Trial Condition(s):

Prostate Cancer Non-Metastatic, Castration-Resistant

Efficacy and Safety Study of Darolutamide (ODM-201) in Men With High-risk Non-metastatic Castration-resistant Prostate Cancer (ARAMIS)

Bayer Identifier:

17712

ClinicalTrials.gov Identifier:

NCT02200614

EudraCT Number:

2013-003820-36

Study Completed

Trial Purpose

The purpose of this study is to assess the safety and efficacy of BAY1841788 (ODM-201) in patients with non-metastatic castration-resistant prostate cancer.

Inclusion Criteria
-  Histologically or cytologically confirmed adenocarcinoma of prostate without neuroendocrine differentiation or small cell features.
-   Castration-resistant prostate cancer (CRPC) with castrate level of serum testosterone.
-  Prostate-specific Antigen (PSA) doubling time of ≤ 10 months and PSA > 2ng/ml.
-  Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
-  Blood counts at screening: haemoglobin ≥ 9.0 g/dl,absolute neutrophil count ≥ 1500/µl, platelet count ≥ 100,000/µl.
-  Screening values of serum alanine aminotransferase (ALT) and/or aspartate transaminase (AST) ≤ 2.5 x upper limit of normal (ULN), total bilirubin ≤ 1.5 x ULN, creatinine ≤ 2.0 x ULN.
-  Sexually active patients, unless surgically sterile, must agree to use condoms as an effective barrier method and refrain from sperm donation during the study treatment and for 3 months after the end of the study treatment.
Exclusion Criteria
-  History of metastatic disease at any time or presence of detectable metastases.
-  Acute toxicities of prior treatments and procedures not resolved to grade ≤ 1 or baseline before randomisation.
-  Prior treatment with: second generation androgen receptor (AR) inhibitors, other investigational AR inhibitors, or CYP17 enzyme inhibitor.
-  Use of estrogens or 5-α reductase inhibitors or AR inhibitors.
-  Prior chemotherapy or immunotherapy for prostate cancer.
-  Use of systemic corticosteroid.
-  Radiation therapy within 12 weeks before randomisation.
-  Severe or uncontrolled concurrent disease, infection or co-morbidity.
-  Treatment with bisphosphonate or denosumab within 12 weeks before randomisation.
-  Known hypersensitivity to the study treatment or any of its ingredients.
-  Major surgery within 28 days before randomisation.
-  Any of the following within 6 months before randomisation: stroke, myocardial infarction, severe/unstable angina pectoris, coronary/peripheral artery bypass graft; congestive heart failure New York Heart Association (NYHA) Class III or IV.
-  Uncontrolled hypertension.
-  Prior malignancy.
-  Gastrointestinal disorder or procedure which expects to interfere significantly with absorption of study treatment.
-  Active viral hepatitis, active human immunodeficiency virus (HIV) or chronic liver disease.
- Treatment with any investigational drug within 28 days before randomisation.
-  Any condition that in the opinion of the investigator would impair the patients' ability to comply with the study procedures.

Trial Summary

Enrollment Goal
1509
Trial Dates
black-arrow
Phase
3
Could I receive a placebo?
Yes
Products
Nubeqa (Darolutamide, BAY1841788)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

Investigative Site

Tampere, Finland, 33521

Status
Completed
 
Locations

Investigative Site

Helsinki, Finland, 00290

Status
Completed
 
Locations

Investigative Site

Turku, Finland, FIN-20521

Status
Completed
 
Locations

Investigative Site

Seinäjoki, Finland, 60220

Status
Completed
 
Locations

Investigative Site

Kuopio, Finland, 70210

Status
Completed
 
Locations

Investigative Site

Santa Fé, Argentina, S3000FFV

Status
Completed
 
Locations

Investigative Site

San Miguel de Tucumán, Argentina, T4000HXU

Status
Completed
 
Locations

Investigative Site

Moscow, Russia, 105425

Status
Completed
 
Locations

Investigative Site

Nizhny Novgorod, Russia, 603006

Status
Completed
 
Locations

Investigative Site

Obninsk, Russia, 249036

Status
Completed
 
Locations

Investigative Site

Pyatigorsk, Russia, 357502

Status
Completed
 
Locations

Investigative Site

Lima, Peru, 15073

Status
Completed
 
Locations

Investigative Site

Homewood, United States, 35209

Status
Completed
 
Locations

Investigative Site

Indianapolis, United States, 46202

Status
Completed
 
Locations

Investigative Site

Jeffersonville, United States, 47130

Status
Completed
 
Locations

Investigative Site

Bala Cynwyd, United States, 19004

Status
Completed
 
Locations

Investigative Site

VILLEJUIF CEDEX, France, 94805

Status
Completed
 
Locations

Investigative Site

MONTPELLIER CEDEX, France, 34298

Status
Completed
 
Locations

Investigative Site

Angers, France, 49100

Status
Completed
 
Locations

Investigative Site

PARIS, France, 75014

Status
Completed
 
Locations

Investigative Site

PARIS, France, 75010

Status
Completed
 
Locations

Investigative Site

CRETEIL, France, 94010

Status
Completed
 
Locations

Investigative Site

REIMS cedex, France, 51726

Status
Completed
 
Locations

Investigative Site

NANTES CEDEX, France, 44093

Status
Completed
 
Locations

Investigative Site

POITIERS cedex, France, 86021

Status
Completed
 
Locations

Investigative Site

TOURS, France, 37044

Status
Completed
 
Locations

Investigative Site

SURESNES, France, 92151

Status
Completed
 
Locations

Investigative Site

BAYONNE, France, 64100

Status
Completed
 
Locations

Investigative Site

ROUEN CEDEX, France, 76031

Status
Completed
 
Locations

Investigative Site

CLERMONT FERRAND CEDEX 1, France, 63011

Status
Completed
 
Locations

Investigative Site

LA ROCHE SUR YON cedex, France, 85925

Status
Completed
 
Locations

Investigative Site

NANCY, France, 54100

Status
Completed
 
Locations

Investigative Site

PIERRE BENITE, France, 69495

Status
Completed
 
Locations

Investigative Site

RENNES CEDEX, France, 35033

Status
Completed
 
Locations

Investigative Site

Parma, Italy, 43126

Status
Completed
 
Locations

Investigative Site

Messina, Italy, 98125

Status
Completed
 
Locations

Investigative Site

Catanzaro, Italy, 88100

Status
Completed
 
Locations

Investigative Site

Chieti, Italy, 66100

Status
Completed
 
Locations

Investigative Site

Napoli, Italy, 80131

Status
Completed
 
Locations

Investigative Site

Modena, Italy, 41124

Status
Completed
 
Locations

Investigative Site

Forlì Cesena, Italy, 47014

Status
Completed
 
Locations

Investigative Site

Roma, Italy, 00144

Status
Completed
 
Locations

Investigative Site

Lecce, Italy, 73100

Status
Completed
 
Locations

Investigative Site

San Diego, United States, 92120

Status
Completed
 
Locations

Investigative Site

Barcelona, Spain, 08036

Status
Completed
 
Locations

Investigative Site

Córdoba, Argentina, X5004FHP

Status
Completed
 
Locations

Investigative Site

La Rioja, Argentina, F5300COE

Status
Completed
 
Locations

Investigative Site

Córdoba, Argentina, X5016KEH

Status
Completed
 
Locations

Investigative Site

Córdoba, Argentina, X5000HXL

Status
Completed
 
Locations

Investigative Site

Kaohsiung City ,, Taiwan, China, 807

Status
Completed
 
Locations

Investigative Site

Taipei, Taiwan, China, 100

Status
Completed
 
Locations

Investigative Site

Kaoshiung, Taiwan, China, 81362

Status
Completed
 
Locations

Investigative Site

Taichung, Taiwan, China, 40705

Status
Completed
 
Locations

Investigative Site

Lima, Peru, 15046

Status
Completed
 
Locations

Investigative Site

La Victoria, Peru, 4001

Status
Completed
 
Locations

Investigative Site

San Isidro, Peru, 15036

Status
Completed
 
Locations

Investigative Site

Nyiregyhaza, Hungary, 4400

Status
Completed
 
Locations

Investigative Site

Budapest, Hungary, 1086

Status
Completed
 
Locations

Investigative Site

Budapest, Hungary, 1204

Status
Completed
 
Locations

Investigative Site

Szeged, Hungary, 6725

Status
Completed
 
Locations

Investigative Site

Debrecen, Hungary, 4032

Status
Completed
 
Locations

Investigative Site

Szolnok, Hungary, 5000

Status
Completed
 
Locations

Investigative Site

Zalaegerszeg, Hungary, 8900

Status
Completed
 
Locations

Investigative Site

Szekszard, Hungary, 7100

Status
Completed
 
Locations

Investigative Site

Budapest, Hungary, 1145

Status
Completed
 
Locations

Investigative Site

Gyor, Hungary, 9023

Status
Completed
 
Locations

Investigative Site

Izmir, Turkey, 35340

Status
Completed
 
Locations

Investigative Site

Denver, United States, 80220

Status
Completed
 
Locations

Investigative Site

Asheboro, United States, 27203

Status
Completed
 
Locations

Investigative Site

Los Angeles, United States, 90048

Status
Completed
 
Locations

Investigative Site

Coeur d'Alene, United States, 83814

Status
Completed
 
Locations

Investigative Site

Anchorage, United States, 99503

Status
Completed
 
Locations

Investigative Site

Dallas, United States, 75231

Status
Completed
 
Locations

Investigative Site

Nashville, United States, 37209

Status
Completed
 
Locations

Investigative Site

Oklahoma City, United States, 73104

Status
Completed
 
Locations

Investigative Site

Cincinnati, United States, 45212

Status
Completed
 
Locations

Investigative Site

Canton, United States, 44718

Status
Completed
 
Locations

Investigative Site

Cleveland, United States, 44195

Status
Completed
 
Locations

Investigative Site

Grand Rapids, United States, 49546

Status
Completed
 
Locations

Investigative Site

Denver, United States, 80211

Status
Completed
 
Locations

Investigative Site

Wheeling, United States, 26003

Status
Completed
 
Locations

Investigative Site

La Jolla, United States, 92093

Status
Completed
 
Locations

Investigative Site

Springfield, United States, 62702

Status
Completed
 
Locations

Investigative Site

Fountain Valley, United States, 92708

Status
Completed
 
Locations

Investigative Site

Greenwood, United States, 46143

Status
Completed
 
Locations

Investigative Site

Chicago, United States, 60612

Status
Completed
 
Locations

Investigative Site

Evanston, United States, 60201-1613

Status
Completed
 
Locations

Investigative Site

Myrtle Beach, United States, 29572

Status
Completed
 
Locations

Investigative Site

Parker, United States, 80134

Status
Completed
 
Locations

Investigative Site

Annapolis, United States, 21401

Status
Completed
 
Locations

Investigative Site

Bronx, United States, 10469

Status
Completed
 
Locations

Investigative Site

Port St. Lucie, United States, 34952

Status
Completed
 
Locations

Investigative Site

Salisbury, United States, 21801

Status
Completed
 
Locations

Investigative Site

Granby, Canada, J2G 8Z9

Status
Completed
 
Locations

Investigative Site

Halifax, Canada, B3H 2Y9

Status
Completed
 
Locations

Investigative Site

Pointe-Claire, Canada, H9R 4S3

Status
Completed
 
Locations

Investigative Site

Toronto, Canada, M4N 3M5

Status
Completed
 
Locations

Investigative Site

Kingston, Canada, K7L 3J7

Status
Completed
 
Locations

Investigative Site

Hamilton, Canada, L8N 4A6

Status
Completed
 
Locations

Investigative Site

London, Canada, N6A 5W9

Status
Completed
 
Locations

Investigative Site

SINT-TRUIDEN, Belgium, 3800

Status
Completed
 
Locations

Investigative Site

LIEGE, Belgium, 4000

Status
Completed
 
Locations

Investigative Site

KORTRIJK, Belgium, 8500

Status
Completed
 
Locations

Investigative Site

BONHEIDEN, Belgium, 2820

Status
Completed
 
Locations

Investigative Site

Wien, Austria, 1090

Status
Completed
 
Locations

Investigative Site

Wien, Austria, 1020

Status
Completed
 
Locations

Investigative Site

Passo Fundo, Brazil, 99010-080

Status
Completed
 
Locations

Investigative Site

São Paulo, Brazil, 01209-000

Status
Completed
 
Locations

Investigative Site

Fortaleza, Brazil, 60430-230

Status
Completed
 
Locations

Investigative Site

São Paulo, Brazil, 04014-002

Status
Completed
 
Locations

Investigative Site

Itajaí, Brazil, 88301-220

Status
Completed
 
Locations

Investigative Site

São Paulo, Brazil, 01246-000

Status
Completed
 
Locations

Investigative Site

Goiânia, Brazil, 74605-070

Status
Completed
 
Locations

Investigative Site

Jau, Brazil, 17210-080

Status
Completed
 
Locations

Investigative Site

São Paulo, Brazil, 04039-004

Status
Completed
 
Locations

Investigative Site

Porto Alegre, Brazil, 90610-000

Status
Completed
 
Locations

Investigative Site

Porto Alegre, Brazil, 90050 170

Status
Completed
 
Locations

Investigative Site

Ribeirao Preto - SP, Brazil, 14048-900

Status
Completed
 
Locations

Investigative Site

Curitiba, Brazil, 81520-060

Status
Completed
 
Locations

Investigative Site

São Paulo, Brazil, 01236-030

Status
Completed
 
Locations

Investigative Site

Juiz de Fora, Brazil, 36010-510

Status
Completed
 
Locations

Investigative Site

Seoul, South Korea, 06273

Status
Completed
 
Locations

Investigative Site

Cheongju, South Korea, 28644

Status
Completed
 
Locations

Investigative Site

Seoul, South Korea, 06351

Status
Completed
 
Locations

Investigative Site

Seoul, South Korea, 03080

Status
Completed
 
Locations

Investigative Site

Gwangju, South Korea, 61469

Status
Completed
 
Locations

Investigative Site

Seoul, South Korea, 05505

Status
Completed
 
Locations

Investigative Site

Seoul, South Korea, 06591

Status
Completed
 
Locations

Investigative Site

Seoul, South Korea, 03722

Status
Completed
 
Locations

Investigative Site

Haifa, Israel, 35152

Status
Completed
 
Locations

Investigative Site

Moscow, Russia, 125284

Status
Completed
 
Locations

Investigative Site

Tyumen, Russia, 625041

Status
Completed
 
Locations

Investigative Site

Saratov, Russia, 410054

Status
Completed
 
Locations

Investigative Site

Omsk, Russia, 644013

Status
Completed
 
Locations

Investigative Site

Moscow, Russia, 129301

Status
Completed
 
Locations

Investigative Site

Novosibirsk, Russia, 630099

Status
Completed
 
Locations

Investigative Site

Krasnoyarsk, Russia, 660133

Status
Completed
 
Locations

Investigative Site

St. Petersburg, Russia, 197022

Status
Completed
 
Locations

Investigative Site

Ivanovo, Russia, 153040

Status
Completed
 
Locations

Investigative Site

Kazan, Russia, 420029

Status
Completed
 
Locations

Investigative Site

Rostov-on-Don, Russia, 344022

Status
Completed
 
Locations

Investigative Site

Vladimir, Russia, 600009

Status
Completed
 
Locations

Investigative Site

Chelyabinsk, Russia, 454087

Status
Completed
 
Locations

Investigative Site

Gdansk, Poland, 80-952

Status
Completed
 
Locations

Investigative Site

Elblag, Poland, 82-300

Status
Completed
 
Locations

Investigative Site

Otwock, Poland, 05-400

Status
Completed
 
Locations

Investigative Site

Wroclaw, Poland, 54-144

Status
Completed
 
Locations

Investigative Site

Lodz, Poland, 90-302

Status
Completed
 
Locations

Investigative Site

Siedlce, Poland, 08-110

Status
Completed
 
Locations

Investigative Site

Rzeszow, Poland, 35-021

Status
Completed
 
Locations

Investigative Site

Lublin, Poland, 20-718

Status
Completed
 
Locations

Investigative Site

Warszawa, Poland, 04-125

Status
Completed
 
Locations

Investigative Site

Warszawa, Poland, 02-616

Status
Completed
 
Locations

Investigative Site

Warszawa, Poland, 02-781

Status
Completed
 
Locations

Investigative Site

LIBRAMONT, Belgium, 6800

Status
Completed
 
Locations

Investigative Site

Jelgava, Latvia, LV-3001

Status
Completed
 
Locations

Investigative Site

Riga, Latvia, LV-1002

Status
Completed
 
Locations

Investigative Site

Leipaja, Latvia, LV-3401

Status
Completed
 
Locations

Investigative Site

Riga, Latvia, LV-1001

Status
Completed
 
Locations

Investigative Site

Riga, Latvia, LV-1038

Status
Completed
 
Locations

Investigative Site

Belgrade, Serbia, 11000

Status
Completed
 
Locations

Investigative Site

Belgrade, Serbia, 11080

Status
Completed
 
Locations

Investigative Site

Nis, Serbia, 18000

Status
Completed
 
Locations

Investigative Site

ISTANBUL, Turkey, 34724

Status
Completed
 
Locations

Investigative Site

Ankara, Turkey, 06500

Status
Completed
 
Locations

Investigative Site

Izmir, Turkey, 35100

Status
Completed
 
Locations

Investigative Site

Manisa, Turkey, 45030

Status
Completed
 
Locations

Investigative Site

Sivas, Turkey, 58140

Status
Completed
 
Locations

Investigative Site

Kharkiv, Ukraine, 61037

Status
Completed
 
Locations

Investigative Site

Dnipro, Ukraine, 49102

Status
Completed
 
Locations

Investigative Site

Kyiv, Ukraine, 04053

Status
Completed
 
Locations

Investigative Site

Kyiv, Ukraine, 2660

Status
Completed
 
Locations

Investigative Site

Zaporozhye, Ukraine, 69600

Status
Completed
 
Locations

Investigative Site

Uzhgorod, Ukraine, 88014

Status
Completed
 
Locations

Investigative Site

Chernivtsi, Ukraine, 58002

Status
Completed
 
Locations

Investigative Site

Fitzroy, Australia, 3065

Status
Completed
 
Locations

Investigative Site

Maidstone, United Kingdom, ME16 9QQ

Status
Completed
 
Locations

Investigative Site

Preston, United Kingdom, PR2 4HT

Status
Completed
 
Locations

Investigative Site

Huddersfield, United Kingdom, HD3 3EA

Status
Completed
 
Locations

Investigative Site

Romford, United Kingdom, RM7 0AG

Status
Completed
 
Locations

Investigative Site

Bebington, United Kingdom, CH63 4JY

Status
Completed
 
Locations

Investigative Site

Wakefield, United Kingdom, WF1 4DG

Status
Completed
 
Locations

Investigative Site

Cardiff, United Kingdom, CF14 4XN

Status
Completed
 
Locations

Investigative Site

Llanelli, United Kingdom, SA14 8QF

Status
Completed
 
Locations

Investigative Site

London, United Kingdom, SW17 0QT

Status
Completed
 
Locations

Investigative Site

Reading, United Kingdom, RG1 5AN

Status
Completed
 
Locations

Investigative Site

Stevenage, United Kingdom, SG1 4AB

Status
Completed
 
Locations

Investigative Site

Stoke-on-Trent, United Kingdom, ST4 6QG

Status
Completed
 
Locations

Investigative Site

Manacor, Spain, 07500

Status
Completed
 
Locations

Investigative Site

Elche, Spain, 03203

Status
Completed
 
Locations

Investigative Site

Terrassa, Spain, 08221

Status
Completed
 
Locations

Investigative Site

Barcelona, Spain, 08035

Status
Completed
 
Locations

Investigative Site

Sabadell, Spain, 08208

Status
Completed
 
Locations

Investigative Site

Sevilla, Spain, 41013

Status
Completed
 
Locations

Investigative Site

Alcorcón, Spain, 28922

Status
Completed
 
Locations

Investigative Site

Granada, Spain, 18012

Status
Completed
 
Locations

Investigative Site

Sevilla, Spain, 41009

Status
Completed
 
Locations

Investigative Site

Madrid, Spain, 28007

Status
Completed
 
Locations

Investigative Site

Salamanca, Spain, 37007

Status
Completed
 
Locations

Investigative Site

Valencia, Spain, 46009

Status
Completed
 
Locations

Investigative Site

Madrid, Spain, 28040

Status
Completed
 
Locations

Investigative Site

Cádiz, Spain, 11009

Status
Completed
 
Locations

Investigative Site

L'Hospitalet de Llobregat, Spain, 08907

Status
Completed
 
Locations

Investigative Site

Bilbao, Spain, 48013

Status
Completed
 
Locations

Investigative Site

Scunthorpe, United Kingdom, DN15 7BH

Status
Completed
 
Locations

Investigative Site

Dudley, United Kingdom, DY1 2HQ

Status
Completed
 
Locations

Investigative Site

Martin, Slovakia, 036 59

Status
Completed
 
Locations

Investigative Site

St Leonards, Australia, 2065

Status
Completed
 
Locations

Investigative Site

Stockholm, Sweden, 171 76

Status
Completed
 
Locations

Investigative Site

Örebro, Sweden, 701 85

Status
Completed
 
Locations

Investigative Site

Göteborg, Sweden, 413 45

Status
Completed
 
Locations

Investigative Site

Uppsala, Sweden, 751 85

Status
Completed
 
Locations

Investigative Site

Randwick, Australia, 2031

Status
Completed
 
Locations

Investigative Site

Douglas, Australia, 4814

Status
Completed
 
Locations

Investigative Site

South Brisbane, Australia, 4101

Status
Completed
 
Locations

Investigative Site

Kurralta Park, Australia, 5037

Status
Completed
 
Locations

Investigative Site

Porto, Portugal, 4200-319

Status
Completed
 
Locations

Investigative Site

Almada, Portugal, 2801-951

Status
Completed
 
Locations

Investigative Site

Guimaraes, Portugal, 4835-044

Status
Completed
 
Locations

Investigative Site

Lisboa, Portugal, 1400-038

Status
Completed
 
Locations

Investigative Site

Lisboa, Portugal, 1099-023

Status
Completed
 
Locations

Investigative Site

Matosinhos, Portugal, 4464-513

Status
Completed
 
Locations

Investigative Site

Lisboa, Portugal, 1150-199

Status
Completed
 
Locations

Investigative Site

Braga, Portugal, 4710-243

Status
Completed
 
Locations

Investigative Site

Lisboa, Portugal, 1500-650

Status
Completed
 
Locations

Investigative Site

Bratislava, Slovakia, 851 01

Status
Completed
 
Locations

Investigative Site

Trencin, Slovakia, 91101

Status
Completed
 
Locations

Investigative Site

Bratislava, Slovakia, 851 05

Status
Completed
 
Locations

Investigative Site

Bucuresti, Romania, 22328

Status
Completed
 
Locations

Investigative Site

Bucuresti, Romania, 75000

Status
Completed
 
Locations

Investigative Site

Targu-Mures, Romania, 540103

Status
Completed
 
Locations

Investigative Site

Bucuresti, Romania, 50659

Status
Completed
 
Locations

Investigative Site

Bucuresti, Romania, 41345

Status
Completed
 
Locations

Investigative Site

Oradea, Romania, 410159

Status
Completed
 
Locations

Investigative Site

Pretoria, South Africa, 0083

Status
Completed
 
Locations

Investigative Site

George, South Africa, 6530

Status
Completed
 
Locations

Investigative Site

Pretoria, South Africa, 0002

Status
Completed
 
Locations

Investigative Site

Paarl, South Africa, 7646

Status
Completed
 
Locations

Investigative Site

Minsk, Belarus, 220013

Status
Completed
 
Locations

Investigative Site

Lesnoy, Belarus, 223040

Status
Completed
 
Locations

Investigative Site

Rondebosch, South Africa, 7700

Status
Completed
 
Locations

Investigative Site

Cape Town, South Africa, 7925

Status
Completed
 
Locations

Investigative Site

Cape Town, South Africa, 7505

Status
Completed
 
Locations

Investigative Site

Port Elizabeth, South Africa, 6045

Status
Completed
 
Locations

Investigative Site

Sofia, Bulgaria, 1680

Status
Completed
 
Locations

Investigative Site

Varna, Bulgaria, 9000

Status
Completed
 
Locations

Investigative Site

Praha 6, Czech Republic, 160 00

Status
Completed
 
Locations

Investigative Site

Olomouc, Czech Republic, 779 00

Status
Completed
 
Locations

Investigative Site

Praha 2, Czech Republic, 128 08

Status
Completed
 
Locations

Investigative Site

Jablonec nad Nisou, Czech Republic, 466 60

Status
Completed
 
Locations

Investigative Site

Opava, Czech Republic, 746 01

Status
Completed
 
Locations

Investigative Site

Kolin, Czech Republic, 280 00

Status
Completed
 
Locations

Investigative Site

Praha 2, Czech Republic, 120 00

Status
Completed
 
Locations

Investigative Site

Praha 8, Czech Republic, 180 81

Status
Completed
 
Locations

Investigative Site

Madrid, Spain, 28041

Status
Completed
 
Locations

Investigative Site

Berlin, Germany, 12203

Status
Completed
 
Locations

Investigative Site

Holzminden, Germany, 37603

Status
Completed
 
Locations

Investigative Site

Emmendingen, Germany, 79312

Status
Completed
 
Locations

Investigative Site

Nürtingen, Germany, 72622

Status
Completed
 
Locations

Investigative Site

Mühlheim, Germany, 45468

Status
Completed
 
Locations

Investigative Site

Magdeburg, Germany, 39120

Status
Completed
 
Locations

Investigative Site

Marburg, Germany, 35039

Status
Completed
 
Locations

Investigative Site

Tübingen, Germany, 72076

Status
Completed
 
Locations

Investigative Site

Hamburg, Germany, 20246

Status
Completed
 
Locations

Investigative Site

Mainz, Germany, 55131

Status
Completed
 
Locations

Investigative Site

Hagenow, Germany, 19230

Status
Completed
 
Locations

Investigative Site

Dresden, Germany, 01307

Status
Completed
 
Locations

Investigative Site

Münster, Germany, 48149

Status
Completed
 
Locations

Investigative Site

Hamburg, Germany, 22081

Status
Completed
 
Locations

Investigative Site

Köln, Germany, 50937

Status
Completed
 
Locations

Investigative Site

Reutlingen, Germany, 72764

Status
Completed
 
Locations

Investigative Site

Düsseldorf, Germany, 40225

Status
Completed
 
Locations

Investigative Site

Kirchheim unter Teck, Germany, 73230

Status
Completed
 
Locations

Investigative Site

Zirndorf, Germany, 90513

Status
Completed
 
Locations

Investigative Site

Muehlacker, Germany, 75417

Status
Completed
 
Locations

Investigative Site

Wuppertal, Germany, 42103

Status
Completed
 
Locations

Investigative Site

Omaha, United States, 68130

Status
Completed
 
Locations

Investigative Site

Boca Raton, United States, 33486

Status
Completed
 
Locations

Investigative Site

Porto, Portugal, 4200-072

Status
Completed
 
Locations

Investigative Site

Buenos Aires, Argentina, C1120AAT

Status
Completed
 
Locations

Investigative Site

BESANCON, France, 25030

Status
Completed
 
Locations

Investigative Site

Toronto, Canada, M5G 2M9

Status
Completed
 
Locations

Investigative Site

Torino, Italy, 10043

Status
Completed
 
Locations

Investigative Site

Lugo, Spain, 27003

Status
Completed
 
Locations

Investigative Site

Madrid, Spain, 28046

Status
Completed
 
Locations

Investigative Site

Valencia, Spain, 46015

Status
Completed
 
Locations

Investigative Site

Charlotte, United States, 28277

Status
Completed
 
Locations

Investigative Site

Royal Oak, United States, 48073

Status
Completed
 
Locations

Investigative Site

Montería, Colombia, 230002

Status
Completed
 
Locations

Investigative Site

Medellín, Colombia, 050034

Status
Completed
 
Locations

Investigative Site

Floridablanca, Colombia, 681004

Status
Completed
 
Locations

Investigative Site

Torino, Italy, 10060

Status
Completed
 
Locations

Investigative Site

Palermo, Italy, 90127

Status
Completed
 
Locations

Investigative Site

Burlington, Canada, L7N 3V2

Status
Completed
 
Locations

Investigative Site

Vilnius, Lithuania, LT-08661

Status
Completed
 
Locations

Investigative Site

Klaipeda, Lithuania, LT-92288

Status
Completed
 
Locations

Investigative Site

Vilnius, Lithuania, LT-08660

Status
Completed
 
Locations

Investigative Site

Kaunas, Lithuania, LT-50009

Status
Completed
 
Locations

Investigative Site

Kaunas, Lithuania, LT-45434

Status
Completed
 
Locations

Investigative Site

Kryvyi Rih, Ukraine, 50048

Status
Completed
 
Locations

Investigative Site

Belo Horizonte, Brazil, 30150-320

Status
Completed
 
Locations

Investigative Site

Valencia, Spain, 46026

Status
Completed
 
Locations

Investigative Site

Palma de Mallorca, Spain, 07120

Status
Completed
 
Locations

Investigative Site

Córdoba, Spain, 14004

Status
Completed
 
Locations

Investigative Site

Arezzo, Italy, 52100

Status
Completed
 
Locations

Investigative Site

Roma, Italy, 00189

Status
Completed
 
Locations

Investigative Site

Sapporo, Japan, 060-8543

Status
Completed
 
Locations

Investigative Site

Sendai, Japan, 981-8563

Status
Completed
 
Locations

Investigative Site

Maebashi, Japan, 371-8511

Status
Completed
 
Locations

Investigative Site

Utsunomiya, Japan, 321-0974

Status
Completed
 
Locations

Investigative Site

Chiba, Japan, 260-8717

Status
Completed
 
Locations

Investigative Site

Sagamihara, Japan, 252-0375

Status
Completed
 
Locations

Investigative Site

Yokosuka, Japan, 238-8558

Status
Completed
 
Locations

Investigative Site

Yokohama, Japan, 232-0024

Status
Completed
 
Locations

Investigative Site

Mitaka, Japan, 181-8611

Status
Completed
 
Locations

Investigative Site

Itabashi-ku, Japan, 173-0015

Status
Completed
 
Locations

Investigative Site

Nakano-ku, Japan, 164-8541

Status
Completed
 
Locations

Investigative Site

Shinjuku-ku, Japan, 160-8582

Status
Completed
 
Locations

Investigative Site

Sumida-ku, Japan, 130-8587

Status
Completed
 
Locations

Investigative Site

Bunkyo-ku, Japan, 113-8603

Status
Completed
 
Locations

Investigative Site

Bunkyo-ku, Japan, 113-8431

Status
Completed
 
Locations

Investigative Site

Minato-ku, Japan, 105-8471

Status
Completed
 
Locations

Investigative Site

Toyama, Japan, 930-0194

Status
Completed
 
Locations

Investigative Site

Kanazawa, Japan, 920-8530

Status
Completed
 
Locations

Investigative Site

Fukui, Japan, 910-8526

Status
Completed
 
Locations

Investigative Site

Ueda, Japan, 386-8610

Status
Completed
 
Locations

Investigative Site

Hamamatsu, Japan, 431-3192

Status
Completed
 
Locations

Investigative Site

Nagoya, Japan, 466-8560

Status
Completed
 
Locations

Investigative Site

Kyoto, Japan, 602-8566

Status
Completed
 
Locations

Investigative Site

Osaka, Japan, 541-8567

Status
Completed
 
Locations

Investigative Site

Osaka, Japan, 558-8558

Status
Completed
 
Locations

Investigative Site

Osaka, Japan, 545-8586

Status
Completed
 
Locations

Investigative Site

Kobe, Japan, 650-0047

Status
Completed
 
Locations

Investigative Site

Kashihara, Japan, 634-8522

Status
Completed
 
Locations

Investigative Site

Okayama, Japan, 700-8558

Status
Completed
 
Locations

Investigative Site

Hiroshima, Japan, 730-8518

Status
Completed
 
Locations

Investigative Site

Otake, Japan, 739-0696

Status
Completed
 
Locations

Investigative Site

Ube, Japan, 755-8505

Status
Completed
 
Locations

Investigative Site

Kurume, Japan, 839-0863

Status
Completed
 
Locations

Investigative Site

Nagasaki, Japan, 852-8511

Status
Completed
 
Locations

Investigative Site

Yufu, Japan, 879-5593

Status
Completed
 
Locations

Investigative Site

Kashiwa, Japan, 277-8577

Status
Completed
 
Locations

Investigative Site

Koriyama, Japan, 963-8563

Status
Completed
 
Locations

Investigative Site

Wako, Japan, 351-0102

Status
Completed
 
Locations

Investigative Site

Higashiibaraki, Japan, 311-3193

Status
Completed
 
Locations

Investigative Site

Osakasayama, Japan, 589-8511

Status
Completed
 
Locations

Investigative Site

Nagasaki, Japan, 852-8501

Status
Completed
 
Locations

Investigative Site

Craiova, Romania, 200385

Status
Completed
 
Locations

Investigative Site

Cluj-Napoca, Romania, 400015

Status
Completed
 
Locations

Investigative Site

Craiova, Romania, 200542

Status
Completed
 
Locations

Investigative Site

Ploiesti, Romania, 100337

Status
Completed
 
Locations

Investigative Site

St. Petersburg, Russia, 194017

Status
Completed
 
Locations

Investigative Site

St. Petersburg, Russia, 191014

Status
Completed
 
Locations

Investigative Site

Orenburg, Russia, 460021

Status
Completed
 
Locations

Investigative Site

Incheon, South Korea, 21565

Status
Completed
 
Locations

Investigative Site

Daegu, South Korea, 41404

Status
Completed
 
Locations

Investigative Site

Dartford, United Kingdom, DA2 8DA

Status
Completed
 
Locations

Investigative Site

Barretos, Brazil, 14784-400

Status
Completed
 
Locations

Investigative Site

Taoyuan, Taiwan, China, 33305

Status
Completed
 
Locations

Investigative Site

Bath, United Kingdom, BA1 3NG

Status
Completed
 
Locations

Investigative Site

Wichita, United States, 67226

Status
Completed
 
Locations

Investigative Site

Omaha, United States, 68114

Status
Completed
 
Locations

Investigative Site

DIJON, France, 21000

Status
Completed
 
Locations

Investigative Site

LIMOGES CEDEX, France, 87042

Status
Completed
 
Locations

Investigative Site

MONTPELLIER CEDEX, France, 34295

Status
Completed
 
Locations

Investigative Site

Tallinn, Estonia, 13419

Status
Completed
 
Locations

Investigative Site

Orlando, United States, 32803

Status
Completed
 
Locations

Investigative Site

Los Angeles, United States, 90073-1003

Status
Completed
 
Locations

Investigative Site

Frankfurt, Germany, 60590

Status
Completed
 
Locations

Investigative Site

Lebanon, United States, 03756-1000

Status
Completed
 
Locations

Investigative Site

Fairfax, United States, 22031

Status
Completed
 
Locations

Investigative Site

St. Petersburg, Russia, 194354

Status
Completed
 
Locations

Investigative Site

CERGY PONTOISE, France, 95303

Status
Completed
 
Locations

Investigative Site

Recife, Brazil, 50070-550

Status
Completed
 
Locations

Investigative Site

Salvador, Brazil, 40050-001

Status
Completed
 
Locations

Investigative Site

Uberlandia, Brazil, 38408-150

Status
Completed
 
Locations

Investigative Site

Sorocaba, Brazil, 18035-300

Status
Completed
 
Locations

Investigative Site

Laguna Hills, United States, 92653

Status
Completed
 
Locations

Investigative Site

Richmond, United States, 23235

Status
Completed
 
Locations

Investigative Site

Gahanna, United States, 43230

Status
Completed
 
Locations

Investigative Site

STRASBOURG, France, 67000

Status
Completed
 
Locations

Investigative Site

SAINT MANDE, France, 94160

Status
Completed
 
Locations

Investigative Site

Herzberg Am Harz, Germany, 37412

Status
Completed
 
Locations

Investigative Site

Syracuse, United States, 13210

Status
Completed
 
Locations

Investigative Site

Málaga, Spain, 29010

Status
Completed
 
Locations

Investigative Site

Jerez de la Frontera, Spain, 11407

Status
Completed
 
Locations

Investigative Site

CAEN cedex 05, France, 14076

Status
Completed
 
Locations

Investigative Site

Calgary, Canada, T2V 1P9

Status
Completed
 
Locations

Investigative Site

Tucson, United States, 85704

Status
Completed
 
Locations

Investigative Site

Boston, United States, 02114

Status
Completed
 
Locations

Investigative Site

West Des Moines, United States, 50266

Status
Completed
 
Locations

Investigative Site

Voorhees, United States, 08043

Status
Completed
 
Locations

Investigative Site

Glasgow, United Kingdom, G12 0YN

Status
Completed
 
Locations

Investigative Site

Moscow, Russia, 117997

Status
Completed
 
Locations

Investigative Site

Daegu, South Korea, 42601

Status
Completed
 
Locations

Investigative Site

BORDEAUX CEDEX, France, 33076

Status
Completed
 
Locations

Investigative Site

Daugavpils, Latvia, LV5401

Status
Completed
 
Locations

Investigative Site

Middleburg Heights, United States, 44130

Status
Completed
 
Locations

Investigative Site

Whittier, United States, 90603

Status
Completed
 
Locations

Investigative Site

Virginia Beach, United States, 23462

Status
Completed
 
Locations

Investigative Site

Baltimore, United States, 21204

Status
Completed
 
Locations

Investigative Site

Bronx, United States, 10461

Status
Completed
 
Locations

Investigative Site

New Orleans, United States, 70121

Status
Completed
 
Locations

Investigative Site

Ufa, Russia, 450008

Status
Completed
 

Trial Design