A Randomized, Placebo Controlled Study to Determine the Efficacy and Speed of a Nasal Spray in Allergen Induced Seasonal Allergic Rhinitis (GEYSER)
Finding out how fast azelastine nasal spray works in subjects with hay fever.
- History of seasonal allergic rhinitis to ragweed pollen for last 2 consecutive seasons; - Positive response to skin prick test to ragweed allergen at screening; - Be willing to participate in the trial.
- History of hypersensitivity to azelastine; - Females who are pregnant or lactating; - Relative chronic sinusitis or nasal structural abnormalities causing greater than 50% obstruction; - Asthma that requires other than occasional use of inhaled short-acting beta-2 antagonist; - Known non-responsiveness to antihistamines; - Alcoholism or drug abuse within 2 yrs. of screening; - Current or regular use within 6 months of any type of tobacco product; - Evidence of any clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic or malignancies within the last 5 years; - History of a positive test to HIV, TB, hepatitis B or C.
Kingston General Hospital
Kingston, Canada, K7L 2V7
E-mail: [email protected]
Phone: Not Available
A Four-Way Double-Blind, Randomized, Placebo Controlled Study to Determine the Efficacy and Speed of Azelastine Nasal Spray and Antihistaminic Agents in Adult Subjects with Allergen Induced Seasonal Allergic Rhinitis