Trial Condition(s):

Medical Oncology

Thorough ECG (electrocardiogram) and drug interaction study with anetumab ravtansine and itraconazole

Bayer Identifier:

18329

ClinicalTrials.gov Identifier:

NCT02824042

EudraCT Number:

2017-001978-42

Study Completed

Trial Purpose

Characterize the safety, tolerability, ECG effects, pharmacokinetics and immunogenicity of anetumab ravtansine given as single agent and after inhibition of CYP3A4 and P-gp by concomitant administration of itraconazole in subjects with mesothelin-expressing advanced solid cancers

Inclusion Criteria
- Subjects must have histologically confirmed, locally advanced or metastatic solid cancers of the following histological types:
 a.) predominantly epithelial (≥50% tumor component) pleural or peritoneal mesothelioma
 b.) epithelial ovarian cancer (fallopian tube and primary peritoneal cancers are eligible)
 c.) adenocarcinoma of the pancreas,
 d.) triple-negative adenocarcinoma of the breast
 e.) non-small-cell adenocarcinoma of the lung
 f.)  gastric cancer (including gastro-esophageal junction)
 g.)  colon cancer
 h.)  cholangiocarcinoma
 i.)  Thymic carcinoma
 - Subjects must have no standard therapy available, or have actively refused standard therapy
 - Subjects must provide samples of archival tumor tissue collected and submitted anytime during the study
 - Subjects must have a life expectancy of at least 12 weeks
 - Subjects must have ECOG (Eastern Cooperative Oncology Group) performance status of 0 or 1
 - Subjects must have adequate bone marrow, renal and hepatic function and coagulation
 - Subjects must have normal or clinically insignificant ECG at screening
 - Women of reproductive potential must have a negative serum pregnancy test obtained within 3 days before the start of anetumab ravtansine
- Women of childbearing potential and fertile men must agree to use adequate contraception when sexually active. This applies from the time period between signing of the informed consent until at least 6 months after the last administration of the last study drug. Male patients with a female partner of childbearing potential must use a condom and ensure that an additional form of contraception is also used during treatment and until 6 months after last study drug administration.
Exclusion Criteria
- Previous or concurrent cancer that is distinct in primary site or histology from the cancer being evaluated in this study, except cervical carcinoma in situ, treated basal cell carcinoma, superficial noninvasive bladder tumors or any previous cancer curatively treated ≥ 3 years before the start of anetumab ravtansine
 - New or progressive brain or meningeal or spinal metastases
 - Corneal epitheliopathy or any eye disorder that may predispose the subjects to drug-induced corneal epitheliopathy, or may interfere with diagnosis of treatment-emergent corneal epitheliopathy at the ophthalmologist’s or the investigator’s discretion
 - History or current evidence of
 -- biliary cirrhosis
 -- malignant biliary obstruction unless the bile flow to the gastrointestinal tract is maintained by a fully operational biliary stent
 -- CTCAE (Common Terminology Criteria for Adverse Events) Grade ≥2 bleeding disorder within 4 weeks before the start of anetumab ravtansine
 -- uncontrolled cardiovascular disease or uncontrolled hypertension
 -- Long QT Syndrome
 -- HIV infection
 -- Hepatitis B or C infection
 - Had a major surgery or significant trauma within 4 weeks before the start of anetumab ravtansine
 - Had solid organ or bone marrow transplantation
 - Have LVEF (left ventricular ejection fraction) <50% at screening
 - Have QTc >450 ms or heart rate ≥100 bpm or ≤45 bpm at screening
 - Poor CYP2D6 metabolizers based on the screening test for genetic polymorphisms in CYP2D6 metabolizing capacity

Trial Summary

Enrollment Goal
63
Trial Dates
black-arrow
Phase
1
Could I receive a placebo?
No
Products
Anetumab ravtansine (BAY94-9343)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

UCLA-Santa Monica Medical Center

Santa Monica, United States, 90404

Status
Completed
 
Locations

University Hospitals Cleveland Medical Center

Cleveland, United States, 44106

Status
Completed
 
Locations

Henry Ford Health System

Detroit, United States, 48202

Status
Completed
 
Locations

Washington University School of Medicine

St. Louis, United States, 63110

Status
Completed
 
Locations

Mary Crowley Medical Research Center

Dallas, United States, 75230

Status
Completed
 
Locations

Epworth HealthCare

Richmond, Australia, 3122

Status
Completed
 
Locations

Blacktown Cancer & Haematology Centre

Blacktown, Australia, 2148

Status
Completed
 
Locations

Ciutat Sanitària i Universitaria de la Vall d'Hebron

Barcelona, Spain, 08035

Status
Completed
 
Locations

Fundacion Jimenez Diaz (Clinica de la Concepcion)

Madrid, Spain, 28040

Status
Completed
 
Locations

Hospital Virgen de la Victoria

Málaga, Spain, 29010

Status
Completed
 
Locations

Centre Georges Francois Leclerc Dijon

DIJON, France, 21079

Status
Completed
 
Locations

Hôpital Henri Mondor

CRETEIL, France, 94010

Status
Completed
 
Locations

Hôpital de la Timone - Marseille

MARSEILLE, France, 13005

Status
Completed
 
Locations

CU Saint-Luc/UZ St-Luc

BRUXELLES - BRUSSEL, Belgium, 1200

Status
Completed
 
Locations

UZ Gent

GENT, Belgium, 9000

Status
Completed
 
Locations

Universitair Medisch Centrum St. Radboud

NIJMEGEN, Netherlands, 6525 GA

Status
Completed
 
Locations

Nederlands Kanker Instituut

AMSTERDAM, Netherlands, 1066 CX

Status
Completed
 
Locations

VUmc

AMSTERDAM, Netherlands, 1081 HV

Status
Completed
 

Trial Design