Trial Condition(s):

Lymphoma, Non-Hodgkin

Study of copanlisib in combination with standard immunochemotherapy in relapsed indolent non-Hodgkin’s lymphoma (iNHL) (CHRONOS-4)

Bayer Identifier:

17833

ClinicalTrials.gov Identifier:

NCT02626455

EudraCT Number:

2015-001088-38

Recruitment Complete

Trial Purpose

The purpose of this study is to assess whether copanlisib in combination with standard immunochemotherapy (rituximab in combination with bendamustine [R-B] and rituximab in combination with a 4 drug combination of cyclophosphamide, doxorubicin, vincristine and prednisone/prednisolone [R-CHOP]) is effective and safe, compared with placebo in combination with standard immunochemotherapy (R-B or R-CHOP) in patients with relapsed iNHL who have received at least one, but at most three, lines of treatment, including rituximab-based immunochemotherapy and alkylating agents.

Inclusion Criteria
:
 - Histologically confirmed diagnosis of B lymphocyte antigen CD20 positive iNHL with histological subtype limited to:
 -- Follicular lymphoma G1-2-3a
 -- Small lymphocytic lymphoma with absolute lymphocyte count <5x10E9/L at study entry
 -- Lymphoplasmacytoid lymphoma / Waldenström macroglobulinemia (LPL / WM)
 -- Marginal zone lymphoma (MZL) (splenic, nodal, or extra-nodal)
- Patients must have relapsed (recurrence after complete response or presented progression after partial response) or progressed after at least one but at most three prior lines of therapy, including rituximab, and/or rituximab biosimilars, and/or anti-CD20 monoclonal antibody (e.g. obinutuzumab) -based immunochemotherapy and alkylating agents (if given concomitantly is considered one line of therapy). A previous regimen is defined as one of the following: at least 2 months of single-agent therapy (less than 2 months of therapy with single agent rituximab, or rituximab biosimilars, or anti-CD20 monoclonal antibody can be considered a previous regimen in the case the patient responded to it); at least 2 consecutive cycles of polychemotherapy; autologous transplant; or radioimmunotherapy. Previous exposure to other PI3K Inhibitors (except copanlisib) is acceptable provided there is no resistance (resistance defined as no response (response defined as partial response [PR] or complete response [CR]) at any time during therapy, or progressive disease (PD) after any response (PR/CR) or after stable disease within 6 months from the end of the therapy with a PI3K inhibitor.
 - Non-WM patients must have at least one bi-dimensionally measurable lesion (that has not been previously irradiated) according to the Lugano Classification. For patients with splenic MZL this requirement may be restricted to splenomegaly alone since that is usually the only manifestation of measurable disease.
 - Patients affected by WM who do not have at least one bi-dimensionally measurable lesion in the baseline radiologic assessment must have measurable disease, defined as presence of immunoglobulin M (IgM) paraprotein with a minimum IgM level ≥ 2 x upper limit of normal and positive immunofixation test.
 - Male or female patients ≥ 18 years of age
 - Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2
 - Life expectancy of at least 3 months
 - Availability of fresh tumor tissue and/or archival tumor tissue at Screening
 - Adequate baseline laboratory values as assessed within 7 days before
starting study treatment.
 - Left ventricular ejection fraction ≥ 50%
Exclusion Criteria
- Histologically confirmed diagnosis of follicular lymphoma grade 3b or transformed disease, or chronic lymphocytic leukemia. In patients with clinical suspicion of transformed disease, a fresh biopsy is recommended.
 -  Rituximab, or rituximab biosimilars, or anti-CD20 monoclonal antibody (e.g. obinutuzumab) resistance at any line of therapy (resistance defined as lack of response, or progression within 6 months of the last date of rituximab, or rituximab biosimilars, or anti-CD20 monoclonal antibody administration, including maintenance with these drugs).
 - HbA1c > 8.5% at screening
 - History or concurrent condition of interstitial lung disease and/or severely impaired lung function (as judged by the investigator)
 - Known lymphomatous involvement of the central nervous system
 - Known history of human immunodeficiency virus (HIV) infection
 - Hepatitis B (HBV) or hepatitis C (HCV) infection. Patients positive for hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb) will be eligible if they are negative for HBV-DNA, these patients should receive prophylactic antiviral therapy as per rituximab label. Patients positive for anti-HCV antibody will be eligible if they are negative for HCV-RNA.
- Cytomegalovirus (CMV) infection. Patients who are CMV PCR positive at baseline will not be eligible.CMV PCR test is considered positive if, the result can be interpreted as a CMV viremia according to local standard of care.
- Uncontrolled hypertension despite optimal medical management (per investigator´s assessment)
- Congestive heart failure > New York Heart Association (NYHA) class 2

Trial Summary

Enrollment Goal
551
Trial Dates
black-arrow
Phase
3
Could I receive a placebo?
Yes
Products
Copanlisib/RB or RCHOP (BAY80-6946)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

The Alfred Hospital

Prahran, Australia, 3181

Status
Active, not recruiting
 
Locations

Klinikum der Universität München Grosshadern

München, Germany, 81377

Status
Active, not recruiting
 
Locations

Universitätsklinikum Münster (UKM)

Münster, Germany, 48149

Status
Completed
 
Locations

HUS, Meilahden sairaala

Helsinki, Finland, 00290

Status
Active, not recruiting
 
Locations

Tampereen yliopistollinen sairaala, keskussairaala

Tampere, Finland, 33521

Status
Active, not recruiting
 
Locations

National Cancer Center Singapore

Singapore, Singapore, 169610

Status
Active, not recruiting
 
Locations

National Taiwan University Hospital

Taipei, Taiwan, China, 10002

Status
Active, not recruiting
 
Locations

Taipei Veterans General Hospital

Taipei, Taiwan, China, 11217

Status
Active, not recruiting
 
Locations

Rigshospitalet

Copenhagen, Denmark, 2100

Status
Completed
 
Locations

Hôpital Dupuytren

LIMOGES CEDEX, France, 87042

Status
Active, not recruiting
 
Locations

Hôpital de la Milétrie

POITIERS, France, 86021

Status
Active, not recruiting
 
Locations

Wojew. Szpital Specjalistyczny im. M. Kopernika

Lodz, Poland, 93-513

Status
Completed
 
Locations

UZ Leuven Gasthuisberg

LEUVEN, Belgium, 3000

Status
Completed
 
Locations

Seoul National University Hospital

Seoul, South Korea, 110-744

Status
Active, not recruiting
 
Locations

Samsung Medical Center

Seoul, South Korea, 06351

Status
Active, not recruiting
 
Locations

Hospital Universitario Clinica Puerta de Hierro

Majadahonda, Spain, 28222

Status
Completed
 
Locations

UZ Gent

GENT, Belgium, 9000

Status
Active, not recruiting
 
Locations

Istituto Clinico Humanitas - Humanitas Mirasole S.p.A.

Milano, Italy, 20089

Status
Active, not recruiting
 
Locations

Fiona Stanley Hospital

Murdoch, Australia, 6150

Status
Active, not recruiting
 
Locations

Dokuz Eylul Universitesi Tip Fakultesi

Izmir, Turkey, 35340

Status
Active, not recruiting
 
Locations

Marmara Uni. Tip Fakultesi Pendik Egitim ve Aras. Hastanesi

Istanbul, Turkey, 34899

Status
Active, not recruiting
 
Locations

Ashford Cancer Centre Research Pty Ltd

Kurralta Park, Australia, 5037

Status
Active, not recruiting
 
Locations

Fakultni nemocnice Kralovske Vinohrady

Praha 10, Czech Republic, 100 34

Status
Active, not recruiting
 
Locations

Memorial Sloan Kettering Cancer Center

New York, United States, 10021

Status
Active, not recruiting
 
Locations

Gabrail Cancer Center

Canton, United States, 44718

Status
Active, not recruiting
 
Locations

Tianjin Union Medicine Centre (People's Hospital of Tianjin)

Tianjin, China, 300121

Status
Active, not recruiting
 
Locations

The 1st Affiliated Hospital of Zhejiang University

Hangzhou, China, 310003

Status
Active, not recruiting
 
Locations

Zhejiang Cancer Hospital

Hangzhou, China, 310022

Status
Active, not recruiting
 
Locations

Fudan University Shanghai Cancer Center

Shanghai, China, 200030

Status
Active, not recruiting
 
Locations

1st Affiliated hospital of Soochow University

Suzhou, China, 215006

Status
Active, not recruiting
 
Locations

Fifth Medical Center, General Hospital of the Chinese People

Beijing, China, 100071

Status
Active, not recruiting
 
Locations

FuJian Medical University Union Hospital

Fuzhou, China, 350001

Status
Completed
 
Locations

Beijing Friendship Hospital, Capital Medical University

Beijing, China, 100050

Status
Active, not recruiting
 
Locations

Jiangsu Cancer Hospital

Nanjing, China, 210009

Status
Active, not recruiting
 
Locations

Singleton Hospital

Swansea, United Kingdom, SA2 8QA

Status
Active, not recruiting
 
Locations

Dorset County Hospital

Dorchester, United Kingdom, DT1 2JY

Status
Completed
 
Locations

West China Hospital Sichuan University

Chengdu, China, 610041

Status
Active, not recruiting
 
Locations

Oulun yliopistollinen sairaala

Oulu, Finland, 90020

Status
Active, not recruiting
 
Locations

Turun yliopistollinen keskussairaala

Turku, Finland, 20520

Status
Completed
 
Locations

Hadassah Hebrew University Hospital Ein Kerem

Jerusalem, Israel, 9112001

Status
Active, not recruiting
 
Locations

Rambam Health Corporation

Haifa, Israel, 3109601

Status
Active, not recruiting
 
Locations

Shamir Medical Center (Assaf Harofeh)

Zerifin, Israel, 6093000

Status
Active, not recruiting
 
Locations

Mater Misericordiae Hospital

Dublin, Ireland, D07 R2WY

Status
Completed
 
Locations

Cork University Hospital

Cork, Ireland

Status
Active, not recruiting
 
Locations

Centre Universitaire de Sante de l'Estrie

Sherbrooke, Canada, J1H 5N4

Status
Active, not recruiting
 
Locations

Recherche soins intensifs, hôpital Maisonneuve-Rosemont

Montréal, Canada, H1T 2M4

Status
Completed
 
Locations

Hopital de L'Enfant Jesus

Quebec City, Canada, G1J 1Z4

Status
Active, not recruiting
 
Locations

Calvary Mater Hospital Newcastle

Waratah, Australia, 2298

Status
Completed
 
Locations

Instituto Nacional del Cáncer

Santiago, Chile, 838-0455

Status
Active, not recruiting
 
Locations

Centro de Investigaciones Clínicas Vina del Mar Ltda.

Vina del Mar, Chile, 2540364

Status
Terminated
 
Locations

Hôpital Saint Louis

PARIS, France, 75010

Status
Completed
 
Locations

Hôpital Saint-Eloi

MONTPELLIER CEDEX, France, 34295

Status
Active, not recruiting
 
Locations

St. George's Hospital

London, United Kingdom, SW17 OQT

Status
Completed
 
Locations

Guangdong Provincial People's Hospital

Guangzhou, China, 510100

Status
Active, not recruiting
 
Locations

Tianjin Medical University Cancer Institiute & Hospital

Tianjin, China, 300060

Status
Active, not recruiting
 
Locations

Asan Medical Center

Seoul, South Korea, 05505

Status
Active, not recruiting
 
Locations

Severance Hospital, Yonsei University Health System

Seoul, South Korea, 03722

Status
Active, not recruiting
 
Locations

Northwick Park Hospital

Harrow, United Kingdom, HA1 3UJ

Status
Completed
 
Locations

Royal Devon & Exeter Hospital

Exeter, United Kingdom, EX2 5AX

Status
Active, not recruiting
 
Locations

Changhua Christian Hospital

Changhua, Taiwan, China, 50006

Status
Active, not recruiting
 
Locations

National Cheng Kung University Hospital

Tainan, Taiwan, China, 704

Status
Active, not recruiting
 
Locations

Chang Gung Memorial Hospital Kaohsiung

Kaohsiung, Taiwan, China, 833

Status
Active, not recruiting
 
Locations

Fondazione IRCCS Policlinico San Matteo

Pavia, Italy, 27100

Status
Active, not recruiting
 
Locations

A.O.U. Ospedali Riuniti "Umberto I - G.M.Lancisi - G.Salesi"

Ancona, Italy, 60126

Status
Completed
 
Locations

Narodny onkologicky ustav

Bratislava, Slovakia, 833 10

Status
Active, not recruiting
 
Locations

Centre Hospitalier Universite de Grenoble

Grenoble, France, 38043

Status
Active, not recruiting
 
Locations

Centre François Magendie - Pessac

PESSAC, France, 33600

Status
Active, not recruiting
 
Locations

Ankara Universitesi Tip Fakultesi Hastanesi

Ankara, Turkey, 06100

Status
Active, not recruiting
 
Locations

Karadeniz Teknik Universitesi Tip Fakultesi

Trabzon, Turkey, 61080

Status
Active, not recruiting
 
Locations

Erciyes Universitesi Tip Fakultesi

Kayseri, Turkey, 38039

Status
Active, not recruiting
 
Locations

Xinhua Hos Affiliated to SH Jiaotong Uni School of Medicine

Shanghai, China, 200092

Status
Active, not recruiting
 
Locations

Istanbul Universitesi Istanbul Tip Fakultesi

Istanbul, Turkey, 34093

Status
Active, not recruiting
 
Locations

Jilin Cancer Hospital

Changchun, China, 130000

Status
Active, not recruiting
 
Locations

Henan Cancer Hospital

Zhengzhou, China, 450008

Status
Active, not recruiting
 
Locations

Tumor Hospital of Hebei Province

Shijiazhuang, China, 050011

Status
Active, not recruiting
 
Locations

Prince of Wales Hospital Hong Kong

Shatin, Hong Kong, China

Status
Active, not recruiting
 
Locations

Med. Fakultät der Martin-Luther-Universität Halle-Wittenberg

Halle, Germany, 06120

Status
Completed
 
Locations

Fakultni Nemocnice Hradec Kralove

Hradec Kralove, Czech Republic, 50005

Status
Active, not recruiting
 
Locations

Ege Universitesi Tip Fakultesi

Izmir, Turkey, 35100

Status
Active, not recruiting
 
Locations

Trakya Univ. Tip Fak.

Edirne, Turkey, 22030

Status
Completed
 
Locations

Ondokuz Mayis Uni Tip Fakultesi

Samsun, Turkey, 55139

Status
Active, not recruiting
 
Locations

Institut Jules Bordet/Jules Bordet Instituut

BRUXELLES - BRUSSEL, Belgium, 1000

Status
Completed
 
Locations

CHU de Liège

LIEGE, Belgium, 4000

Status
Completed
 
Locations

Albert Alberts Stem Cell Transplant Research Centre

Pretoria, South Africa, 0044

Status
Active, not recruiting
 
Locations

Outeniqua Cancercare Oncology Unit

George, South Africa, 6530

Status
Active, not recruiting
 
Locations

Cancercare Langenhoven

Port Elizabeth, South Africa, 6045

Status
Active, not recruiting
 
Locations

Institute of Blood Pathology and Transfusion medicine

Lviv, Ukraine, 79044

Status
Active, not recruiting
 
Locations

National Cancer Institute-Ukraine

Kiev, Ukraine, 03022

Status
Active, not recruiting
 
Locations

Zaporizhzhia Regional Clinical Hospital

Zaporizhzhya, Ukraine, 69600

Status
Active, not recruiting
 
Locations

Cherkasy Oncological Dispensary

Cherkasy, Ukraine, 18009

Status
Active, not recruiting
 
Locations

IPO Porto

Porto, Portugal, 4200-072

Status
Active, not recruiting
 
Locations

Centro Hospitalar Universitario do Porto

Porto, Portugal, 4099-001

Status
Active, not recruiting
 
Locations

CHVNGE - Hospital Eduardo Santos Silva

Vila Nova de Gaia, Portugal, 4434-502

Status
Active, not recruiting
 
Locations

Centro Clinico Academico - Braga

Braga, Portugal, 4710-243

Status
Active, not recruiting
 
Locations

Centro Multidisciplinar de Estudos Clínicos EPP - Ltda.

Santo Andre, Brazil

Status
Active, not recruiting
 
Locations

IRCCS Ospedale Policlinico San Martino

Genova, Italy, 16132

Status
Active, not recruiting
 
Locations

Odense OUH, Haematologisk afdeling

Odense C, Denmark, 5000

Status
Active, not recruiting
 
Locations

Institut Català d'Oncologia Hospitalet

L'Hospitalet de Llobregat, Spain, 08907

Status
Active, not recruiting
 
Locations

Hospital Regional de Malaga | Oncologia

Malaga, Spain, 29010

Status
Active, not recruiting
 
Locations

Hospital Clínico Universitario Lozano Blesa

Zaragoza, Spain, 50009

Status
Active, not recruiting
 
Locations

The Affiliated Hospital of Qingdao University

Qingdao, China, 266500

Status
Active, not recruiting
 
Locations

Gemeinschaftspraxis Dr.Heinrich/ Prof.Bangerter

Augsburg, Germany, 86150

Status
Active, not recruiting
 
Locations

Institut Català d'Oncologia Badalona

Badalona, Spain, 08916

Status
Active, not recruiting
 
Locations

Flinders Medical Centre

Adelaide, Australia, 5042

Status
Active, not recruiting
 
Locations

LAIKO General Hospital of Athens

Athens, Greece, 115 26

Status
Active, not recruiting
 
Locations

University General Hospital of Athens "ATTIKON"

Chaidari, Greece, 12462

Status
Completed
 
Locations

EVANGELISMOS General Hospital of Athens

Athens, Greece, 106 76

Status
Active, not recruiting
 
Locations

University General Hospital of Patras

Patras, Greece, 26500

Status
Active, not recruiting
 
Locations

Univ. General Hospital of Larissa

Larissa, Greece, 41100

Status
Completed
 
Locations

Hospital de Clínicas de Porto Alegre

Porto Alegre, Brazil

Status
Active, not recruiting
 
Locations

Hospital Israelita Albert Einstein

Sao Paulo, Brazil, 05651-901

Status
Active, not recruiting
 
Locations

Instituto Nacional do Cancer Jose Alencar Gomes da Silva

Rio de Janeiro, Brazil, 20230 130

Status
Active, not recruiting
 
Locations

Centro de Pesquisas Oncológicas

Florianópolis, Brazil, 88034-000

Status
Active, not recruiting
 
Locations

Centro Integrado de Oncologia de Curitiba

Curitiba, Brazil, 80810-050

Status
Active, not recruiting
 
Locations

UMHAT Sveti Georgi

Plovdiv, Bulgaria, 4002

Status
Active, not recruiting
 
Locations

University Multiprofile Hosp. for Active Treat. Sveti Ivan

Sofia, Bulgaria, 1431

Status
Active, not recruiting
 
Locations

SHATHD Spec. Hospi. for Active Treatm. of Haematol. Dis. EAD

Sofia, Bulgaria, 1756

Status
Completed
 
Locations

Multiprofile Hospital for Active Treatment Hristo Botev AD

Vratsa, Bulgaria, 3000

Status
Active, not recruiting
 
Locations

Semmelweis University

Budapest, Hungary, 1083

Status
Completed
 
Locations

Pecsi Tudomanyegyetem Klinikai Kozpont

Pecs, Hungary, 7624

Status
Active, not recruiting
 
Locations

Somogy Megyei Kaposi Mor Oktato Korhaz

Kaposvar, Hungary, 7400

Status
Completed
 
Locations

Szent Borbala Hospital

Tatabanya, Hungary, 2800

Status
Completed
 
Locations

Semmelweis University

Budapest, Hungary, 1088

Status
Active, not recruiting
 
Locations

Oncology Dispensary #2

Sochi, Russia, 354057

Status
Active, not recruiting
 
Locations

Republican Clinical Oncology Dispensary Ufa

Ufa, Russia, 450054

Status
Active, not recruiting
 
Locations

RSRI of Hematology and Transfusiology

Saint-Petersburg, Russia, 191024

Status
Active, not recruiting
 
Locations

Siberian State Medical University

Tomsk, Russia, 634050

Status
Completed
 
Locations

Oncologianova GmbH

Recklinghausen, Germany, 45659

Status
Completed
 
Locations

Eastern Health Integrated Renal Service

Box Hill, Australia, 3128

Status
Active, not recruiting
 
Locations

Stauferklinikum Schwäbisch-Gmünd

Mutlangen, Germany, 73557

Status
Active, not recruiting
 
Locations

Singapore General Hospital

Singapore, Singapore, 169856

Status
Active, not recruiting
 
Locations

National University Hospital

Singapore, Singapore, 119228

Status
Active, not recruiting
 
Locations

National Cancer Center Hospital

Chuo-ku, Japan, 104-0045

Status
Completed
 
Locations

Tohoku University Hospital

Sendai, Japan, 980-8574

Status
Active, not recruiting
 
Locations

Nagoya City University Hospital

Nagoya, Japan, 467-8602

Status
Active, not recruiting
 
Locations

Kobe University Hospital

Kobe, Japan, 650-0017

Status
Active, not recruiting
 
Locations

Orszagos Onkologiai Intezet

Budapest, Hungary, 1122

Status
Active, not recruiting
 
Locations

Research Institute of Oncology

Rostov-on-Don, Russia, 344037

Status
Active, not recruiting
 
Locations

Clinical Oncological Dispensary of Omsk Region

Omsk, Russia, 644013

Status
Active, not recruiting
 
Locations

Kemerovo Regional Clinical Hospital

Kemerovo, Russia, 650066

Status
Completed
 
Locations

Pramongkutklao Hospital

Bangkok, Thailand, 10400

Status
Active, not recruiting
 
Locations

Siriraj Hospital, Mahidol

Bangkok, Thailand, 10700

Status
Active, not recruiting
 
Locations

Hospital General de México SS

Ciudad de México, Mexico, 06729

Status
Completed
 
Locations

Malopolskie Centrum Medyczne

Krakow, Poland, 30-510

Status
Active, not recruiting
 
Locations

Szpital Morski im. PCK

Gdynia, Poland, 81-519

Status
Active, not recruiting
 
Locations

S.C. Policlinica de Diagnostic Rapid S.A.

Brasov, Romania, 500152

Status
Active, not recruiting
 
Locations

Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare

Baia Mare, Romania, 430031

Status
Active, not recruiting
 
Locations

Fundeni Clinical Institute

Bucharest, Romania, 022328

Status
Active, not recruiting
 
Locations

Spitalul Clinic Colentina

Bucuresti, Romania, 020125

Status
Active, not recruiting
 
Locations

Spitalul Clinic Coltea

Bucharest, Romania, 030171

Status
Active, not recruiting
 
Locations

Institutul Regional de Oncologie Iasi

Iasi, Romania, 700111

Status
Completed
 
Locations

Spitalul Clinic Municipal Filantropia Craiova

Craiova, Romania, 200143

Status
Active, not recruiting
 
Locations

Centre Hospitalier Intercommunal de la Côte Basque-Bayonne

BAYONNE, France, 64100

Status
Completed
 
Locations

Centro de Investigación Clínica Chapultepec S.A. de C.V.

Morelia, Mexico, 58260

Status
Active, not recruiting
 
Locations

Lewis Hall Singletary Oncology Center

Thomasville, United States, 31792

Status
Completed
 
Locations

Chaim Sheba Medical Center

Ramat Gan, Israel, 5262000

Status
Active, not recruiting
 
Locations

IEP São Lucas

São Paulo, Brazil, 01236-030

Status
Completed
 
Locations

Hospital das Clínicas da Faculdade de Medicina da USP

São Paulo, Brazil, 05403-000.

Status
Active, not recruiting
 
Locations

Faculdade de Ciencias Medicas-Universidade Estadual Campinas

Campinas, Brazil, 130839 970

Status
Active, not recruiting
 
Locations

Centre Hospitalier Universitaire - Angers

Angers, France, 49100

Status
Active, not recruiting
 
Locations

Sun Yat-sen University Cancer Center

Guangzhou, China, 510060

Status
Active, not recruiting
 
Locations

National Hospital Organization Kyushu Cancer Center

Fukuoka, Japan, 811-1395

Status
Active, not recruiting
 
Locations

Aichi Cancer Center Hospital

Nagoya, Japan, 464-8681

Status
Active, not recruiting
 
Locations

Gunma University Hospital

Maebashi, Japan, 371-8511

Status
Active, not recruiting
 
Locations

Osaka Metropolitan University Hospital

Osaka, Japan, 545-8586

Status
Completed
 
Locations

Yamagata University Hospital

Yamagata, Japan, 990-9585

Status
Active, not recruiting
 
Locations

Hyogo Cancer Center

Akashi, Japan, 673-8558

Status
Active, not recruiting
 
Locations

Aomori Prefectural Central Hospital

Aomori, Japan, 030-8553

Status
Active, not recruiting
 
Locations

National Hospital Organization Kumamoto Medical Center

Kumamoto, Japan, 860-0008

Status
Active, not recruiting
 
Locations

SzSzBMK es EOK Josa Andras Oktatokorhaz

Nyiregyhaza, Hungary, 4400

Status
Active, not recruiting
 
Locations

Clinique Saint Anne

STRASBOURG, France, 67000

Status
Active, not recruiting
 
Locations

Marienhospital Herne Universitätsklinik

Herne, Germany, 44625

Status
Completed
 
Locations

Brian J. LeBerthon, MD

West Covina, United States, 91790

Status
Active, not recruiting
 
Locations

Constantiaberg Medi Clinic

Cape Town, South Africa, 7800

Status
Completed
 
Locations

Sociedad de Investigaciones Medicas Ltda

Temuco, Chile, 4810469

Status
Active, not recruiting
 
Locations

New York Cancer and Blood Specialists

Port Jefferson Station, United States, 11776

Status
Active, not recruiting
 
Locations

Ironwood Physicians P.C. DBA Ironwood Cancer & Res. Ctr.

Chandler, United States, 85224

Status
Active, not recruiting
 
Locations

SCL Health Research at St Joseph's Hospital Denver CO

Denver, United States, 80218

Status
Completed
 
Locations

Centro Especializado en Investigación Clínica S.C.

Boca del Río, Mexico, 94290

Status
Active, not recruiting
 
Locations

Centro de Atencion e Investigacion Clinica en Oncologia SCP

Merida, Mexico, 97134

Status
Active, not recruiting
 
Locations

Medizinische Hochschule Hannover (MHH)

Hannover, Germany, 30625

Status
Completed
 
Locations

Ciutat Sanitària i Universitaria de la Vall d'Hebron

Barcelona, Spain, 08035

Status
Completed
 
Locations

Oncology Consultants

Houston, United States, 77030

Status
Active, not recruiting
 
Locations

Irmandade Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Brazil, 90050 170

Status
Active, not recruiting
 
Locations

Hospital Universitario "José Eleuterio González"

Monterrey, Mexico, 64460

Status
Completed
 
Locations

Hopital du Sacre-Coeur de Montreal

Montreal, Canada, H4J 1C5

Status
Active, not recruiting
 
Locations

Texas Oncology- McAllen

McAllen, United States, 78503

Status
Active, not recruiting
 
Locations

Multidisciplinary Clinical Hosp. 4 Dnipro

Dnipro, Ukraine, 49102

Status
Active, not recruiting
 
Locations

Kindai University Hospital

Osakasayama, Japan, 589-8511

Status
Active, not recruiting
 
Locations

Kumamoto University Hospital

Kumamoto, Japan, 860-8556

Status
Active, not recruiting
 
Locations

Saitama Medical University International Medical Center

Hidaka, Japan, 350-1298

Status
Active, not recruiting
 
Locations

JCHO Kyushu Hospital

Kitakyushu, Japan, 806-8501

Status
Completed
 
Locations

Hopital Hotel Dieu - Nantes

NANTES CEDEX, France, 44093

Status
Completed
 
Locations

Clinique Victor Hugo - Le Mans

LE MANS CEDEX 2, France, 72015

Status
Active, not recruiting
 
Locations

Centre Hospitalier de la Durance - Avignon

AVIGNON, France, 84000

Status
Completed
 
Locations

Hiroshima Red Cross & Atomic-bomb Survivors Hospital

Hiroshima, Japan, 730-8619

Status
Active, not recruiting
 
Locations

Osaka Red Cross Hospital

Osaka, Japan, 543-8555

Status
Active, not recruiting
 
Locations

Kanagawa Cancer Center

Yokohama, Japan, 241-8515

Status
Active, not recruiting
 
Locations

Tenri Hospital

Tenri, Japan, 632-8552

Status
Active, not recruiting
 
Locations

Spitalul Clinic Judetean de Urgenta Sibiu

Sibiu, Romania, 550245

Status
Active, not recruiting
 

Trial Design