Clinical Pharmacology

Inclusion Criteria

- Age: 18 to 45 years or  >= 65 years (according to the group the subjects had been assigned to).
- Race : white.
- Body mass index (BMI): above/equal to 18.0 kg/m2 and below/equal to 29.9 kg/m2.

Exclusion Criteria

- Medical disorder, condition, or history of such that would have impaired the subjects ability to participate or complete this study, in the opinion of the investigator or the sponsor.
- Incompletely cured pre-existing diseases, for which it was assumed that the absorption, distribution, metabolism, elimination, and effects of the study drugs would not be normal.
- Relevant diseases within the last 4 weeks prior to the first study drug administration.
- No past or present hepatic impairment.
- No past renal impairment.
- For the population of young female and young male subjects: no present renal impairment, including but not limited to glomerulonephritis, glomerulosclerosis, diabetic nephropathy, as determined by an estimated glomerular filtration rate (eGFR) >90 mL/min/1.73 m2, and normal urine tests.
- For the population of elderly female and elderly male subjects: no present renal impairment, including but not limited to glomerulonephritis; glomerulosclerosis; diabetic nephropathy, as determined by eGFR >30 mL/min/1.73 m2; normal urine tests; urinary protein-to-creatinine ratio <=200 mg/g (creatinine); and urinary albumin-to-creatinine ratio <30 mg/g (creatinine).
- No past or present diagnosed maligna s (active substances or excipients of the preparations).
- Known severe allergies, non-allergic drug reactions, or multiple drug allergies.