Trial Condition(s):

Multiple Sclerosis, Relapsing-Remitting

BEYOND: Betaferon/Betaseron efficacy yielding outcomes of a new dose in Multiple Sclerosis (MS) Patients

Bayer Identifier:

91162

ClinicalTrials.gov Identifier:

NCT00099502

EudraCT Number:

Not Available

Study Completed

Trial Purpose

The purpose of this study is to determine
- whether treatment with Betaferon / Betaseron (interferon beta-1b) 500 micrograms safe, tolerable and more efficacious than treatment with interferon beta-1b 250 micrograms
- whether treatment with Betaferon / Betaseron (interferon beta-1b) tolerable and more efficacious than treatment with Copaxone (Glatiramer Acetate) 20 mg

Inclusion Criteria
- Female and male patients
 - Aged 18-55 years
 - Diagnosis of RRMS (Relapsing-Remitting Multiple Sclerosis), EDSS score of 0 to 5.0
 - Treatment-naive to IFNB or Copaxone
Exclusion Criteria
- Neurological progression at disease onset or between relapses
 - Serious or acute heart diseases
 - History of severe depression or suicide attempt
 - Serious or acute liver, renal or bone marrow dysfunction
 - Monoclonal gammopathy
 - Known allergy to Gadolinium-DTPA, to IFNs (Interferons), to glatiramer acetate, to human albumin or to mannitol
 - Pregnancy or lactation

Trial Summary

Enrollment Goal
2244
Trial Dates
black-arrow
Phase
3
Could I receive a placebo?
No
Products
Betaseron (Interferon beta-1b, BAY86-5046)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

Sanatorio Britanico

Rosario, Argentina, S2000CVB

Status
Completed
 
Locations

Queen Elizabeth II Health Sciences Centre

Halifax, Canada, B3H 3A7

Status
Completed
 
Locations

Aarhus Universitetshospital

Aarhus C, Denmark, 8000

Status
Completed
 
Locations

Ciutat Sanitària i Universitària de Bellvitge

L'Hospitalet de Llobregat, Spain, 08907

Status
Completed
 
Locations

Tampereen yliopistollinen sairaala, keskussairaala

Tampere, Finland, 33521

Status
Completed
 
Locations

Hopital Roger Salengro

Lille, France, 59037

Status
Completed
 
Locations

Neurology Departmant of Latvian

Riga, Latvia, LV-1015

Status
Completed
 
Locations

Moskva City MS Center

Moskva, Russia, 127018

Status
Completed
 
Locations

Danderyds sjukhus

Stockholm, Sweden, 182 88

Status
Completed
 
Locations

City Clinical Hospital #4

Kiev, Ukraine, 03110

Status
Completed
 
Locations

University of California Davis Medical Center

Sacramento, United States, 95817

Status
Completed
 
Locations

Fundacion de Neurorehabilitacion

Rosario, Argentina, S2000ZBL

Status
Completed
 
Locations

A. ö. Krankenhaus St. Pölten

St. Pölten, Austria, 3100

Status
Completed
 
Locations

National Centrum voor MS

MELSBROEK, Belgium, 1820

Status
Completed
 
Locations

Faculdade de Ciencias Medicas-Universidade Estadual Campinas

Campinas, Brazil, 13081- 970

Status
Completed
 
Locations

LNK Wagner Jauregg

Linz, Austria, 4020

Status
Completed
 
Locations

UZ Brussel

BRUXELLES - BRUSSEL, Belgium, 1090

Status
Completed
 
Locations

Universidade Federal de Sao Paulo - UNIFESP

Sao Paulo, Brazil, 04039

Status
Completed
 
Locations

Kliniken der Medizinischen Hochschule Hannover

Hannover, Germany, 30625

Status
Completed
 
Locations

Zala Megyei Korhaz

Zalaegerszeg, Hungary, 8900

Status
Completed
 
Locations

Beaumont Hospital

Dublin, Ireland, 9

Status
Completed
 
Locations

Sourasky Medical Center

Tel-Aviv, Israel, 64239

Status
Completed
 
Locations

Ospedale San Raffaele

Milano, Italy, 20132

Status
Completed
 
Locations

Multiple Sclerose Centrum Nijmegen

NIJMEGEN, Netherlands, 6533 PA

Status
Completed
 
Locations

Haukeland University Hospital, Bergen

Bergen, Norway, N-5021

Status
Completed
 
Locations

SP Szpital Kliniczny nr 5

Wroclaw, Poland, 50-417

Status
Completed
 
Locations

Klinicni center

Ljubljana, Slovenia, 1000

Status
Completed
 
Locations

St. George Private Medical Centre

Kogarah, Australia, 2217

Status
Completed
 
Locations

CHUM - Hopital Notre-Dame

Montreal, Canada, H2L 4M1

Status
Completed
 
Locations

Hospital Universitario Virgen de la Macarena

Sevilla, Spain, 41071

Status
Completed
 
Locations

Centre Hospitalier Universitaire

Nimes, France, 30029

Status
Completed
 
Locations

Klinikum der Ernst-Moritz-Arndt-Universität

Greifswald, Germany, 17489

Status
Completed
 
Locations

Oulun yliopisto

Oulu, Finland

Status
Completed
 
Locations

A IKA General Hospital

Athens, Greece, 15127

Status
Completed
 
Locations

Petz Aladar Megyei Korhaz

Györ, Hungary, 9024

Status
Completed
 
Locations

Akademiska Sjukhuset

Uppsala, Sweden, 75185

Status
Completed
 
Locations

Splosna Bolnisnica Marobor

Maribor, Slovenia, 2000

Status
Completed
 
Locations

Medizinische Universität Graz

Graz, Austria, 8036

Status
Completed
 
Locations

Gosford Hospital

Gosford, Australia, 2250

Status
Completed
 
Locations

AHEPA University General Hospital of Thessaloniki

Thessaloniki, Greece, 546 36

Status
Completed
 
Locations

Peterfy Sandor utcai Korhaz - Rendelointezet

Budapest, Hungary, 1076

Status
Completed
 
Locations

A.O.U. Careggi

Firenze, Italy, 50134

Status
Completed
 
Locations

Szpital im. N. Barlickiego

Lodz, Poland, 90-153

Status
Completed
 
Locations

Privatlakarna

Helsingborg, Sweden, 25278

Status
Completed
 
Locations

Institute of Neurology, Psychiatric and Narcology of AMSU

Kharkiv, Ukraine, 61068

Status
Completed
 
Locations

UZ Leuven Gasthuisberg

LEUVEN, Belgium, 3000

Status
Completed
 
Locations

Hospital das Clínicas da Faculdade de Medicina da USP

Sao Paulo, Brazil, 05403-900

Status
Completed
 
Locations

St Vincents University Hospital

Dublin, Ireland, DUBLIN 4

Status
Completed
 
Locations

Carmel Medical Center

Haifa, Israel, 34362

Status
Completed
 
Locations

Policlinico Consorziale

Bari, Italy, 70122

Status
Completed
 
Locations

Orbis Medisch Centrum

SITTARD, Netherlands, 6131 BK

Status
Completed
 
Locations

II Klinika Neurologii

Warszawa, Poland, 02957

Status
Completed
 
Locations

Institute of Neurology of Russian Academy of Medical Science

Moskva, Russia, 123367

Status
Completed
 
Locations

Donetsk state medical university

Donetsk, Ukraine, 83003

Status
Completed
 
Locations

University of Chicago Hospitals

Chicago, United States, 60637-1470

Status
Completed
 
Locations

Policlinica Bancaria

Buenos Aires, Argentina, C1416CRJ

Status
Completed
 
Locations

Hospital Israelita Albert Einstein

Sao Pulo, Brazil, 05651-901

Status
Completed
 
Locations

Ottawa Hospital-General Campus

Ottawa, Canada, K1H 8L6

Status
Completed
 
Locations

Krankenhaus Hennigsdorf

Hennigsdorf, Germany, 16761

Status
Completed
 
Locations

Hospital Regional Carlos Haya

Málaga, Spain, 29010

Status
Completed
 
Locations

Hopital Pontchaillou

Rennes, France, 35038

Status
Completed
 
Locations

Cork University Hospital

Cork, Ireland

Status
Completed
 
Locations

Hebrew University - Hadassah Medical School

Jerusalem, Israel, 91120

Status
Completed
 
Locations

Centre Hospitalier des Vallees de l'outaouais

Hull, Canada, J8Y 1W7

Status
Completed
 
Locations

Kantonsspital St. Gallen

St. Gallen, Switzerland, 9007

Status
Completed
 
Locations

Städt. Krankenhaus Martha-Maria Halle-Dölau gGmbH

Halle, Germany, 06120

Status
Completed
 
Locations

G. Gennimatas General State Hospital of Athens

Athens, Greece, 11527

Status
Completed
 
Locations

Ospedale San Luigi Gonzaga

Orbassano, Italy, 10043

Status
Completed
 
Locations

St. Petersburg Medical University n.a. Pavlov

St. Petersburg, Russia, 197022

Status
Completed
 
Locations

Fundacion FACENE

Buenos Aires, Argentina, C1117ABE

Status
Completed
 
Locations

Montreal Neurological Hospital

Montreal, Canada, H3A 2B4

Status
Completed
 
Locations

Rabin Medical Center

Petach Tikva, Israel, 49100

Status
Completed
 
Locations

A.O. di Padova

Padova, Italy, 35128

Status
Completed
 
Locations

Sir Charles Gardiner Hospital

Nedlands, Australia, 6009

Status
Completed
 
Locations

Hospital da Restauracao

Recife, Brazil, 52010-040

Status
Completed
 
Locations

Health Science Centre

Winnipeg, Canada, R3A 1R9

Status
Completed
 
Locations

Uzsoki utkai Korhaz

Budapest, Hungary, 1145

Status
Completed
 
Locations

Bnai Zion Medical Center

Haifa, Israel, 31048

Status
Completed
 
Locations

1st Medical Academy Municipal Hospital N61

Moscow, Russia, 119048

Status
Completed
 
Locations

1st Pirogov Clinical Hospital

Moscow, Russia, 117049

Status
Completed
 
Locations

Neurology Associates

Tualatin, United States, 97062

Status
Completed
 
Locations

Hospital Británico

Buenos Aires, Argentina, C1280AEB

Status
Completed
 
Locations

St Vincents Hospital

Melbourne, Australia, 3065

Status
Completed
 
Locations

Centre hospitalier universitaire

nancy, France, 54035

Status
Completed
 
Locations

Borsod County Hospital

Miskolc, Hungary, 3526

Status
Completed
 
Locations

Misericordiae Hospital

Dublin, Ireland, 7

Status
Completed
 
Locations

Sheba Medical Center

Tel Hashomer, Israel, 52621

Status
Completed
 
Locations

Centralny Szpital Kliniczny AM

Warszawa, Poland, 02-097

Status
Completed
 
Locations

Regional Clinical Hospital

Lviv, Ukraine, 79000

Status
Completed
 
Locations

University of Alabama at Birmingham

Birmingham, United States, 35294

Status
Completed
 
Locations

Universitätsklinikum Innsbruck

Innsbruck, Austria, 6020

Status
Completed
 
Locations

Liverpool Hospital

Liverpool, Australia, 2170

Status
Completed
 
Locations

Medizinische Fakultät Carl Gustav Carus

Dresden, Germany, 01307

Status
Completed
 
Locations

Hopital general

Dijon, France, 21033

Status
Completed
 
Locations

Pecsi TE Neurologiai Klinika

Pecs, Hungary, 7623

Status
Completed
 
Locations

Adelaide & Meath Hospital

Dublin, Ireland

Status
Completed
 
Locations

Jüdisches Krankenhaus

Berlin, Germany, 13347

Status
Completed
 
Locations

CHRU Cote de Nacre

CAEN, France, F-14033

Status
Completed
 
Locations

Barzili Medical Center

Ashkelon, Israel, 78306

Status
Completed
 
Locations

Siberian District Medical Center

Novosibirsk, Russia, 630007

Status
Completed
 
Locations

Hosp. Univ. Clementino Fraga Filho - Univ. do Rio de Janeiro

Rio de Janeiro, Brazil, 21949 900

Status
Completed
 
Locations

Bezirkskrankenhaus Bayreuth

Bayreuth, Germany, 95445

Status
Completed
 
Locations

C. H. U. Hopital Purpan

Toulouse, France, 31059

Status
Completed
 
Locations

Assaf Harofeh Medical Center

Zerifin, Israel, 70300

Status
Completed
 
Locations

MONIKI

Moskva, Russia, 129110

Status
Completed
 
Locations

Blake Neurology

Englewood, United States, 80110

Status
Completed
 
Locations

University of British Columbia Hospital

Vancouver, Canada, V6T 2B5

Status
Completed
 
Locations

Kamillus Klinik Asbach

Asbach, Germany, 53567

Status
Completed
 
Locations

Axiom Clinical Research

Tampa, United States, 33609

Status
Completed
 
Locations

Universitäts-Krankenhaus Eppendorf

Hamburg, Germany, 20251

Status
Completed
 
Locations

Northwest NeuroSpecialists, PLLC

Tucson, United States, 85741-3537

Status
Completed
 
Locations

Trilium Health Centre

Mississauga, Canada, L5B 1B8

Status
Completed
 
Locations

Hopital gabriel montpied

Clermont ferrand, France, 63003

Status
Completed
 
Locations

Amphia Ziekenhuis, locatie Langendijk

BREDA, Netherlands, 4819 EV

Status
Completed
 
Locations

Wojewodzki Szpital Specjalistyczny im. M. Kopernika

Gdansk, Poland, 80-803

Status
Completed
 
Locations

Institute of Brain of Russian

Sankt-Peterburg, Russia, 197376

Status
Completed
 
Locations

University of Kentucky

Lexington, United States, 40536

Status
Completed
 
Locations

Hospital Militar de Cordoba

Cordoba, Argentina, X5000HGX

Status
Completed
 
Locations

Inselspital Bern

Bern, Switzerland, 3010

Status
Completed
 
Locations

Städtisches Klinikum "St. Georg" Leipzig

Leipzig, Germany, 04129

Status
Completed
 
Locations

Centre hospitalier universitaire

nice, France, 06000

Status
Completed
 
Locations

A.O. S.Andrea

Roma, Italy, 00189

Status
Completed
 
Locations

SP Szpital Kliniczny nr 2

Poznan, Poland, 60-355

Status
Completed
 
Locations

University of Nevada-Reno

Reno, United States, 89557-0035

Status
Completed
 
Locations

Royal Melbourne Hospital

Parkville, Australia, 3050

Status
Completed
 
Locations

Hospital das Clinicas da Universidade Federal do Paraná

Curitiba, Brazil, 80060-900

Status
Completed
 
Locations

Foothills Medical Centre

Calgary, Canada, T2N 2T9

Status
Completed
 
Locations

Katedra i Klinika Neurologii Sl.A.M

Katowice, Poland, 40752

Status
Completed
 
Locations

St. Mary's/Duluth Clinic Health System

Duluth, United States, 55805-1984

Status
Completed
 
Locations

Universitätsklinikum Heidelberg

Heidelberg, Germany, 69112

Status
Completed
 
Locations

East Bay Region Associates in Neurology

Berkeley, United States, 94705

Status
Completed
 
Locations

Vivantes Klinikum Spandau

Berlin, Germany, 13578

Status
Completed
 
Locations

SUNY at Stony Brook

Stony Brook, United States, 11794

Status
Completed
 
Locations

Universitätsklinikum Münster

Münster, Germany, 48149

Status
Completed
 
Locations

Klinikum der Universität Regensburg

Regensburg, Germany, 93053

Status
Completed
 
Locations

University of Rochester Medical Center

Rochester, United States, 14642

Status
Completed
 
Locations

Klinikum Offenbach

Offenbach, Germany, 63069

Status
Completed
 
Locations

Alfried Krupp Krankenhaus

Essen, Germany, 45177

Status
Completed
 
Locations

Neurological Associates of Albany

Albany, United States, 12208

Status
Completed
 
Locations

Advanced Neurosciences Institute

Nashville, United States, 37205

Status
Completed
 
Locations

Dartmouth Hitchock Medical Center

Lebanon, United States, 03756-0001

Status
Completed
 
Locations

Wake Forest University Medical Center

Winston-Salem, United States, 27157-1009

Status
Completed
 
Locations

Virginia Mason Medical Center

Seattle, United States, 98101

Status
Completed
 
Locations

Thomas Jefferson University

Philadelphia, United States, 19107

Status
Completed
 
Locations

St. Michael's Hospital Health Centre

Toronto, Canada, M5C 2T2

Status
Completed
 
Locations

Hospital de Clínicas de Porto Alegre

Porto Alegre, Brazil

Status
Completed
 
Locations

Klinikum der Philipps-Universität

Marburg, Germany, 35043

Status
Completed
 
Locations

Yaroslavl Medical Academy

Yaroslavl, Russia, 150039

Status
Completed
 
Locations

Washington University School of Medicine

St. Louis, United States, 63110

Status
Completed
 
Locations

London Health Sciences Centre

London, Canada, N6A 5A5

Status
Completed
 
Locations

Klinikum der Justus-Liebig-Universität

Gießen, Germany, 35392

Status
Completed
 
Locations

Hospital Pellegrin

Bordeaux, France, 33076

Status
Completed
 
Locations

City Hospital N 33

Nizhny Novogorod, Russia, 603076

Status
Completed
 
Locations

University of Medicine and Dentistry of New Jersey

New Brunswick, United States, 08901

Status
Completed
 
Locations

Hopital Charles LeMoyne

Greenfield Park, Canada, J4V 2H1

Status
Completed
 
Locations

Centre René Gauducheau

Nantes, France, 44805

Status
Completed
 
Locations

Medical Military Academy

Sankt-Peterburg, Russia, 194044

Status
Completed
 
Locations

Ottawa Headache Centre West

Nepean, Canada, K2G 6E2

Status
Completed
 
Locations

Hopital Neurologique

Lyon, France, 69003

Status
Completed
 
Locations

Asklepios Klinik St. Georg

Hamburg, Germany, 20099

Status
Completed
 
Locations

University of Kansas Medical Center

Kansas City, United States, 66160

Status
Completed
 
Locations

George Washington University

Washington, United States, 20037

Status
Completed
 
Locations

Integra Clinical Research, LLC

San Antonio, United States, 78229

Status
Completed
 
Locations

North Central Neurology Associates

Cullman, United States, 35058

Status
Completed
 
Locations

Louisiana State University Medical Center

Shreveport, United States, 71130

Status
Completed
 
Locations

University of Pittsburgh Medical Center Health System

Pittsburgh, United States, 15213-2592

Status
Completed
 
Locations

Riverhills Healthcare, Inc.

Cincinnati, United States, 45219

Status
Completed
 
Locations

Coastal Neurological Medical Group

La Jolla, United States, 92037

Status
Completed
 
Locations

Ohio State University Medical Center

Columbus, United States, 43210-1240

Status
Completed
 
Locations

Marshfield Clinic

Marshfield, United States, 54449

Status
Completed
 
Locations

Neurology Associates, PA

Wilmington, United States, 19806

Status
Completed
 
Locations

High Point Neurological Associates

High Point, United States, 27262

Status
Completed
 
Locations

Medical University of South Carolina

Charleston, United States, 29425

Status
Completed
 
Locations

Neurology & Neurosurgery Associates of Tacoma, Inc.

Tacoma, United States, 98405

Status
Completed
 
Locations

Tampa General Hospital

Tampa, United States, 33606-3508

Status
Completed
 
Locations

Henry Ford Health System

Detroit, United States, 48202

Status
Completed
 
Locations

Medizinische Einrichtungen der Heinrich-Heine-Universität

Düsseldorf, Germany, 40225

Status
Completed
 
Locations

University of New Mexico

Albuquerque, United States, 87131

Status
Completed
 
Locations

Henriettenstiftung

Hannover, Germany, 30171

Status
Completed
 
Locations

University of California, San Francisco

San Francisco, United States, 94117

Status
Completed
 
Locations

Bereich Humanmed. d. Georg-August-Universität Göttingen

Göttingen, Germany, 37075

Status
Completed
 
Locations

Winthrop-University Hospital

Mineola, United States, 11501-3987

Status
Completed
 
Locations

Fort Wayne Neurological Center

Fort Wayne, United States, 46805

Status
Completed
 
Locations

Mercy Ruan Neurology Clinic

Des Moines, United States, 50314

Status
Completed
 
Locations

Medical College of GA

Augusta, United States, 30912

Status
Completed
 
Locations

Duke University Medical Center

Durham, United States, 27710

Status
Completed
 
Locations

Nevada Neurological Consultants, Ltd.

Henderson, United States, 89052

Status
Completed
 
Locations

Carolinas Medical Center

Charlotte, United States, 28203

Status
Completed
 
Locations

St Lukes Medical Center

Milwaukee, United States, 53215

Status
Completed
 
Locations

University Neurologists, PSC

Louisville, United States, 40202

Status
Completed
 
Locations

Hospital of the University of Pennsylvania

Philadelphia, United States, 19104

Status
Completed
 
Locations

Indiana University

Indianapolis, United States, 46202

Status
Completed
 
Locations

Baylor College

Houston, United States, 77030

Status
Completed
 
Locations

Neurology Foundation, Inc.

Providence, United States, 02905

Status
Completed
 
Locations

Neurology Center of Fairfax, Ltd.

Fairfax, United States, 22031

Status
Completed
 
Locations

University of Miami

Miami, United States, 33125

Status
Completed
 
Locations

Shepherd Center

Atlanta, United States, 30309-1465

Status
Completed
 
Locations

Barrow Neurology Clinic

Phoenix, United States, 85013

Status
Completed
 
Locations

Dr. Tamara Miller, MD

Fort Collins, United States, 80528

Status
Completed
 

Trial Design