Carcinoma, Hepatocellular

Inclusion Criteria

- Male or female patients aged equal or above 18 years.
 - BCLC stage Category A, B or C that cannot benefit from treatments of established efficacy with higher priority such as resection, liver transplantation, local ablation, chemoembolization or systemic sorafenib.
 - Liver function status Child-Pugh class A. 
 - Failure to prior treatment with sorafenib (defined as radiological progression under sorafenib therapy)
 - Local or loco-regional therapy (eg, surgery, radiation therapy, hepatic arterial embolization, chemoembolization, radiofrequency ablation, percutaneous ethanol injection, or cryoablation) must have been completed = 4 weeks before first dose of BAY73-4506.
 - ECOG PS of 0 or 1.
 - Adequate bone marrow, liver and renal function

Exclusion Criteria

- Prior systemic treatment with molecular targeted agents for HCC, except sorafenib. Prior chemotherapy treatment is allowed.
 - Known history or symptomatic metastatic brain or meningeal tumors (head CT or MRI at screening to confirm the absence of central nervous system [CNS] disease if patient has symptoms suggestive or consistent with CNS disease).
 - Congestive heart failure NYHA>/= class 2
 - Unstable angina (angina symptoms at rest, new onset angina within the last 3 months) or myocardial infarction (MI) within the past 6 months before start of study medication.
 - Cardiac arrhythmias requiring anti-arrhythmic therapy (beta blockers or digoxin are permitted).
 - Uncontrolled hypertension (systolic blood pressure  > 150 mmHg or diastolic pressure > 90 mmHg despite optimal medical management).
 - Arterial or venous thrombotic or embolic events such as cerebrovascular accident (including transient ischemic attacks), deep vein thrombosis or pulmonary embolism within 6 months before the start of study treatment.