Cardiovascular Disease, Colorectal Cancer

Inclusion Criteria

- Age and CVD characteristics
-- Primary prevention:
--- 50-70 years of age
--- Self-report clinical characteristics that result to 20% or higher, 10-year risk of CVD based on the Progetto Cuore scores
-- Secondary prevention:
--- 18 years or older
--- Having a self-reported history of CV event (e.g., myocardial infarction (MI), ischaemic stroke or Transient Ischaemic stroke, , and angina)
- Able to read and understand Italian
- No participation in an investigational program with interventions outside of routine clinical practice
- For qualitative interviews:
-- Willing and able to provide (electronic) informed consent to participate in the study
-- Willing and able to participate in a telephone interview, and to be audio-recorded
- For pilot/cognitive interviews :
-- Willing and able to complete an online survey 
-- Willing and able to provide (electronic) informed consent to participate in the study
-- Willing and able to participate in an in-person interview, and to be audio-recorded
- For quantitative main survey:
-- Willing and able to complete an online survey 
-- Willing and able to provide (electronic) informed consent to participate in the study

Exclusion Criteria

- Have glucose-6-phosphate dehydrogenase (G6PD) deficiency (which commonly causes haemolytic anaemia, which is often triggered from eating fava beans, a condition called Favism) 
- Have the following conditions (which are contraindications to low-dose aspirin)
-- Known hypersensitivity to salicylates 
-- Known to have had asthma induced by salicylates
-- Having been diagnosed with acute gastroduodenal ulcers
-- Haemorrhagic diathesis
-- Renal failure
-- Hepatic failure
- Concomitant treatment with methotrexate
- Cognitive impairment, hearing difficulty, visual impairment, acute psychopathology, or insufficient knowledge of Italian that—in the opinion of the investigator/interviewer—could interfere with a patient’s ability to provide written consent and complete an interview or survey
- To be currently pregnant
- Are pharmaceutical company employees or employed in a position where they have a direct role in treating patients with CVD

Physician Eligibility Criteria:

- A medically trained physician
- Able to read, speak, and understand Italian sufficiently to complete an interview
- Able to provide informed consent electronically
- Have at least five year experience prescribing low-dose aspirin for primary and secondary prevention of CVD
- Willing to be audio-recorded, including adherence to the interview instructions