Trial Condition(s):

Prostatic Neoplasms

First-in-man dose escalation study of BAY2010112 in patients with prostate cancer

Bayer Identifier:

15590

ClinicalTrials.gov Identifier:

NCT01723475

EudraCT Number:

2012-000691-42

Study Completed

Trial Purpose

This is the first study where BAY2010112 is given to humans. Patients with castration resistant prostate cancer will be treated. Every patient will receive drug treatment, there is no placebo group. Patients will receive different dosages of BAY2010112 to determine the safety, tolerability and maximum tolerated dose (MTD) of BAY2010112.
The study will also assess the pharmacokinetics and the clinical efficacy of BAY2010112.
BAY2010112 will be given daily as subcutaneous injection or as continuous intravenous infusion. Treatment will be stopped if the tumor continues to grow, if side effects, which the patient cannot tolerate, occur or if the patient decides to exit treatment.

Inclusion Criteria
- Male subjects, aged >/= 18 years
- Subjects with histologically or cytologically proven
advanced castration-resistant prostate cancer (CRPC)
-- who failed at least 1 taxane regimen and are
refractory to abiraterone and/or enzalutamide therapy
OR
-- who have actively refused any treatment which would
be regarded standard.
- Subjects should have undergone bilateral orchiectomy
or should be on continuous androgen deprivation
therapy with a gonadotropin releasing hormone agonist
or antagonist.
- Subjects must have shown progressive disease after
discontinuation of anti-androgen therapy (i.e. flutamide,
bicalutamide or nilutamide) before study drug treatment.
- Total serum testosterone should be less than 50 ng/ml
or 1.7 nmol/L
- Evidence of progressive disease, defined as one or
more (Prostate Cancer Working Group 2 (PCWG2)
criteria):
- PSA level of at least 2 ng/ml that has risen on at least
2 successive occasions at least 1 week apart
- Nodal (in lymph nodes >/= 2cm) or visceral
progression as defined by Response Evaluation Criteria
in Solid Tumors (RECIST)
- Appearance of one more new lesions in bone scan
- Eastern Cooperative Oncology Group (ECOG)
performance status of 0 – 2
- Life expectancy of at least 3 months
Exclusion Criteria
- Any anticancer therapy or immunotherapy within 4 weeks of start of first dose
 - Confirmed history or current autoimmune disease or other diseases resulting in permanent immunosuppression or requiring permanent immunosuppressive therapy
 - Prior radiotherapy (local palliative radiotherapy is permitted)
 - History of allergic reactions to monoclonal antibody therapy
 - History of clinical significant cardiac disease: including  unstable angina, acute myocardial infarction within 6 months prior to first study treatment, congestive heart failure ≥New York Heart Association (NYHA) Class III), and arrhythmia requiring therapy except for beta-blockers, calcium channel blockers and digoxin or uncontrolled hypertension, despite optimal medical management
 - Clinically relevant findings in the electrocardiogram (ECG) such as a second- or third-degree AV block, prolongation of the QRS complex over 120 msec or of the QT interval corrected for heart rate (QTc)-interval over 450 msec 
 - Current evidence or history of uncured (i.a. any absolute risk of latent infection) of hepatitis B or C or human immunodeficiency virus (HIV) infection
 - Chronic systemic corticosteroid therapy or any other immunosuppressive therapies should have been stopped at screening start 
 - Seizure disorder requiring therapy (such as steroids or anti-epileptics)
 - Subjects unable to inject the study drug subcutaneously for intended s.c. application
- Non-suitable for a central venous access for intended c.i.v. administration

Trial Summary

Enrollment Goal
47
Trial Dates
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Phase
1
Could I receive a placebo?
No
Products
BAY2010112
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

Investigative Site

Würzburg, Germany, 97080

Status
Completed
 
Locations

Investigative Site

Heidelberg, Germany, 69120

Status
Completed
 
Locations

Investigative Site

Linz, Austria, 4010

Status
Completed
 
Locations

Investigative Site

Berlin, Germany, 12200

Status
Completed
 
Locations

Investigative Site

Wien, Austria, 1100

Status
Completed
 

Trial Design