Endometriosis

Inclusion Criteria

PART A
 - Postmenopausal state, revealed by 
a) Medical history. One of the following:
 --- Natural menopause at least 12 months prior to first study drug administration,
 --- Surgical menopause by bilateral ovariectomy at least 3 months prior to first study drug administration) or
 --- Hysterectomy
AND 
b) Follicle-stimulating hormone (FSH) > 40 IU/L
 - Age 45 to 68 years

PART B
 - Healthy female subjects
 -- Sterilized by tubal-ligation
 -- Pre-treatment menstrual cycle assessed as ovulatory
 - Completion of more than 3 menstrual cycles after delivery, abortion or lactation
 - Age 18 to 48 years

Exclusion Criteria

- Body mass index (kg/m2) greater or equal 32 (or less or equal 18)
 - Smoking: PART A: non-smoking; PART B: less than 10 cigarettes per day
 - Use of medicines including but not restricted to contraceptives and NSAIDs (details regarding previous use of medicines provided by the study center)
 - Ability and willingness to adhere to restrictions regarding diet (PART A and B) and to eat standardised meals (PART A only)
 - Significant diseases of the heart, gastrointestinal tract and/or liver and/or kidney and/or reproductive organs (present or in the past; details will be provided by the study center)
 - Recent infectious diseases (details will be provided by the study center)
 - Migraine or depression
 - Thyroid disease which requires treatment
 - Metabolic disorders, for example diabetes mellitus or hypertriglyceridemia
 - Drug or alcohol abuse; regular consumption of more than 800 ml of beer per day (or other drinks resembling 40 g of alcohol)