Malignant solid tumors, Coronavirus disease 2019 (COVID-19), SARS-CoV-2 Infection

Inclusion Criteria

TKIs Treated Group
- Patients ≥18 years old at index date
- Patients who had any healthcare encounter with a primary or secondary diagnosis of Coronavirus disease 2019 (COVID-19) or positive results from Polymerase Chain Reaction (PCR) lab test for Severe acute respiratory syndrome coronavirus 2 (SARs-CoV-2) during the patient
identification period (January 1, 2020 to May 31, 2021 or one month before the latest data cut)
- Patient who was under TKIs on index date or the last episode of TKIs treatment ended within 30 days before index date
- Patient who had any diagnosis of solid tumors at any time before index date (identified using ICD-9 or ICD-10 diagnosis codes, Supplementary Table 5)
- Continuous insurance enrollment for at least 90 days before index date

Non-TKIs Treated Group
- Patients ≥18 years old at index date
- Patients who had any healthcare encounter with a primary or secondary diagnosis of COVID-19 or positive results from PCR lab test for SARs-CoV-2 during the patient identification period 
- Patient who had any diagnosis of solid tumors any time before the index
- Patient who was under anti-neoplastic medications on index date or the last episode of the anti-neoplastic treatment ended within 30 days before index date 
- Continuous insurance enrollment for at least 90 days before index date

Exclusion Criteria

TKIs treated Group
- Patients who had secondary cancer without site specification (only had ICD-10 codes C79.9 or C80 for metastasis) from 90 days before index

Non-TKIs Treated Group
- Patients who had any claims of TKIs treatment during the study period
- Patients who had secondary cancer without site specification (only had ICD-10 codes C79.9 or C80 for metastasis) from 90 days before index