Trial Condition(s):
Atrial Fibrillation
Burden of ischemic stroke and intake of oral anticoagulants in patients with atrial fibrillation in the UK primary care (BEST-AF)
Bayer Identifier:
21094
ClinicalTrials.gov Identifier:
EudraCT Number:
Not Available
EU CT Number:
Not Available
Study Completed
Trial Purpose
This study will characterize patients with ischemic stroke, a condition which occurs when a vessel supplying blood to the brain is obstructed, and a subpopulation of patients with irregular and often rapid heart rate (atrial fibrillation) in a UK general population using The Health Improvement Network (THIN) database.
The main aim of the study is to estimate in how many patients atrial fibrillation was diagnosed at the moment of stroke and to describe whether these patients received OAC at the time of the stroke. In addition, researchers want to learn about the relative risk of ischemic stroke when such patients did not continue OAC treatment.
Inclusion Criteria
- Occurrence of an ischemic stroke that lead to hospitalization between 01-Jul-2016 to 30-Jun-2018 and concerned adults registered in the THIN database - Subgroup: Patients with diagnosed NVAF prior or at the time of ischemic stroke
Exclusion Criteria
- None
Trial Summary
Enrollment Goal
3739
Trial Dates
Phase
4
Could I receive a placebo?
No
Products
Unspecified
Accepts Healthy Volunteers
No
Where to Participate
Loading...
Locations
Status
| Locations | Status | |
|---|---|---|
Locations Many facilities Many locations, United Kingdom | Status Completed | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Trial Design
Burden of ischemic stroke and adherence to oral anticoagulants in atrial fibrillation in the UK primary care
Trial Type:
Observational
Intervention Type:
Drug
Trial Purpose:
Other
Allocation:
N/A
Blinding:
N/A
Assignment:
N/A
Trial Arms:
2
Primary Outcome
- Number of subjects with ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2018
- Incidence of ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2018
- Number of NVAF patients with OAC prescription prior to ischemic strokeFor NVAF subgroup onlyTimeframe: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
- Duration of OAC treatment before OAC discontinuation for NVAF patientsFor NVAF subgroup onlyTimeframe: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
- Time period from OAC discontinuation to ischemic stroke for NVAF patientsFor NVAF subgroup onlyTimeframe: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
- Relative risk of NVAF patients for ischemic stroke after OAC discontinuationFor NVAF subgroup onlyTimeframe: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
- Relative risk of NVAF patients for ischemic stroke by time since OAC discontinuationFor NVAF subgroup onlyTimeframe: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
- Relative risk of NVAF patients for ischemic stroke by OAC treatment duration before OAC discontinuationFor NVAF subgroup onlyTimeframe: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
- Relative risk of NVAF patients for ischemic stroke after VKA discontinuationFor NVAF subgroup onlyTimeframe: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
- Relative risk of NVAF patients for ischemic stroke by time since VKA discontinuationFor NVAF subgroup onlyTimeframe: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
- Relative risk of NVAF patients for ischemic stroke by VKA treatment duration before VKA discontinuationFor NVAF subgroup onlyTimeframe: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
- Relative risk of NVAF patients for ischemic stroke after NOAC discontinuationFor NVAF subgroup onlyTimeframe: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
- Relative risk of NVAF patients for ischemic stroke by time since NOAC discontinuationFor NVAF subgroup onlyTimeframe: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
- Relative risk of NVAF patients for ischemic stroke by NOAC treatment duration before NOAC discontinuationFor NVAF subgroup onlyTimeframe: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
Secondary Outcome
- Number of subjects with first diagnosis of NVAF at time of ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2018
- Number of subjects with first diagnosis of NVAF within 1 month after ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jul-2018
- Number of subjects with first diagnosis of NVAF within 12 months after ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
- Prevalence of cardiovascular co-morbidities one year before ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
- Prevalence of cardiovascular co-morbidities 12 months after ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
- Descriptive analysis of pharmacological treatments of patients with known NVAF diagnosis within 12 months before ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
- Descriptive analysis of pharmacological treatments of patients with known NVAF diagnosis within 12 months after ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
- Descriptive analysis of pharmacological treatments of patients without known NVAF diagnosis within 12 months before ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
- Descriptive analysis of pharmacological treatments of patients without known NVAF diagnosis within 12 months after ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
- Case-fatality of patients with known NVAF diagnosis at 1 month after ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
- Case-fatality for patients with known NVAF diagnosis at 12 months after ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
- Case-fatality of patients with unknown NVAF diagnosis at 1 month after ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
- Case-fatality of patients with unknown NVAF diagnosis at 12 months after ischemic strokeTimeframe: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
Additional Information
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