check_circleStudy Completed
Prevention & control
Bayer Identifier:
15786
ClinicalTrials.gov Identifier:
EudraCT Number:
EU CT Number:
Not Available
Rivaroxaban for the prevention of major cardiovascular events in coronary or peripheral artery disease
Trial purpose
The primary objectives of this study are:
• To determine whether rivaroxaban 2.5 mg twice daily (bid) + aspirin 100 mg once daily (od) compared with aspirin 100 mg od reduces the risk of a composite of myocardial infarction, stroke, or cardiovascular death in subjects with coronary artery disease (CAD) or peripheral artery disease (PAD);
• To determine whether rivaroxaban 5 mg bid compared with aspirin 100 mg od reduces the risk of a composite of myocardial infarction, stroke or cardiovascular death in subjects with CAD or PAD.
• To determine whether rivaroxaban 2.5 mg twice daily (bid) + aspirin 100 mg once daily (od) compared with aspirin 100 mg od reduces the risk of a composite of myocardial infarction, stroke, or cardiovascular death in subjects with coronary artery disease (CAD) or peripheral artery disease (PAD);
• To determine whether rivaroxaban 5 mg bid compared with aspirin 100 mg od reduces the risk of a composite of myocardial infarction, stroke or cardiovascular death in subjects with CAD or PAD.
Key Participants Requirements
Sex
BothAge
18 - N/ATrial summary
Enrollment Goal
27395Trial Dates
February 2013 - June 2021Phase
Phase 3Could I Receive a placebo
NoProducts
Xarelto (Rivaroxaban, BAY59-7939)Accepts Healthy Volunteer
NoWhere to participate
Status | Institution | Location |
---|---|---|
Completed | Lugano, 6900, Switzerland | |
Completed | Forlì Cesena, 47100, Italy | |
Completed | Trieste, 34149, Italy | |
Completed | Catania, 95126, Italy | |
Completed | Arezzo, 52044, Italy | |
Completed | Foggia, 71100, Italy | |
Completed | Caserta, 81027, Italy | |
Completed | Lecce, 73042, Italy | |
Completed | Firenze, 50053, Italy | |
Completed | Cremona, 26100, Italy | |
Completed | Udine, 33038, Italy | |
Completed | Perugia, 06024, Italy | |
Completed | Terni, 05100, Italy | |
Completed | LIMOGES CEDEX, 87042, France | |
Completed | NICE, 06280, France | |
Completed | PARIS CEDEX 15, 75908, France | |
Completed | Paris, 75018, France | |
Completed | Bunkyo-ku, 113-8431, Japan | |
Completed | Toyoake, 470-1192, Japan | |
Completed | PARIS, 75012, France | |
Completed | MONTPELLIER, 34059, France | |
Completed | Komatsushima, 773-8502, Japan | |
Completed | Itabashi-ku, 173-8610, Japan | |
Completed | Osaka, 530-0001, Japan | |
Completed | Yokohama, 232-0024, Japan | |
Completed | Osaka, 543-0035, Japan | |
Completed | Zefat, 1311001, Israel | |
Completed | Holon, 5822012, Israel | |
Completed | Tel Aviv, 64239, Israel | |
Completed | Afula, 1834111, Israel | |
Completed | Bnei Brak, Israel | |
Completed | Haifa, 3436212, Israel | |
Completed | Ashkelon, 7830604, Israel | |
Completed | Nahariya, 2210001, Israel | |
Completed | Tel Aviv, Israel | |
Completed | Gifu, 500-8717, Japan | |
Completed | Hamilton, L8L 2X2, Canada | |
Completed | Hamilton, L8L 2X2, Canada | |
Completed | Debrecen, 4032, Hungary | |
Completed | Pecs, 7624, Hungary | |
Completed | Szekszard, 7100, Hungary | |
Completed | Balatonfured, 8230, Hungary | |
Completed | Budapest, H-1125, Hungary | |
Completed | Mosonmagyarovar, 9200, Hungary | |
Completed | Szekesfehervar, 8000, Hungary | |
Completed | Budapest, H-1096, Hungary | |
Completed | Budapest, 1085, Hungary | |
Completed | Osaka, 558-8558, Japan | |
Completed | Ballinasloe, Ireland | |
Completed | Dublin, 9, Ireland | |
Completed | Galway, Ireland | |
Completed | Dublin, D08 NHY1, Ireland | |
Completed | Dublin, D07 R2WY, Ireland | |
Completed | Cork, Ireland | |
Completed | ARNHEM, 6815 AD, Netherlands | |
Completed | Campina Grande do Sul, 83430 000, Brazil | |
Completed | Porto Alegre, 90020-090, Brazil | |
Completed | Campinas, 13010-001, Brazil | |
Completed | Blumenau, 89010 500, Brazil | |
Completed | Goiania, 74223 130, Brazil | |
Completed | Oshawa, L1J 2K1, Canada | |
Completed | Oakville, L6K 3W7, Canada | |
Completed | Stockholm, 171 76, Sweden | |
Completed | Östersund, 831 83, Sweden | |
Completed | Göteborg, 413 45, Sweden | |
Completed | Kristianstad, 291 85, Sweden | |
Completed | Göteborg, 413 45, Sweden | |
Completed | Skellefteå, 931 86, Sweden | |
Completed | Stockholm, 111 35, Sweden | |
Completed | Örebro, 701 85, Sweden | |
Completed | Stockholm, 141 86, Sweden | |
Completed | Helsingborg, 251 87, Sweden | |
Completed | Stockholm, 114 46, Sweden | |
Completed | Vällingby, 162 68, Sweden | |
Completed | Trebic, 674 01, Czechia | |
Completed | Trinec, 739 61, Czechia | |
Completed | Olomouc, 779 00, Czechia | |
Withdrawn | Mlada Boleslav, 293 50, Czechia | |
Completed | Kolin, 280 02, Czechia | |
Completed | Pardubice, 530 03, Czechia | |
Completed | Praha 2, 128 08, Czechia | |
Completed | Praha 4, 140 21, Czechia | |
Completed | Jablonec nad Nisou, 466 60, Czechia | |
Completed | Slany, 274 01, Czechia | |
Completed | Susice, 342 01, Czechia | |
Completed | Uherske Hradiste, 686 68, Czechia | |
Completed | Ostrava, 728 80, Czechia | |
Completed | Praha 10, 100 34, Czechia | |
Completed | Brno, 625 00, Czechia | |
Completed | Praha 6, 169 02, Czechia | |
Completed | Hradec Kralove, 500 05, Czechia | |
Completed | Ceske Budejovice, 370 01, Czechia | |
Completed | Olomouc, 779 00, Czechia | |
Completed | Praha 5, 150 30, Czechia | |
Completed | Praha 2, 128 08, Czechia | |
Completed | Brno, 656 91, Czechia | |
Completed | Praha 5, 150 06, Czechia | |
Completed | Praha 10, 100 34, Czechia | |
Completed | Rosario, 2000, Argentina | |
Completed | La Plata, 1900, Argentina | |
Completed | Zárate, B2800DGH, Argentina | |
Completed | Santa Fe, S3000FWO, Argentina | |
Completed | San Miguel de Tucumán, 4000, Argentina | |
Completed | Coronel Suarez, B7540GHD, Argentina | |
Completed | Buenos Aires, C1119ACN, Argentina | |
Completed | Bahía Blanca, 8000, Argentina | |
Completed | Quilmes, 1878, Argentina | |
Completed | Adrogue, 1846, Argentina | |
Completed | Salta, A4406CLA, Argentina | |
Completed | Mar del Plata, B7600FZN, Argentina | |
Completed | San Martín, 1650, Argentina | |
Completed | Buenos Aires, C1428ART, Argentina | |
Completed | Córdoba, X5000AAW Córdoba, Argentina | |
Completed | Ramos Mejía, B1740ETD, Argentina | |
Completed | La Plata, B1902AGY, Argentina | |
Completed | Venado Tuerto, S2600KUE, Argentina | |
Completed | San Nicolás, B2900DMH, Argentina | |
Completed | Córdoba, X5000AAX, Argentina | |
Completed | Rafaela, S2300MMA, Argentina | |
Completed | Villa María, X5900JKA, Argentina | |
Completed | Junín, B6000BHA, Argentina | |
Completed | Santa Rosa, 6300, Argentina | |
Completed | San luis, 5700, Argentina | |
Completed | Villa Allende, Argentina | |
Completed | San Juan, 5400, Argentina | |
Completed | Rosario, 2000, Argentina | |
Completed | Corrientes, 3400, Argentina | |
Completed | Munro, B1605DSX, Argentina | |
Completed | São Paulo, 04012-909, Brazil | |
Completed | Pelotas, 96015-290, Brazil | |
Completed | Porto Alegre, 90840-440, Brazil | |
Completed | Belo Horizonte, 30150-240, Brazil | |
Completed | Campinas, 13060904, Brazil | |
Completed | São José do Rio Preto, 15090, Brazil | |
Completed | Votuporanga, Brazil | |
Completed | Canoas, 92425-900, Brazil | |
Completed | Campinas, 13020-421, Brazil | |
Completed | Uberlândia, 38400-368, Brazil | |
Completed | Porto Alegre, 90.620-001, Brazil | |
Completed | São Paulo, 04012-909, Brazil | |
Completed | Sao Paulo, 05403-000, Brazil | |
Completed | São Paulo, 04012-909, Brazil | |
Completed | São José do Rio Preto, 15015-750, Brazil | |
Completed | Curitiba, 80730-150, Brazil | |
Completed | BREDA, 4818 CK, Netherlands | |
Completed | HOORN, 1624 NP, Netherlands | |
Completed | HELMOND, 5707 HA, Netherlands | |
Completed | LEEUWARDEN, 8901 BR, Netherlands | |
Completed | AMSTERDAM, 1091 AC, Netherlands | |
Completed | HEERLEN, 6401 CX, Netherlands | |
Completed | DEVENTER, 7416 SE, Netherlands | |
Completed | GORINCHEM, 4204 AA, Netherlands | |
Completed | SNEEK, 8601 ZK, Netherlands | |
Completed | GOUDA, 2803 HH, Netherlands | |
Completed | ROERMOND, 6043 CV, Netherlands | |
Completed | HOOGEVEEN, 7909 AA, Netherlands | |
Completed | ROOSENDAAL, 4708 AE, Netherlands | |
Completed | NIJMEGEN, 6532 SZ, Netherlands | |
Completed | ROTTERDAM, 3083 AN, Netherlands | |
Completed | Galway, Ireland | |
Completed | Kasuga, 816-0864, Japan | |
Completed | Kobe, 654-0026, Japan | |
Completed | Grimsby, L3M 1P3, Canada | |
Completed | Udine, Italy | |
Completed | Udine, 33057, Italy | |
Completed | Isernia, 86170, Italy | |
Completed | Ancona, 60126, Italy | |
Completed | Palermo, 90146, Italy | |
Completed | Cambridge, N1R 7R1, Canada | |
Completed | Würzburg, 97078, Germany | |
Completed | Magdeburg, 39120, Germany | |
Completed | Berlin, 13353, Germany | |
Completed | Frankfurt, 65929, Germany | |
Completed | Bielefeld, 33604, Germany | |
Completed | Nürnberg, 90402, Germany | |
Completed | Kassel, 34128, Germany | |
Completed | Berlin, 12559, Germany | |
Completed | Frankfurt, 60596, Germany | |
Completed | Kyoto, 600-8558, Japan | |
Completed | Quebec, G1V 4G5, Canada | |
Completed | Moncton, E1G 1A7, Canada | |
Completed | Dortmund, 44137, Germany | |
Completed | Warendorf, 48231, Germany | |
Completed | Osaka, 530-8480, Japan | |
Completed | Stamford, 06905, United States | |
Completed | Winnipeg, R2V 4W3, Canada | |
Completed | Burlington, L7R 1E2, Canada | |
Completed | Kielce, 25-315, Poland | |
Completed | Krakow, 31-534, Poland | |
Completed | Krakow, 31-271, Poland | |
Completed | Tarnow, 33-100, Poland | |
Completed | Gdansk, 80 -126, Poland | |
Completed | Lodz, 91-347, Poland | |
Completed | Wroclaw, 53-114, Poland | |
Completed | Krakow, 31-501, Poland | |
Completed | Winnipeg, R2H 0R8, Canada | |
Completed | DEN BOSCH, 5223 GZ, Netherlands | |
Completed | ZWOLLE, 8011 JW, Netherlands | |
Completed | DELFT, 2625 AD, Netherlands | |
Completed | Tiel, 4002 WP, Netherlands | |
Completed | Temuco, 2170000, Chile | |
Completed | Santiago, Chile | |
Completed | Viña del Mar, 2570017, Chile | |
Completed | Osorno, 5311092, Chile | |
Completed | Burlington, L7M 4Y1, Canada | |
Completed | Hamilton, L8M 1K7, Canada | |
Completed | Trumbull, 06611, United States | |
Completed | Norwalk, 06851, United States | |
Completed | Anaheim, 92801, United States | |
Completed | Jacksonville Beach, 32250, United States | |
Completed | Haverhill, 01830, United States | |
Completed | Largo, 33770, United States | |
Completed | Langhorne, 19047, United States | |
Completed | Pinehurst, 28374, United States | |
Completed | Asahikawa, 070-8610, Japan | |
Completed | Kishiwada, 596-0042, Japan | |
Completed | Alpena, 49707, United States | |
Completed | Santa Rosa, 95494, United States | |
Completed | Coral Springs, 33065, United States | |
Completed | Yardley, 19067, United States | |
Completed | Mobile, 36608, United States | |
Completed | Clearwater, 33756, United States | |
Completed | Kalispell, 59901, United States | |
Completed | Saratoga Springs, 12866, United States | |
Completed | Cortlandt Manor, 10567, United States | |
Completed | Safety Harbor, 34695, United States | |
Completed | Kingston, 12401, United States | |
Completed | Birmingham, 35294, United States | |
Completed | Sandusky, 44870, United States | |
Completed | Seattle, 98195, United States | |
Completed | Puyallup, 98372, United States | |
Completed | Elyria, 44035, United States | |
Completed | West Des Moines, 50266, United States | |
Completed | Northridge, 91324, United States | |
Completed | New Port Richey, 34653, United States | |
Completed | Sarasota, 34239, United States | |
Completed | Spokane, 99204, United States | |
Completed | Meridian, 83716, United States | |
Completed | San Antonio, 78229, United States | |
Completed | Laguna Hills, 92653, United States | |
Completed | Sylmar, 91342, United States | |
Completed | Toledo, 43606, United States | |
Completed | St. Louis, 63136, United States | |
Completed | Brampton, L6W 2X7, Canada | |
Completed | Observatory, 7925, South Africa | |
Completed | Bloemfontein, 9300, South Africa | |
Completed | Somerset West, 7130, South Africa | |
Completed | Port Elizabeth, 6014, South Africa | |
Completed | Worcester, 6850, South Africa | |
Completed | Pinelands, 7405, South Africa | |
Completed | Cape Town, 7531, South Africa | |
Completed | Pinelands, 7503, South Africa | |
Completed | Somerset West, 7130, South Africa | |
Completed | Johannesburg, 2157, South Africa | |
Completed | Peterborough, K9J 0B2, Canada | |
Completed | Mississauga, L5K 2L3, Canada | |
Completed | Quebec, G1V 4G5, Canada | |
Completed | Levis, G6V 4Z5, Canada | |
Completed | Waterloo, ON N2T 0C1, Canada | |
Completed | Newmarket, L3Y 8C3, Canada | |
Completed | Kiev, 03 049, Ukraine | |
Completed | Kiev, 02660, Ukraine | |
Completed | Kharkiv, 61039, Ukraine | |
Completed | Kharkiv, 61176, Ukraine | |
Completed | Kharkiv, 61002, Ukraine | |
Completed | Galway, Ireland | |
Completed | Haifa, 3109601, Israel | |
Completed | Sopron, 9400, Hungary | |
Completed | Budapest, 1115, Hungary | |
Completed | Balatonfured, 8230, Hungary | |
Completed | Barranquilla, Colombia | |
Completed | Barranquilla, Colombia | |
Completed | Oshawa, L1J 2J9, Canada | |
Completed | Providencia, 7500520, Chile | |
Completed | San Miguel, 8910108, Chile | |
Completed | Valdivia, Chile | |
Completed | Concepción, 4070038, Chile | |
Completed | Victoria, V8R 4R2, Canada | |
Completed | Scarborough, M1E 5E9, Canada | |
Completed | Newmarket, L3Y 2P6, Canada | |
Completed | Ottawa, K2H 8T5, Canada | |
Completed | Ostrava, 708 52, Czechia | |
Completed | Floridablanca, 681004, Colombia | |
Completed | Wolverhampton, WV10 0QP, United Kingdom | |
Completed | Nuneaton, CV10 7DJ, United Kingdom | |
Completed | Portadown, United Kingdom | |
Completed | Harrow, HA1 3UJ, United Kingdom | |
Completed | Basildon, SS16 5NL, United Kingdom | |
Completed | Blackpool, FY4 3AD, United Kingdom | |
Completed | Belfast, BT16 1RH, United Kingdom | |
Completed | Worcester, WR5 1DD, United Kingdom | |
Completed | Hardwick, TS29 6NH, United Kingdom | |
Completed | Londonderry Co. Londonderry, BT47 6SB, United Kingdom | |
Completed | Cesky Krumlov, 381 27, Czechia | |
Completed | Espinal, Colombia | |
Completed | Cartagena, Colombia | |
Completed | Pereira, Colombia | |
Completed | Armenia, Colombia | |
Completed | Liberec, 460 63, Czechia | |
Completed | Batu Caves, Selangor, 68100, Malaysia | |
Completed | Sungai Buloh Selangor, 47000, Malaysia | |
Completed | Kedah, 05460, Malaysia | |
Withdrawn | Kelantan, 15200, Malaysia | |
Completed | Kuala Lumpur, 59100, Malaysia | |
Completed | Quezon City, 1109, Philippines | |
Completed | Vantaa, 01600, Finland | |
Completed | Brno, 656 91, Czechia | |
Completed | Ostrava, 708 52, Czechia | |
Completed | Bologna, 40133, Italy | |
Completed | Windsor, N8X 5A6, Canada | |
Completed | Sherbrooke, J1H 5N4, Canada | |
Completed | Kuopio, 70100, Finland | |
Completed | Kuusankoski, 45700, Finland | |
Completed | Fukuoka, 814-0180, Japan | |
Completed | Tampere, 33200, Finland | |
Completed | Zlin, 762 75, Czechia | |
Completed | Praha 4, 140 21, Czechia | |
Completed | Praha 5, 150 30, Czechia | |
Completed | Manizales, Colombia | |
Completed | Jeju, 690767, Korea, Republic Of | |
Completed | Montreal, H3G 1A4, Canada | |
Completed | New Westminster, V3L 3W4, Canada | |
Completed | Thetford Mines, G6G 2V4, Canada | |
Completed | Sudbury, P3E 1H5, Canada | |
Completed | Calgary, T2N 4Z6, Canada | |
Completed | Santafe de Bogotá, Colombia | |
Completed | Cambridge, N1R 6V6, Canada | |
Completed | Zaporozhye, 69118, Ukraine | |
Completed | Lviv, 79659, Ukraine | |
Completed | Simferopol, 95006, Ukraine | |
Completed | Barranquilla, Colombia | |
Completed | Pasto, Colombia | |
Completed | Cartagena, Colombia | |
Completed | Sioux Falls, 57108, United States | |
Completed | Davenport, 52803, United States | |
Completed | DAEJEON, 302-718, Korea, Republic Of | |
Completed | Seongnam-si, 463-707, Korea, Republic Of | |
Completed | Seoul, 134-727, Korea, Republic Of | |
Completed | Busan, 614-735, Korea, Republic Of | |
Completed | Seoul, 110-744, Korea, Republic Of | |
Completed | Seoul, 03722, Korea, Republic Of | |
Completed | Seoul, 150-713, Korea, Republic Of | |
Completed | Goyang-si, 10326, Korea, Republic Of | |
Completed | Quezon City, NCR 1100, Philippines | |
Completed | Iloilo City, 5000, Philippines | |
Completed | Manila, 1000, Philippines | |
Completed | Durham, 27713, United States | |
Completed | Houston, 77030-4298, United States | |
Completed | Hazel Crest, 60429, United States | |
Completed | New Brunswick, 08901, United States | |
Completed | Montreal, H2W 1T8, Canada | |
Completed | Montreal, H2W 1T8, Canada | |
Completed | Trois-Rivieres, G8Z 4K4, Canada | |
Completed | Chicoutimi, G7H 5H6, Canada | |
Completed | Pavia, 27100, Italy | |
Completed | Atlantis, 33462, United States | |
Completed | Tokorozawa, 359-1141, Japan | |
Completed | SAINT-PRIEST-EN-JAREZ, 42270, France | |
Completed | São Paulo, 01506-001, Brazil | |
Completed | Matão, 15990-060, Brazil | |
Completed | Porto Alegre, Brazil | |
Completed | Uberaba, 38025-260, Brazil | |
Completed | Sao Paulo, 05403-000, Brazil | |
Completed | Akishima, 196-0003, Japan | |
Completed | Onomichi, 722-8503, Japan | |
Completed | Matsudo, 270-2251, Japan | |
Completed | Sapporo, 006-0852, Japan | |
Completed | Takatsuki, 569-1096, Japan | |
Completed | Fukuoka, 812-0033, Japan | |
Completed | Wonju, 26426, Korea, Republic Of | |
Completed | Naha, 902-8511, Japan | |
Completed | Chiba, 263-0043, Japan | |
Completed | Nagoya, 453-8511, Japan | |
Completed | Miura-gun, 240-0116, Japan | |
Completed | Shimonoseki, 750-0061, Japan | |
Completed | Kisarazu, 292-8535, Japan | |
Completed | Sapporo, 060-0004, Japan | |
Completed | Imabari, 794-0006, Japan | |
Completed | Laval, H7M 3L9, Canada | |
Completed | Asahikawa, 070-0038, Japan | |
Completed | GRONINGEN, 9721 SW, Netherlands | |
Completed | EDE, 6716 RP, Netherlands | |
Completed | ROTTERDAM, 3045 PM, Netherlands | |
Completed | MEPPEL, 7943 KA, Netherlands | |
Completed | APELDOORN, 7334 DZ, Netherlands | |
Completed | DOETINCHEM, 7009 BL, Netherlands | |
Completed | Sapporo, 006-8555, Japan | |
Completed | Manila, Philippines | |
Completed | Metro Manila, 1502, Philippines | |
Completed | Palawan, 5300, Philippines | |
Completed | Dasmarinas, 4114, Philippines | |
Completed | Pasig city, 1605, Philippines | |
Completed | Quezon City, 1102, Philippines | |
Completed | Cebu City, 6000, Philippines | |
Completed | Moscow, 101990, Russian Federation | |
Completed | Moscow, 107084, Russian Federation | |
Completed | Moscow, 117556, Russian Federation | |
Completed | Zhukovskiy, 140160, Russian Federation | |
Completed | Kemerovo, 650002, Russian Federation | |
Completed | Novosibirsk, 630089, Russian Federation | |
Completed | Tomsk, 634012, Russian Federation | |
Completed | Tomsk, 634012, Russian Federation | |
Completed | Barnaul, 656038, Russian Federation | |
Completed | Barnaul, 656038, Russian Federation | |
Completed | Moscow, 119435, Russian Federation | |
Completed | Moscow, 111539, Russian Federation | |
Completed | Moscow, 121309, Russian Federation | |
Completed | Moscow, 127206, Russian Federation | |
Completed | Hamburg, 20099, Germany | |
Completed | Praha 13, 158 00, Czechia | |
Completed | Bratislava, 811 04, Slovakia | |
Withdrawn | Kosice, 04011, Slovakia | |
Completed | Nitra, 94901, Slovakia | |
Completed | Presov, 080 81, Slovakia | |
Completed | Bratislava, 813 69, Slovakia | |
Completed | Kosice, 040 22, Slovakia | |
Completed | Vrable, 952 01, Slovakia | |
Completed | Osaka, 540-0006, Japan | |
Completed | Stockholm, 171 76, Sweden | |
Completed | Brescia, 25123, Italy | |
Completed | Miyako-gun, 800-0344, Japan | |
Completed | Sagamihara, 252-0375, Japan | |
Completed | Onga-gun, 811-4342, Japan | |
Completed | Temuco, 4791348, Chile | |
Completed | Santiago, Chile | |
Completed | Temuco, 4781156, Chile | |
Completed | Kaga, 922-8522, Japan | |
Completed | Matsuyama, 790-0062, Japan | |
Completed | Murdoch, 6150, Australia | |
Completed | New Lambton Heights, 2305, Australia | |
Completed | Hobart, 7000, Australia | |
Completed | Gosford, 2250, Australia | |
Completed | Redcliffe, 4020, Australia | |
Completed | Brisbane, 4064, Australia | |
Completed | Prahran, 3181, Australia | |
Completed | Melbourne, 3181, Australia | |
Withdrawn | Melbourne, 3004, Australia | |
Completed | Geelong, 3220, Australia | |
Completed | Bruce, 2617, Australia | |
Completed | Melbourne, 3052, Australia | |
Completed | Launceston, 7250, Australia | |
Completed | Adelaide, 5042, Australia | |
Completed | Nedlands, 6009, Australia | |
Completed | Gifu, 500-8384, Japan | |
Completed | Tomakomai, 053-8567, Japan | |
Completed | Takarazuka, 665-0873, Japan | |
Completed | Bellevue, 98004-4623, United States | |
Completed | Dallas, 75216-7167, United States | |
Completed | Doylestown, 18901, United States | |
Completed | Doylestown, 18901, United States | |
Completed | Arlington Heights, 60005, United States | |
Completed | Bucaramanga, Colombia | |
Completed | Ravenna, 48010, Italy | |
Completed | Merlo, B1722COV, Argentina | |
Completed | Rosario, Argentina | |
Completed | Brisbane, 4029, Australia | |
Completed | Woolloongabba, 4102, Australia | |
Completed | Cali, 760032, Colombia | |
Completed | Osaka, 559-0012, Japan | |
Completed | Torrance, 90502-2004, United States | |
Completed | Terrebonne, J6V 2H2, Canada | |
Completed | Winnipeg, R2H 2A6, Canada | |
Completed | Saint John, E2L 4L2, Canada | |
Completed | Barranquilla, Colombia | |
Withdrawn | Chía, Colombia | |
Completed | Xi'an, 710061, China | |
Completed | Beijing, 100029, China | |
Completed | Beijing, 100730, China | |
Completed | Beijing, 100029, China | |
Completed | Beijing, 100038, China | |
Completed | Beijing, China | |
Completed | Guangzhou, 510100, China | |
Completed | Shanghai, 200080, China | |
Completed | Shenyang, 110004, China | |
Completed | Changchun, 130000, China | |
Completed | Changchun, 130033, China | |
Completed | Hangzhou, 310003, China | |
Completed | Chengdu, 610041, China | |
Completed | Beijing, 100088, China | |
Completed | Wudan, 430022, China | |
Completed | Beijing, China | |
Withdrawn | Changsha, 410008, China | |
Completed | Maebashi, 371-0821, Japan | |
Completed | København, DK-2400, Denmark | |
Completed | Hellerup, 2900, Denmark | |
Completed | Holbaek, 4300, Denmark | |
Completed | Hvidovre, 2650, Denmark | |
Completed | Kolding, 6000, Denmark | |
Completed | Kolding, 6000, Denmark | |
Completed | Shanghai, 200003, China | |
Completed | shanghai, 200001, China | |
Completed | Shanghai, 200032, China | |
Completed | Shanghai, 200025, China | |
Completed | Beijing, China | |
Completed | Nanjing, 210006, China | |
Completed | Beijing, 100034, China | |
Completed | Wenzhou, 325000, China | |
Completed | Hangzhou, 310016, China | |
Completed | Nanjing, 210029, China | |
Completed | Guangzhou, 510080, China | |
Completed | Shanghai, 200032, China | |
Completed | Changsha, 410011, China | |
Completed | København Ø, 2100, Denmark | |
Completed | Viborg, 8800, Denmark | |
Completed | Aalborg, DK-9000, Denmark | |
Completed | Aarhus N, 8200, Denmark | |
Completed | Wuhan, China | |
Completed | Córdoba, X5006IKK, Argentina | |
Completed | Córdoba, X5003DCE, Argentina | |
Completed | Córdoba, X5004CDT, Argentina | |
Completed | La Plata, B1902COS, Argentina | |
Completed | Vicente López, B1602ABQ, Argentina | |
Completed | Ciudad Auton. de Buenos Aires, C1405BUB, Argentina | |
Completed | Rosario, S2005PAF, Argentina | |
Completed | Ciudad Autón. de Buenos Aires, C1425AGC, Argentina | |
Completed | La Plata, B1902CNF, Argentina | |
Completed | Ciudad Auton. de Buenos Aires, C1181ACL, Argentina | |
Completed | Buenos Aires, C1440AAD, Argentina | |
Completed | San Miguel de Tucumán, T4000IFL, Argentina | |
Completed | Kyoto, 615-8256, Japan | |
Completed | Dresden, 01067, Germany | |
Completed | Bottrop, 46242, Germany | |
Completed | DRACHTEN, 9205 NN, Netherlands | |
Completed | Kyoto, 601-1495, Japan | |
Completed | Berlin, 12351, Germany | |
Completed | Shanghai, 200030, China | |
Completed | Kiev, 02 091, Ukraine | |
Completed | Lviv, 790 34, Ukraine | |
Completed | Ciudad Auton. de Buenos Aires, C1023AAB, Argentina | |
Completed | Córdoba, X5003DCP, Argentina | |
Completed | Santiago, 7500739, Chile | |
Completed | Halifax, B3H 3A7, Canada | |
Completed | Winnipeg, R3T 2E8, Canada | |
Completed | Kitakyushu, 802-8555, Japan | |
Completed | Crestview Hills, 41017-5460, United States | |
Completed | Kumamoto, 861-4193, Japan | |
Completed | West Bromich, B71 4HJ, United Kingdom | |
Completed | Northampton, NN1 5BD, United Kingdom | |
Completed | Middlesborough, TS4 3BW, United Kingdom | |
Completed | Stevenage, SG1 4AB, United Kingdom | |
Completed | Bucharest, 050098, Romania | |
Completed | Bucharest, 050098, Romania | |
Completed | Bucharest, 041915, Romania | |
Completed | Bucharest, 022322, Romania | |
Completed | Bucharest, 061114, Romania | |
Completed | Bucharest, 021659, Romania | |
Completed | BIRTINYA, 4575, Australia | |
Completed | Taree, 2430, Australia | |
Completed | Iasi, 700503, Romania | |
Completed | Targu Mures, 540124, Romania | |
Completed | Targu Mures, 540136, Romania | |
Completed | Brasov, 500326, Romania | |
Completed | Timisoara, 300310, Romania | |
Completed | Cluj Napoca, 400001, Romania | |
Completed | Bucuresti, 50659, Romania | |
Completed | Timisoara, 300254, Romania | |
Completed | Timisoara, 300310, Romania | |
Completed | Bucharest, 042122, Romania | |
Completed | Iasi, 700732, Romania | |
Completed | Bucharest, 022322, Romania | |
Completed | Bucharest, 011461, Romania | |
Completed | Hodonin, 695 01, Czechia | |
Completed | LEUVEN, 3000, Belgium | |
Completed | ROESELARE, 8800, Belgium | |
Completed | LIEGE, 4000, Belgium | |
Completed | CHARLEROI, 6000, Belgium | |
Completed | GENK, 3600, Belgium | |
Completed | BRUXELLES - BRUSSEL, 1070, Belgium | |
Completed | BONHEIDEN, 2820, Belgium | |
Completed | Bad Homburg, 61348, Germany | |
Completed | Leipzig, 04289, Germany | |
Completed | Wuppertal, 42117, Germany | |
Completed | Baltimore, 21215, United States | |
Completed | Quito, Ecuador | |
Completed | Guayaquil, Ecuador | |
Completed | Guayaquil, Ecuador | |
Completed | Quito, Ecuador | |
Completed | Sudbury, P3E 6C3, Canada | |
Completed | London, N6A 5A5, Canada | |
Completed | Ontario, P3E 5M4, Canada | |
Completed | London, N6G 2M1, Canada | |
Completed | Turku, FIN-20520, Finland | |
Completed | Laoag City, 2900, Philippines | |
Completed | Tacloban City, 6500, Philippines | |
Completed | Batangas, Philippines | |
Completed | Muntinlupa City, 1780, Philippines | |
Completed | Dagupan City, 2400, Philippines | |
Completed | Amiens cedex 1, 80054, France | |
Completed | BRUGGE, 8000, Belgium | |
Completed | KORTRIJK, 8500, Belgium | |
Completed | Dnipropetrovsk, 49 006, Ukraine | |
Completed | Zaporozhye, 69 000, Ukraine | |
Completed | Lviv, 79044, Ukraine | |
Completed | NIMES cedex 9, 30029, France | |
Completed | CLERMONT FERRAND, 63000, France | |
Completed | Montería, 230002, Colombia | |
Completed | Edmonton, T6G 2B7, Canada | |
Withdrawn | Evanston, 60201, United States | |
Completed | Jackson, 49201, United States | |
Completed | Kuala Lumpur, 50400, Malaysia | |
Completed | Palo Alto, 94304-1207, United States | |
Completed | Houston, 77030, United States | |
Completed | Toronto, M4N 3M5, Canada | |
Completed | ANTWERPEN, 2020, Belgium | |
Completed | HASSELT, 3500, Belgium | |
Completed | Moscow, 101990, Russian Federation | |
Completed | Selangor, 47000, Malaysia | |
Completed | Vinnitsa, 21029, Ukraine | |
Completed | Balatonfured, 8230, Hungary | |
Completed | Quito, Ecuador | |
Completed | Quito, Ecuador | |
Completed | Quito, Ecuador | |
Completed | Krakow, 30-002, Poland | |
Completed | Guayaquil, Ecuador |
Primary Outcome
- The first occurrence of the composite primary efficacy outcome, myocardial infarction (MI), stroke, or cardiovascular (CV) deathCount of participants and time from randomization to the first occurrence of the composite primary efficacy outcome, MI, stroke, or CV death were evaluated. Hazard ratios were calculated and reported as statistical analysis.date_rangeTime Frame:For each participant, the first occurrence of the composite primary efficacy outcome after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.enhanced_encryptionNoSafety Issue:
- The first occurrence of the primary safety outcome major bleeding based on a modification of the International Society on Thrombosis and Haemostasis (ISTH) criteriaModified ISTH major bleeding is defined as: i) Fatal bleeding, or ii) Symptomatic bleeding in a critical area or organ, such as intraarticular, intracranial, intramuscular with compartment syndrome, intraocular, intraspinal, liver, pancreas, pericardial, respiratory, retroperitoneal, adrenal gland or kidney; or bleeding into the surgical site requiring reoperation, or iii) Bleeding leading to hospitalization (major bleeding also includes presentation to an acute care facility with discharge on the same day). Count of participants and time from randomization to the first occurrence of the primary safety outcome major bleeding were evaluated. Hazard ratios were calculated and reported as statistical analysis.date_rangeTime Frame:For each participant, the first occurrence of modified ISTH major bleeding after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.enhanced_encryptionYesSafety Issue:
Secondary Outcome
- The first occurrence of myocardial infarction (MI), ischemic stroke, acute limb ischemia (ALI), or coronary heart disease (CHD) deathCount of participants and time from randomization to the first occurrence of MI, ischemic stroke, ALI, or CHD death were evaluated. Hazard ratios were calculated and reported as statistical analysis.date_rangeTime Frame:For each participant, the first occurrence of MI, ALI, or CHD death after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.enhanced_encryptionNoSafety Issue:
- The first occurrence of MI, ischemic stroke, ALI, or cardiovascular (CV) deathCount of participants and time from randomization to the first occurrence of MI, ischemic stroke, ALI, or CV death were evaluated. Hazard ratios were calculated and reported as statistical analysis.date_rangeTime Frame:For each participant, the first occurrence of MI, ischemic stroke, ALI, or CV death after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.enhanced_encryptionNoSafety Issue:
- All-cause mortalityCount of participants and time from randomization to death by all cause were evaluated. Hazard ratios were calculated and reported as statistical analysis.date_rangeTime Frame:For each participants, death by any cause after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.enhanced_encryptionNoSafety Issue:
Trial design
Trial Type
InterventionalIntervention Type
DrugTrial Purpose
PreventionAllocation
RandomizedBlinding
Double BlindAssignment
Parallel AssignmentTrial Arms
3