do_not_disturb_altRecruitment Complete
Neovascular Age-Related Macular Degeneration
Bayer Identifier:
20968
ClinicalTrials.gov Identifier:
EudraCT Number:
EU CT Number:
Not Available
Study of the effects of high dose aflibercept injected into the eye of patients with an age-related disorder that causes loss of vision due to growth of abnormal blood vessels at the back of the eye
Trial purpose
In this study researchers want to learn more about changes in visual acuity (clarity of vision) with a high dose treatment with Aflibercept (Eylea) in patients suffering from neovascular age-related macular degeneration (nAMD). Neovascular AMD is an eye disease that causes blurred vision or a blind spot due to abnormal blood vessels that leak fluid or blood into the light sensitive lining inside the eye (retina). The fluid buildup causes the central part of the retina (macula) responsible for sharp, straight-ahead vision to swell and thicken (edema), which distorts vision.
Key Participants Requirements
Sex
AllAge
50 - N/ATrial summary
Enrollment Goal
1011Trial Dates
August 2020 - August 2024Phase
Phase 3Could I Receive a placebo
NoProducts
Aflibercept (VEGF Trap-Eye, BAY86-5321)Accepts Healthy Volunteer
NoWhere to participate
Status | Institution | Location |
---|---|---|
Completed | Kobe University Hospital | Kobe, 650-0017, Japan |
Completed | Hyogo Prefectural Amagasaki General Medical Center | Amagasaki, 660-8550, Japan |
Completed | Nagoya City University Hospital | Nagoya, 467-8602, Japan |
Completed | University of the Ryukyus Hospital | Nakagami, 903-0215, Japan |
Withdrawn | Universitätsklinikum Aachen | Aachen, 52074, Germany |
Withdrawn | Universitätsmedizin der Georg-August-Universität Göttingen | Göttingen, 37075, Germany |
Withdrawn | Klinikum Darmstadt | Darmstadt, 64297, Germany |
Withdrawn | Medizinische Hochschule Hannover (MHH) | Hannover, 30625, Germany |
Withdrawn | Universitätsklinikum Leipzig AöR | Leipzig, 4289, Germany |
Withdrawn | Augenzentrum am St. Franziskus-Hospital | Münster, 48145, Germany |
Withdrawn | Medizinische Einrichtungen der Universität Bonn | Bonn, 53105, Germany |
Withdrawn | Hopital Avicenne - Bobigny | BOBIGNY, 93009, France |
Completed | AXON Clinical s.r.o. | Praha 5, 150 00, Czech Republic |
Completed | Fakultni nemocnice Ostrava | Ostrava, 708 52, Czech Republic |
Completed | Fakultni Nemocnice Hradec Kralove | Hradec Kralove, 500 05, Czech Republic |
Completed | Charles University in Prague | Prague, 110 00, Czech Republic |
Completed | Sydney Retina Clinic | Sydney, 2000, Australia |
Completed | Marsden Eye Surgery Center | Parramatta, 2150, Australia |
Completed | Westmead Hospital | Westmead, 2145, Australia |
Completed | Eyeclinic Albury Wodonga | Albury, 2640, Australia |
Completed | Hobart Eye Surgeons | Hobart, 7000, Australia |
Withdrawn | Hong Kong Eye Hospital | Hong Kong, Hong Kong |
Withdrawn | Queen Mary Hospital | Hong Kong, Hong Kong |
Completed | Klinikum Klagenfurt am Wörthersee | Klagenfurt, 9020, Austria |
Completed | Pusan National University Hospital | Busan, 49241, Korea,_republic_of |
Completed | Asan Medical Center | Seoul, 138-736, Korea,_republic_of |
Completed | Samsung Medical Center | Seoul, 6351, Korea,_republic_of |
Completed | Seoul National University Hospital (b) | Seoul, 03080, Korea,_republic_of |
Completed | Seoul National University Bundang Hospital | Seongnam-si, 13620, Korea,_republic_of |
Completed | Samsung Medical Center | Seoul, 6351, Korea,_republic_of |
Withdrawn | Moorfields Eye Hospital | London, EC1V2PD, United Kingdom |
Withdrawn | Frimley Park Hospital NHS | Frimley, GU167UJ, United Kingdom |
Withdrawn | Bristol Eye Hospital | Bristol, BS12LX, United Kingdom |
Withdrawn | Sunderland Eye Infirmary | Sunderland, SR29HP, United Kingdom |
Completed | New England Retina Associates | New London, 06320, United States |
Completed | Ophthalmic Consultants of Boston (OCB) - Boston | Boston, 02114-2539, United States |
Completed | Palmetto Retina Center (PRC)- West Columbia Retina Center | West Columbia, 29169-2429, United States |
Withdrawn | Gulf Coast Institute / Valley Retina Institute | McAllen, 78503, United States |
Completed | Medical Center Ophthalmology Associates | San Antonio, 78240, United States |
Completed | Hayashi Eye Hospital | Fukuoka, 812-0011, Japan |
Withdrawn | Shiga University of Medical Science Hospital | Otsu, 520-2192, Japan |
Completed | Daiyukai Daiichi Hospital | Ichinomiya, 491-8551, Japan |
Withdrawn | Aomori Prefectural Central Hospital | Aomori, 030-8553, Japan |
Withdrawn | Sugita Eye Hospital | Nagoya, 460-0008, Japan |
Completed | National Hospital Organization Tokyo Medical Center | Meguro-ku, 152-8902, Japan |
Completed | Fakultna nemocnica Trencin | Trencin, 911 71, Slovakia |
Completed | Stadtspital Triemli | Zürich, 8063, Switzerland |
Active, not recruiting | Chang Gung Memorial Hospital at Linkou | Taoyuan, 33305, Taiwan |
Active, not recruiting | Shin Kong Wu Ho-Su Memorial Hospital | Taipei, 111, Taiwan |
Withdrawn | Veterans General Hospital | Kaohsiung City, 813414, Taiwan |
Active, not recruiting | National University Hospital | Singapore, 119074, Singapore |
Completed | Organizacion Medica de Investigacion (OMI) | Buenos Aires, C1015ABO, Argentina |
Withdrawn | Fundación Zambrano | Buenos Aires, C1023AAQ, Argentina |
Active, not recruiting | Konventhospital Barmherzige Brüder Linz | Linz, 4021, Austria |
Completed | Hanusch-Krankenhaus Wien | Wien, 1140, Austria |
Completed | Mie University Hospital | Tsu, 514-8507, Japan |
Completed | Akita University Hospital | Akita, 010-8543, Japan |
Completed | Nagoya University Hospital | Nagoya, 466-8560, Japan |
Completed | Kansai Medical University Hospital | Hirakata, 573-1191, Japan |
Completed | Hiroshima University Hospital | Hiroshima, 734-8551, Japan |
Withdrawn | Hacettepe Universitesi Tip Fakultesi | Ankara, 6100, Turkey |
Withdrawn | Oogziekenhuis | ROTTERDAM, 3011 BH, Netherlands |
Withdrawn | Region Nordjylland | Aalborg University Hospital - Cardiology Department | Aalborg, 9000, Denmark |
Withdrawn | Copenhagen University Hospital Roskilde | Roskilde, 4000, Denmark |
Withdrawn | Hospital de Vila Franca de Xira | Centro de Desenvolvimento e Investigacao | Vila Franca de Xira, 2600-178, Portugal |
Completed | AIBILI | Coimbra, 3000-548, Portugal |
Active, not recruiting | Oita University Hospital | Yufu, 879-5593, Japan |
Withdrawn | National Taiwan University Hospital | Taipei, 100, Taiwan |
Active, not recruiting | Taipei Veterans General Hospital | Taipei, 11217, Taiwan |
Completed | Fukushima Medical University Hospital | Fukushima, 960-1295, Japan |
Completed | Okayama University Hospital | Okayama-city, 700-8558, Japan |
Completed | Kurume University Hospital | Kurume, 830-0011, Japan |
Completed | Yamaguchi University Hospital | Ube, 755-8505, Japan |
Completed | Kanazawa University Hospital | Kanazawa, 920-8641, Japan |
Completed | Fakultni nemocnice Kralovske Vinohrady | Praha 10, 10034, Czech Republic |
Withdrawn | Changhua Christian Hospital | Changhua, 50006, Taiwan |
Withdrawn | Juntendo University Urayasu Hospital | Urayasu, 279-0021, Japan |
Withdrawn | Kochi Medical School Hospital | Nankoku, 783-8505, Japan |
Completed | Hospital of LT University of Health Sciences Kaunas Clinics | Kaunas, LT-50161, Lithuania |
Completed | Vilnius University Hospital Santaros Klinikos | Vilnius, LT-08661, Lithuania |
Completed | PI Klaipedos University Hospital | Klaipeda, LT-92288, Lithuania |
Withdrawn | Dr. Kai Noor Silmakabinet OU | Tallinn, 11412, Estonia |
Completed | East Tallinn Central Hospital | Tallinn, 10138, Estonia |
Completed | Latvian American Eye Center | Riga, LV-1009, Latvia |
Completed | Department of Ophthalmology | Riga, 1002, Latvia |
Withdrawn | Universitätsklinik Gießen und Marburg GmbH | Marburg, 35043, Germany |
Withdrawn | Sankt Gertrauden Krankenhaus | Berlin, 10713, Germany |
Withdrawn | Universitätsklinikum Freiburg | Freiburg, 79106, Germany |
Withdrawn | Universitätsklinikum Köln | Köln, 50937, Germany |
Withdrawn | Charité Campus Benjamin Franklin (CBF) | Berlin, 12203, Germany |
Withdrawn | Universitätsklinikum Schleswig-Holstein (UKSH) | Kiel, 24105, Germany |
Withdrawn | Universitätsklinikum Regensburg | Regensburg, 93042, Germany |
Completed | Long Island Vitreoretinal Consultants | Great Neck, 11021, United States |
Active, not recruiting | Ophthalmic Consultants of Long Island | Lynbrook, 11563, United States |
Completed | Long Island Vitreoretinal Consultants - Hauppauge | Hauppauge, 11788, United States |
Completed | NJ Retina - Edison Office | Edison, 08820, United States |
Completed | Texas Retina Associates | Fort Worth, 76104, United States |
Completed | Retina Northwest, PC - Opthalmology | Portland, 97210, United States |
Completed | Retina Care Center | Baltimore, 21209, United States |
Completed | Retina Consultants of Nevada | Las Vegas, 89144, United States |
Completed | Retina Center of New Jersey | Bloomfield, 07003, United States |
Completed | Retina Vitreous Associates of Florida - Saint Petersburg | Saint Petersburg, 33711-1141, United States |
Completed | West Virginia University | Morgantown, 26505, United States |
Completed | Spokane Eye Clinical Research | Spokane, 99204, United States |
Completed | Arizona Retina and Vitreous Consultants - North Phoenix | Phoenix, 85021-8865, United States |
Completed | Florida Retina Institute- Jacksonville Oak | Jacksonville, 32204-4505, United States |
Completed | California Eye Specialists Medical Group, Inc. | Pasadena, 91107, United States |
Completed | Retinal Consultants of Texas - San Antonio | San Antonio, 78240, United States |
Completed | Mid Atlantic Retina | Bethlehem, 18017, United States |
Completed | Retina Consultants of Texas - The Woodlands | The Woodlands, 77384, United States |
Completed | Charles Retina Institute | Memphis, 38119, United States |
Completed | Retina Consultants of Texas (Retina Consultants of Houston) - Texas Medical Center | The Woodlands, 77384, United States |
Completed | Vitreo Retinal Surgery PA - Edina | Edina, 55435, United States |
Completed | Retina Consultants San Diego | Poway, 92064, United States |
Completed | University Retina and Macula Associates | Oak Forest, 60452, United States |
Completed | Florida Retina Institute | Orlando, 32806, United States |
Completed | Southern Vitreoretinal Associates, P.L. - Tallahassee | Tallahassee, 32308, United States |
Completed | Vitreo Retinal Associates PA - The Millennium Center Location | Gainesville, 32607-2557, United States |
Active, not recruiting | Retina Group of Florida - Fort Lauderdale | Fort Lauderdale, 33308, United States |
Completed | Vanderbilt University Medical School | Nashville, 37212-1610, United States |
Completed | Eye Associates of New Mexico | Albuquerque, 87109-5853, United States |
Completed | Black Hills Regional Eye Institute | Rapid City, 57701-7374, United States |
Completed | Eye Care Specialists | Kingston, 18704, United States |
Completed | Northern California Retina-Vitreous Associates | Mountain View, 94040, United States |
Completed | Charleston Neuroscience Institute - Charleston | Charleston, 29414, United States |
Withdrawn | UCLA - Jules Stein Eye Institute | Los Angeles, 90095, United States |
Withdrawn | Mayo Clinic - Rochester | Rochester, 55905, United States |
Completed | Retina Macula Specialists Of Miami | Miami, 33126, United States |
Withdrawn | University of Virginia Health System | Charlottesville, 22903, United States |
Completed | Midwest Retina - Main Office | Dublin, 43016, United States |
Withdrawn | Retina Institute of Virginia | Richmond, 23235, United States |
Withdrawn | Illinois Retina Associates, S.C. | Skokie, 60076, United States |
Completed | Retina Consultants of Hawaii | Aiea, 96701, United States |
Completed | The University of Vermont Medical Center (Fletcher Allen Health Care) - Main Campus | Burlington, 05401-1473, United States |
Completed | Retina Associates IL | Elmhurst, 60126, United States |
Completed | Florida Eye Associates | Melbourne, 32901, United States |
Withdrawn | Palmetto Retina Center, LLC - Florence | Florence, 29501, United States |
Active, not recruiting | Erie Retinal Surgery, Inc. | Erie, 16507, United States |
Completed | Austin Retina Associates | Austin, 78705, United States |
Completed | Retina Consultants of Southern California | Redlands, 92374, United States |
Completed | University of Wisconsin - Madison | Madison, 53792, United States |
Active, not recruiting | Wake Forest Baptist Health | Winston-Salem, 27103, United States |
Completed | University of California San Diego (UCSD) | La Jolla, 92093, United States |
Completed | Retina Specialists | Pensacola, 32503, United States |
Completed | Retina Consultants of Orange County | Fullerton, 92835, United States |
Active, not recruiting | Ophthalmic Consultants of the Capital Region | Troy, 12180, United States |
Completed | Retina Consultants, LLC | Salem, 97302-2152, United States |
Completed | Kaiser Permanente Riverside Medical Center | Riverside, 92505, United States |
Completed | Kozawa Eye Hospital and Diabetes Center | Mito, 310-0845, Japan |
Withdrawn | Tohoku Medical and Pharmaceutical University Hospital | Center for Clinical Research Promotion and Development | Sendai-city, 983-8512, Japan |
Completed | The University of Tokyo Hospital | Bunkyo-ku, 113-8655, Japan |
Completed | Kansai Medical University Medical Center | Moriguchi, 570-8507, Japan |
Completed | Kindai University Hospital | Osakasayama-shi, 589-8511, Japan |
Completed | Aichi Medical University Hospital | Nagakute, 480-1195, Japan |
Withdrawn | Oogartsenpraktijk Alken | Alken, 3570, Belgium |
Completed | Lexum a.s., Evropska ocni klinika | Praha 4, 140 00, Czech Republic |
Completed | Fakultni nemocnice Plzen - Lochotin | Plzen-Lochotin, 323 00, Czech Republic |
Completed | Szent-Gyorgyi Albert Orvostudomanyi Egyetem | Szeged, 6720, Hungary |
Withdrawn | Clínica Oftalmológica San Diego | Medellín, Colombia |
Withdrawn | Clínica Imbanaco S.A.S | Cali, 760042, Colombia |
Completed | Tartu University Hospital | Tartu, 50406, Estonia |
Completed | Riga East Clinical University Hospital "Gailezers" | Riga, LV-1038, Latvia |
Withdrawn | Signes Ozolinas Doctor Praxis in Ophthalmology | Jelgava, LV-3001, Latvia |
Completed | Shinshu University Hospital | Matsumoto, 390-8621, Japan |
Active, not recruiting | Japanese Red Cross Saitama Hospital | Saitama, 330-8553, Japan |
Completed | Kokura Memorial Hospital | Kitakyushu, 802-8555, Japan |
Completed | Japanese Red Cross Nagasaki Genbaku Hospital | Nagasaki, 852-8511, Japan |
Completed | Japanese Red Cross Wakayama Medical center | Wakayama, 640-9558, Japan |
Withdrawn | Hospital of St. Cross | Rugby, CV22 5PX, United Kingdom |
Withdrawn | Ideta Heisei Retina Consultants | Kumamoto, 862-0968, Japan |
Completed | Singapore National Eye Centre | Singapore, 168751, Singapore |
Withdrawn | Tan Tock Seng Hospital | Singapore, 308433, Singapore |
Completed | University of Miyazaki Hospital | Miyazaki, 889-1692, Japan |
Completed | Keio University Hospital | Shinjuku-ku, 160-8582, Japan |
Withdrawn | Sumitomo Hospital | Osaka, 530-0005, Japan |
Withdrawn | Ophthalmology Clinic of Professor Sergienko | Vinnitsya, Ukraine |
Withdrawn | Kharkiv Ophthalmological Clinic #14 named by Hirshman | Kharkiv, 61000, Ukraine |
Completed | Poltava Regional Clinical Hospital n.a. M.V. Skliphosovskyi | Poltava, 36011, Ukraine |
Completed | Centralna Polyclinica MVS Ukraiiny | Kyiv, 1024, Ukraine |
Withdrawn | Health Technology Ltd. - Ophthalmic Medical Center | Odesa, 65048, Ukraine |
Withdrawn | A.S.U. Giuliano Isontina | Trieste, 34129, Italy |
Withdrawn | A.O.U. di Bologna Policlinico S.Orsola Malpighi | Bologna, 40138, Italy |
Completed | Ospedale San Raffaele s.r.l. - Oculistica | Milano, 20132, Italy |
Withdrawn | ASL2 Lanciano-Vasto-Chieti | Chieti, 66013, Italy |
Completed | Fondazione PTV Policlinico Tor Vergata | Roma, 00133, Italy |
Completed | IRCCS Fondazione G.B. Bietti Studio e Ricerca in Otalmologia | Roma, 198, Italy |
Completed | A.O. di Perugia | Perugia, 6129, Italy |
Withdrawn | A.O.U. Policlinico G.Rodolico-San Marco | Catania, 95123, Italy |
Active, not recruiting | A.O.U. di Cagliari | Cagliari, 9042, Italy |
Withdrawn | A.O.U. di Padova | Padova, 35128, Italy |
Withdrawn | Fakultni Nemocnice Brno | Brno, 625 00, Czech Republic |
Completed | ALM Oftalmolaser - Oftalmologia Medica e Cirurgica | Lisbon, 1050-078, Portugal |
Completed | Centro Hospitalar Universitario do Porto | Porto, 4099-001, Portugal |
Completed | Centro Hospitalar Vila Nova de Gaia e Espinho | Unit 1 - Clinical Research Center | Porto, 4434-502, Portugal |
Withdrawn | Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center | Leiria, 2410-197, Portugal |
Withdrawn | ULSAM - Hospital Santa Luzia | Viana do Castelo, 4901-858, Portugal |
Withdrawn | CHLC - Hospital dos Capuchos - Servico de Oftalmologia | Lisboa, 1169-050, Portugal |
Completed | Fakultna nemocnica s poliklinikou Zilina | Zilina, 012 07, Slovakia |
Completed | Fakultna nemocnica Nitra | Nitra, 950 01, Slovakia |
Completed | Nemocnica s Poliklinikou Trebisov, Svet zdravia a.s. | Trebisov, 075 01, Slovakia |
Completed | University of Yamanashi Hospital | Chuo, 409-3898, Japan |
Withdrawn | Dokkyo Medical University Saitama Medical Center | Koshigaya, 343-8555, Japan |
Active, not recruiting | Kanazawa Medical University Hospital | Kahoku-gun, 920-0293, Japan |
Completed | Otakeganka Tsukimino Clinic | Yamato, 242-0001, Japan |
Withdrawn | Osaka Metropolitan University Hospital | Osaka, 545-8586, Japan |
Completed | Kagawa University Hospital | Kita-gun, 761-0793, Japan |
Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Roma, 00168, Italy |
Completed | ASST Fatebenefratelli Sacco | Milano, 20122, Italy |
Completed | Nara Medical University Hospital | Kashihara, 634-8522, Japan |
Completed | Tokushima University Hospital | Tokushima, 770-8503, Japan |
Completed | Gunma University Hospital | Maebashi, 371-8511, Japan |
Withdrawn | Chofu Eye Clinic | Chofu, 182-0024, Japan |
Completed | Medical corporation Eiwakai Dannoue Ophthalmology clinic | Kawasaki, 211-0053, Japan |
Withdrawn | Dokkyo Medical University Hospital | Shimotsuga-gun, 321-0293, Japan |
Withdrawn | Yamanashi Prefectural Central Hospital | Kofu, 400-8506, Japan |
Completed | Tokiwadai Muranaka Eye Clinic | Itabashi-ku, 174-0071, Japan |
Completed | Kurashiki Medical Center | Kurashiki, 710-8522, Japan |
Withdrawn | Fundacion Ver Centro privado de Ojos Romagosa SA | Córdoba, 5000, Argentina |
Withdrawn | Grupo Laser Vision | Rosario, S2000ANJ, Argentina |
Withdrawn | Centro Oftalmologico Miramar (COMir) | Miramar, B7607AKL, Argentina |
Withdrawn | Clínia Panamericana - Centro de Ojos Dr. Nano | Olivos, B1636CSS, Argentina |
Completed | Medizinische Universität Graz | Graz, 8036, Austria |
Withdrawn | Universitätsklinikum AKH Wien | Wien, 1090, Austria |
Active, not recruiting | Kepler Universitätsklinikum Campus III | Linz, 4020, Austria |
Completed | Hospital de la Santa Creu i Sant Pau | Gynecology Department | Barcelona, 8041, Spain |
Withdrawn | Hospital del Rio Hortega | Valladolid, 47012, Spain |
Completed | Hospital Clínic i Provincial de Barcelona | Barcelona, 8036, Spain |
Completed | Hospital Reina Sofía | Córdoba, 14004, Spain |
Withdrawn | Vissum Corporacion Alicante | Alicante, 03016, Spain |
Completed | Hospital Miguel Servet | Zaragoza, 50009, Spain |
Completed | Hospital General Universitario de Valencia | Valencia, 46014, Spain |
Withdrawn | Hospital de l'Esperança | Barcelona, 8024, Spain |
Completed | Instituto Oftalmológico Francisco Gomez Ulla | Santiago de Compostela, 15706, Spain |
Completed | La Fe University and Polytechnic Hospital | Nephrology Department | Valencia, 46026, Spain |
Active, not recruiting | Meir Medical Center | Kfar Saba, 4428164, Israel |
Completed | Chaim Sheba Medical Center | Ramat Gan, 5262000, Israel |
Completed | Assuta Medical Centers - HaShalom | Tel Aviv, 6789140, Israel |
Withdrawn | Shamir Medical Center (Assaf Harofeh) | Zerifin, 7030000, Israel |
Withdrawn | Barzilai Medical Center | Ashkelon, 7830604, Israel |
Completed | Lady Davis Carmel Medical Center | Haifa, 3436212, Israel |
Withdrawn | Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department | Petach Tikva, 4941492, Israel |
Completed | Rambam Health Corporation | Haifa, 3109601, Israel |
Active, not recruiting | Kaplan Medical Center | Rehovot, 7610001, Israel |
Withdrawn | Tel-Aviv Sourasky Medical Center | Tel Aviv, 6423906, Israel |
Withdrawn | HaEmek Medical Center | Internal Medicine C Department - Research Unit | Afula, 1834111, Israel |
Withdrawn | Clalit Health | Soroka Medical Center - Internal Medicine Department | Beer Sheva, 8410101, Israel |
Withdrawn | Bnai Zion Medical Center | Cardiology Department | Haifa, 3339419, Israel |
Withdrawn | Shaare Zedek Medical Center | Jerusalem, 9103102, Israel |
Completed | Hadassah Hebrew University Hospital Ein Kerem | Jerusalem, 9112001, Israel |
Completed | RétinElysée | Lausanne, 1006, Switzerland |
Completed | Berner Augenklinik am Lindenhofspital | Bern, TBC, Switzerland |
Withdrawn | Universitätsspital Basel | Basel, 4056, Switzerland |
Withdrawn | Stadtspital Triemli | Zürich, 8063, Switzerland |
Withdrawn | Centre Ophtalmologique de Rive | Genève, 1204, Switzerland |
Active, not recruiting | Inje University Haeundae Paik Hospital | Busan, 612-862, Korea,_republic_of |
Completed | Nune Eye Hospital - Retina Center Ophthalmology | Seoul, 135-280, Korea,_republic_of |
Completed | SEHAT Pentagram | Sofia, 1309, Bulgaria |
Completed | Sveta Petka Eye Hospital | Varna, 9000, Bulgaria |
Completed | Multiprofile Hospital for Active Treatment Sveta Sofia | Internal Diseases Department | Sofia, 1618, Bulgaria |
Completed | UMHAT Alexandrovska EAD | Sofia, 1431, Bulgaria |
Completed | Specialized Hospital For Active Treatment of Eye Diseases Zora | Sofia, 1784, Bulgaria |
Completed | Spec. Hosp. for Active Treatment for Eye Diseases Zrenie | Sofia, 1408, Bulgaria |
Withdrawn | University Eye Hospital - Akad. Pashev | Sofia, 1517, Bulgaria |
Completed | St.Joseph's Health Care-London | London, N6A 4V2, Canada |
Completed | Toronto Retina Institute | Toronto, M3C 0G9, Canada |
Active, not recruiting | Institut de l'Oeil des Laurentides | Boisbriand, J7H1S6, Canada |
Withdrawn | Misericordia Health Centre | Winnipeg, R3C 1A2, Canada |
Completed | Scientific Research Institution of Ophthalmic Diseases | Moscow, 119021, Russia |
Completed | FBSI IRTC Eye Microsurgery n.a. acad. S.N. Fyodorov | Moscow, 127486, Russia |
Withdrawn | St. Petersburg Medical University n.a. I.P. Pavlov | St. Petersburg, 197022, Russian Federation |
Withdrawn | Regional Ophthalmological Hospital n. a. T.I. Eroshevsky | Samara, 443079, Russia |
Withdrawn | Irkutsk Branch of FBSI IRTC "Eye Microsurgery" | Irkutsk, 664033, Russia |
Completed | Southern Tohoku Eye Clinic | Koriyama, 963-8052, Japan |
Withdrawn | Clinical Center Nis | Nis, 18000, Serbia |
Active, not recruiting | Clinical hospital center Zvezdara | Belgrade, 11000, Serbia |
Completed | Clinical Center of Serbia | Belgrade, 11000, Serbia |
Active, not recruiting | Klinicki centar Vojvodine | Novi Sad, 21000, Serbia |
Completed | St.Luke's International Hospital | Chuoku, 104-8560, Japan |
Completed | LTD "Innova" | Tbilisi, 105, Georgia |
Completed | LTD "Chichua Medical Center MZERA" | Tbilisi, 114, Georgia |
Withdrawn | Aversi Clinic | Tbilisi, Georgia |
Completed | JSC "Evex Hospitals' | Tbilisi, 0186, Georgia |
Withdrawn | LTD Israeli-Georgian Medical Research Clinic “Helsicore” | Tbilisi, 112, Georgia |
Completed | LTD "Clinic LJ" - Opthalmology | Kutaisi, 4600, Georgia |
Completed | Tokyo Women's Medical University Hospital | Shinjuku-ku, 162-8666, Japan |
Active, not recruiting | Yamagata University Hospital | Yamagata, 990-9585, Japan |
Withdrawn | Kurashiki Medical Clinic | Kurashiki, 710-0824, Japan |
Active, not recruiting | Sapporo City General Hospital | Sapporo, 060-8604, Japan |
Completed | Nishikasai Inouye Eye Hospital | Edogawa-ku, 134-0088, Japan |
Withdrawn | John Radcliffe Hospital | Oxford, OX3 9DU, United Kingdom |
Withdrawn | Western Eye Hospital | London, NW1 5QH, United Kingdom |
Withdrawn | Royal Victoria Hospital | Belfast, BT12 6BA, United Kingdom |
Completed | Shanghai General Hospital | Shanghai, 200080, China |
Completed | Tianjin Eye Hospital | Tianjin, 300384, China |
Completed | The Affiliated Eye Hospital of Wenzhou Medical College | Wenzhou, China |
Withdrawn | Peking Union Medical College Hospital CAMS | Beijing, 100730, China |
Completed | Peking University People's Hospital | Beijing, 100032, China |
Active, not recruiting | Tianjin Medical University Eye Hospital | Tianjin, 300384, China |
Completed | Retina Consultants of Southern Colorado, PC | Colorado Springs, 80909, United States |
Completed | Wolfe Eye Clinic - Des Moines | West Des Moines, 50266-7705, United States |
Withdrawn | Retina Associates, P.A. - Shawnee Mission | Overland Park, 66204-2235, United States |
Withdrawn | Oftalmólogos especialistas | Rosario, S2000ANJ, Argentina |
Completed | OFTALMOS, Instituto Oftalmologico de Alta Complejidad | Buenos Aires, C1120AAN, Argentina |
Completed | Tokyo Medical University Hachioji Medical Center | Hachioji, 193-0998, Japan |
Completed | KKR Sapporo Medical Center | Sapporo, 062-0931, Japan |
Completed | Espaco Medico de Coimbra | Coimbra, 3000-548, Portugal |
Completed | St. Marianna University Hospital | Kawasaki, 216-8511, Japan |
Completed | Guangzhou Aier Eye Hospital | Guangzhou, 634050, China |
Completed | Centre d'Ophtalmologie - Paradis-Monticelli | MARSEILLE, 13008, France |
Completed | Centre ophtalmologique Saint-Exupéry | Saint-Cyr-Sur-Loire, 37540, France |
Completed | Private enterprise private production company " Acinus" | Kropyvnytskyi, 25006, Ukraine |
Completed | Union Hospt Tongji Medical Colleg. Huazhong univ. Scien&Tech | Wuhan, 430030, China |
Completed | Henan Provincial Eye Hospital | Henan, 450008, China |
Active, not recruiting | The First Affiliated Hospital of Xinjiang Medical University | Urumchi, MISSING, China |
Completed | Beijing Hospital | Beijing, 100730, China |
Completed | Eye Center of the second Bethune Hospital, jinlin University | Changchun, 130022, China |
Completed | Tianjin Medical University General Hospital | Tianjin, 300052, China |
Completed | Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech. | Wuhan, 430030, China |
Completed | People's Hospital of Ningxia Hui Autonomous Region - Opthalmology | Ningxia, 750002, China |
Completed | Beijing Aier Intech Eye Hospital | Beijing, 100000, China |
Completed | Aier Eye Hospital (Chengdu) | Chengdu, N/A, China |
Completed | Shenyang He Eye Specialist Hospital | Shenyang, 110034, China |
Completed | ZheJiang Provincial People's Hospital | Hangzhou, 310014, China |
Completed | The 1st Affiliated Hospital of Zhejiang University | Hangzhou, 310000, China |
Completed | The 1st Affiliated Hospital Fujian Medical University | Fuzhou, TBC, China |
Completed | Chongqing Aier Ophthalmology Hospital | Chongqing, 400020, China |
Completed | Beijing Tongren Hospital, Capital Medical University (East) | Beijing, 100005, China |
Completed | The Second Hospital of Anhui medical university | Hefei, 230601, China |
Completed | The First People's Hospital of Xuzhou | Xuzhou, 221002, China |
Completed | Hebei eye hospital | Hebei, 050010, China |
Completed | Jiangxi Provincial People’s Hospital | Nanchang, 330006, China |
Completed | The First Affiliated Hospital of NanChang University | Nanchang, 330006, China |
Completed | The First Affiliated Hospital of Xi'an Jiaotong University | Xi'an, 710061, China |
Completed | Shanghai Tongji Hospital of Tongji University | Shanghai, TBC, China |
Completed | Tonghua Central Hospital | Tonghua, 134001, China |
Completed | Shijiazhuang General Hospital | Shijiazhuang, 50000, China |
Active, not recruiting | Hôpital Lariboisière - Paris | PARIS, 75475, France |
Active, not recruiting | Budapest Retina Associates | Budapest, 1133, Hungary |
Completed | Rand Eye Institute | Deerfield Beach, 33064, United States |
Primary Outcome
- Change from baseline in BCVA measured by the ETDRS letter score at Week 48date_rangeTime Frame:At baseline and Week 48
Secondary Outcome
- Change from baseline in BCVA measured by the ETDRS letter score at Week 60date_rangeTime Frame:At baseline and Week 60
- Proportion of participants with no intraretinal fluid (IRF) and no subretinal fluid (SRF) in central subfield at Week 16date_rangeTime Frame:At Week 16
- Proportion of participants gaining at least 15 letters in BCVA from baseline at Week 48date_rangeTime Frame:At baseline and Week 48
- Proportion of participants achieving an ETDRS letter score of at least 69 (approximate 20/40 Snellen equivalent) at Week 48date_rangeTime Frame:At Week 48
- Change in choroidal neovascularization (CNV) size from baseline to Week 48date_rangeTime Frame:At baseline and Week 48
- Change in total lesion area from baseline to Week 48date_rangeTime Frame:At baseline and Week 48
- Proportion of participants with no IRF and no SRF in the center subfield at Week 48date_rangeTime Frame:At Week 48
- Change from baseline in central subfield retinal thickness (CST) at Week 48date_rangeTime Frame:At baseline and Week 48
- Change from baseline in National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25) total score at Week 48NEI VFQ-25 was a 25-item questionnaire that gave a score on a scale from 0 (worst) to 100 (best = no vision problems)date_rangeTime Frame:At baseline and Week 48
- Number of participants with treatment-emergent adverse events (TEAEs) and serious AEs (SAEs)date_rangeTime Frame:Up to 156 weeks
- Systemic exposure to aflibercept as assessed by plasma concentrations of free, adjusted bound and total aflibercept from baseline through Week 48date_rangeTime Frame:Up to Week 48
- Assessment of immunogenicity to aflibercept by measuring the incidence of treatment-emergent anti-drug antibodies (ADA) response through end of masked studydate_rangeTime Frame:Up to week 96
Trial design
Trial Type
InterventionalIntervention Type
DrugTrial Purpose
TreatmentAllocation
RandomizedBlinding
N/AAssignment
Parallel AssignmentTrial Arms
3