Prostatic Neoplasms

Inclusion Criteria

- Male ≥ 20 years of age
 - Histologically or cytologically confirmed  adenocarcinoma of the prostate
 - Presents with at least 2 bone metastases, confirmed by scintigraphic imaging within the previous 4 weeks
 - Patients who has failed initial hormonal therapy using either an orchiectomy or a Gonadotropin releasing hormone (GnRH) agonist in combination with an antiandrogen must first progress through antiandrogen withdrawal prior to being eligible. The minimum timeframe to document failure of anti-androgen withdrawal will be four weeks
 - Progressive castration resistant metastatic disease
 - Castrate level of testosterone (<50 ng/dL), treatment to maintain castrate levels of testosterone must be continued

Exclusion Criteria

- Has received an investigational drug in the 4 weeks before or is scheduled to receiving one during or in the 8 weeks after study drug administration.
 - Has received chemo-, immuno-, or radiotherapy within the last 4 weeks prior to entry in the study, or has not recovered from acute adverse events as a result of such therapy
 - Has received prior hemibody external radiotherapy
 - Has a need for immediate external radiotherapy
 - Has received systemic radiotherapy with radium-223, strontium-89, samarium-153, rhenium-186 or rhenium-188 for the treatment of bony metastases within the last 24 weeks prior to administration of study drug
 - When receiving bisphosphonates, has changed the dose within 4 weeks before administration of study drug