Kidney Diseases

Inclusion Criteria

- Presence of chronic kidney disease (CKD) not on dialysis assessed by medical history and eGFR (MDRD) = < 60 mL/min estimated at the pre-study visit
 - Stable renal disease, ie not expected to begin dialysis during the study
 - Systolic blood pressure =>110 mmHg and =<160 mmHg
 - Heart rate =<100 BPM
 - Hemoglobin = >9 g/dL
 - Female subjects without child-bearing potential, ie postmenopausal women with 12 months of spontaneous amenorrhea or with 6 months of spontaneous amenorrhea and serum FSH levels >30 mIU/mL, women with 6 weeks post bilateral ovariectomy, women with bilateral tubal ligation, and women with hysterectomy
 - Body mass index (BMI): = >18 and = < 35 kg/m2 at the pre-study visit

Exclusion Criteria

- Incompletely cured pre-existing diseases for which a relevant impairment of absorption, distribution, metabolism, elimination or effects of the study drug is assumed
 - Known hypersensitivity to the study drugs (active substances or excipients of the preparations)
 - Known severe allergies, non-allergic drug reactions, or multiple drug allergies
 - Chronic heart failure, New York Heart Association (NYHA) III-IV
 - Coronary artery disease with uncured significant stenosis
 - Angina pectoris
 - Significant stenosis of cerebral vessels
 - Significant uncorrected rhythm or conduction disturbances such as a second- or third-degree atrioventricular block without a cardiac pacemaker or episodes of sustained ventricular tachycardia
 - Subjects with impaired liver function (Child Pugh B to C based on medical history)
 - History of thrombotic or thromboembolic events (eg myocardial infarction, stroke, transient ischemic attack, deep vein thrombosis, pulmonary embolism) within the recent 6 months
 - Proliferative choroidal or retinal disease, such as neovascular age-related macular degeneration or proliferative diabetic retinopathy that required or is likely to require treatment (intraocular injections or laser photocoagulation) during the study
 - Subjects with a history of malignant disease during the last 5 years
 - Treatment with EPO-stimulating agents (ESA) or rhEPO within the last 2 weeks before first intake of study drug
 - Suspicion of drug or alcohol abuse
 - Positive results for hepatitis B virus surface antigen (HBsAg), hepatitis C virus antibodies (anti-HCV), human immune deficiency virus antibodies (anti-HIV 1+2) at the pre-study visit