Trial Condition(s):

Hypertension, Pulmonary, Ventricular Dysfunction, Left

A study to test the effects of Riociguat in patients with pulmonary hypertension associated with left ventricular systolic dysfunction (LEPHT)

Bayer Identifier:

14308

ClinicalTrials.gov Identifier:

NCT01065454

EudraCT Number:

2009-015878-35

Recruitment Complete

Trial Purpose

The aim of this study is to assess whether increasing oral doses of Riociguat are safe and improve the well-being, symptoms and outcome in patients with pulmonary hypertension associated with left ventricular systolic dysfunction

Inclusion Criteria
- Male and female patients with symptomatic pulmonary hypertension due to left ventricular systolic dysfunction despite optimized heart failure therapy
Exclusion Criteria
- Types of pulmonary hypertension other than group 2.1 of Dana Point Classification

Trial Summary

Enrollment Goal
202
Trial Dates
black-arrow
Phase
2
Could I receive a placebo?
Yes
Products
Adempas (Riociguat, BAY63-2521)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

Investigative Site

Heidelberg, Germany, 69120

Status
Completed
 
Locations

Investigative Site

Augsburg, Germany, 86156

Status
Completed
 
Locations

Investigative Site

Cambridge, United Kingdom, CB23 3RE

Status
Completed
 
Locations

Investigative Site

Rochester, United States, 55905

Status
Completed
 
Locations

Investigative Site

Torrance, United States, 90502

Status
Completed
 
Locations

Investigative Site

Greifswald, Germany, 17475

Status
Completed
 
Locations

Investigative Site

Köln, Germany, 50924

Status
Active, not recruiting
 
Locations

Investigative Site

Erfurt, Germany, 99089

Status
Completed
 
Locations

Investigative Site

St. Louis, United States, 63110

Status
Completed
 
Locations

Investigative Site

San Diego, United States, 92103

Status
Completed
 
Locations

Investigative Site

Falls Church, United States, 22042

Status
Active, not recruiting
 
Locations

Investigative Site

Boston, United States, 02114

Status
Completed
 
Locations

Investigative Site

Fairfield, United States, 45014

Status
Completed
 
Locations

Investigative Site

Miami, United States, 33136

Status
Completed
 
Locations

Investigative Site

NANTES, France, 44035

Status
Completed
 
Locations

Investigative Site

TOULOUSE, France, 31403

Status
Completed
 
Locations

Investigative Site

Rouen, France, 76031

Status
Completed
 
Locations

Investigative Site

Sendai, Japan, 980-8574

Status
Completed
 
Locations

Investigative Site

Tsu, Japan, 514-1101

Status
Completed
 
Locations

Investigative Site

Osaka, Japan, 541-8567

Status
Completed
 
Locations

Investigative Site

Osaka, Japan, 530-8480

Status
Completed
 
Locations

Investigative Site

Pavia, Italy, 27100

Status
Completed
 
Locations

Investigative Site

Pavia, Italy, 27100

Status
Active, not recruiting
 
Locations

Investigative Site

Napoli, Italy, 80131

Status
Completed
 
Locations

Investigative Site

Barcelona, Spain, 08003

Status
Completed
 
Locations

Investigative Site

Valencia, Spain, 46026

Status
Completed
 
Locations

Investigative Site

Palma, Spain, 07198

Status
Completed
 
Locations

Investigative Site

Quebec, Canada, G1V 4G5

Status
Completed
 
Locations

Investigative Site

Lille Cedex, France, 59037

Status
Completed
 
Locations

Investigative Site

Bydgoszcz, Poland, 85-168

Status
Active, not recruiting
 
Locations

Investigative Site

Sunto, Japan, 411-8611

Status
Completed
 
Locations

Investigative Site

Nagoya, Japan, 466-8560

Status
Completed
 
Locations

Investigative Site

Kusatsu, Japan, 525-8585

Status
Completed
 
Locations

Investigative Site

Suita, Japan, 565-0871

Status
Completed
 
Locations

Investigative Site

Madrid, Spain, 28041

Status
Completed
 
Locations

Investigative Site

Majadahonda, Spain, 28222

Status
Completed
 
Locations

Investigative Site

Edmonton, Canada, T6G 2B7

Status
Completed
 
Locations

Investigative Site

Vancouver, Canada, V5Z 1M9

Status
Completed
 
Locations

Investigative Site

BRUXELLES - BRUSSEL, Belgium, 1070

Status
Completed
 
Locations

Investigative Site

Montreal, Canada, H3T 1E2

Status
Active, not recruiting
 
Locations

Investigative Site

AMSTERDAM, Netherlands, 1081 HV

Status
Completed
 
Locations

Investigative Site

Aarhus N, Denmark, 8200

Status
Completed
 
Locations

Investigative Site

DARLINGHURST, Australia, 2010

Status
Completed
 
Locations

Investigative Site

Prahran, Australia, 3181

Status
Completed
 
Locations

Investigative Site

CHERMSIDE, Australia, 4032

Status
Completed
 
Locations

Investigative Site

Innsbruck, Austria, 6020

Status
Completed
 
Locations

Investigative Site

Zürich, Switzerland, 8091

Status
Active, not recruiting
 
Locations

Investigative Site

Lugano, Switzerland, 6900

Status
Completed
 
Locations

Investigative Site

Singapore, Singapore, 308433

Status
Completed
 
Locations

Investigative Site

Singapore, Singapore, 119228

Status
Completed
 
Locations

Investigative Site

Singapore, Singapore, 168752

Status
Completed
 
Locations

Investigative Site

LEUVEN, Belgium, 3000

Status
Completed
 
Locations

Investigative Site

Wien, Austria, 1090

Status
Completed
 
Locations

Investigative Site

El Palmar, Spain, 30120

Status
Completed
 
Locations

Investigative Site

A Coruña, Spain, 15006

Status
Completed
 
Locations

Investigative Site

Genève, Switzerland, 1205

Status
Completed
 
Locations

Investigative Site

Cincinnati, United States, 45219

Status
Completed
 
Locations

Investigative Site

BRON, France, 69500

Status
Completed
 
Locations

Investigative Site

PESSAC, France, 33604

Status
Completed
 
Locations

Investigative Site

Beijing, China, 100020

Status
Completed
 
Locations

Investigative Site

Shanghai, China

Status
Completed
 
Locations

Investigative Site

Shanghai, China, 200433

Status
Completed
 
Locations

Investigative Site

Fountain Valley, United States, 92708

Status
Completed
 
Locations

Investigative Site

NIJMEGEN, Netherlands, 6500HB

Status
Completed
 
Locations

Investigative Site

Baltimore, United States, 21201

Status
Completed
 
Locations

Investigative Site

Los Angeles, United States, 90073

Status
Completed
 
Locations

Investigative Site

Iowa City, United States, 52242

Status
Completed
 
Locations

Investigative Site

Seto, Japan, 489-8642

Status
Completed
 
Locations

Investigative Site

GENT, Belgium, 9000

Status
Completed
 
Locations

Investigative Site

Shinjuku-ku, Japan, 162-8666

Status
Completed
 
Locations

Investigative Site

Arakawa-ku, Japan, 116-8567

Status
Completed
 
Locations

Investigative Site

Higashiibaraki, Japan, 311-3193

Status
Completed
 
Locations

Investigative Site

Milwaukee, United States, 53215

Status
Completed
 
Locations

Investigative Site

AALST, Belgium, 9300

Status
Completed
 
Locations

Investigative Site

London, United Kingdom, SW3 6NP

Status
Completed
 
Locations

Investigative Site

Praha 4, Czech Republic, 140 21

Status
Completed
 
Locations

Investigative Site

Praha 2, Czech Republic, 12808

Status
Active, not recruiting
 
Locations

Investigative Site

Brno, Czech Republic, 656 91

Status
Completed
 
Locations

Investigative Site

Olomouc, Czech Republic, 779 00

Status
Completed
 
Locations

Investigative Site

Warszawa, Poland, 04-628

Status
Completed
 
Locations

Investigative Site

Ogaki, Japan, 503-8502

Status
Completed
 
Locations

Investigative Site

Tanabe, Japan, 646-8558

Status
Completed
 
Locations

Investigative Site

Gdansk, Poland, 80-214

Status
Completed
 
Locations

Investigative Site

AMSTERDAM, Netherlands, 1091 AC

Status
Completed
 

Trial Design