Kidney Diseases

Inclusion Criteria

- Post menopausal females 
 - Surgically sterile females 
 - Body Mass Index between 18-37 
 - Subjects with Clcr greater than 80 mL/min 
 - Subjects with Clcr 50 to 80 mL/min
 - Subjects with Clcr 30 to 50 mL/min
 - Clcr less than 30 mL/min but not on dialysis
 - Subjects must test negative for HIV
 - Subjects must test negative for drugs of abuse at screening

Exclusion Criteria

All Subjects :

 - Concomitant Medication: Treatment with CYP3A4 inducers, such as  rifampin and St. John's Wort within 14 days of Day 1 until they leave the clinic on Day 7
 - Donation of blood within 30 days of Day 1 
 - Recent participation in an investigational drug study during which active medication was given within 30 days of Day 1 
 - History of gastrointestinal disorder that could result in incomplete absorption of study drug 
 - Malignancy 
 - Significant neurologic or psychiatric disorders 
 - History of drug or alcohol abuse in year prior to screening for this trial, or current intake or >14 standard alcoholic drinks per week 
 - Prior history of epilepsy or other seizure disorders 
 - Known hypersensitivity to inhibitors of raf kinase or VEGFR-2 
 - Females of child-bearing potential 
 - Smoking > 10 cigarettes/day or equivalent 
 - Excessive consumption (more than five 8-oz. cups/day) of coffee or caffeine

Healthy Volunteer: 

 - Existing failure of a major organ system, or a medical disorder that would impair the subject's ability to complete the study (in the opinion of the investigator or the sponsor), eg history of blood coagulation disorders 
 - Hematocrit value < 34% in the control group at screening

Renal Impairment Groups: 

 - Existing failure of a major organ system or a medical disorder (other than the target disease) which would impair the subject's ability to complete the study (in the opinion of the investigator or the sponsor) 
 - Concomitant Medication: Renal impairment subjects taking phosphate binders, ion exchange resins and/or iron supplements may take them with their meals, but must withhold them on the morning of Day 1 (dosing day) until after their 4 hour post-dose tests and procedures are performed. 
 - Myocardial infarction, coronary artery bypass graft or percutaneous transluminal coronary angiography within 6 months of Day 1; unstable angina; uncontrolled significant hypertension within 3 months of Day 1; cerebral vascular accident or transient ischemic attack within 12 months of Day 1 
 - Subjects with hypertension who have had a medication or dose change within one week of Day 1 
 - Subjects requiring dialysis 
 - Subjects with kidney transplants 
 - Liver transaminase (AST, ALT) greater than 5 times the ULN at screening; any active liver disease or unexplained or persistent elevations in liver function tests 
 - Hematocrit value < 24% in the renal impaired groups