Atrial Fibrillation

Inclusion Criteria

-NVAF will be defined as the occurrence of 2 or more inpatient or outpatient claims with ICD-9 427.31 as the diagnosis code at any time in the patient’s data history prior to inclusion
-Patients will be required to have 180 days of enrollment for the assessment of baseline characteristics
-CHA2DS2-Vasc (C: Congestive heart failure; H: Hypertension; A2: Age ≥75 years; D: Diabetes mellitus; S2: prior Stroke or TIA or Thromboembolism; V: Vascular disease; A: Age 65–74 years; Sc: Sex category) score ≥2 during the 180 days prior to index apixaban use baseline period

Exclusion Criteria

-Patients <18 years of age
-Patients with valvular AF (Atrial fibrillation)
-Pregnancy
-Malignant cancers
-Transient cause of AF
-Patients with VTE (Venous thromboembolism)  (pulmonary embolism or DVT (Deep Vein Thrombosis))
-Patients with major surgery defined as hip or knee replacement
-Prescriptions of OACs (Oral anticoagulants) (apixaban, warfarin, dabigatran, rivaroxaban) before index date
-Prescription of more than one OAC on the index date
-Patient with any of the events defined in the composite endpoint