Trial Condition(s):

Myopia, pathological

VEGF Trap-Eye in choroidal neovascularization secondary to pathologic myopia (mCNV) (Myrror)

Bayer Identifier:

15170

ClinicalTrials.gov Identifier:

NCT01249664

EudraCT Number:

Not Available

Study Completed

Trial Purpose

VEGF Trap-Eye will be tested for safety and efficacy in patients with vision loss due to choroidal neovascularization secondary to pathologic myopia. This will be a placebo-controlled trial. 3 out of 4 patients will receive an injection of VEGF Trap-Eye into the affected eye (and repeated injections if required), and 1 out of 4 patients will receive a sham injection requiring no needle stick, but making the patient unaware of whether or not he received active treatment.
Outcome of the two treatment groups will be compared after 24 weeks. From week 24, sham patients may receive active treatment.
Total duration of the study will be 48 weeks.

Inclusion Criteria
- Able to read (or, if unable to read due to visual impairment, be read to verbatim by the person administering the informed consent form or a family member) and understand the informed consent form and willing to sign the informed consent form
 - Signed informed consent form. In Japan only, the informed consent form for a subject under the age of 20 years will require the co-signature of the subject’s legally authorized representative. 
 - Men and women ≥ 18 years of age
 - Myopia of greater than or equal to -6 D OR axial length of greater than or equal to 26.5 mm
 - Active subfoveal or juxtafoveal (within 1 to 199 μm of the center of the fovea) CNV secondary to pathologic myopia as defined by leakage on FA
 - Best-corrected visual acuity of 73 to 35 letters (ETDRS equivalent of 20/40 to 20/200) in the study eye at 4 meters
 - Decrease in vision in the study eye is determined by the investigator, using his/her medical judgment, to be primarily the result of the current active mCNV
 - Willing, committed, and able to return for all clinic visits and complete all study-related procedures
Exclusion Criteria
- Only one functional eye
 - Ocular media of insufficient quality to obtain fundus and OCT images in the study eye
 - Greatest linear dimension (GLD) of the lesion in the study eye is greater than 12 disc areas
 - Recurrent mCNV in the study eye
 - Aphakia in the study eye
 - History or presence of CNV with an origin other than pathologic myopia in the study eye
 - Ocular inflammation or external ocular inflammation in the study eye
 - Concurrent disease in the study eye that would compromise BCVA or require medical or surgical intervention during the study period
 - Any ocular disorder in the study eye that, in the opinion of the investigator, may confound interpretation of the study results
 - Significant scarring or atrophy in the fovea that indicates substantial irreversible vision loss in the study eye
 - History of idiopathic or autoimmune-associated uveitis in either eye
 - Evidence at examination of infectious blepharitis, keratitis, scleritis, or conjunctivitis in either eye or current treatment for serious systemic infection
 - Vitreomacular traction or traction retinal detachment, epiretinal membrane in either eye
 - Any iris neovascularization and/or vitreous hemorrhage in either eye
 - Uncontrolled glaucoma, or previous filtration surgery in either eye
 - Prior and concomitant treatments
 - In the study eye:
 -- Any prior or concomitant treatment with another investigational agent for mCNV
 -- Any previous panretinal photocoagulation or subfoveal thermal laser therapy
 -- Any prior treatment with photodynamic therapy
 -- Cataract surgery within 3 months prior to Day 1
 -- Yttrium-aluminum-garnet laser capsulotomy within 2 months prior to Day 1
 -- Any other intraocular surgery within 3 months prior to Day 1
 -- History of vitreoretinal surgery and/or scleral buckle surgery
 - Any prior treatment with anti-VEGF agents
 - Previous use of intraocular or periocular corticosteroids in either eye within 3 months prior to Day 1
 - Previous assignment to treatment during this study
 - Uncontrolled hypertension
 - History of cerebrovascular disease or myocardial infarction within 6 months prior to Baseline/Day 1
 - History of other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug, may affect interpretation of the results of the study, or renders the subject at high risk from treatment complications
 - Women of childbearing potential without contraception, women who intend to breastfeed during the study. All subjects (both men and women) of childbearing potential who are unwilling to use adequate birth control measures during the course of the study.
 - Renal failure requiring dialysis or renal transplant
 - Participation in an investigational study within 30 days prior to Screening/Visit 1 that involved treatment with any drug (excluding vitamins and minerals) or device
 - Known serious allergy to the fluorescein sodium for injection in angiography or Verteporfin
 - Inability to obtain fundus photographs or fluorescein angiograms of sufficient quality

Trial Summary

Enrollment Goal
122
Trial Dates
black-arrow
Phase
3
Could I receive a placebo?
No
Products
Eylea (Aflibercept, VEGF Trap-Eye, BAY86-5321)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

Fukushima Medical University Hospital

Fukushima, Japan, 960-1295

Status
Completed
 
Locations

Juntendo University Urayasu Hospital

Urayasu, Japan, 279-0021

Status
Completed
 
Locations

Tokyo Medical and Dental University Hospital

Bunkyo-ku, Japan, 113-8519

Status
Completed
 
Locations

Surugadai Nihon University Hospital

Chiyoda-ku, Japan, 101-8309

Status
Completed
 
Locations

Keio University Hospital

Shinjuku-ku, Japan, 160-8582

Status
Completed
 
Locations

Nagoya University Hospital

Nagoya, Japan, 466-8560

Status
Completed
 
Locations

Nagoya City University Hospital

Nagoya, Japan, 467-8602

Status
Completed
 
Locations

Shiga University of Medical Science Hospital

Otsu, Japan, 520-2192

Status
Completed
 
Locations

Kyoto University Hospital

Kyoto, Japan, 606-8507

Status
Completed
 
Locations

Osaka University Hospital

Suita, Japan, 565-0871

Status
Completed
 
Locations

Kyushu University Hospital

Fukuoka, Japan, 812-8582

Status
Completed
 
Locations

Singapore National Eye Centre

Singapore, Singapore, 168751

Status
Completed
 
Locations

Hong Kong Eye Hospital

Kowloon, Hong Kong, China

Status
Completed
 
Locations

Seoul St. Mary's Hospital

Seoul, South Korea, 137 701

Status
Completed
 
Locations

Chang Gung Memorial Hospital at Linkou

Taoyuan, Taiwan, China, 333

Status
Completed
 
Locations

Veterans General Hospital

Taipei, Taiwan, China, 11217

Status
Completed
 
Locations

Matsuyama Red Cross Hospital

Matsuyama, Japan, 790-8524

Status
Completed
 
Locations

NTT East Japan Tohoku Hospital

Sendai, Japan, 984-8560

Status
Completed
 
Locations

Osaka General Medical Center

Osaka, Japan, 558-8558

Status
Completed
 
Locations

Osaka City University Medical School Hospital

Osaka, Japan, 545-8586

Status
Completed
 

Trial Design