Trial Condition(s):

Cough

Repeat doses of BAY1902607 in healthy males and proof of concept in chronic cough patients

Bayer Identifier:

19430

ClinicalTrials.gov Identifier:

NCT03535168

EudraCT Number:

2018-000129-29

Study Completed

Trial Purpose

The primary objectives of this study:
-To investigate the safety and tolerability of ascending repeated oral doses of BAY1902607 in healthy subjects (Part 1).
-To investigate the effect of BAY1902607 on the pharmacokinetics (PK) of a sub-therapeutic 1 mg dose of midazolam (Part 1).
-To investigate the safety, tolerability and efficacy of BAY1902607 in patients with refractory chronic cough (Part 2).

Inclusion Criteria
Part 1:
-Male; healthy according to complete medical history, including the physical examination, vital signs (blood pressure, heart rate), 12-lead ECG, clinical laboratory tests
-Age: 18–45 years (inclusive) at the first screening visit
-Non-smoker for at least 6 months and with a pack year history of equal to or less than 5 years
-Subjects, who are sexually active and have not been surgically sterilized, must agree to use two reliable and acceptable methods of contraception simultaneously, when having sexual intercourse with women of childbearing potential (one method used by the subject, one method used by the partner) during the study and for 90 days after receiving the investigational medicinal product, and not to act as sperm donor for 90 days after dosing. [Acceptable methods of contraception include for example: (a) condoms (male or female) with or without a spermicidal agent, (b) diaphragm or cervical cap with spermicide, (c) intrauterine device, (d) hormone-based contraception]
Part 2:
-Age: ≥18 years at the first screening visit
-Refractory chronic cough for at least one year that has been shown to be unresponsive to treatment of cough according to the 2006 British Thoracic Society (BTS) guideline
-Score of ≥ 40 mm on the Cough Severity visual analogue scale (VAS) at screening
-For female patients:
Confirmed post-menopausal woman (defined as exhibiting spontaneous amenorrhea for at least 12 months before screening or as exhibiting spontaneous amenorrhea for 6 months before screening with documented serum follicle-stimulating hormone (FSH) levels > 40 mIU/mL)
or
Woman without childbearing potential based on surgical treatment at least 6 weeks before screening, such as bilateral tubal ligation, bilateral oophorectomy with or without hysterectomy (documented by medical report verification)
or
Woman of childbearing potential that agrees to use two reliable and acceptable methods of contraception simultaneously (one method used by the study patient and one method used by the partner) during the study and for at least 31 days (1 average menstrual cycle of 28 days plus approx. 5 half-lives of BAY 1902607) after the last dose. In addition during the study and for at least 31 days after the last dose women of child bearing potential are not allowed to donate oocytes.
Exclusion Criteria
Part 1:
-Relevant diseases potentially interfering with the study objectives (e.g. respiratory diseases) within the four weeks before screening or between screening and randomization
-Any febrile illness within the four weeks before screening or between screening and randomization
-Medical history of hypogeusia/dysgeusia or the subject has a dysfunction in his ability to taste, as revealed by the taste-disturbance questionnaire during screening and the predose procedures
Part 2:
-FEV1(Forced Expiratory Volume in 1 second) or FVC(Forced Vital Capacity ) of less than 60% of predicted normal, at screening
-History of upper or lower respiratory tract infection or recent significant change in pulmonary status within the 4 weeks before screening
-Current smoking habit or history of smoking within the 6 months before the screening visit
-History of smoking (at any time) for more than 20 pack-years in total (20 cigarettes per pack)

Trial Summary

Enrollment Goal
59
Trial Dates
black-arrow
Phase
1/2
Could I receive a placebo?
Yes
Products
Filapixant (BAY1902607)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

Medicines Evaluation Unit

Manchester, United Kingdom, M23 9GP

Status
Completed
 
Locations

University Hospital of South Manchester

Manchester, United Kingdom, M23 9LT

Status
Completed
 
Locations

Castle Hill Hospital

Cottingham, United Kingdom, HU16 5JQ

Status
Completed
 
Locations

King's College Hospital - NHS Foundation Trust

London, United Kingdom, SE5 9RS

Status
Completed
 
Locations

Birmingham Heartlands Hospital

Birmingham, United Kingdom, B9 5SS

Status
Completed
 
Locations

Isala

ZWOLLE, Netherlands, 8025 AB

Status
Completed
 
Locations

Catharina Ziekenhuis

EINDHOVEN, Netherlands, 5623 EJ

Status
Completed
 
Locations

Queen's University

Belfast, United Kingdom, BT9 7BL

Status
Completed
 

Trial Design