Macular degeneration

Inclusion Criteria

- Age: ≥18 years of age for DME patients,
- Age: ≥55 for wAMD patients
- Decision to treat with intravitreal aflibercept in the study eye prior to patient enrolment as per the physician’s routine clinical practice and following the local Product monograph recommendations. Patients who are treatment naïve (no previous intravitreal treatment received, including, anti- VEGF agents, steroids, steroid implants and/or PDT) and patients that are switching from a different anti-VEGF therapy are both eligible to be included. DME patients that have received previous laser only will be classified as treatment naïve.
- If of childbearing potential, female willing to use effective contraception during treatment and for at least 3 months after the last intravitreal injection of aflibercept

Exclusion Criteria

- Patients participating in an investigational program with interventions outside of routine clinical practice.
- Patients currently being treated with intravitreal aflibercept in the study eye. 
- Patients who are hypersensitive to this drug, to any ingredient in the formulation, or to any component of the container. For a complete listing, see the DOSAGE FORMS,
COMPOSITION AND PACKAGING section of the local product monograph.
- Ocular or peri-ocular infection in either eye.
- Active intraocular inflammation in the study eye.
- Scar, fibrosis, or atrophy involving the center of the fovea in the study eye.
- Patients with advanced glaucoma, visually significant cataracts, or any eye disease likely to require surgery during the study period in the study eye.
- Concomitant ocular or systemic administration of drugs that could interfere with or potentiate the mechanism of action of intravitreal aflibercept, including anti-VEGF agents.
- Patients receiving a different anti-VEGF agent other than intravitreal aflibercept for the fellow eye.