Trial Condition(s):

Physician education

A Phase 4 study of regorafenib in metastatic colorectal cancer - Does educating physicians change patient outcomes? (SMART)

Bayer Identifier:

17347

ClinicalTrials.gov Identifier:

NCT02287025

EudraCT Number:

Not Available

Terminated/Withdrawn

Trial Purpose

Randomized trial to evaluate impact of healthcare provider( clinician and nursing staff) support and education on treatment discontinuation rates in the absence of progression in patients with metastatic colorectal cancer treated with regorafenib. Intensified education and support will be provided through an application for iPad which has automatic links to grading, dose reduction and side effect management ,as well as, references for additional articles.

Inclusion Criteria
- Histologically or cytologically-proven metastatic CRC for which the decision of treatment with regorafenib was made
 - Previous treatment with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild type, an anti-EGFR therapy
 - Male or female patients ≥ 18 years of age
 - Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 or 1
 - Signed informed consent obtained before any study specific procedure is performed.Patients must be able to understand and willing to sign the written ICF.
 - Life expectancy of at least 12 weeks
 - Adequate bone marrow, liver and renal function as assessed by the following
laboratory requirements:
a. Total bilirubin ≤ 1.5 x the upper limits of normal (ULN)
b. Alanine aminotransferase (ALT) and aspartate aminotransferease (AST)
≤ 3.0 x ULN (≤ 5 x ULN for patients with liver involvement of their cancer)
c. Alkaline phosphastase limit ≤ 2.5 x ULN (≤ 5 x ULN for patients with liver
involvement of their cancer)
d. Lipase ≤ 1.5 x the ULN
e. Amylase ≤ 1.5 x the ULN
f. Serum creatinine ≤ 1.5 x the ULN
g. International normalized ratio (INR) ≤ 1.5 x ULN and partial thromboplastin time (PTT) or activated partial thromboplastin time (aPTT) ≤ 1.5 x ULN unless
receiving treatment with therapeutic anticoagulation. Patients being treated with anticoagulant (e.g., heparin), will be allowed to participate provided no prior evidence of an underlying abnormality in these parameters exists. Close monitoring of at least weekly evaluations will be performed until INR and PTT are stable based on a pre-dose measurement as defined by the local standard of
care.
h. Platelet count ≥ 100000 /mm3, hemoglobin (Hb) ≥ 9 g/dL, absolute neutrophil count (ANC) ≥ 1500/mm3. Blood transfusion to meet the inclusion criteria will not be allowed.
 - Estimated creatinine clearance (CLcr) ≥ 30 mL/min as calculated using the Cockroft-Gault (C-G) equation.
 - Women of childbearing potential must have a blood or urine pregnancy test performed a maximum of 7 days before start of study treatment, and a negative result must be documented before start of study treatment.
 - Women of childbearing potential and men must agree to use adequate contraception before entering the program until at least 8 weeks after the last study drug administration.
Exclusion Criteria
- Unable to swallow oral medications.
 - Prior use of regorafenib
 - Previous assignment to treatment during this study. Patients permanently withdrawn from study participation will not be allowed to re-enter study.
 - Uncontrolled hypertension (systolic blood pressure > 140 millimeters of mercury (mmHg) or diastolic pressure > 90 mmHg despite optimal medical management)
 - Active or clinically significant cardiac disease including:
a. Congestive heart failure – New York Heart Association (NYHA) > Class II
b. Active coronary artery disease
c. Cardiac arrhythmias requiring anti-arrhythmic therapy other than beta blockers
or digoxin
d. Unstable angina (anginal symptoms at rest), new-onset angina within 3 months before randomization, or myocardial infarction within 6 months before randomization
 - Evidence or history of bleeding diathesis or coagulopathy, irrespective of severity
 - Any hemorrhage or bleeding event > National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) Grade 3 within 4 weeks prior to the start of study medication
- Arterial or venous thrombotic or embolic events such as cerebrovascular accident (including transient ischemic attacks), deep vein thrombosis or pulmonary embolism within 6 month before the start of study medication (except for adequately treated catheter-related venous thrombosis occurring more than one month before the start of study medication)
- Previously untreated or concurrent cancer that is distinct in primary site or histology from colorectal cancer except cervical cancer in-situ, treated basal cell carcinoma, or superficial bladder tumor. Patients surviving a cancer that was curatively treated and without evidence of disease for more than 3 years before randomization are allowed.All cancer treatments must be completed at least 3 years prior to study entry (i.e.,signature date of the ICF).

Trial Summary

Enrollment Goal
23
Trial Dates
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Phase
4
Could I receive a placebo?
No
Products
Stivarga (Regorafenib, BAY73-4506)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

Investigative Site

Gettysburg, United States, 17325

Status
Completed
 
Locations

Investigative Site

Skokie, United States, 60077

Status
Completed
 
Locations

Investigative Site

Lake City, United States, 32024

Status
Completed
 
Locations

Investigative Site

Kingsport, United States, 37660

Status
Terminated
 
Locations

Investigative Site

Lafayette, United States, 47905

Status
Terminated
 
Locations

Investigative Site

Portsmouth, United States, 23704

Status
Terminated
 
Locations

Investigative Site

Canton, United States, 44718

Status
Terminated
 
Locations

Investigative Site

Fayetteville, United States, 28304

Status
Terminated
 
Locations

Investigative Site

Bristol, United States, 24201

Status
Terminated
 
Locations

Investigative Site

Anaheim, United States, 92801

Status
Completed
 
Locations

Investigative Site

Orange, United States, 92668

Status
Terminated
 
Locations

Investigative Site

Skokie, United States, 60076

Status
Completed
 
Locations

Investigative Site

Houston, United States, 77024

Status
Completed
 
Locations

Investigative Site

Anniston, United States, 36207

Status
Completed
 
Locations

Investigative Site

Columbia, United States, 21044

Status
Completed
 
Locations

Investigative Site

Tulsa, United States, 74146

Status
Completed
 
Locations

Investigative Site

Tyler, United States, 75701

Status
Completed
 

Trial Design