Trial Condition(s):

Neovascular Age-Related Macular Degeneration

Study to gather information on safety and use of high dose aflibercept injection into the eye in patients with an age related eye disorder that causes blurred vision or a blind spot due to abnormal blood vessels that leak fluid into the light sensitive lining inside the eye (PULSAR)

Bayer Identifier:

20968

ClinicalTrials.gov Identifier:

NCT04423718

EudraCT Number:

2019-003851-12

Recruitment Complete

Trial Purpose

In this study researchers want to learn more about changes in visual acuity (clarity of vision) with a high dose treatment with Aflibercept (Eylea) in patients suffering from neovascular age-related macular degeneration (nAMD). Neovascular AMD is an eye disease that causes blurred vision or a blind spot due to abnormal blood vessels that leak fluid or blood into the light sensitive lining inside the eye (retina). The fluid buildup causes the central part of the retina (macula) responsible for sharp, straight-ahead vision to swell and thicken (edema), which distorts vision.

Inclusion Criteria
- Active subfoveal CNV secondary to nAMD, including juxtafoveal lesions that affect the fovea as assessed in the study eye.
- Total area of CNV (including both classic and occult components) must comprise greater than 50% of the total lesion area in the study eye.
- BCVA ETDRS letter score of 78 to 24 (corresponding to a Snellen equivalent of approximately 20/32 to 20/320) in the study eye.
- Decrease in BCVA determined to be primarily the result of nAMD in the study eye.
- Presence of IRF and/or SRF affecting the central subfield of the study eye on OCT. 
- Contraceptive use by men or women should be consistent with local regulations regarding the methods of highly effective contraception for those participating in clinical studies.
- Other protocol-specified inclusion criteria.
Additional inclusion criteria for Year 3:
- At least one BCVA value and one central subfield retinal thickness (CST) value from measurements at one of the following visits: Visit 24 (Week 84), Visit 25 (Week 88) or Visit 26 (Week 92).
- Participant is enrolled at a site that participates in the extension period.
Exclusion Criteria
- Causes of CNV other than nAMD in the study eye.
- Scar, fibrosis, or atrophy involving the central subfield in the study eye. 
- Presence of retinal pigment epithelial tears or rips involving the central subfield in the study eye. 
- Uncontrolled glaucoma (defined as IOP >25 mmHg despite treatment with anti-glaucoma medication) in the study eye.
- History of idiopathic or autoimmune uveitis in the study eye. 
- Myopia of a spherical equivalent of at least 8 diopters in the study eye prior to any refractive or cataract surgery. 
- History or clinical evidence of diabetic retinopathy, diabetic macular edema, or any retinal vascular disease other than nAMD in either eye. 
- Evidence of extraocular or periocular infection or inflammation (including infectious blepharitis, keratitis, scleritis, or conjunctivitis) in either eye at the time of screening/randomization.
- Uncontrolled blood pressure (defined as systolic >160 mmHg or diastolic >95 mmHg). 
- Any prior or concomitant ocular (in the study eye) or systemic treatment (with an investigational or approved, anti-VEGF or other agent) or surgery for nAMD, except dietary supplements or vitamins.
- Other protocol-specified exclusion criteria

Trial Summary

Enrollment Goal
1011
Trial Dates
black-arrow
Phase
3
Could I receive a placebo?
No
Products
Aflibercept (VEGF Trap-Eye, BAY86-5321)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

Kobe University Hospital

Kobe, Japan, 650-0017

Status
Active, not recruiting
 
Locations

Hyogo Prefectural Amagasaki General Medical Center

Amagasaki, Japan, 660-8550

Status
Active, not recruiting
 
Locations

Nagoya City University Hospital

Nagoya, Japan, 467-8602

Status
Active, not recruiting
 
Locations

University of the Ryukyus Hospital

Nakagami, Japan, 903-0215

Status
Active, not recruiting
 
Locations

AXON Clinical s.r.o.

Praha 5, Czech Republic, 150 00

Status
Active, not recruiting
 
Locations

Fakultni nemocnice Ostrava

Ostrava, Czech Republic, 708 52

Status
Active, not recruiting
 
Locations

Fakultni Nemocnice Hradec Kralove

Hradec Kralove, Czech Republic, 500 05

Status
Active, not recruiting
 
Locations

Charles University in Prague

Prague, Czech Republic, 110 00

Status
Active, not recruiting
 
Locations

Sydney Retina Clinic

Sydney, Australia, 2000

Status
Active, not recruiting
 
Locations

Marsden Eye Surgery Center

Parramatta, Australia, 2150

Status
Active, not recruiting
 
Locations

Westmead Hospital

Wentworthville, Australia, 2145

Status
Active, not recruiting
 
Locations

Eyeclinic Albury Wodonga

Albury, Australia, 2640

Status
Active, not recruiting
 
Locations

Hobart Eye Surgeons

Hobart, Australia, 7000

Status
Active, not recruiting
 
Locations

Klinikum Klagenfurt am Wörthersee

Klagenfurt, Austria, 9020

Status
Active, not recruiting
 
Locations

Pusan National University Hospital

Busan, South Korea, 49241

Status
Terminated
 
Locations

Asan Medical Center

Seoul, South Korea, 05505

Status
Active, not recruiting
 
Locations

Samsung Medical Center

Seoul, South Korea, 06351

Status
Active, not recruiting
 
Locations

Seoul National University Hospital

Seoul, South Korea, 03080

Status
Active, not recruiting
 
Locations

Seoul National University Bundang Hospital

Seongnam-si, South Korea, 13620

Status
Active, not recruiting
 
Locations

New England Retina Associates

New London, United States, 06320

Status
Active, not recruiting
 
Locations

Ophthalmic Consultants of Boston

Boston, United States, 02114

Status
Active, not recruiting
 
Locations

Palmetto Retina Center, LLC

West Columbia, United States, 29169

Status
Active, not recruiting
 
Locations

Medical Center Ophthalmology Associates

San Antonio, United States, 78240

Status
Active, not recruiting
 
Locations

Hayashi Eye Hospital

Fukuoka, Japan, 812-0011

Status
Completed
 
Locations

Daiyukai Daiichi Hospital

Ichinomiya, Japan, 491-8551

Status
Active, not recruiting
 
Locations

National Hospital Organization Tokyo Medical Center

Meguro-ku, Japan, 152-8902

Status
Completed
 
Locations

Fakultna nemocnica Trencin

Trencin, Slovakia, 911 71

Status
Active, not recruiting
 
Locations

Stadtspital Triemli

Zürich, Switzerland, 8063

Status
Active, not recruiting
 
Locations

Chang Gung Memorial Hospital at Linkou

Taoyuan, Taiwan, China, 33305

Status
Completed
 
Locations

Shin Kong Wu Ho-Su Memorial Hospital

Taipei City, Taiwan, China, 111

Status
Completed
 
Locations

National University Hospital

Singapore, Singapore, 119074

Status
Completed
 
Locations

Organizacion Medica de Investigacion (OMI)

Buenos Aires, Argentina, C1015ABO

Status
Active, not recruiting
 
Locations

Konventhospital Barmherzige Brüder Linz

Linz, Austria, 4021

Status
Completed
 
Locations

Hanusch-Krankenhaus Wien

Wien, Austria, 1140

Status
Active, not recruiting
 
Locations

Mie University Hospital

Tsu, Japan, 514-8507

Status
Completed
 
Locations

Akita University Hospital

Akita, Japan, 010-8543

Status
Active, not recruiting
 
Locations

Nagoya University Hospital

Nagoya, Japan, 466-8560

Status
Active, not recruiting
 
Locations

Kansai Medical University Hospital

Hirakata, Japan, 573-1191

Status
Active, not recruiting
 
Locations

Hiroshima University Hospital

Hiroshima, Japan, 734-8551

Status
Active, not recruiting
 
Locations

AIBILI

Coimbra, Portugal, 3000-548

Status
Active, not recruiting
 
Locations

Oita University Hospital

Yufu, Japan, 879-5593

Status
Terminated
 
Locations

Taipei Veterans General Hospital

Taipei, Taiwan, China, 11217

Status
Completed
 
Locations

Fukushima Medical University Hospital

Fukushima, Japan, 960-1295

Status
Active, not recruiting
 
Locations

Okayama University Hospital

Okayama, Japan, 700-8558

Status
Active, not recruiting
 
Locations

Kurume University Hospital

Kurume, Japan, 830-0011

Status
Active, not recruiting
 
Locations

Yamaguchi University Hospital

Ube, Japan, 755-8505

Status
Active, not recruiting
 
Locations

Kanazawa University Hospital

Kanazawa, Japan, 920-8641

Status
Active, not recruiting
 
Locations

Fakultni nemocnice Kralovske Vinohrady

Praha 10, Czech Republic, 100 34

Status
Active, not recruiting
 
Locations

Hospital of LT University of Health Sciences Kaunas Clinics

Kaunas, Lithuania, LT-50161

Status
Active, not recruiting
 
Locations

Vilnius University Hospital Santaros Klinikos

Vilnius, Lithuania, LT-08661

Status
Active, not recruiting
 
Locations

PI Klaipedos University Hospital

Klaipeda, Lithuania, LT-92288

Status
Active, not recruiting
 
Locations

East Tallinn Central Hospital

Tallinn, Estonia, 10138

Status
Completed
 
Locations

Latvian American Eye Center

Riga, Latvia, LV-1009

Status
Active, not recruiting
 
Locations

Department of Ophthalmology

Riga, Latvia, 1002

Status
Active, not recruiting
 
Locations

Long Island Vitreoretinal Consultants

Great Neck, United States, 11021

Status
Active, not recruiting
 
Locations

Ophthalmic Consultants of Long Island

Lynbrook, United States, 11563

Status
Completed
 
Locations

Long Island Vitreoretinal Consultants

Hauppauge, United States, 11788

Status
Active, not recruiting
 
Locations

NJ Retina

Edison, United States, 08820

Status
Active, not recruiting
 
Locations

Texas Retina Associates

Fort Worth, United States, 76104

Status
Active, not recruiting
 
Locations

Retina Northwest, PC

Portland, United States, 97210

Status
Active, not recruiting
 
Locations

Retina Care Center

Baltimore, United States, 21209

Status
Active, not recruiting
 
Locations

Retina Consultants of Nevada

Las Vegas, United States, 89144

Status
Completed
 
Locations

Retina Center of New Jersey

Bloomfield, United States, 07003

Status
Active, not recruiting
 
Locations

Retina Vitreous Associates of Florida - Saint Petersburg

Saint Petersburg, United States, 33711-1141

Status
Active, not recruiting
 
Locations

West Virginia University

Morgantown, United States, 26506

Status
Active, not recruiting
 
Locations

Spokane Eye Clinical Research

Spokane, United States, 99204

Status
Active, not recruiting
 
Locations

Arizona Retina and Vitreous Consultants - Research

Phoenix, United States, 85021

Status
Active, not recruiting
 
Locations

Florida Retina Institute

Jacksonville, United States, 32204

Status
Active, not recruiting
 
Locations

California Eye Specialists

Pasadena, United States, 91107

Status
Active, not recruiting
 
Locations

Retinal Consultants of Texas - San Antonio

San Antonio, United States, 78240

Status
Active, not recruiting
 
Locations

Mid Atlantic Retina

Bethlehem, United States, 18017

Status
Active, not recruiting
 
Locations

Retina Consultants of Houston

Houston, United States, 77030

Status
Active, not recruiting
 
Locations

Charles Retina Institute

Memphis, United States, 38119

Status
Active, not recruiting
 
Locations

Retina Consultants of Houston

The Woodlands, United States, 77384

Status
Active, not recruiting
 
Locations

Vitreo Retinal Surgery PA

Edina, United States, 55435

Status
Active, not recruiting
 
Locations

Retina Consultants San Diego

San Diego, United States, 92071

Status
Active, not recruiting
 
Locations

University Retina and Macula Associates

Oak Forest, United States, 60452

Status
Active, not recruiting
 
Locations

Florida Retina Institute

Orlando, United States, 32806

Status
Active, not recruiting
 
Locations

Southern Vitreoretinal Associates

Tallahassee, United States, 32308

Status
Active, not recruiting
 
Locations

Vitreo-Retinal Associates

Gainesville, United States, 32607

Status
Active, not recruiting
 
Locations

Retina Group of Florida

Ft. Lauderdale, United States, 33308

Status
Completed
 
Locations

Vanderbilt University Medical School

Nashville, United States, 37232

Status
Active, not recruiting
 
Locations

Eye Associates of New Mexico

Albuquerque, United States, 87106

Status
Active, not recruiting
 
Locations

Black Hills Regional Eye Institute

Rapid City, United States, 57701

Status
Active, not recruiting
 
Locations

Eye Care Specialists

Kingston, United States, 18704

Status
Active, not recruiting
 
Locations

Northern California Retina-Vitreous Associates

Mountain View, United States, 94040

Status
Active, not recruiting
 
Locations

Charleston Neuroscience Center

Charleston, United States, 29414

Status
Active, not recruiting
 
Locations

Retina Macula Specialists of Miami

Miami, United States, 33126

Status
Completed
 
Locations

Midwest Retina - Main Office

Dublin, United States, 43016

Status
Active, not recruiting
 
Locations

Retina Consultants of Hawaii

Aiea, United States, 96701

Status
Completed
 
Locations

Fletcher Allen Health Care

Burlington, United States, 05401-1420

Status
Active, not recruiting
 
Locations

Retina Associates IL

Elmhurst, United States, 60126

Status
Active, not recruiting
 
Locations

Florida Eye Associates

Melbourne, United States, 32901

Status
Active, not recruiting
 
Locations

Erie Retinal Surgery, Inc.

Erie, United States, 16507

Status
Completed
 
Locations

Austin Retina Associates

Austin, United States, 78705

Status
Active, not recruiting
 
Locations

Retina Consultants of Southern California

Redlands, United States, 92374

Status
Active, not recruiting
 
Locations

University of Wisconsin - Madison

Madison, United States, 53792

Status
Active, not recruiting
 
Locations

Wake Forest Baptist Health

Winston-Salem, United States, 27157-1045

Status
Completed
 
Locations

University of California San Diego

La Jolla, United States, 92093-0698

Status
Active, not recruiting
 
Locations

Retina Specialists

Pensacola, United States, 32503

Status
Active, not recruiting
 
Locations

Retina Consultants of Orange County

Fullerton, United States, 92835

Status
Active, not recruiting
 
Locations

Ophthalmic Consultants of the Capital Region

Troy, United States, 12180

Status
Completed
 
Locations

Retina Consultants, LLC

Salem, United States, 97302

Status
Active, not recruiting
 
Locations

Kaiser Permanente Riverside Medical Center

Riverside, United States, 92505

Status
Active, not recruiting
 
Locations

Kozawa Eye Hospital and Diabetes Center

Mito, Japan, 310-0845

Status
Active, not recruiting
 
Locations

The University of Tokyo Hospital

Bunkyo-ku, Japan, 113-8655

Status
Active, not recruiting
 
Locations

Kansai Medical University Medical Center

Moriguchi, Japan, 570-8507

Status
Active, not recruiting
 
Locations

Kindai University Hospital

Osakasayama, Japan, 589-8511

Status
Active, not recruiting
 
Locations

Aichi Medical University Hospital

Nagakute, Japan, 480-1195

Status
Active, not recruiting
 
Locations

Lexum a.s., Evropska ocni klinika

Praha 4, Czech Republic, 140 00

Status
Active, not recruiting
 
Locations

Fakultni nemocnice Plzen - Lochotin

Plzen, Czech Republic, 304 60

Status
Active, not recruiting
 
Locations

Szent-Gyorgyi Albert Orvostudomanyi Egyetem

Szeged, Hungary, 6720

Status
Active, not recruiting
 
Locations

Tartu University Hospital

Tartu, Estonia

Status
Active, not recruiting
 
Locations

Riga East Clinical University Hospital "Gailezers"

Riga, Latvia, LV-1006

Status
Active, not recruiting
 
Locations

Shinshu University Hospital

Matsumoto, Japan, 390-8621

Status
Active, not recruiting
 
Locations

Japanese Red Cross Saitama Hospital

Saitama, Japan, 330-8553

Status
Terminated
 
Locations

Kokura Memorial Hospital

Kitakyushu, Japan, 802-8555

Status
Active, not recruiting
 
Locations

Japanese Red Cross Nagasaki Genbaku Hospital

Nagasaki, Japan, 852-8511

Status
Active, not recruiting
 
Locations

Japanese Red Cross Wakayama Medical center

Wakayama, Japan, 640-8558

Status
Active, not recruiting
 
Locations

Singapore National Eye Centre

Singapore, Singapore, 168751

Status
Active, not recruiting
 
Locations

University of Miyazaki Hospital

Miyazaki, Japan, 889-1692

Status
Completed
 
Locations

Keio University Hospital

Shinjuku-ku, Japan, 160-8582

Status
Active, not recruiting
 
Locations

Poltava Regional Clinical Hospital n.a. M.V. Skliphosovskyi

Poltava, Ukraine, 36011

Status
Active, not recruiting
 
Locations

Centralna Polyclinica MVS Ukraiiny

Kyiv, Ukraine, 01024

Status
Active, not recruiting
 
Locations

Ospedale San Raffaele s.r.l.

Milano, Italy, 20132

Status
Active, not recruiting
 
Locations

Fondazione PTV Policlinico Tor Vergata

Roma, Italy, 00133

Status
Active, not recruiting
 
Locations

IRCCS Fondazione G.B. Bietti Studio e Ricerca in Otalmologia

Roma, Italy, 00198

Status
Completed
 
Locations

A.O. di Perugia

Perugia, Italy, 06129

Status
Completed
 
Locations

A.O.U. di Cagliari

Cagliari, Italy, 09124

Status
Completed
 
Locations

ALM Oftalmolaser - Oftalmologia Medica e Cirurgica

Lisboa, Portugal, 1050-078

Status
Active, not recruiting
 
Locations

Centro Hospitalar Universitario do Porto

Porto, Portugal, 4099-001

Status
Active, not recruiting
 
Locations

CHVNGE - Hospital Eduardo Santos Silva

Vila Nova de Gaia, Portugal, 4434-502

Status
Completed
 
Locations

Fakultna nemocnica s poliklinikou Zilina

Zilina, Slovakia, 012 07

Status
Active, not recruiting
 
Locations

Fakultna nemocnica Nitra

Nitra, Slovakia, 950 01

Status
Active, not recruiting
 
Locations

Nemocnica s Poliklinikou Trebisov, Svet zdravia a.s.

Trebisov, Slovakia, 075 01

Status
Active, not recruiting
 
Locations

University of Yamanashi Hospital

Chuo, Japan, 409-3898

Status
Active, not recruiting
 
Locations

Kanazawa Medical University Hospital

Kahoku-gun, Japan, 920-0293

Status
Terminated
 
Locations

Otakeganka Tsukimino Clinic

Yamato, Japan, 242-0001

Status
Active, not recruiting
 
Locations

Kagawa University Hospital

Kita-gun, Japan, 761-0793

Status
Active, not recruiting
 
Locations

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, Italy, 00168

Status
Active, not recruiting
 
Locations

ASST Fatebenefratelli Sacco

Milano, Italy, 20157

Status
Active, not recruiting
 
Locations

Nara Medical University Hospital

Kashihara, Japan, 634-8522

Status
Active, not recruiting
 
Locations

Tokushima University Hospital

Tokushima, Japan, 770-8503

Status
Completed
 
Locations

Gunma University Hospital

Maebashi, Japan, 371-8511

Status
Active, not recruiting
 
Locations

Dannoue Eye Clinic

Kawasaki, Japan, 211-0053

Status
Active, not recruiting
 
Locations

Tokiwadai Muranaka Eye Clinic

Itabashi-ku, Japan, 174-0071

Status
Active, not recruiting
 
Locations

Kurashiki Medical Center

Kurashiki, Japan, 710-8522

Status
Completed
 
Locations

Medizinische Universität Graz

Graz, Austria, 8036

Status
Active, not recruiting
 
Locations

Kepler Universitätsklinikum Campus III

Linz, Austria, 4020

Status
Completed
 
Locations

Hospital de la Santa Creu i de Sant Pau

Barcelona, Spain, 08041

Status
Active, not recruiting
 
Locations

Hospital Clínic i Provincial de Barcelona

Barcelona, Spain, 08036

Status
Active, not recruiting
 
Locations

Hospital Reina Sofía

Córdoba, Spain, 14004

Status
Active, not recruiting
 
Locations

Hospital Miguel Servet

Zaragoza, Spain, 50009

Status
Active, not recruiting
 
Locations

Hospital General Universitario de Valencia

Valencia, Spain, 46014

Status
Active, not recruiting
 
Locations

Instituto Oftalmológico Francisco Gomez Ulla

Santiago de Compostela, Spain, 15706

Status
Active, not recruiting
 
Locations

Hospital Universitari i Politècnic La Fe

Valencia, Spain, 46026

Status
Active, not recruiting
 
Locations

Meir Medical Center

Kfar Saba, Israel, 4428164

Status
Completed
 
Locations

Chaim Sheba Medical Center

Ramat Gan, Israel, 5262000

Status
Active, not recruiting
 
Locations

Assuta Medical Centers - HaShalom

Tel Aviv, Israel, 6789140

Status
Active, not recruiting
 
Locations

Lady Davis Carmel Medical Center

Haifa, Israel, 3436212

Status
Active, not recruiting
 
Locations

Rambam Health Corporation

Haifa, Israel, 3109601

Status
Active, not recruiting
 
Locations

Kaplan Medical Center

Rehovot, Israel, 7610001

Status
Completed
 
Locations

Hadassah Hebrew University Hospital Ein Kerem

Jerusalem, Israel, 9112001

Status
Active, not recruiting
 
Locations

RétinElysée

Lausanne, Switzerland, 1006

Status
Active, not recruiting
 
Locations

Berner Augenklinik am Lindenhofspital

Bern, Switzerland

Status
Active, not recruiting
 
Locations

Inje University Haeundae Paik Hospital

Busan, South Korea, 612-862

Status
Completed
 
Locations

Retina Center Nune Eye Hospital

Seoul, South Korea, 135-280

Status
Active, not recruiting
 
Locations

SEHAT Pentagram

Sofia, Bulgaria, 1309

Status
Active, not recruiting
 
Locations

Sveta Petka Eye Hospital

Varna, Bulgaria, 9002

Status
Active, not recruiting
 
Locations

Multiprofile Hospital for Active Treatment Sveta Sofia

Sofia, Bulgaria, 1618

Status
Active, not recruiting
 
Locations

UMHAT Alexandrovska EAD

Sofia, Bulgaria, 1431

Status
Active, not recruiting
 
Locations

Spec. Hospital For Active Treatment of Eye Diseases Zora

Sofia, Bulgaria, 1784

Status
Active, not recruiting
 
Locations

Spec. Hosp. for Active Treatment for Eye Diseases Zrenie

Sofia, Bulgaria, 1408

Status
Active, not recruiting
 
Locations

St.Joseph's Health Care-London

London, Canada, N6A 4V2

Status
Active, not recruiting
 
Locations

Toronto Retina Institute

Toronto, Canada, M3C 0G9

Status
Active, not recruiting
 
Locations

Institut de l'Oeil des Laurentides

Boisbriand, Canada, J7H 1S6

Status
Completed
 
Locations

Scientific Research Institution of Ophthalmic Diseases

Moscow, Russia, 119021

Status
Active, not recruiting
 
Locations

FBSI IRTC Eye Microsurgery n.a. acad. S.N. Fyodorov

Moscow, Russia, 127486

Status
Active, not recruiting
 
Locations

Southern Tohoku Eye Clinic

Koriyama, Japan, 963-8052

Status
Active, not recruiting
 
Locations

Clinical hospital center Zvezdara

Belgrade, Serbia, 11000

Status
Completed
 
Locations

Clinical Center of Serbia

Belgrade, Serbia, 11000

Status
Active, not recruiting
 
Locations

Klinicki centar Vojvodine

Novi Sad, Serbia, 21000

Status
Completed
 
Locations

St.Luke's International Hospital

Chuoku, Japan, 104-8560

Status
Active, not recruiting
 
Locations

LTD "Innova"

Tbilisi, Georgia, 105

Status
Active, not recruiting
 
Locations

LTD "Chichua Medical Center MZERA"

Tbilisi, Georgia, 114

Status
Active, not recruiting
 
Locations

JSC "Evex Hospitals'

Tbilisi, Georgia, 0186

Status
Active, not recruiting
 
Locations

LTD "Clinic LJ"

Kutaisi, Georgia, 4600

Status
Active, not recruiting
 
Locations

Tokyo Women's Medical University Hospital

Shinjuku-ku, Japan, 162-8666

Status
Active, not recruiting
 
Locations

Yamagata University Hospital

Yamagata, Japan, 990-9585

Status
Terminated
 
Locations

Sapporo City General Hospital

Sapporo, Japan, 060-8604

Status
Terminated
 
Locations

Nishikasai Inouye Eye Hospital

Edogawa-ku, Japan, 134-0088

Status
Active, not recruiting
 
Locations

Shanghai General Hospital

Shanghai, China, 200080

Status
Active, not recruiting
 
Locations

TianJin eye hospital

Tianjin, China

Status
Active, not recruiting
 
Locations

The Affiliated Eye Hospital of Wenzhou Medical College

Wenzhou, China

Status
Active, not recruiting
 
Locations

Peking University People's Hospital

Beijing, China, 100044

Status
Active, not recruiting
 
Locations

Tianjin Medical University Eye Hospital

Tianjin, China, 300384

Status
Completed
 
Locations

Retina Consultants of Southern Colorado, PC

Colorado Springs, United States, 80909

Status
Active, not recruiting
 
Locations

Wolfe Eye Clinic, PC

West Des Moines, United States, 50266

Status
Active, not recruiting
 
Locations

OFTALMOS, Instituto Oftalmologico de Alta Complejidad

Buenos Aires, Argentina, C1120AAN

Status
Active, not recruiting
 
Locations

Tokyo Medical University Hachioji Medical Center

Hachioji, Japan, 193-0998

Status
Active, not recruiting
 
Locations

KKR Sapporo Medical Center

Sapporo, Japan, 062-0931

Status
Completed
 
Locations

Espaco Medico de Coimbra

Coimbra, Portugal, 3000-548

Status
Active, not recruiting
 
Locations

St. Marianna University School of Medicine Hospital

Kawasaki, Japan, 216-8511

Status
Active, not recruiting
 
Locations

Guangzhou Aier Eye Hospital

Guangzhou, China,  634050

Status
Active, not recruiting
 
Locations

Centre d'Ophtalmologie - Paradis-Monticelli

MARSEILLE, France, 13008

Status
Active, not recruiting
 
Locations

Centre ophtalmologique Saint-Exupéry

Saint-Cyr-Sur-Loire, France, 37540

Status
Active, not recruiting
 
Locations

Private enterprise private production company " Acinus"

Kropyvnytskyi, Ukraine, 25006

Status
Active, not recruiting
 
Locations

Union Hospt Tongji Medical Colleg. Huazhong univ. Scien&Tech

Wuhan, China, 430022

Status
Active, not recruiting
 
Locations

Henan Provincial Ophthalmology Hospital (Henan Eye Institute

Zhengzhou, China, 450003

Status
Active, not recruiting
 
Locations

The First Affiliated Hospital of Xinjiang Medical University

Urumqi, China, 830054

Status
Completed
 
Locations

Beijing Hospital

Beijing, China, 100730

Status
Active, not recruiting
 
Locations

Eye Center of the second Bethune Hospital, jinlin University

Changchun, China, 130022

Status
Active, not recruiting
 
Locations

Tianjin Medical University General Hospital

Tianjin, China, 300052

Status
Active, not recruiting
 
Locations

Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech.

Wuhan, China, 430030

Status
Active, not recruiting
 
Locations

The People's Hospital of Ningxia Hui Autonomous Region

Yinchuan, China, 750000

Status
Active, not recruiting
 
Locations

Beijing Aier Intech Eye Hospital Co. LTD - Ophthalmology

Beijing, China, 100021

Status
Active, not recruiting
 
Locations

Aier Eye Hospital (Chengdu)

Chengdu, China

Status
Active, not recruiting
 
Locations

SHENYANG HE EYE HOSPITAL

Shenyang, China, 110034

Status
Active, not recruiting
 
Locations

ZheJiang Provincial People's Hospital

Hangzhou, China, 310014

Status
Active, not recruiting
 
Locations

The 1st Affiliated Hospital of Zhejiang University

Hangzhou, China, 310003

Status
Active, not recruiting
 
Locations

The 1st Affiliated Hospital Fujian Medical University

Fuzhou, China

Status
Completed
 
Locations

Chongqing Aier Ophthalmology Hospital

Chongqing, China, 400000

Status
Active, not recruiting
 
Locations

Beijing Tongren Hospital, Capital Medical University (East)

Beijing, China, 100005

Status
Active, not recruiting
 
Locations

The Second Hospital of Anhui medical university

Hefei, China, 230601

Status
Active, not recruiting
 
Locations

The First People's Hospital of Xuzhou

Xuzhou, China, 221002

Status
Active, not recruiting
 
Locations

Hebei Eye Hospital

Xingtai, China

Status
Active, not recruiting
 
Locations

Jiangxi Provincial People’s Hospital

Nanchang, China, 330006

Status
Active, not recruiting
 
Locations

The First Affiliated Hospital of NanChang University

Nanchang, China, 330006

Status
Active, not recruiting
 
Locations

The First Affiliated Hospital of Xi'an Jiaotong University

Xi'an, China, 710061

Status
Active, not recruiting
 
Locations

Shanghai Tongji Hospital of Tongji University

Shanghai, China, 200065

Status
Active, not recruiting
 
Locations

Tonghua Central Hospital

Tonghua, China

Status
Active, not recruiting
 
Locations

Shijiazhuang General Hospital

Shijiazhuang, China, 050000

Status
Active, not recruiting
 
Locations

Hôpital Lariboisière - Paris

PARIS, France, 75475

Status
Completed
 
Locations

Budapest Retina Associates

Budapest, Hungary, 1133

Status
Completed
 
Locations

Rand Eye Institute

Deerfield Beach, United States, 33064

Status
Active, not recruiting
 

Trial Design