A study to learn more about the relationship between the development of a gap in the upper lip (cleft lip) or in the roof of the mouth (cleft palate) in newborns and the use of glucocorticoids by the mother during pregnancy: a meta-analysis
Glucocorticoids are drugs that have many effects on body metabolism, raise sugar level in the blood, and reduce inflammation. By applying a statistical technique for combining the findings from a systematic literature review (meta analysis), researchers want to learn more about the relationship of the risk to develop a separation in the roof of the mouth (cleft palate) in newborns and contact with glucocorticoids during pregnancy.
- Population: Pregnant women - Intervention: Any glucocorticoid or corticosteroid or steroids use irrespective of mode of administration - Comparator: Any/none - Outcomes: Incidence/ risk of cleft lip/palate in infants - Study Design: -- Meta-analysis and systematic literature reviews -- Observational studies (such as cohort study, case-control study, registries data) -- Clinical trials – Phase IIb, III, and IV -- Conference abstracts/posters - Time period: No time period restriction - Geography: No geography restriction
- Population: Nonpregnant women - Intervention: Drugs other than glucocorticoid or corticosteroid or steroid - Outcomes: Incidence/ risk of cleft lip/palate in infants - Study Design: -- Animal Study -- In vitro studies -- Editorial, letters, comment -- Clinical trials – Phase I or preclinical -- Case reports, case series -- Reviews - Studies focusing on: -- Diagnosis and surgical procedure for cleft repair -- Impact of Increased internal corticosteroids due to stress -- The relationship between genetic mutations and cleft patients -- Adverse events for other drugs -- Safety profiles of glucocorticoid or corticosteroid
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Risk association of orofacial cleft and glucocorticoids exposure during pregnancy: a meta-analysis