Trial Condition(s):
Wound Healing, Cell proliferation, Gene expression
Study to assess on a molecular level the influence of a 5 % dexpanthenol ointment in subjects with superficial injuries
Bayer Identifier:
13069
ClinicalTrials.gov Identifier:
EudraCT Number:
EU CT Number:
Not Available
Trial Purpose
In previous in vitro studies it could be shown, that Dexpanthenol has an influence on the gene expression of fibroblasts. The genes which are influenced by Dexpanthenol play mainly a role during cell proliferating processes.The aim of this study is to investigate the molecular effect of Dexpanthenol on human living skin, during wound healing.
Inclusion Criteria
- Skin type I to IV - Willingness to avoid intensive sunlight exposure two weeks before the start of the study and at least 2 months after removal of the stitches
Exclusion Criteria
- Active skin disease, moles, tattoos, strong pigmentation at the test area or scars in the test area that would influence the visual scoring - History of keloids and hypertrophic scars - Frequent visits of tanning booths - Intake of drugs interfering with the immune system (e.g. antiphlogistics, corticosteroids, immunosuppressants, and antihistamines) within 30 days before day 1 as well as during the study.
Trial Summary
Enrollment Goal
Trial Dates
Phase
Could I receive a placebo?
Products
Accepts Healthy Volunteers
Where to Participate
| Locations | |
|---|---|
Locations proDerm Hamburg, Germany, 22869 | Contact Us: E-mail: [email protected] Phone: Not Available |
Trial Design
A randomized, double-blind, single centre, placebo-controlled pilot study to assess on a molecular level the influence of a 5 % dexpanthenol ointment in subjects with previously injured skin by investigation of skin biopsies
Trial Type:
Interventional
Intervention Type:
Drug
Trial Purpose:
Basic Science
Allocation:
Randomized
Blinding:
Double Blind
Assignment:
Parallel Assignment
Trial Arms:
2
Primary Outcome
- Investigation of gene expression in dermal fibroblasts and keratinocytes on a molecular level.Timeframe: Analysis of skin biopsies taken 24h, 72h and 144h after wounding
Additional Information
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