Prostatic Neoplasms

Inclusion Criteria

- Members of the mPC cohort will have to fulfill all of the following criteria:
 -- Valid information on sex, age and the region of residence
 -- A period of at least 12 months of continuous insurance preceding cohort entry
 -- Diagnosis of PC (ICD-10 Code C61) in the study period (01-Jan-2004 to 31-Dec-2011)
 -- Diagnosis of bone metastases (ICD-10 Code C79.5) in the enrolment period (01-Jan-2005 to 31-Dec-2011)
 -- In addition to the criteria of the mPC cohort, members of the mCRPC will additionally have to fulfill: 
 -- One of the following in the enrolment period and before or at the same time with bone metastases
 --- Discontinuation of the initial chemical castration, change of the agent or modality of the Androgen deprivation therapy (ADT), or start of treatment for advanced Prostate cancer (PC) after the primary ADT.
 --- Surgical castration and initiation of ADT treatment
--- Treatment with medication specific to mCRPC.

Exclusion Criteria

- Patients will be excluded from the mPC and from the mCRPC populations if they meet one of the following criteria:
 -- First PC diagnosis later than 2 months after the diagnosis of bone metastases, or
 -- Use of any radiopharmaceuticals for bone metastases (e.g., samarium, strontium, rhenium, radium)