Janeiro, Brazil

Status
Completed
 
Locations

Investigative Site

Belo Horizonte, Brazil, 30150-221

Status
Completed
 
Locations

Investigative Site

Hull, United Kingdom, HU3 2JZ

Status
Completed
 
Locations

Investigative Site

Bloemfontein, South Africa, 9301

Status
Completed
 
Locations

Investigative Site

Roodepoort, South Africa, 1724

Status
Completed
 
Locations

Investigative Site

Raleigh, United States, 27607

Status
Completed
 
Locations

Investigative Site

Jacksonville, United States, 32207

Status
Terminated
 
Locations

Investigative Site

Spokane, United States, 99216

Status
Completed
 
Locations

Investigative Site

Bern, Switzerland, 3010

Status
Completed
 
Locations

Investigative Site

Plymouth, United Kingdom, PL6 8DH

Status
Completed
 
Locations

Investigative Site

Philadelphia, United States, 19104

Status
Terminated
 
Locations

Investigative Site

Detroit, United States, 48202

Status
Completed
 
Locations

Investigative Site

Ottawa, Canada, K1H 8L6

Status
Completed
 
Locations

Investigative Site

Montreal, Canada, H1T 2M4

Status
Completed
 
Locations

Investigative Site

León, Mexico, 37000

Status
Terminated
 
Locations

Investigative Site

Monterrey, Mexico, 64718

Status
Terminated
 
Locations

Investigative Site

Guadalajara, Mexico, 44340

Status
Completed
 
Locations

Investigative Site

Xalapa, Mexico, 91020

Status
Completed
 
Locations

Investigative Site

Guadalajara, Mexico, 44280

Status
Terminated
 
Locations

Investigative Site

Glostrup, Denmark, 2600

Status
Completed
 
Locations

Investigative Site

Beijing, China, 100029

Status
Completed
 
Locations

Investigative Site

Auckland, New Zealand, 2024

Status
Completed
 
Locations

Investigative Site

New Taipei City, Taiwan, China, 220

Status
Completed
 
Locations

Investigative Site

München, Germany, 80336

Status
Completed
 
Locations

Investigative Site

Erfurt, Germany, 99089

Status
Completed
 
Locations

Investigative Site

Darmstadt, Germany, 64297

Status
Completed
 
Locations

Investigative Site

Halifax, Canada, B3H 3A7

Status
Completed
 
Locations

Investigative Site

Edmonton, Canada, T6G 2B7

Status
Completed
 
Locations

Investigative Site

Aguascalientes, Mexico, 20230

Status
Completed
 
Locations

Investigative Site

Merida, Mexico, 97129

Status
Completed
 
Locations

Investigative Site

Johannesburg, South Africa, 2132

Status
Completed
 
Locations

Investigative Site

Santo André, Brazil, 09190-615

Status
Completed
 
Locations

Investigative Site

Shijiazhuang, China, 050000

Status
Completed
 
Locations

Investigative Site

Khon Kaen, Thailand, 40002

Status
Completed
 
Locations

Investigative Site

LE MANS, France, 72037

Status
Completed
 
Locations

Investigative Site

ASSEN, Netherlands, 9401 RK

Status
Completed
 
Locations

Investigative Site

St. Petersburg, Russia

Status
Completed
 
Locations

Investigative Site

Rostov-on-Don, Russia, 344022

Status
Completed
 
Locations

Investigative Site

Tver, Russia, 170036

Status
Completed
 
Locations

Investigative Site

Moscow, Russia, 121552

Status
Completed
 
Locations

Investigative Site

St. Petersburg, Russia, 197022

Status
Completed
 
Locations

Investigative Site

Ryazan, Russia, 390026

Status
Completed
 
Locations

Investigative Site

Barnaul, Russia, 656045

Status
Completed
 
Locations

Investigative Site

Moscow, Russia, 111539

Status
Completed
 
Locations

Investigative Site

Novosibirsk, Russia, 630087

Status
Completed
 
Locations

Investigative Site

Novosibirsk, Russia, 630055

Status
Completed
 
Locations

Investigative Site

CLERMONT FERRAND, France, 63000

Status
Completed
 
Locations

Investigative Site

BREST CEDEX, France, 29609

Status
Completed
 
Locations

Investigative Site

Saint John, Canada, E2L 4L2

Status
Completed
 
Locations

Investigative Site

Ho Chi Minh, Vietnam, 70000

Status
Completed
 
Locations

Investigative Site

Worcester, South Africa, 6850

Status
Completed
 
Locations

Investigative Site

Usti nad Labem, Czech Republic, 401 13

Status
Completed
 
Locations

Investigative Site

Chihuahua, Mexico, 31203

Status
Terminated
 
Locations

Investigative Site

PARIS, France, 75674

Status
Terminated
 
Locations

Investigative Site

Guangzhou, China, 510120

Status
Completed
 
Locations

Investigative Site

Qingdao, China, 266000

Status
Terminated
 
Locations

Investigative Site

Clayton, Australia, 3168

Status
Completed
 
Locations

Investigative Site

Concord, Australia, 2139

Status
Completed
 
Locations

Investigative Site

Kogarah, Australia, 2217

Status
Completed
 
Locations

Investigative Site

Tacoma, United States, 98405-2433

Status
Completed
 
Locations

Investigative Site

Fredericksburg, United States, 22401

Status
Terminated
 
Locations

Investigative Site

La Jolla, United States, 92037

Status
Completed
 
Locations

Investigative Site

Seattle, United States, 98104

Status
Completed
 
Locations

Investigative Site

Las Vegas, United States, 89169

Status
Completed
 
Locations

Investigative Site

Sochi, Russia, 354057

Status
Completed
 
Locations

Investigative Site

Basel, Switzerland, 4031

Status
Completed
 
Locations

Investigative Site

Fribourg, Switzerland, 1700

Status
Completed
 
Locations

Investigative Site

DORDRECHT, Netherlands, 3318 AT

Status
Completed
 
Locations

Investigative Site

Donggu,, South Korea, 501-757

Status
Completed
 
Locations

Investigative Site

Seoul, South Korea, 03080

Status
Completed
 
Locations

Investigative Site

Seoul, South Korea, 135-710

Status
Completed
 
Locations

Investigative Site

Busan, South Korea, 602-739

Status
Completed
 
Locations

Investigative Site

Daegu, South Korea, 705-718

Status
Completed
 
Locations

Investigative Site

shanghai, China, 200433

Status
Completed
 
Locations

Investigative Site

guangzhou, China, 510080

Status
Completed
 
Locations

Investigative Site

Hangzhou, China, 310016

Status
Completed
 
Locations

Investigative Site

Kunming, China, 650032

Status
Completed
 
Locations

Investigative Site

Taiyuan, China, 030001

Status
Completed
 
Locations

Investigative Site

shanghai, China, 200001

Status
Terminated
 
Locations

Investigative Site

Beijing, China, 100730

Status
Terminated
 
Locations

Investigative Site

Beijing, China, 100037

Status
Terminated
 
Locations

Investigative Site

Changsha, China, 410011

Status
Completed
 
Locations

Investigative Site

Beijing, China, 100730

Status
Completed
 
Locations

Investigative Site

Shanghai, China, 200032

Status
Completed
 
Locations

Investigative Site

Beijing, China, 100053

Status
Terminated
 
Locations

Investigative Site

Jinan, China, 250012

Status
Completed
 
Locations

Investigative Site

Chengdu, China, 610041

Status
Terminated
 
Locations

Investigative Site

Shenyang, China, 110001

Status
Terminated
 
Locations

Investigative Site

Xi'an, China, 710061

Status
Completed
 
Locations

Investigative Site

Hangzhou, China, 310003

Status
Completed
 
Locations

Investigative Site

Harbin, China

Status
Completed
 
Locations

Investigative Site

Beijing, China, 100020

Status
Terminated
 
Locations

Investigative Site

Xi'an, China, 710032

Status
Terminated
 
Locations

Investigative Site

Nantong, China, 226001

Status
Completed
 
Locations

Investigative Site

Wuhan, China, 430032

Status
Completed
 
Locations

Investigative Site

Shanghai, China, 200025

Status
Completed
 
Locations

Investigative Site

Shengyang, China, 110004

Status
Terminated
 
Locations

Investigative Site

Tianjin, China, 300052

Status
Completed
 
Locations

Investigative Site

Shanghai, China, 200233

Status
Terminated
 
Locations

Investigative Site

Changchun, China, 130000

Status
Completed
 
Locations

Investigative Site

Tianjin, China, 300211

Status
Completed
 
Locations

Investigative Site

Tianjin, China, 300121

Status
Completed
 
Locations

Investigative Site

Ha Noi, Vietnam

Status
Completed
 
Locations

Investigative Site

Suzhou, China, 215004

Status
Completed
 
Locations

Investigative Site

Changsha, China, 410013

Status
Completed
 
Locations

Investigative Site

Shanghai, China, 200433

Status
Terminated
 
Locations

Investigative Site

Fuzhou, China, 350025

Status
Completed
 
Locations

Investigative Site

LE KREMLIN BICETRE CEDEX, France, 94275

Status
Completed
 
Locations

Investigative Site

San Antonio, United States, 78229

Status
Completed
 
Locations

Investigative Site

Hamilton, Canada, L8N 4A6

Status
Terminated
 
Locations

Investigative Site

ALMERE, Netherlands, 1315 RA

Status
Completed
 
Locations

Investigative Site

BOIS-GUILLAUME, France, 76320

Status
Completed
 
Locations

Investigative Site

QUIMPER, France, 29000

Status
Completed
 
Locations

Investigative Site

BREST Cedex 9, France, 29240

Status
Completed
 
Locations

Investigative Site

Hamilton, Canada, L8L 2X2

Status
Completed
 
Locations

Investigative Site

Hamilton, Canada, L8V 1C3

Status
Completed
 
Locations

Investigative Site

Istanbul, Turkey, 34760

Status
Completed
 
Locations

Investigative Site

Bialystok, Poland, 15-276

Status
Completed
 
Locations

Investigative Site

Leon, Mexico, 37000

Status
Terminated
 
Locations

Investigative Site

Wenzhou, China, 325000

Status
Completed
 
Locations

Investigative Site

Heidelberg, Germany, 69120

Status
Completed
 
Locations

Investigative Site

Gyula, Hungary, 5700

Status
Completed
 
Locations

Investigative Site

Miskolc, Hungary, 3526

Status
Completed
 
Locations

Investigative Site

Baja, Hungary, 6500

Status
Terminated
 
Locations

Investigative Site

Szombathely, Hungary, 9700

Status
Completed
 
Locations

Investigative Site

Pecs, Hungary, 7624

Status
Completed
 
Locations

Investigative Site

Szentes, Hungary, 6600

Status
Terminated
 
Locations

Investigative Site

Zalaegerszeg, Hungary, 8900

Status
Terminated
 
Locations

Investigative Site

Westmead, Australia, 2145

Status
Completed
 
Locations

Investigative Site

Boston, United States, 02215

Status
Completed
 
Locations

Investigative Site

Ventura, United States, 93003

Status
Terminated
 
Locations

Investigative Site

Denver, United States, 80262

Status
Terminated
 
Locations

Investigative Site

Treviso, Italy, 31033

Status
Completed
 
Locations

Investigative Site

Columbus, United States, 43210-1240

Status
Completed
 
Locations

Investigative Site

Joliet, United States, 60435

Status
Completed
 
Locations

Investigative Site

Beverly Hills, United States, 90211

Status
Completed
 
Locations

Investigative Site

Toledo, United States, 43606

Status
Completed
 
Locations

Investigative Site

Boston, United States, 02115

Status
Terminated
 
Locations

Investigative Site

Bellevue, United States, 98004

Status
Completed
 
Locations

Investigative Site

Piacenza, Italy, 29121

Status
Completed
 
Locations

Investigative Site

Cardiff, United Kingdom, CF14 4XW

Status
Completed
 
Locations

Investigative Site

Auckland, New Zealand, 1309

Status
Completed
 
Locations

Investigative Site

Boston, United States, 02114-2696

Status
Terminated
 

Trial Design