Trial Condition(s):

Cerebrovascular Circulation

Imaging study to compare effects of darolutamide and enzalutamide with respect to placebo on the blood flow in the brain in healthy male volunteers.

Bayer Identifier:

18426

ClinicalTrials.gov Identifier:

NCT03704519

EudraCT Number:

2018-001599-39

Study Completed

Trial Purpose

The current study would investigate the effects of a single dose of darolutamide and enzalutamide compared with placebo and compared to each other on human brain blood flow using arterial spin labeling magnetic resonance imaging (ASL-MRI), a non-invasive MRI technique. The change in cerebral blood flow was an indirect measure of brain penetration.
The risk of drug-associated CNS-related adverse events was likely to be correlated with the concentration of the drug in the brain. In contrast to enzalutamide, preclinical studies of darolutamide indicate that its brain penetration was much lower.
The aim of this study was to determine whether there was a difference between darolutamide and enzalutamide compared to placebo in cerebral blood flow and thus in brain penetration.

Inclusion Criteria
- Participants who are healthy as determined by medical history, physical examination, laboratory tests, and cardiac monitoring.
Exclusion Criteria
- Existing or recent relevant diseases of vital organs (eg, liver diseases, heart diseases, renal disease, lung disease), central nervous system or other organs (eg, Diabetes mellitus, myasthenia gravis).
                - Known contraindication to magnetic resonance imaging.
                - Any structural variants or pathological abnormalities on structural brain MRI during screening.
                - Any history of seizures including a febrile seizure in childhood, loss of consciousness, transient ischemic attack, or any condition that may pre-dispose to seizure.
                - Participant with any type of neurological problems or history of psychiatric disorder, especially mood disorders including medical history with suicidal ideation and/or suicide attempts, which may disable the participant to consent to the study.
                - Participants who use prescription or oral over the counter medications which might influence the study objectives, dietary/nutritional supplements, (including vitamins, natural and herbal remedies, eg, St. John’s wort) within 2 weeks prior to first study intervention administration or during the study.

Trial Summary

Enrollment Goal
26
Trial Dates
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Phase
1
Could I receive a placebo?
Yes
Products
Nubeqa (Darolutamide, BAY1841788)
Accepts Healthy Volunteers
Yes

Where to Participate

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Locations
Status
LocationsStatus
Locations

Centre for Neuroimaging Sciences, King's College

London, United Kingdom, SE5 8AF

Status
Completed
 

Trial Design