check_circleStudy Completed

Diabetic Kidney Disease

Bayer Identifier:
17530
ClinicalTrials.gov Identifier:
NCT02545049
EudraCT Number:
2015-000950-39
EU CT Number:
Not Available
Efficacy and safety of finerenone in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disease

Trial purpose

The purpose of this study was to evaluate whether oral finerenone (study drug), in addition to standard daily therapy, is effective and safe in treating patients with
type 2 diabetes mellitus and diabetic kidney disease, when compared to a placebo.

Key Participants Requirements

Sex

Both

Age

18 - N/A
  • - Men or women ≥18 years of age
    - Subjects with Type Type 2 Diabetes Mellitus as defined by the American Diabetes Association
    - Diagnosis of Diabetic Kidney Disease with persistent high albuminuria or persistent very high albuminuria at the Run-In and Screening Visit
    - Pretreated with either angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) at maximal tolerated labeled dose without adjustments
    - Serum potassium <=4.8 mmol/L
  • - Confirmed significant non-diabetic renal disease, including clinically relevant renal artery stenosis
    - Uncontrolled arterial hypertension (ie, mean sitting systolic blood pressure (SBP) ≥170 mmHg or mean sitting diastolic blood pressure(DBP) ≥110 mmHg at run in visit, or mean sitting SBP ≥160 mmHg or mean sitting DBP ≥100 mmHg at screening)
    - Clinical diagnosis of chronic heart failure with reduced ejection fraction (HFrEF) and persistent symptoms {New York Heart Association (NYHA) class II – IV} at Run in visit [class 1A recommendation for mineralcorticoid receptor antagonist (MRAs)]
    - Dialysis for acute renal failure within 12 weeks of Run-in visit
    - Renal allograft in place or scheduled kidney transplant within next 12 months
    - Glycated hemoglobin (HbA1c) >12%

Trial summary

Enrollment Goal
7352
Trial Dates
September 2015 - February 2021
Phase
Phase 3
Could I Receive a placebo
Yes
Products
Kerendia (Finerenone, BAY94-8862)
Accepts Healthy Volunteer
No

Where to participate

StatusInstitutionLocation
Completed
London, E1 1BB, United Kingdom
Completed
Middlesborough, TS4 3BW, United Kingdom
Completed
Chichester, PO19 6SE, United Kingdom
Completed
Liverpool, L7 8XP, United Kingdom
Completed
Sugar Land, 77478, United States
Completed
Atlanta, 30342, United States
Completed
Poway, 92064, United States
Completed
Iowa City, 52242, United States
Completed
Flint, 48504, United States
Completed
Beaver, 15009, United States
Completed
Phoenix, 85032, United States
Completed
Sarasota, 34239, United States
Completed
Los Angeles, 90017, United States
Withdrawn
Portland, 97227, United States
Completed
Miami, 33186, United States
Withdrawn
Miami, 33134, United States
Completed
Hershey, 17033, United States
Completed
Hollywood, 33024, United States
Completed
Albuquerque, 87106, United States
Completed
Manassas, 20110, United States
Completed
West Palm Beach, 33401-3430, United States
Completed
Chula Vista, 91910, United States
Completed
Omaha, 68124, United States
Completed
Lawrenceville, 30046, United States
Completed
Huntsville, 35801-4317, United States
Completed
Miami Lakes, 33016, United States
Completed
Rosedale, 11422, United States
Completed
San Diego, 92117, United States
Completed
Atlanta, 30342, United States
Completed
Fresno, 93721, United States
Completed
Jersey Shore, 17740, United States
Withdrawn
Alexandria, 22304, United States
Completed
Miami, 33155, United States
Completed
Miami, 33126, United States
Completed
Willoughby Hills, 44094, United States
Completed
Salem, 24153, United States
Completed
New Orleans, 70112, United States
Completed
Brooklyn, 11229, United States
Completed
Ocala, 34471, United States
Completed
Hialeah, 33012, United States
Completed
Fort Payne, 35967, United States
Completed
Kansas City, 64128, United States
Completed
Miami, 33144, United States
Completed
Burlington, 05401, United States
Completed
McKinney, 75069, United States
Completed
Kansas City, 64111, United States
Completed
Honolulu, 96814, United States
Completed
Madrid, 28007, Spain
Completed
Madrid, 28041, Spain
Completed
Burela, 27880, Spain
Completed
Ferrol, 15405, Spain
Completed
Sagunto, 46520, Spain
Completed
Barcelona, 08003, Spain
Completed
Barcelona, 08025, Spain
Completed
A Coruña, 15006, Spain
Completed
Jaén, 23007, Spain
Completed
Valencia, 46014, Spain
Completed
Valencia, 46010, Spain
Completed
Manresa, 08243, Spain
Completed
Granada, 18012, Spain
Completed
Málaga, 29010, Spain
Withdrawn
Kitchener, N2H 5Z8, Canada
Completed
Cambridge, N1R 7L6, Canada
Completed
Mount Pearl, A1N 1W7, Canada
Completed
Hamilton, L8M 1K7, Canada
Completed
Burnaby, V3J 1N4, Canada
Completed
Smith Falls, K7A 4W8, Canada
Completed
Hamilton, L8N 4A6, Canada
Completed
Thornhill, L4J 1W3, Canada
Completed
Halifax, B3H 1V8, Canada
Completed
Oshawa, L1G 2B9, Canada
Completed
Toronto, M4G 3E8, Canada
Completed
Kitchener, N2G 4V5, Canada
Completed
Aarhus N, 8200, Denmark
Completed
Holstebro, DK-7500, Denmark
Completed
Kolding, 6000, Denmark
Completed
Herlev, 2730, Denmark
Completed
Herlev, 2730, Denmark
Completed
København NV, 2400, Denmark
Completed
Holbæk, 4300, Denmark
Completed
Hillerød, DK-3400, Denmark
Completed
Odense C, 5000, Denmark
Completed
Esbjerg, 6700, Denmark
Completed
Viborg, 8800, Denmark
Completed
Lukovit, 5770, Bulgaria
Completed
Stara Zagora, 6000, Bulgaria
Completed
Plovdiv, 4002, Bulgaria
Completed
Wien, 1030, Austria
Completed
Wien, 1060, Austria
Completed
Linz, 4020, Austria
Completed
Wels, 4600, Austria
Completed
Salzburg, 5020, Austria
Completed
Innsbruck, 6020, Austria
Completed
Zams, 6511, Austria
Completed
Feldkirch, 6807, Austria
Withdrawn
Wolfsberg, 9400, Austria
Withdrawn
Santiago, Chile
Completed
Providencia, 7500922, Chile
Withdrawn
Temuco, 4790869, Chile
Completed
San Miguel, 8910108, Chile
Withdrawn
Concepción, 4070038, Chile
Completed
Osorno, 5311092, Chile
Completed
Santiago, 8331143, Chile
Withdrawn
Viña del Mar, Chile
Completed
Santiago, 7500710, Chile
Completed
Szekesfehervar, 8000, Hungary
Completed
Papa, 8500, Hungary
Completed
Eger, 3300, Hungary
Completed
Lausanne, 1011, Switzerland
Completed
Bern, 3010, Switzerland
Completed
St. Gallen, 9007, Switzerland
Withdrawn
Basel, 4056, Switzerland
Completed
Oulu, 90100, Finland
Completed
Turku, 20521, Finland
Completed
Kuopio, 70100, Finland
Completed
Jyväskylä, 40620, Finland
Completed
Kajaani, 87140, Finland
Completed
Kerava, 04200, Finland
Completed
Nurmijärvi, 01900, Finland
Completed
Taipei, 100, Taiwan
Completed
New Taipei City, 220, Taiwan
Completed
Kaohsiung, 833, Taiwan
Completed
Taipei, 11217, Taiwan
Completed
Changhua, 50006, Taiwan
Completed
Taipei, 110, Taiwan
Completed
Taichung, 40705, Taiwan
Completed
Nashville, 37205, United States
Completed
San Antonio, 78215, United States
Completed
Topeka, 66606, United States
Completed
Chicago, 60612, United States
Completed
Dallas, 75251, United States
Completed
San Antonio, 78212, United States
Completed
Waterbury, 06708, United States
Completed
Houston, 77095, United States
Completed
Elgin, 60123, United States
Completed
New York, 10029, United States
Completed
Waco, 76708, United States
Completed
Minneapolis, 55455, United States
Completed
Sofia, 1407, Bulgaria
Completed
Sofia, 1680, Bulgaria
Completed
Sofia, 1233, Bulgaria
Completed
Auckland, New Zealand
Completed
Hamilton, 3204, New Zealand
Completed
Wellington, New Zealand
Completed
Christchurch, 8011, New Zealand
Completed
Tauranga, 3110, New Zealand
Completed
Düsseldorf, 40210, Germany
Completed
Hannover, 30625, Germany
Completed
Hamburg, 22041, Germany
Completed
Münster, 48145, Germany
Completed
Bad Oeynhausen, 32545, Germany
Completed
Ludwigshafen, 67059, Germany
Completed
Göttingen, 37075, Germany
Completed
Buenos Aires, C1426ABP, Argentina
Completed
Buenos Aires, C1429BWN, Argentina
Completed
San Luis, D5702AAx, Argentina
Completed
Sarandí, 1872, Argentina
Completed
Junín, B6000GMA, Argentina
Completed
Mar del Plata, B7602CBM, Argentina
Completed
Buenos Aires, C1428ART, Argentina
Completed
Buenos Aires, C1056ABJ, Argentina
Completed
Córdoba, X5000JHQ, Argentina
Completed
Heidelberg, 3081, Australia
Completed
Fitzroy, 3065, Australia
Completed
Reservoir, 3073, Australia
Completed
Richmond, 3121, Australia
Completed
Liverpool, 2170, Australia
Completed
Adelaide, 5000, Australia
Completed
New Lambton Heights, 2305, Australia
Withdrawn
Dormagen, 41540, Germany
Completed
Witten, 58455, Germany
Completed
Mainz, 55128, Germany
Completed
Berlin, 10437, Germany
Completed
Morton, 61550, United States
Completed
Los Angeles, 90025, United States
Completed
Myrtle Beach, 29588, United States
Withdrawn
Auburn, 04240, United States
Completed
Winston Salem, 27157, United States
Completed
Ft. Lauderdale, 33316-1958, United States
Completed
Miami, 33126, United States
Completed
Miami, 33156, United States
Completed
Birmingham, 35294-2041, United States
Completed
Kalamazoo, 49009, United States
Completed
Dallas, 75216, United States
Completed
Vista, 92083, United States
Completed
Albany, 12203, United States
Completed
Miami Beach, 33140, United States
Completed
Arlington, 76014, United States
Completed
Virginia Beach, 23462, United States
Completed
Ashkelon, 7830604, Israel
Completed
Holon, 5822012, Israel
Completed
Tel Aviv, 6937947, Israel
Completed
Jerusalem, 9112001, Israel
Completed
Tel Aviv, 6203854, Israel
Completed
Kfar Saba, 4428164, Israel
Withdrawn
Riyadh, 11211, Saudi Arabia
Completed
Llanelli, SA14 8QF, United Kingdom
Withdrawn
Jeddah, 21589, Saudi Arabia
Withdrawn
Riyadh, 11461, Saudi Arabia
Completed
Bristol, BS10 5NB, United Kingdom
Completed
Manchester, M8 5RB, United Kingdom
Withdrawn
Stoke on Trent, ST4 6QG, United Kingdom
Completed
London, SE5 9RS, United Kingdom
Completed
Corpus Christi, 78414, United States
Completed
Kingwood, 77339, United States
Completed
Orlando, 32825, United States
Completed
Las Vegas, 89113-2215, United States
Withdrawn
Lubbock, 79430, United States
Completed
La Mesa, 91942, United States
Completed
Miami, 33173, United States
Completed
Port Hueneme, 93041, United States
Completed
El Centro, 92243, United States
Completed
Shreveport, 71101, United States
Completed
San Antonio, 78229-3900, United States
Completed
Lawrenceville, 30046, United States
Completed
Charlotte, 28207, United States
Completed
Northridge, 91325, United States
Completed
Miami Lakes, 33014, United States
Completed
Pflugerville, 78660, United States
Completed
New Port Richey, 34652, United States
Completed
Columbia, 65212, United States
Completed
Rialto, 92377, United States
Completed
Dallas, 75246, United States
Completed
Miami, 33032, United States
Completed
Houston, 77040, United States
Completed
Bergamo, 24020, Italy
Completed
Bergamo, 24127, Italy
Completed
Milano, 20157, Italy
Completed
Napoli, 80131, Italy
Completed
Cagliari, 09134, Italy
Completed
Monza Brianza, 20832, Italy
Completed
Bergamo, 24047, Italy
Completed
Sassari, 07026, Italy
Completed
Parma, 43126, Italy
Completed
Bologna, 40138, Italy
Completed
Catania, 95124, Italy
Completed
Messina, 98125, Italy
Withdrawn
Udine, 33100, Italy
Completed
Milano, 20132, Italy
Completed
Verona, 37126, Italy
Completed
Genova, 16132, Italy
Completed
Napoli, 80131, Italy
Completed
Milano, 20024, Italy
Completed
Ottawa, K1K 4L2, Canada
Completed
Milano, 20142, Italy
Completed
Pisa, 56124, Italy
Completed
Prahran, 3181, Australia
Completed
Wollongong, 2500, Australia
Completed
Las Vegas, 89119, United States
Withdrawn
Mineola, 11501, United States
Completed
Miami Lakes, 33016, United States
Completed
Miami, 33175, United States
Completed
New Orleans, 70112, United States
Completed
Houston, 77008, United States
Completed
Asheboro, 27203, United States
Completed
Memphis, 38163, United States
Completed
Columbia, 65201, United States
Completed
New Haven, 06520, United States
Completed
Greenville, 29607, United States
Completed
Pearland, 77584, United States
Completed
Tomball, 77375, United States
Completed
GRONINGEN, 9713 GZ, Netherlands
Completed
HOOGEVEEN, 7909 AA, Netherlands
Completed
EINDHOVEN, 5600 PD, Netherlands
Completed
ALKMAAR, 1815 JD, Netherlands
Completed
ZWIJNDRECHT, 3331 LZ, Netherlands
Completed
DEN HAAG, 2545 CH, Netherlands
Completed
ALMERE, 1315 RA, Netherlands
Completed
Varna, 9000, Bulgaria
Withdrawn
Jeddah, 21499, Saudi Arabia
Withdrawn
Riyadh, 11426, Saudi Arabia
Withdrawn
Jeddah, Saudi Arabia
Withdrawn
Al Ahsa, Riyadh 11426, Saudi Arabia
Completed
Dimitrovgrad, 6400, Bulgaria
Completed
Plovdiv, 4004, Bulgaria
Completed
Yambol, 8600, Bulgaria
Completed
Botevgrad, 2140, Bulgaria
Completed
Gorna Oryahovitsa, 5100, Bulgaria
Completed
Zabrze, 41-800, Poland
Completed
Wroclaw, 51-162, Poland
Completed
Warszawa, Poland
Completed
Krakow, 31-261, Poland
Completed
Krakow, 31-156, Poland
Terminated
Warszawa, 01-868, Poland
Completed
Zerifin, 7030000, Israel
Completed
Tel Aviv, 6423906, Israel
Withdrawn
Hadera, 3810101, Israel
Completed
Zefat, 1311001, Israel
Completed
Beer Sheva, 8410101, Israel
Completed
Ramat Gan, 5262000, Israel
Completed
Afula, 1834111, Israel
Completed
Nazareth, 16100, Israel
Completed
Tiberius, 1528001, Israel
Completed
Nahariya, 2210001, Israel
Completed
Nahariya, 2210001, Israel
Completed
Rehovot, 7610001, Israel
Completed
Kazanlak, 6102, Bulgaria
Completed
Blagoevgrad, 2700, Bulgaria
Completed
Sliven, 8800, Bulgaria
Completed
Plovdiv, 4002, Bulgaria
Completed
Szeged, 6725, Hungary
Completed
Budapest, 1135, Hungary
Completed
Balatonfured, 8230, Hungary
Completed
Baja, 6500, Hungary
Completed
Debrecen, 4031, Hungary
Completed
Budapest, 1042, Hungary
Completed
Nyiregyhaza, 4405, Hungary
Completed
Budapest, 1089, Hungary
Completed
Kistarcsa, H-2143, Hungary
Completed
Toronto, M5C 2T2, Canada
Completed
Coquitlam, V3K 3P4, Canada
Completed
EDEGEM, 2650, Belgium
Completed
LEUVEN, 3000, Belgium
Completed
BRUXELLES - BRUSSEL, 1070, Belgium
Completed
GENT, 9000, Belgium
Withdrawn
HASSELT, 3500, Belgium
Withdrawn
ANTWERPEN, 2060, Belgium
Completed
ROESELARE, 8800, Belgium
Completed
Hamar, Norway
Completed
Kløfta, 2040, Norway
Completed
Ålesund, 6017, Norway
Completed
Larissa, 41100, Greece
Completed
Alexandroupolis, 68100, Greece
Completed
Thessaloniki, 54642, Greece
Completed
Chaidari, 12462, Greece
Completed
Thessaloniki, 56403, Greece
Completed
Vilnius, LT-08661, Lithuania
Completed
Klaipeda, LT-92304, Lithuania
Completed
Utena, LT-28142, Lithuania
Withdrawn
Kaunas, LT-50161, Lithuania
Completed
Kaunas, LT-48259, Lithuania
Completed
Kaunas, LT-49449, Lithuania
Completed
Singapore, 169608, Singapore
Completed
Singapore, 768828, Singapore
Completed
Singapore, 169609, Singapore
Completed
Leipzig, 04103, Germany
Completed
Leipzig, 04249, Germany
Completed
Leipzig, 04103, Germany
Completed
Elsterwerda, 04910, Germany
Completed
Dresden, 01307, Germany
Completed
Fresno, 93720, United States
Completed
Metairie, 70006, United States
Completed
Hialeah, 33012, United States
Completed
Santa Rosa, 95405, United States
Completed
Tomball, 77375, United States
Completed
McAllen, 78503, United States
Completed
Nashville, 37232-1371, United States
Completed
Newark, 07103, United States
Completed
Houston, 77024, United States
Completed
Hialeah, 33016, United States
Completed
Miami Gardens, 33014, United States
Completed
Winter Haven, 33880, United States
Completed
Las Vegas, 89128, United States
Completed
Palm Harbor, 34684, United States
Completed
Houston, 77061, United States
Completed
Missouri City, 77459, United States
Completed
Houston, 77018, United States
Completed
Greenfield Park, J4V 2H1, Canada
Completed
Laval, H7T 2P5, Canada
Completed
Montreal, H1M 1B1, Canada
Completed
Mirabel, J7J 2K8, Canada
Completed
Montreal, H4A 3T2, Canada
Completed
Quebec, G1V 4W2, Canada
Completed
Montreal, H4A 3J1, Canada
Completed
LIEGE, 4000, Belgium
Completed
Svendborg, 5700, Denmark
Completed
Melbourne, 3052, Australia
Completed
Sofia, 1431, Bulgaria
Completed
Hong Kong, Hong Kong
Completed
Shatin, Hong Kong
Completed
Fort Lauderdale, 33308, United States
Completed
Bethlehem, 18017, United States
Completed
Sao Paulo, 04039-000, Brazil
Completed
Sao Paulo, 01228-200, Brazil
Completed
Porto Alegre, 90610-000, Brazil
Completed
Juiz de Fora, 36036-330, Brazil
Completed
Rio de Janeiro, 21941-913, Brazil
Completed
Rio de Janeiro, 20241-180, Brazil
Completed
Curitiba, 80030-110, Brazil
Completed
Aparecida de Goiania, 74935-530, Brazil
Completed
Fortaleza, 60430-140, Brazil
Completed
São Paulo, Brazil
Completed
Wong Tai Sin, Hong Kong
Withdrawn
Hong Kong, Hong Kong
Completed
SIVAS, 58140, Turkey
Completed
Antalya, 07059, Turkey
Completed
ISTANBUL, 34722, Turkey
Completed
Istanbul, 34899, Turkey
Terminated
Antalya, 07003, Turkey
Completed
Ankara, Turkey
Withdrawn
Adana, 1000, Turkey
Completed
Los Angeles, 90073, United States
Completed
Dublin, 94568, United States
Completed
Torrance, 90502, United States
Completed
Bakersfield, 93309, United States
Completed
Omaha, 68131, United States
Completed
Izmir, 35100, Turkey
Completed
Izmir, 35180, Turkey
Completed
Bangkok, Thailand
Completed
Bangkok, 10400, Thailand
Completed
Praha 2, 128 08, Czechia
Completed
Krnov, 794 01, Czechia
Completed
Koprivnice, 742 21, Czechia
Withdrawn
Melnik, 276 01, Czechia
Completed
Plzen, 301 66, Czechia
Completed
Ceska Lipa, 470 01, Czechia
Completed
Frydek-Mistek, 738 01, Czechia
Completed
Olomouc, 775 20, Czechia
Completed
Brandys nad Labem, 250 01, Czechia
Completed
Holesov, 769 01, Czechia
Completed
Hodonin, 695 01, Czechia
Completed
Mlada Boleslav, 293 50, Czechia
Withdrawn
Benatky nad Jizerou, 294 71, Czechia
Completed
Khon Kaen, 40002, Thailand
Completed
Chiangmai, 50200, Thailand
Completed
Waterloo, N2J 1C4, Canada
Completed
St. John's, A1A 3R5, Canada
Completed
São Bernardo do Campo, 09715-090, Brazil
Completed
Dresden, 01277, Germany
Withdrawn
Berlin, 12157, Germany
Completed
GRENOBLE CEDEX 9, 38043, France
Completed
LYON CEDEX, 69437, France
Completed
PARIS, 75018, France
Withdrawn
LA ROCHELLE, 17019, France
Completed
Wien, 1130, Austria
Completed
Graz, 8036, Austria
Completed
Wichita, 67214, United States
Completed
Salt Lake City, 84108, United States
Completed
Cidra, 00739, Puerto Rico
Completed
San Juan, 00917, Puerto Rico
Completed
San Juan, 00909-3004, Puerto Rico
Completed
Seoul, 05505, Korea, Republic Of
Completed
Anyang-si, 14068, Korea, Republic Of
Completed
Seoul, 02841, Korea, Republic Of
Completed
Seoul, 05278, Korea, Republic Of
Completed
Busan, 49241, Korea, Republic Of
Completed
Seoul, 06351, Korea, Republic Of
Completed
Seoul, 03080, Korea, Republic Of
Completed
Seoul, 03722, Korea, Republic Of
Completed
Wonju, 26426, Korea, Republic Of
Completed
Seoul, 110-746, Korea, Republic Of
Completed
Daegu, 42601, Korea, Republic Of
Completed
Würzburg, 97080, Germany
Completed
Dortmund, 44137, Germany
Completed
Magdeburg, 39120, Germany
Completed
Heidelberg, 69115, Germany
Completed
Nettetal, 41334, Germany
Completed
Oslo, 0586, Norway
Completed
Sayama, 350-1305, Japan
Completed
Osaka, 530-0001, Japan
Completed
Fujisawa, 251-0041, Japan
Completed
Obihiro, 080-0848, Japan
Completed
Ushiku, 300-1207, Japan
Completed
Takamatsu, 760-0017, Japan
Completed
Fukuoka, 815-8555, Japan
Completed
Atsugi, 243-0035, Japan
Completed
Kamakura, 247-8533, Japan
Completed
Osaka, 530-8480, Japan
Withdrawn
Tamana, 865-0064, Japan
Completed
Fukuoka, 814-0180, Japan
Completed
Kasuga, 816-0864, Japan
Completed
Toyota, 471-8513, Japan
Completed
Sasebo, 857-1195, Japan
Completed
Fukui, 918-8503, Japan
Completed
Kitakyushu, 807-0857, Japan
Completed
Yokohama, 247-8581, Japan
Completed
Otsu, 520-0804, Japan
Completed
Nagoya, 456-0058, Japan
Completed
Iwata, 438-8550, Japan
Completed
Matsuyama, 790-0024, Japan
Completed
Isipingo Rail, 4110, South Africa
Withdrawn
Johannesburg, 1818, South Africa
Completed
Somerset West, 7130, South Africa
Completed
Witbank, 1035, South Africa
Completed
Port Elizabeth, 6045, South Africa
Completed
Lisboa, 1449-005, Portugal
Completed
Lisboa, 1500-650, Portugal
Completed
Almada, 2801-951, Portugal
Completed
Lisboa, 1069-166, Portugal
Completed
Loures, 2674-514, Portugal
Completed
Lisboa, 1250-189, Portugal
Completed
Porto, 4200-319, Portugal
Completed
Porto, 4099-001, Portugal
Completed
Braga, 4710-243, Portugal
Completed
Leiria, 2410-197, Portugal
Completed
Matosinhos, 4464-513, Portugal
Completed
Viana do Castelo, 4901-858, Portugal
Completed
El Paso, 79902-4672, United States
Completed
Boston, 02215, United States
Completed
Komatsu, 923-8560, Japan
Completed
Chapel Hill, 27312, United States
Completed
Fukui, 910-8526, Japan
Completed
Rauma, 26100, Finland
Withdrawn
Evergreen Park, 60805, United States
Completed
Los Angeles, 90022, United States
Completed
BREDA, 4818 CK, Netherlands
Completed
Durban, 4030, South Africa
Completed
Klaukkala, 01800, Finland
Withdrawn
Järvenpää, 04400, Finland
Withdrawn
Lappeenranta, 53130, Finland
Completed
Seinäjoki, 60100, Finland
Completed
Vantaa, 01600, Finland
Completed
Soweto, 1818, South Africa
Withdrawn
Makkah, P.O Box 57657-Makkah, Saudi Arabia
Completed
Krakow, 31-559, Poland
Completed
Krakow, 30-510, Poland
Completed
Gdansk, 80-952, Poland
Completed
Szczecin, 70-111, Poland
Completed
Poznan, 60-834, Poland
Completed
Stockholm, 114 46, Sweden
Completed
Lund, 222 21, Sweden
Completed
Göteborg, 413 46, Sweden
Completed
Örebro, 703 62, Sweden
Completed
Pasig City, 1600, Philippines
Completed
Quezon City, 1112, Philippines
Completed
Marikina City, Philippines
Completed
Quezon City, 1110, Philippines
Withdrawn
Aachen, 52074, Germany
Completed
Uppsala, 752 37, Sweden
Completed
Jerez de la Frontera, 11407, Spain
Withdrawn
Boadilla del Monte, 28660, Spain
Withdrawn
Pamplona, 31008, Spain
Completed
Montreal, H2K 1H2, Canada
Completed
Cesky Krumlov, 381 27, Czechia
Completed
Breclav, 690 02, Czechia
Completed
Praha 4, 140 00, Czechia
Completed
Seongnam-si, 13620, Korea, Republic Of
Completed
Pretoria, 0181, South Africa
Completed
Montreal, H4J 1C5, Canada
Completed
Pretoria, 0002, South Africa
Completed
Newtown, 2113, South Africa
Completed
Lenasia South, 1835, South Africa
Completed
Worcester, 6850, South Africa
Completed
Cape Town, 7570, South Africa
Withdrawn
Merebank, 4052, South Africa
Withdrawn
St. Petersburg, 194156, Russian Federation
Completed
Berlin, 12203, Germany
Completed
Bad König, 64732, Germany
Completed
Nürnberg, 90443, Germany
Completed
Staten Island, 10301, United States
Withdrawn
Fleming Island, 32003, United States
Completed
Sugarland, 77479, United States
Completed
Tacoma, 98405, United States
Completed
Novosibirsk, 630117, Russian Federation
Completed
St. Petersburg, 195067, Russian Federation
Completed
Irkutsk, 664079, Russian Federation
Completed
Kazan, 420101, Russian Federation
Completed
Kemerovo, 650055, Russian Federation
Completed
Moscow, 117292, Russian Federation
Completed
Moscow, 125101, Russian Federation
Withdrawn
Moscow, 119991, Russian Federation
Completed
St. Petersburg, 195257, Russian Federation
Withdrawn
St. Petersburg, 197022, Russian Federation
Withdrawn
Petrozavodsk, 185019, Russian Federation
Completed
St. Petersburg, 195112, Russian Federation
Completed
Moscow, 111539, Russian Federation
Completed
St. Petersburg, 193312, Russian Federation
Completed
Chelyabinsk, 454021, Russian Federation
Completed
Yaroslavl, 150062, Russian Federation
Completed
St. Petersburg, 197762, Russian Federation
Withdrawn
Miami, 33180, United States
Completed
Kemerovo, 650066, Russian Federation
Completed
Kirov, 610014, Russian Federation
Withdrawn
Ryazan, 390026, Russian Federation
Completed
Moscow, 125315, Russian Federation
Completed
Kursk, 305004, Russian Federation
Completed
Oyama, 323-0022, Japan
Completed
Naka, 311-0113, Japan
Completed
Asahikawa, 078-8234, Japan
Completed
Nagasaki, 852-8511, Japan
Completed
Saitama, 331-8577, Japan
Completed
Ho Chi Minh City, 84, Viet Nam
Completed
Ha Noi, 10000, Viet Nam
Completed
Ho Chi Minh City, 70000, Viet Nam
Completed
Ho Chi Minh City, Viet Nam
Completed
Ha Noi, Viet Nam
Withdrawn
Ha Noi, Viet Nam
Completed
Göteborg, 413 45, Sweden
Completed
Bangkok, 10400, Thailand
Completed
VENISSIEUX, 69200, France
Terminated
LE CREUSOT, 71200, France
Completed
Olten, 4600, Switzerland
Completed
Kitakyushu, 800-0296, Japan
Completed
Higashihiroshima, 739-0041, Japan
Completed
Fukuoka, 811-0213, Japan
Completed
Maebashi, 371-0821, Japan
Completed
Suita, 565-0862, Japan
Completed
Yatsushiro, 866-0824, Japan
Completed
Tamana, 865-0016, Japan
Completed
Praha 5, 150 00, Czechia
Completed
Uppsala, 751 85, Sweden
Completed
Budapest, 1134, Hungary
Completed
Budapest, 1088, Hungary
Completed
Budapest, 1134, Hungary
Completed
Budapest, 1036, Hungary
Completed
Siofok, 8600, Hungary
Completed
Kiev, 04114, Ukraine
Completed
Kiev, 04050, Ukraine
Completed
Kiev, 01021, Ukraine
Completed
Zaporozhye, 69000, Ukraine
Completed
Lodz, 92-213, Poland
Completed
Gdynia, 81-537, Poland
Completed
Rzeszow, 35-055, Poland
Completed
Bialystok, 15-351, Poland
Completed
Torun, 87-100, Poland
Completed
Lublin, 20-538, Poland
Completed
Katowice, 40-040, Poland
Withdrawn
Bogotá, Colombia
Completed
Manizales, Colombia
Completed
Barranquilla, Colombia
Completed
Barranquilla, Colombia
Withdrawn
Stockholm, 141 86, Sweden
Completed
Bogotá, Colombia
Completed
Medellín, Colombia
Completed
Barranquilla, Colombia
Completed
Bogotá, Colombia
Completed
Bogotá, Colombia
Completed
Bogota, Colombia
Completed
Armenia, Colombia
Completed
Floridablanca, Colombia
Completed
Pasto, Colombia
Completed
Barranquilla, Colombia
Completed
Cundinamarca, Colombia
Completed
Cali, 760032, Colombia
Completed
Medellin, 050034, Colombia
Completed
Cali, Colombia
Completed
Medellín, Colombia
Completed
Bogotá, Colombia
Completed
Zipaquirá, Colombia
Completed
Pereira, Colombia
Withdrawn
Cali, Colombia
Completed
Medellín, Colombia
Completed
Bogotá, Colombia
Completed
Medellín, Colombia
Completed
Bogotá, Colombia
Completed
Medellín, Colombia
Completed
Nagoya, 460-0001, Japan
Completed
Shirakawa, 961-0005, Japan
Completed
Beppu, 874-0011, Japan
Completed
Matsuyama, 791-8026, Japan
Completed
Shibuya-ku, 150-0002, Japan
Completed
Kumamoto, 861-8520, Japan
Completed
Nagoya, 457-8510, Japan
Completed
México D.F., 14080, Mexico
Withdrawn
Monterrey, 64000, Mexico
Completed
Guadalajara, 44600, Mexico
Completed
Cuernavaca, 62250, Mexico
Completed
Culiacán, 80200, Mexico
Completed
México, D. F., 11850, Mexico
Withdrawn
Mexico D.F., 07460, Mexico
Withdrawn
Mexico D.F., 15900, Mexico
Withdrawn
México, D. F., 7330, Mexico
Completed
San Juan del Río, 76800, Mexico
Completed
Xalapa, 91193, Mexico
Completed
Ciudad de México, 06729, Mexico
Withdrawn
Aguascalientes, 20000, Mexico
Withdrawn
Culiacán, 80030, Mexico
Completed
Queretaro, 76000, Mexico
Completed
Culiacán, 80230, Mexico
Completed
Puerto de Veracruz, 91900, Mexico
Completed
México, D. F., 3100, Mexico
Completed
Tongaat, 4400, South Africa
Completed
Voronezh, 394018, Russian Federation
Completed
Voronezh, 394077, Russian Federation
Completed
Omsk, 644033, Russian Federation
Completed
Kemerovo, 650002, Russian Federation
Withdrawn
Smolensk, 214019, Russian Federation
Completed
Krasnoyarsk, 660062, Russian Federation
Completed
Orenburg, 460040, Russian Federation
Completed
Krasnodar, 350086, Russian Federation
Completed
Saratov, 410030, Russian Federation
Completed
Syktyvkar, 167981, Russian Federation
Completed
Moscow, 129110, Russian Federation
Completed
Moscow, 123423, Russian Federation
Withdrawn
Moscow, 123182, Russian Federation
Completed
Omsk, 644112, Russian Federation
Withdrawn
Tyumen, 625023, Russian Federation
Withdrawn
Tomsk, 634050, Russian Federation
Completed
St. Petersburg, 194354, Russian Federation
Completed
St. Petersburg, 194044, Russian Federation
Completed
Arkhangelsk, 163001, Russian Federation
Completed
St. Petersburg, 194223, Russian Federation
Completed
Moscow, 123182, Russian Federation
Completed
Yaroslavl, 150003, Russian Federation
Completed
Moscow, 119192, Russian Federation
Completed
Nizhny Novgorod, 603018, Russian Federation
Withdrawn
Novosibirsk, 630047, Russian Federation
Withdrawn
Nizhny Novgorod, 603001, Russian Federation
Completed
Stavropol, 355030, Russian Federation
Withdrawn
Tomsk, 634012, Russian Federation
Completed
Ivano-Frankivsk, 76008, Ukraine
Completed
Chernivtsi, 58002, Ukraine
Completed
Ternopil, 46002, Ukraine
Completed
Lviv, 79010, Ukraine
Withdrawn
Uzhgorod, 88018, Ukraine
Completed
Dnipro, 49000, Ukraine
Completed
Kharkiv, 61070, Ukraine
Completed
Tucson, 85724, United States
Completed
Santiago, 8380456, Chile
Completed
Athens, 11527, Greece
Completed
Athens, 14455, Greece
Withdrawn
Los Angeles, 90033, United States
Completed
Lodz, 94-060, Poland
Completed
Torrance, 90502, United States
Completed
Kongsvinger, Norway
Completed
GELEEN, 6162 BG, Netherlands
Completed
AMSTERDAM, 1091 AC, Netherlands
Completed
Miami, 33145, United States
Completed
Miami, 33165, United States
Completed
Kagoshima, 890-8760, Japan
Completed
Kitakyushu, 805-8508, Japan
Completed
Ogaki, 503-8502, Japan
Completed
VANDOEUVRE-LES-NANCY, 54500, France
Completed
Springfield, 62702-1311, United States
Completed
Ho Chi Minh City, Viet Nam
Completed
Kitakyushu, 802-8555, Japan
Withdrawn
Kyoto, 615-8256, Japan
Completed
Kobe, 650-0047, Japan
Completed
Las Condes, 7591047, Chile
Completed
San Bernardo, 8053095, Chile
Completed
Yufu, 879-5593, Japan
Completed
Nagoya, 466-8650, Japan
Withdrawn
Montreal, H3G 1A4, Canada
Completed
Middelburg, 1055, South Africa
Completed
Cape Town, 7925, South Africa
Completed
Prague 6, 169 00, Czechia
Completed
Providencia, 7500520, Chile
Completed
Ciudad de México, 6700, Mexico
Completed
Bucuresti, 014142, Romania
Completed
Bucuresti, 020614, Romania
Withdrawn
Bucuresti, 020475, Romania
Completed
Bucuresti, 050538, Romania
Completed
Bucuresti, 010507, Romania
Completed
Brasov, 500269, Romania
Completed
Iasi, 700547, Romania
Completed
Baia Mare, 430222, Romania
Completed
Timisoara, 300456, Romania
Completed
Alba-Iulia, 510053, Romania
Completed
Galati, 800001, Romania
Completed
Bucuresti, 010627, Romania
Completed
Ploiesti, 100179, Romania
Completed
Timisoara, 300736, Romania
Completed
Frankfurt, 60596, Germany
Completed
Cluj-Napoca, 400006, Romania
Completed
Oradea, 410159, Romania
Completed
Satu Mare, 440055, Romania
Completed
Kawaguchi, 332-0012, Japan
Completed
Musashino, 180-8610, Japan
Completed
Ichikawa, 272-8516, Japan
Completed
Osaka, 553-0003, Japan
Completed
Osaka, 553-0003, Japan
Completed
Osaka, 558-8558, Japan
Completed
Chikushino, 818-8502, Japan
Completed
Düsseldorf, 40225, Germany
Completed
Leipzig, 04315, Germany
Completed
Takamatsu, 760-0018, Japan
Completed
Yokohama, 245-8575, Japan
Completed
Hakodate, 041-8680, Japan
Completed
L'Hospitalet de Llobregat, 08907, Spain
Completed
Wien, 1090, Austria
Completed
IEPER, 8900, Belgium
Completed
Hranice, 753 01, Czechia
Completed
Valencia, 46017, Spain
Completed
Barcelona, 08023, Spain
Completed
Córdoba, X5000AAW Córdoba, Argentina
Completed
St. Albans, 3021, Australia
Completed
Linz, 4021, Austria
Completed
Tel Aviv, 6905234, Israel
Completed
Nanjing, 210002, China
Completed
Nanjing, 210008, China
Completed
Shanghai, 200025, China
Completed
Nanjing, 210006, China
Completed
Beijing, 100730, China
Completed
Shenyang, 110016, China
Completed
Changsha, 410008, China
Completed
Changsha, 410013, China
Completed
Chengdu, 610041, China
Completed
Chengdu, 610041, China
Completed
Chengdu, 610072, China
Completed
Shanghai, 200092, China
Completed
Xi'an, 710061, China
Completed
Xi'an, 710061, China
Completed
Shanghai, 200062, China
Completed
Guangzhou, 510120, China
Completed
Shanghai, 200240, China
Completed
Nanning, 530021, China
Completed
Haikou, 570102, China
Completed
Guangzhou, 510150, China
Completed
Shanghai, 200072, China
Completed
Kaunas, LT-45217, Lithuania
Completed
Taichung, 40447, Taiwan
Completed
Taoyuan, 33305, Taiwan
Completed
Athens, 11527, Greece
Completed
Izmir, 35540, Turkey
Completed
Kocaeli, 41380, Turkey
Completed
Changzhou, 213004, China
Completed
Yinchuan, 750004, China
Completed
Shanghai, 201199, China
Completed
Nanchang, 330006, China
Completed
Xiamen, 361004, China
Completed
Tianjin, 300121, China
Completed
Nanjing, 210029, China
Completed
Shenyang, 110022, China
Completed
Changsha, 410011, China
Completed
Changsha, 410013, China
Completed
Chongqing, 400010, China
Completed
Zhuhai, 519000, China
Completed
Guangzhou, 510630, China
Completed
Haikou, 570311, China
Completed
Changchun, 130000, China
Completed
Hangzhou, 310013, China
Completed
Huai'An, 223300, China
Completed
Lianyungang, 222002, China
Completed
Nanjing, 210011, China
Completed
Taizhou, 317000, China
Completed
Wuxi, 214023, China
Completed
Yancheng, 224000, China
Completed
Wuhan, 430034, China
Completed
Nanning, 530031, China
Completed
Wuhan, 430022, China
Completed
Nanchang, 330008, China
Completed
Beijing, 100730, China
Completed
Guangzhou, 510080, China
Completed
Suzhou, 215006, China
Completed
Taiyuan, 030001, China
Completed
Xiamen, 361003, China
Completed
Guangzhou, 510405, China
Completed
Changchun, 130000, China
Completed
Urumqi, 830054, China
Completed
Urumqi, 830054, China
Completed
Beijing, 100071, China
Completed
Changchun, 130021, China
Completed
Wuxi, 214023, China
Completed
Qingdao, 266071, China
Completed
Beijing, 100050, China
Completed
Hohhot, 010017, China
Completed
Beijing, 100028, China
Completed
Birmingham, B15 2SQ, United Kingdom
Completed
Oslo, 0176, Norway
Completed
Medellín, Colombia
Completed
Moscow, 119034, Russian Federation
Completed
Shanghai, 200040, China
Completed
New Westminster, V3L 0A6, Canada
Completed
Sinzheim, 76547, Germany
Completed
Ludwigsburg, 71640, Germany
Completed
Memphis, 38120, United States
Completed
Nashville, 37208, United States
Completed
Perak, 32040, Malaysia
Completed
Pulau Pinang, 10450, Malaysia
Completed
Frankfurt, 60313, Germany
Completed
Kelantan, Malaysia
Completed
Kelantan, 15200, Malaysia
Completed
Atlanta, 30303, United States
Completed
Nyiregyhaza, 4400, Hungary
Completed
Barranquilla, Colombia
Completed
Kuala Lumpur, 59100, Malaysia
Completed
Pahang, 25100, Malaysia
Completed
Curitiba, 80230-130, Brazil
Completed
Brasilia, 70.200-730, Brazil
Completed
Fortaleza, 60115-282, Brazil
Completed
Barranquilla, Colombia
Completed
Glasgow, G20 OSP, United Kingdom
Completed
Chihuahua, 31238, Mexico
Completed
Guadalajara, 44657, Mexico
Completed
Kaunas, LT-51270, Lithuania
Completed
Aguascalientes, 20219, Mexico
Completed
St. Louis, 63106, United States
Completed
Stockholm, 182 88, Sweden
Completed
Ann Arbor, 48109, United States
Completed
Cork, Ireland
Completed
Dublin, DUBLIN 4, Ireland
Completed
Galway, Ireland
Completed
Kyiv, 03049, Ukraine
Completed
Kyiv, 03037, Ukraine
Completed
Cherkasy, 18009, Ukraine
Completed
Novosibirsk, 630047, Russian Federation
Completed
Izhevsk, 426063, Russian Federation
Completed
Mazatlán, 82110, Mexico
Completed
Perm, 614097, Russian Federation
Completed
Novosibirsk, 630068, Russian Federation
Completed
Amadora, 2720-276, Portugal
Completed
Moscow, 117292, Russian Federation
Completed
Torres Novas, 2350-754, Portugal
Completed
Skorzewo, 60-185, Poland
Completed
Nizhny Novgorod, 603126, Russian Federation
Completed
Budapest, 1083, Hungary
Completed
Kazan, 420012, Russian Federation
Completed
Wenzhou, 325000, China
Completed
Yekaterinburg, 620102, Russian Federation
Completed
Córdoba, 14004, Spain
Completed
Barcelona, 08036, Spain
Completed
Hvidovre, 2650, Denmark
Completed
Omsk, 644024, Russian Federation
Completed
Haifa, 3109601, Israel
Completed
Sheung Wan, Hong Kong
Completed
Zefat, 1311001, Israel
Completed
Nahariya, 22100, Israel
Completed
Covilha, 6200-251, Portugal
Completed
Jefferson City, 65109, United States
Completed
Sakhnin, 3081000, Israel
Completed
Hutchinson, 67502-1131, United States
Completed
Lanzhou, 730030, China
Completed
Tianjin, 300142, China
Completed
Stockholm, 113 24, Sweden
Completed
Skedsmokorset, 2020, Norway
Completed
Seoul, 07441, Korea, Republic Of
Completed
Hawkes Bay, 4130, New Zealand
Completed
Auckland, 2025, New Zealand
Completed
Lund, 221 85, Sweden
Completed
Hellerup, 2900, Denmark
Completed
Rättvik, 795 30, Sweden
Completed
Aalborg, 9000, Denmark
Completed
Genova, 16011, Italy
Completed
Reggio Emilia, 42123, Italy
Completed
Hamar, 2317, Norway
Completed
Aydin, 09100, Turkey
Completed
Kayseri, 38039, Turkey
Completed
Istanbul, 34303, Turkey
Completed
Malatya, 44280, Turkey
Completed
Torino, 10043, Italy
Completed
Shimajiri, 901-0493, Japan
Completed
Nakagami-gun, 901-2393, Japan
Completed
Kanwal, 2259, Australia
Completed
Loma Linda, 92357, United States
Completed
Sapporo, 007-0841, Japan
Completed
Torino, 10024, Italy
Completed
Bad Homburg, 61348, Germany
Completed
Skövde, 541 50, Sweden
Completed
Brisbane, 4064, Australia
Completed
Berlin, 13347, Germany
Completed
Roseville, 95661, United States
Completed
Edmonton, T5A 4L8, Canada
Completed
Cesky Krumlov, 381 01, Czechia
Completed
Vlasim, 258 01, Czechia
Completed
Toronto, M3J 1N2, Canada
Completed
Nitra, 949 11, Slovakia
Completed
Roznava, 048 01, Slovakia
Completed
Bardejov, 085 01, Slovakia
Completed
Zilina, 01001, Slovakia
Completed
Sarnia, N7T 4X3, Canada
Completed
Getafe, 28905, Spain
Completed
Valencia, 46026, Spain
Completed
Sant Joan Despi, 08970, Spain
Completed
Barcelona, 08035, Spain
Completed
Alexandria, 22304, United States
Completed
Lierskogen, 3420, Norway
Completed
Gosford, 2250, Australia
Completed
Sanuki, 769-2393, Japan
Completed
Kumamoto, 862-0976, Japan
Completed
Szombathely, 9700, Hungary
Completed
St. Stefan, 8511, Austria
Completed
Las Vegas, 89086, United States
Completed
Lodz, 90-153, Poland
Completed
Alcalá de Henares, 28805, Spain
Completed
Badalona, 08916, Spain
Completed
Iloilo City, 5000, Philippines
Completed
Dnipro, 49023, Ukraine
Completed
Mykolayiv, 54003, Ukraine
Completed
Kharkiv, 61058, Ukraine
Completed
Funchal, 9004-514, Portugal
Completed
Kharkiv, 61037, Ukraine
Completed
St. Gallen, 9016, Switzerland
Completed
Örebro, 701 85, Sweden
Completed
NIMES cedex 9, 30029, France
Completed
Murrells Inlet, 29576, United States
Completed
Newmarket, L3Y 5G8, Canada
Completed
Vinnytsia, 21001, Ukraine
Completed
Kiev, 1601, Ukraine
Completed
Kharkiv, 61039, Ukraine
Completed
Razgrad, 7200, Bulgaria
Completed
Kozloduy, 3320, Bulgaria
Completed
CABA, C1120AAC, Argentina
Completed
Lanús, B1824KAJ, Argentina
Completed
Ciudad Autón. de Buenos Aires, C1425AGC, Argentina
Completed
Houston, 77079, United States
Completed
Miami, 33130, United States
Completed
Tampere, 33520, Finland
Completed
Nea Ionia, 14233, Greece
Completed
AMERSFOORT, 3818 TZ, Netherlands
Completed
APELDOORN, 7334 DZ, Netherlands
Completed
Tampa, 33614, United States
Completed
Rancho Cucamonga, 91730, United States
Completed
Flint, 48532, United States
Completed
Spokane, 99204, United States
Completed
Novosibirsk, 630089, Russian Federation
Completed
Anderson, 29625, United States
Completed
Wroclaw, 51-685, Poland
Completed
Fort Lauderdale, 33312, United States
Completed
Baja, 6500, Hungary
Completed
Szentes, 6600, Hungary
Completed
Genève, 1205, Switzerland
Completed
Chattanooga, 37404, United States
Completed
Metairie, 70006, United States
Completed
Pretoria, 0181, South Africa
Completed
MULHOUSE, 68051, France
Completed
Brest, 29200, France
Completed
AMSTERDAM, 1105 AZ, Netherlands
Completed
New Bern, 28562, United States
Completed
DIJON, 21000, France
Completed
LE COUDRAY, 28630, France
Completed
COLMAR Cedex, 68024, France
Completed
BOULOGNE SUR MER, 62321, France
Completed
Saint Herblain, 44093, France
Completed
Elizabeth Vale, 5112, Australia
Completed
Garran, 2605, Australia
Completed
Johannesburg, 2198, South Africa
Completed
Smithtown, 11787, United States
Completed
Mesa, 85210, United States
Completed
Charleston, 29425, United States
Completed
KORTRIJK, 8500, Belgium
Completed
Zaporizhzhya, 69001, Ukraine
Completed
Quezon City, 1102, Philippines
Completed
Kristiansand, 4604, Norway
Completed
Levanger, 7601, Norway
Completed
Benoni, 1501, South Africa
Completed
Essen, 45136, Germany
Completed
St. Louis, 63136, United States
Completed
Phoenix, 85016, United States
Completed
BOIS-GUILLAUME, 76230, France
Completed
Barnaul, 656024, Russian Federation
Completed
Novosibirsk, 630005, Russian Federation
Completed
Jena, 07747, Germany
Completed
Schweinfurt, 97421, Germany
Completed
Las Vegas, 89128, United States
Completed
Indianapolis, 46202, United States
Completed
Monroe, 71201, United States
Completed
Porto Alegre, 90430-001, Brazil
Completed
Sao Paulo, 01223-001, Brazil
Completed
Goiania, 74605-020, Brazil
Completed
Uberlândia, 38411-186, Brazil
Completed
Curitiba, 80440-020, Brazil
Completed
Campina Grande do Sul, 83430 000, Brazil
Completed
Fortaleza, Brazil
Completed
São José do Rio Preto, 15090-000, Brazil
Completed
São Paulo, 04029-000, Brazil
Completed
São José dos Campos, 12243-280, Brazil
Completed
Selangor, 47000, Malaysia
Completed
Johor Bahru, 80100, Malaysia
Completed
Putrajaya, 62250, Malaysia
Completed
Perak, 30450, Malaysia
Completed
Reno, 89511, United States
Completed
Canton, 44718, United States
Completed
West Des Moines, 50265, United States
Completed
Berlin, 13187, Germany
Completed
Olomouc, 779 00, Czechia
Completed
Setubal, 2900-446, Portugal
Completed
Augusta, 30904, United States
Completed
Sudbury, P3A 1W8, Canada
Completed
Memphis, 38104, United States
Completed
Orangeburg, 29118, United States
Completed
Jacksonville, 32204, United States
Completed
Praha 4, 140 46, Czechia
Completed
Rimavska Sobota, 979 01, Slovakia
Completed
Tucson, 85723, United States
Completed
Monterrey, 64460, Mexico
Completed
Monterrey, 64460, Mexico
Completed
Durango, 34000, Mexico
Completed
Banska Bystrica, 974 01, Slovakia
Completed
Macon, 31210, United States
Completed
St. Petersburg, 199226, Russian Federation
Completed
Prescott, 86301, United States
Completed
Osaka, 543-0035, Japan
Completed
Beroun, 266 01, Czechia
Completed
Charlottesville, 22908, United States
Completed
Bydgoszcz, 85-079, Poland
Completed
Chojnice, 89-600, Poland
Completed
Bucuresti, 010825, Romania
Completed
Bucuresti, 031818, Romania
Completed
Oradea, 410519, Romania
Completed
Northampton, NN1 5BD, United Kingdom
Completed
CABA, C1018DES, Argentina
Completed
Moscow, 119991, Russian Federation
Completed
Palmerston North, 4414, New Zealand
Completed
Las Vegas, 89102, United States
Completed
TOURCOING, 59280, France
Completed
Faro, 8000-386, Portugal
Completed
Brooklyn, 11203, United States
Completed
Greenville, 27834, United States
Completed
Carshalton, SM5 1AA, United Kingdom
Completed
Kumamoto, 861-4193, Japan
Completed
Nagoya, 451-8511, Japan
Completed
Ciudad de México, 11650, Mexico
Completed
Yokohama, 235-0045, Japan
Completed
Minato, 108-0073, Japan
Completed
Ostrava, 702 00, Czechia
Completed
Tacchikawa, 190-8531, Japan
Completed
Matsubara, 580-0032, Japan
Completed
Ocala, 34471, United States
Completed
Funabashi, 273-8588, Japan

Primary Outcome

  • The first occurrence of the composite endpoint of cardiovascular death, non-fatal myocardial infarction, non fatal stroke, or hospitalization for heart failure.
    Number of participants with the first occurrence of the primary cardiovascular (CV) composite outcome, CV death, non-fatal myocardial infarction (MI), non-fatal stroke, or hospitalization for heart failure were reported as descriptive result.
    date_rangeTime Frame:
    From randomization up until the first occurrence of the CV composite endpoint, or censoring at the end of the study, with an average study duration of 41 months.
    enhanced_encryption
    Safety Issue:
    No

Secondary Outcome

  • The first occurrence of the composite endpoint of onset of kidney failure, a sustained decrease of eGFR ≥40% from baseline over at least 4 weeks, or renal death.
    Number of participants with first occurrence of the composite endpoint of onset of kidney failure, a sustained decrease of eGFR ≥40% from baseline over at least 4 weeks, or renal death were reported as descriptive result.
    date_rangeTime Frame:
    From randomization up until the first occurrence of the renal composite endpoint, or censoring at the end of the study, with an average study duration of 41 months.
    enhanced_encryption
    Safety Issue:
    No
  • All-cause hospitalization
    Number of participants with first occurrence of a hospitalization event were reported as descriptive result.
    date_rangeTime Frame:
    From randomization up until the first occurrence of the hospitalization due to any cause, or censoring at the end of study, with an average study duration of 41 months
    enhanced_encryption
    Safety Issue:
    No
  • All-cause mortality
    Number of participants with death due to any cause were reported as descriptive result. Number of participants with outcome death reported here includes deaths occurred after randomization until the end of the study visit. Deaths after end of study visit are not included in this table.
    date_rangeTime Frame:
    From randomization up until death due to any cause, or censoring at the end of the study, with an average study duration of 41 months
    enhanced_encryption
    Safety Issue:
    No
  • Change in urinary albumin-to-creatine ratio (UCAR) from baseline to month 4
    First morning void urine samples were collected to evaluate the urinary albumin-to-creatinine ratio (UACR). Month 4 was the visit closest to day 120 within a time window of 120 ± 30 days after randomization. If no measurements were available in this time window, the participant was excluded from this analysis. Ratio of UACR at Month 4 to UACR at baseline is reported as the change.
    date_rangeTime Frame:
    From baseline up until Month 4
    enhanced_encryption
    Safety Issue:
    No
  • The first occurrence of the composite endpoint of onset of kidney failure, a sustained decrease in eGFR of ≥57% from baseline over at least 4 weeks, or renal death
    Number of participants with first occurrence of the renal composite outcome, onset of kidney failure, a sustained decrease in eGFR of ≥57% from baseline over at least 4 weeks, or renal death were reported as descriptive result.
    date_rangeTime Frame:
    From randomization up until the first occurrence of the renal composite endpoint, or censoring at the end of the study, with an average study duration of 41 months
    enhanced_encryption
    Safety Issue:
    No

Trial design

A randomized, double-blind, placebo-controlled, parallel-group, multicenter, event-driven Phase 3 study to investigate efficacy and safety of finerenone on the reduction of cardiovascular morbidity and mortality in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disease in addition to standard of care.
Trial Type
Interventional
Intervention Type
Drug
Trial Purpose
Treatment
Allocation
Randomized
Blinding
Double Blind
Assignment
Parallel Assignment
Trial Arms
2

Additional Information

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