check_circleStudy Completed
Coronary Artery Disease
Bayer Identifier:
17849
ClinicalTrials.gov Identifier:
EudraCT Number:
EU CT Number:
Not Available
Vericiguat drug-drug interaction with nitroglycerin in stable coronary artery disease patients
Trial purpose
This study is intended to investigate the effect of nitroglycerin on vericiguat in patients with stable coronary artery disease (CAD). Nitroglycerin is the standard therapy to treat acute crisis of angina. Thus there is a high likelihood of co-administration of both drugs in the target indication of vericiguat, worsening heart failure (HF). Therefore, it is important to investigate the safety and tolerability of vericiguat and nitroglycerin, which may be used as unprescribed on-demand treatment by patients with acute episodes of angina pectoris.
Key Participants Requirements
Sex
BothAge
30 - 80 YearsTrial summary
Enrollment Goal
36Trial Dates
November 2015 - August 2016Phase
Phase 1Could I Receive a placebo
YesProducts
Verquvo (Vericiguat, BAY1021189)Accepts Healthy Volunteer
NoWhere to participate
Status | Institution | Location |
---|---|---|
Completed | Bonn, 53105, Germany | |
Completed | Wuppertal, 42283, Germany | |
Completed | Hamburg, 20251, Germany | |
Completed | Heidelberg, 69120, Germany | |
Completed | Berlin, 13353, Germany | |
Withdrawn | Wuppertal, 42113, Germany | |
Completed | Erfurt, 99084, Germany |
Primary Outcome
- Number of participants with adverse events as measure of safety and tolerabilitydate_rangeTime Frame:approximately 1 yearenhanced_encryptionYesSafety Issue:
Secondary Outcome
- Blood pressureRegular measurement of blood pressure (mmHg) in supine, sitting and standing position.date_rangeTime Frame:approximately 1 yearenhanced_encryptionNoSafety Issue:
- Heart rateRegular measurement of heart rate (bpm) in supine, sitting and standing position.date_rangeTime Frame:approximately 1 yearenhanced_encryptionNoSafety Issue:
Trial design
Trial Type
InterventionalIntervention Type
DrugTrial Purpose
TreatmentAllocation
RandomizedBlinding
Double BlindAssignment
Parallel AssignmentTrial Arms
2