Clinical Pharmacology

Inclusion Criteria

- Healthy male subject
-  Age: 21 to 45 years (inclusive) at the first screening examination / visit
- Chinese healthy male subject
- Body weight ≥50 kg, Body Mass Index (BMI) was between 19 and 27 kg/m² (inclusive)

Exclusion Criteria

- Incompletely cured pre-existing diseases for which it could be assumed that the absorption, distribution, metabolism, elimination and effects of the study drugs were not normal
- Known hypersensitivity to the study drugs (active substances or excipients of the preparations) or to the study drugs, the control agent and / or to inactive constituents
- Known severe allergies, non-allergic drug reactions, or multiple drug allergies
- Relevant diseases within the last 4 weeks prior to the first study drug administration
- Febrile illness within 1 week before the first study drug administration
- Regular use of medicines
- Regular use of therapeutic or recreational drugs
- Use of systemic or topical medicines or substances which could oppose the study objectives or which could influence them within 4 weeks before the first study drug administration
- Smoking more than 20 cigarettes daily
- Regular daily consumption of more than 800 mL of usual beer or the equivalent quantity of approximately 32 g of alcohol in another form