Atrial Fibrillation

Inclusion Criteria

-NVAF(non-valvular atrial fibrillation) will be defined as the occurrence of 2 or more inpatient or outpatient
claims with ICD(International Classification of Disease)-9 427.31 as the diagnosis code at any time in the patient’s
data history prior to inclusion
-Patients will be required to have 180 days of enrollment for the assessment of baseline characteristics
-CHA2DS2-Vasc score ≥2 during the 180 days prior to index rivaroxaban use baseline period (CHA2DS2-Vasc: Diabetes mellitus; S2: prior Stroke or TIA or Thromboembolism; V: Vascular disease; A: Age 65–74 years; Sc: Sex category)

Exclusion Criteria

-Patients <18 years of age
-Patients with valvular AF (Atrial fibrillation)
-Pregnancy
-Malignant cancers
-Transient cause of AF
-Patients with venous thromboembolism (pulmonary embolism or deep vein thrombosis)
-Patients with major surgery defined as hip or knee replacement
-Prescriptions of oral anticoagulants (OACs) (apixaban, warfarin, dabigatran, rivaroxaban) before index date
-Prescription of more than one OAC on the index date
-Patient with any of the events defined in the composite endpoint
--Fatal bleeding
--Fatal Stroke/Myocardial infarction
--Intracranial hemorrhage
--Ischemic stroke
--Myocardial infarction