Myopia, pathological

Inclusion Criteria

- Able to read (or, if unable to read due to visual impairment, be read to verbatim by the person administering the informed consent form or a family member) and understand the informed consent form and willing to sign the informed consent form
 - Signed informed consent form. In Japan only, the informed consent form for a subject under the age of 20 years will require the co-signature of the subject’s legally authorized representative. 
 - Men and women ≥ 18 years of age
 - Myopia of greater than or equal to -6 D OR axial length of greater than or equal to 26.5 mm
 - Active subfoveal or juxtafoveal (within 1 to 199 μm of the center of the fovea) CNV secondary to pathologic myopia as defined by leakage on FA
 - Best-corrected visual acuity of 73 to 35 letters (ETDRS equivalent of 20/40 to 20/200) in the study eye at 4 meters
 - Decrease in vision in the study eye is determined by the investigator, using his/her medical judgment, to be primarily the result of the current active mCNV
 - Willing, committed, and able to return for all clinic visits and complete all study-related procedures

Exclusion Criteria

- Only one functional eye
 - Ocular media of insufficient quality to obtain fundus and OCT images in the study eye
 - Greatest linear dimension (GLD) of the lesion in the study eye is greater than 12 disc areas
 - Recurrent mCNV in the study eye
 - Aphakia in the study eye
 - History or presence of CNV with an origin other than pathologic myopia in the study eye
 - Ocular inflammation or external ocular inflammation in the study eye
 - Concurrent disease in the study eye that would compromise BCVA or require medical or surgical intervention during the study period
 - Any ocular disorder in the study eye that, in the opinion of the investigator, may confound interpretation of the study results
 - Significant scarring or atrophy in the fovea that indicates substantial irreversible vision loss in the study eye
 - History of idiopathic or autoimmune-associated uveitis in either eye
 - Evidence at examination of infectious blepharitis, keratitis, scleritis, or conjunctivitis in either eye or current treatment for serious systemic infection
 - Vitreomacular traction or traction retinal detachment, epiretinal membrane in either eye
 - Any iris neovascularization and/or vitreous hemorrhage in either eye
 - Uncontrolled glaucoma, or previous filtration surgery in either eye
 - Prior and concomitant treatments
 - In the study eye:
 -- Any prior or concomitant treatment with another investigational agent for mCNV
 -- Any previous panretinal photocoagulation or subfoveal thermal laser therapy
 -- Any prior treatment with photodynamic therapy
 -- Cataract surgery within 3 months prior to Day 1
 -- Yttrium-aluminum-garnet laser capsulotomy within 2 months prior to Day 1
 -- Any other intraocular surgery within 3 months prior to Day 1
 -- History of vitreoretinal surgery and/or scleral buckle surgery
 - Any prior treatment with anti-VEGF agents
 - Previous use of intraocular or periocular corticosteroids in either eye within 3 months prior to Day 1
 - Previous assignment to treatment during this study
 - Uncontrolled hypertension
 - History of cerebrovascular disease or myocardial infarction within 6 months prior to Baseline/Day 1
 - History of other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug, may affect interpretation of the results of the study, or renders the subject at high risk from treatment complications
 - Women of childbearing potential without contraception, women who intend to breastfeed during the study. All subjects (both men and women) of childbearing potential who are unwilling to use adequate birth control measures during the course of the study.
 - Renal failure requiring dialysis or renal transplant
 - Participation in an investigational study within 30 days prior to Screening/Visit 1 that involved treatment with any drug (excluding vitamins and minerals) or device
 - Known serious allergy to the fluorescein sodium for injection in angiography or Verteporfin
 - Inability to obtain fundus photographs or fluorescein angiograms of sufficient quality