Pharmacokinetics

Inclusion Criteria

- Healthy male subjects
- Age: 18 to 45 years (inclusive)
- Body mass index (BMI) : ≥ 18 and ≤ 29.9 kg/m²
- Race: White

Exclusion Criteria

- Subjects with conspicuous findings in medical history and pre-study examination in the opinion of the investigator
- A history of relevant diseases of vital organs, of the central nervous system or other organs
- Known renal or liver insufficiency
- Subjects with diagnosed malignancy, psychiatric disorders, or thyroid disorders (evaluated by medical history, physical examination, clinical symptoms, and assessment of thyroid stimulating hormone at screening)
- Medical disorder that would impair the subject’s ability to complete the study in the opinion of the investigator
- Incompletely cured pre-existing diseases for which it can be assumed that the absorption, distribution, metabolism, elimination and effects of the study drugs will not be normal
- Relevant diseases within the last 4 weeks prior to the first study drug administration
- Smoking more than 10 cigarettes daily and/ or inability to refrain from smoking on the profile days until 8 h after administration
- Vegetarian or special diets preventing the subjects from eating the standard meals during the study, especially the high-fat high-calorie American breakfast or reluctance to ingest it