Trial Condition(s):
Colorectal Neoplasms
EffectiveNess of low dose Aspirin in GastrointEstinal cancer prevention - Taiwan (ENgAGE-Taiwan)
Bayer Identifier:
19882
ClinicalTrials.gov Identifier:
EudraCT Number:
Not Available
EU CT Number:
Not Available
Study Completed
Trial Purpose
The study evaluates the protective effect of low-dose aspirin use on gastrointestinal cancers (colorectal, esophageal and gastric cancers) in long-term users, episodic users and non-users of aspirin in Taiwan.
Inclusion Criteria
- Age 40 or older at the cohort entry date.
- Taiwanese National Health Insurance enrollees with non-missing and consistent age and gender information.Exclusion Criteria
- Subjects with any cancer diagnosis before cohort entry date.
- No use of National Health Insurance before the cohort entry date.
- Low dose aspirin prescription before cohort entry date.
- Subjects with conditions contra-indicated for low dose aspirin use before cohort entry date.Trial Summary
Enrollment Goal
4710504
Trial Dates
Phase
4
Could I receive a placebo?
No
Products
Aspirin (Acetylsalicylic Acid, BAYE4465)
Accepts Healthy Volunteers
No
Where to Participate
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Locations
| Locations | |
|---|---|
Locations National University of Taiwan Hospital Taipeh, Taiwan, China, 100 | Contact Us: E-mail: [email protected] Phone: (+)1-888-84 22937 |
Trial Design
EffectiveNess of low dose Aspirin in GastrointEstinal cancer prevention - Taiwan
Trial Type:
Observational
Intervention Type:
Drug
Trial Purpose:
N/A
Allocation:
N/A
Blinding:
N/A
Assignment:
N/A
Trial Arms:
4
Primary Outcome
- Number of subjects with colorectal cancerNumber of subjects with colorectal cancer for each cohort (long-term, episodic and former users of aspirin, and non-users).Timeframe: Up to 14 years
- Number of subjects with esophageal cancerNumber of subjects with esophageal cancer for each cohort (long-term, episodic and former users of aspirin, and non-users).Timeframe: Up to 14 years
- Number of subjects with gastric cancerNumber of subjects with gastric cancer for each cohort (long-term, episodic and former users of aspirin, and non-users).Timeframe: Up to 14 years
Secondary Outcome
- Duration of aspirin use to colorectal cancerThe duration of low-dose aspirin use in years to colorectal cancer.Timeframe: Up to 14 years
- Time from aspirin discontinuation to colorectal cancerPeriod of time in years from discontinuation of aspirin use to detection of colorectal cancer.Timeframe: Up to 14 years
- Stage of colorectal cancerThe stage of cancer will be determined according to the International Classification of Diseases for Oncology (ICD-O-3).Timeframe: Up to 14 years
- Number of fatal cases due to colorectal cancerDerived from Taiwan Mortality database.Timeframe: Up to 14 years
Additional Information
Not Available
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