check_circleStudy Completed
Moderate Risk of CVD
Bayer Identifier:
12198
ClinicalTrials.gov Identifier:
EudraCT Number:
EU CT Number:
Not Available
A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease
Trial purpose
The use of acetylsalicylic acid in the primary prevention of cardiovascular events has been extensively studied but to a lesser extent in patients with moderate levels of cardiovascular risk. The current study is designed to prove the efficacy and tolerability of 100 mg enteric-coated Aspirin versus placebo in the prevention of cardiovascular disease (CVD) events, which include fatal and nonfatal myocardial infarction, fatal and nonfatal stroke and CV death, in a population with no history of known CVD who are at moderate risk of major CHD events (approximately 10-20% 10 year CHD risk). This corresponds to a patient population mean 10-year CVD risk of approximately 30%. Subjects are treated in a standard care setting and may receive treatment for the underlying risk factors as defined by the treating physician. Outcome events will be adjudicated by an Endpoint Adjudication Committee and the study will be monitored by an independent Data Safety Monitoring Board.
Key Participants Requirements
Sex
BothAge
55 - N/ATrial summary
Enrollment Goal
12546Trial Dates
July 2007 - November 2016Phase
Phase 3Could I Receive a placebo
YesProducts
Aspirin (Acetylsalicylic Acid, BAYE4465)Accepts Healthy Volunteer
NoWhere to participate
Status | Institution | Location |
---|---|---|
Completed | Arnsberg, 59757, Germany | |
Completed | Apolda, 99510, Germany | |
Completed | Magdeburg, 39104, Germany | |
Completed | Bergkamen, 59192, Germany | |
Withdrawn | Bergisch Gladbach, 51467, Germany | |
Withdrawn | Düsseldorf, 40477, Germany | |
Withdrawn | Worpswede, 27726, Germany | |
Completed | Bad Lippspringe, 33175, Germany | |
Completed | Nassau, 56377, Germany | |
Completed | Winsen, 21423, Germany | |
Completed | Deggingen, 73326, Germany | |
Completed | Köln, 51069, Germany | |
Completed | Gransee, 16775, Germany | |
Completed | Viersen, 41751, Germany | |
Withdrawn | Rodgau, 63110, Germany | |
Completed | Wetter, 35083, Germany | |
Completed | Lienen, 49536, Germany | |
Completed | Bad Salzuflen, 32105, Germany | |
Withdrawn | Otterbach, 67731, Germany | |
Completed | Stuhr, 28816, Germany | |
Completed | Arzberg, 95659, Germany | |
Completed | Frankfurt, 60599, Germany | |
Completed | Bad Bramstedt, 24576, Germany | |
Completed | Löhne, 32584, Germany | |
Withdrawn | Düsseldorf, 40593, Germany | |
Withdrawn | Schwaig, 90571, Germany | |
Withdrawn | Freiburg, 79110, Germany | |
Completed | Hamm, 59069, Germany | |
Withdrawn | Laage, 18299, Germany | |
Completed | Essen, 45136, Germany | |
Completed | Wardenburg, 26203, Germany | |
Completed | Lippetal, 59510, Germany | |
Withdrawn | Heilbronn, 74072, Germany | |
Completed | Netphen, 57250, Germany | |
Completed | Dortmund, 44328, Germany | |
Completed | Weinheim, 69469, Germany | |
Completed | Speyer, 67346, Germany | |
Completed | Hanau, 63450, Germany | |
Completed | Aachen, 52074, Germany | |
Withdrawn | Ense, 59469, Germany | |
Completed | Marl, 45770, Germany | |
Completed | Berlin, 10407, Germany | |
Completed | Wetter, 58300, Germany | |
Withdrawn | Leipzig, 04177, Germany | |
Completed | Langenfeld, 40764, Germany | |
Completed | Marl, 45770, Germany | |
Withdrawn | Offenbach, 63067, Germany | |
Withdrawn | Grevenbroich, 41515, Germany | |
Completed | Künzing, 94550, Germany | |
Withdrawn | Landshut, 84032, Germany | |
Completed | Aachen, 52080, Germany | |
Withdrawn | Leverkusen, 51373, Germany | |
Withdrawn | Frankfurt, 60323, Germany | |
Completed | Kelkheim, 65779, Germany | |
Completed | Berlin, 13057, Germany | |
Completed | Essen, 45355, Germany | |
Withdrawn | Oberursel, 61440, Germany | |
Completed | Potsdam, 14778, Germany | |
Withdrawn | Offenbach, 63073, Germany | |
Completed | Dortmund, 44139, Germany | |
Completed | Leipzig, 04249, Germany | |
Completed | Porta Westfalica, 32457, Germany | |
Withdrawn | Gärtringen, 71116, Germany | |
Completed | Hamburg, 22143, Germany | |
Completed | Spalt, 91174, Germany | |
Withdrawn | Heilbronn, 74072, Germany | |
Withdrawn | Lütjenburg, 24321, Germany | |
Completed | Welver, 59514, Germany | |
Completed | Stockach, 78333, Germany | |
Completed | Berlin, 10249, Germany | |
Withdrawn | Allmendingen, 89604, Germany | |
Completed | Dossenheim, 69221, Germany | |
Withdrawn | Heidelberg, 69129, Germany | |
Withdrawn | Rees, 46459, Germany | |
Completed | Bergrheinfeld, 97493, Germany | |
Completed | Weyhe, 28844, Germany | |
Completed | Greven, 48268, Germany | |
Completed | Hamburg, 22299, Germany | |
Completed | Bad Sassendorf, 59505, Germany | |
Completed | Hünxe, 46569, Germany | |
Completed | Reinfeld, 23858, Germany | |
Completed | Remscheid, 42897, Germany | |
Completed | Blankenhain, 99444, Germany | |
Completed | Bad Salzuflen, 32108, Germany | |
Completed | Sinzheim, 76547, Germany | |
Completed | Graben-Neudorf, 76676, Germany | |
Completed | Benningen, 71726, Germany | |
Completed | Heilbronn, 74080, Germany | |
Completed | Trossingen, 78647, Germany | |
Completed | Schwetzingen, 68723, Germany | |
Completed | Schrobenhausen, 86529, Germany | |
Completed | Ursensollen, 92289, Germany | |
Completed | Sulzbach-Rosenberg, 92237, Germany | |
Completed | Berlin, 13467, Germany | |
Completed | Ketzin, 14669, Germany | |
Withdrawn | Frankfurt, 60529, Germany | |
Completed | Horneburg, 21640, Germany | |
Completed | Bockenem, 31167, Germany | |
Completed | Beucha, 04824, Germany | |
Withdrawn | Dresden, 01219, Germany | |
Completed | Oberwiesenthal, 09484, Germany | |
Completed | Halle, 06124, Germany | |
Completed | Ludwigsburg, 71640, Germany | |
Completed | Gars, 83536, Germany | |
Completed | Strasskirchen, 94342, Germany | |
Completed | Ursensollen, 92289, Germany | |
Completed | München, 80336, Germany | |
Completed | Cottbus, 03046, Germany | |
Completed | Rotenburg, 36199, Germany | |
Completed | Jühnde, 37127, Germany | |
Completed | Braunschweig, 38100, Germany | |
Completed | Essen, 45130, Germany | |
Withdrawn | Köln, 51065, Germany | |
Withdrawn | Neuss, 41468, Germany | |
Completed | Essen, 45359, Germany | |
Completed | Ludwigshafen, 67063, Germany | |
Withdrawn | Norderstedt, 22844, Germany | |
Completed | Bochum, 44797, Germany | |
Completed | Marl, 45770, Germany | |
Completed | Dortmund, 44339, Germany | |
Completed | Freudenberg, 57258, Germany | |
Withdrawn | Mainz, 55128, Germany | |
Completed | Berlin, 13405, Germany | |
Completed | Frankfurt, 65929, Germany | |
Withdrawn | Berlin, 14169, Germany | |
Completed | Riesa, 01587, Germany | |
Completed | Dresden, 01127, Germany | |
Completed | Rhaunen, 55624, Germany | |
Completed | Essen, 45276, Germany | |
Completed | Papenburg, 26871, Germany | |
Completed | Delitzsch, 04509, Germany | |
Completed | Mainz, 55116, Germany | |
Completed | Dresden, 01069, Germany | |
Completed | Meißen, 01662, Germany | |
Completed | Grimma, 04668, Germany | |
Completed | Borna, 04552, Germany | |
Withdrawn | Weimar, 99423, Germany | |
Completed | Marl, 45770, Germany | |
Completed | Münster, 48167, Germany | |
Completed | Berlin, 13055, Germany | |
Completed | Mainz, 55127, Germany | |
Completed | Leipzig, 04103, Germany | |
Completed | Hamburg, 22041, Germany | |
Withdrawn | Berlin, 10437, Germany | |
Completed | Hockenheim, 68766, Germany | |
Completed | Kallstadt, 67169, Germany | |
Completed | Oberaurach, 97514, Germany | |
Completed | Sand am Main, 97522, Germany | |
Completed | Loxstedt, 27612, Germany | |
Completed | Berlin, 12099, Germany | |
Completed | Stuttgart, 70378, Germany | |
Completed | Siegen, 57072, Germany | |
Completed | Siegen, 57072, Germany | |
Completed | Witten, 58455, Germany | |
Withdrawn | Wilhelmshaven, 26384, Germany | |
Completed | Markkleeberg, 04416, Germany | |
Completed | Kamp-Lintfort, 47475, Germany | |
Completed | High Valleyfield, KY12 8SJ, United Kingdom | |
Completed | Saltash, PL12 6DL, United Kingdom | |
Completed | Barry, CF63 4HP, United Kingdom | |
Completed | Penzance, TR19 7HX, United Kingdom | |
Completed | Hamburg, 22335, Germany | |
Completed | Leipzig, 04103, Germany | |
Completed | Dinkelsbühl, 91550, Germany | |
Completed | Elsterwerda, 04910, Germany | |
Completed | Wermsdorf, 04779, Germany | |
Completed | Dresden, 01277, Germany | |
Completed | Berlin, 14050, Germany | |
Completed | Duisburg, 47199, Germany | |
Completed | Krefeld, 47798, Germany | |
Completed | Bitterfeld, 06749, Germany | |
Completed | Hamburg, 22177, Germany | |
Completed | Hohenau, 94545, Germany | |
Completed | Krefeld, 47798, Germany | |
Withdrawn | Schwerin, 19055, Germany | |
Withdrawn | Berlin, 10789, Germany | |
Completed | Boscastle, PL35 0BG, United Kingdom | |
Completed | Ely, CB7 5SQ, United Kingdom | |
Completed | Sheffield, S7 2DW, United Kingdom | |
Completed | Motherwell, ML1 3JX, United Kingdom | |
Completed | St Austell, PL26 7RL, United Kingdom | |
Completed | Ely, CB7 4HF, United Kingdom | |
Completed | Slough, SL1 1TT, United Kingdom | |
Completed | Cardiff, CF5 4AD, United Kingdom | |
Completed | Leeds, LS25 1AN, United Kingdom | |
Withdrawn | Dundee, DD1 5LA, United Kingdom | |
Completed | Peterborough, PE7 3JL, United Kingdom | |
Completed | Hamilton, ML3 ODR, United Kingdom | |
Completed | Darlington, DL2 1AA, United Kingdom | |
Completed | Thedinghausen, 27321, Germany | |
Completed | Nienburg, 31582, Germany | |
Withdrawn | Viersen, 41747, Germany | |
Completed | Ettlingen, 78275, Germany | |
Completed | Northeim, 37154, Germany | |
Completed | Aurich, 26603, Germany | |
Completed | Rehburg-Loccum, 31547, Germany | |
Completed | Daaden, 57567, Germany | |
Completed | Riede, 27339, Germany | |
Completed | Riesa, 01587, Germany | |
Withdrawn | Dresden, 01277, Germany | |
Completed | Chipping Norton, OX75FA, United Kingdom | |
Completed | Bath, BA11 2FH, United Kingdom | |
Completed | Crawley, RH10 7DX, United Kingdom | |
Completed | Letchworth, SG6 4TS, United Kingdom | |
Withdrawn | Ruislip, HA4 7AE, United Kingdom | |
Completed | Wells-Next-The-Sea, NR23 1JP, United Kingdom | |
Completed | Wishaw, ML2 7BQ, United Kingdom | |
Completed | Sandbach, CW11 1EQ, United Kingdom | |
Completed | Leeds, LS25 7AB, United Kingdom | |
Completed | Peterborough, PE8 6PL, United Kingdom | |
Completed | Wymondham, NR18 0RF, United Kingdom | |
Completed | Bath, BA2 4BY, United Kingdom | |
Completed | Penzance, TR18 4EL, United Kingdom | |
Completed | Wellingborough, NN8 4RW, United Kingdom | |
Completed | Plymouth, PL6 7TH, United Kingdom | |
Completed | Bradford-on-Avon, BA15 1DQ, United Kingdom | |
Withdrawn | Bracknell, RG12 7WW, United Kingdom | |
Completed | Fowey, PL23 1DT, United Kingdom | |
Completed | Penzance, TR18 4JH, United Kingdom | |
Completed | Chippenham, SN14 6GT, United Kingdom | |
Completed | Bath, BA2 4JT, United Kingdom | |
Completed | Crawley, RH10 1LL, United Kingdom | |
Completed | Bath, BA2 3HT, United Kingdom | |
Completed | Bath, BA2 3HT, United Kingdom | |
Completed | Chippenham, SN15 2SB, United Kingdom | |
Completed | Westbury, BA13 3FQ, United Kingdom | |
Completed | Annan, DG12 6BG, United Kingdom | |
Completed | New Stevenson, ML1 4LT, United Kingdom | |
Completed | Darlington, DL3 7JR, United Kingdom | |
Completed | Bangor, BT19 1PP, United Kingdom | |
Completed | Antrim, BT36 4PP, United Kingdom | |
Completed | Antrim, BT37 9QN, United Kingdom | |
Completed | Glasgow, G21 1TR, United Kingdom | |
Completed | Aberdeen, AB25 2ZD, United Kingdom | |
Completed | Chestfield, CT5 3QU, United Kingdom | |
Completed | Canterbury, CT1 3HX, United Kingdom | |
Completed | Chesterfield, S40 4AA, United Kingdom | |
Completed | Eccles, S35 9XQ, United Kingdom | |
Completed | Wishaw, ML2 7BQ, United Kingdom | |
Completed | Glasgow, G67 1BJ, United Kingdom | |
Completed | Glasgow, G45 9AW, United Kingdom | |
Completed | Glasgow, G20 0XA, United Kingdom | |
Withdrawn | Ipswich, IP2 0QQ, United Kingdom | |
Completed | London, SW12 8EU, United Kingdom | |
Completed | Trowbridge, BA14 9AR, United Kingdom | |
Completed | Doncaster, DN1 2ET, United Kingdom | |
Completed | Coventry, CV7 8LA, United Kingdom | |
Completed | Blantyre, G72 0BS, United Kingdom | |
Completed | Leigh-on-Sea, SS9 2SQ, United Kingdom | |
Completed | Hamilton, ML3 8AA, United Kingdom | |
Completed | Coatbridge, ML5 3AP, United Kingdom | |
Completed | Chapelhall, ML6 8SR, United Kingdom | |
Completed | Worcester Park, KT4 7BX, United Kingdom | |
Completed | Hinckley, LE10 2SE, United Kingdom | |
Completed | Hitchin, SG4 9TH, United Kingdom | |
Completed | East Horsley, KT24 6QT, United Kingdom | |
Completed | Blackpool, FY3 7EN, United Kingdom | |
Completed | Antrim, BT38 9TG, United Kingdom | |
Completed | Hamilton, ML3 7EN, United Kingdom | |
Completed | Addlestone, KT15 2BH, United Kingdom | |
Completed | Belfast, United Kingdom | |
Completed | Belfast, BT12 5LT, United Kingdom | |
Completed | Belfast, BT12 5EY, United Kingdom | |
Completed | Coventry, CV9 1EU, United Kingdom | |
Completed | Radstock, BA3 2UH, United Kingdom | |
Completed | Luton, LU2 9SB, United Kingdom | |
Completed | Bury St. Edmunds, IP32 7EW, United Kingdom | |
Completed | Bolton, BL3 6TL, United Kingdom | |
Completed | Dronfield, S18 8QY, United Kingdom | |
Completed | Leeds, LS26 8SZ, United Kingdom | |
Completed | Bishop Auckland, DL14 6AB, United Kingdom | |
Completed | Stowmarket, IP14 1NL, United Kingdom | |
Completed | Inverness, IV2 4AG, United Kingdom | |
Completed | Irvine, KA12 0AY, United Kingdom | |
Completed | Blackpool, FY4 3AD, United Kingdom | |
Completed | Peterborough, PE2 5GP, United Kingdom | |
Completed | Antrim, BT41 3AE, United Kingdom | |
Completed | Tyrone, BT80 8BG, United Kingdom | |
Completed | Darlington, DL3 8SQ, United Kingdom | |
Completed | Whitstable, CT5 3SE, United Kingdom | |
Completed | Rugby, CV21 3SP, United Kingdom | |
Completed | Doncaster, DN1 2EU, United Kingdom | |
Completed | Ipswich, IP4 2PU, United Kingdom | |
Completed | Leeds, LS10 3NB, United Kingdom | |
Completed | Newcastle Upon Tyne, NE15 6TQ, United Kingdom | |
Completed | Coatrbridge, ML5 3BJ, United Kingdom | |
Completed | Carstairs, ML11 8QD, United Kingdom | |
Completed | Thornhill, DG3 5AA, United Kingdom | |
Completed | Bolton, BL5 3UB, United Kingdom | |
Completed | Witley Bay, NE26 1NA, United Kingdom | |
Completed | Craigavon, BT67 0LQ, United Kingdom | |
Completed | Newtonabbey, BT37 9QU, United Kingdom | |
Withdrawn | Downingtown, 19335, United States | |
Completed | Belvidere, 07823, United States | |
Completed | Taylors, 29687, United States | |
Withdrawn | Flemington, 08822, United States | |
Completed | Atlanta, 30318, United States | |
Completed | Bury St Edmonds, IP30 9QU, United Kingdom | |
Completed | Tiptree, CO5 0HB, United Kingdom | |
Completed | Bellshill, ML4 1PS, United Kingdom | |
Completed | Brighton, BN2 1ES, United Kingdom | |
Completed | Glasgow, G5 0BQ, United Kingdom | |
Completed | Johnstone, PA5 8EY, United Kingdom | |
Completed | Airedire, ML66DB, United Kingdom | |
Completed | Paisley, United Kingdom | |
Completed | Letchworth, SG6 4UB, United Kingdom | |
Completed | Corsham, SN3 9DL, United Kingdom | |
Completed | Belfast, BT5 7BP, United Kingdom | |
Completed | Glasgow, G52 3QN, United Kingdom | |
Completed | Coventry, CV6 4DD, United Kingdom | |
Completed | Manchester, M13 9WL, United Kingdom | |
Completed | Belfast, BT13 3BW, United Kingdom | |
Completed | Tallahassee Memorial Family | Quincy, 32351, United States |
Completed | Marianna, 32446-2120, United States | |
Withdrawn | Toledo, 43617, United States | |
Withdrawn | Baltimore, 21204, United States | |
Completed | Tucson, 85712, United States | |
Completed | Daingerfield, 75638, United States | |
Withdrawn | Garden Grove, 92843, United States | |
Withdrawn | Trenton, 08618, United States | |
Completed | Carlisle, 45005-3320, United States | |
Withdrawn | Erie, 16504, United States | |
Completed | Clifton, 07013, United States | |
Withdrawn | Bridgewater, 08807, United States | |
Completed | Huntington Park, 90255, United States | |
Completed | Medical Research Centers of South Florida, Inc. | Hollywood, 33021, United States |
Completed | Broken Bow, 68822, United States | |
Completed | Carryduff, BT8 8HR, United Kingdom | |
Completed | Belfast, BT1 2JR, United Kingdom | |
Completed | Belfast, BT15 2GE, United Kingdom | |
Completed | Ballymena, BT43 6JD, United Kingdom | |
Completed | Ballymena, BT42 4JP, United Kingdom | |
Completed | Crumlin, BT29 4LP, United Kingdom | |
Completed | Watford, WD25 7NL, United Kingdom | |
Completed | Bath, BA1 2SR, United Kingdom | |
Completed | Blantyre, G72 0BS, United Kingdom | |
Completed | Dundee, DD19SY, United Kingdom | |
Completed | Hadleigh, IP7 5DN, United Kingdom | |
Completed | Bury St. Edmunds, IP31 2HD, United Kingdom | |
Completed | Leeds, LS15 9JH, United Kingdom | |
Completed | Leeds, LS25 1HB, United Kingdom | |
Completed | Leeds, LS118BS, United Kingdom | |
Withdrawn | Merritt Island, 32953, United States | |
Completed | Vernon Hills, 60061, United States | |
Completed | San Marcos, 78666, United States | |
Withdrawn | Salt Lake City, 84124, United States | |
Withdrawn | Milwaukee, 53218, United States | |
Completed | Montgomery, 45242, United States | |
Completed | Office of Dr.Larry Levinson, DO | Hollywood, 33021, United States |
Completed | Jersey City, 07306, United States | |
Completed | Greensboro, 27401, United States | |
Completed | Scottsdale, 85260, United States | |
Completed | Rancho Cucamonga, 91730, United States | |
Completed | Rolling Hills Estates, 90274, United States | |
Completed | Medical Research Trust | Boynton Beach, 33426, United States |
Completed | Birmingham, 39294, United States | |
Completed | Stratford, 08084, United States | |
Completed | Leeds, LS9 9EF, United Kingdom | |
Completed | Forth, ML1 8AJ, United Kingdom | |
Completed | Lockerbie, D11 2BJ, United Kingdom | |
Completed | Crossgar, BT30 9JU, United Kingdom | |
Completed | Belfast, BT8 6GR, United Kingdom | |
Completed | Kissimmee, 34741, United States | |
Withdrawn | Zionsville, 18092, United States | |
Completed | Port Gibson, 39150, United States | |
Withdrawn | Columbus, 31901, United States | |
Completed | Prince Frederick, 20678, United States | |
Completed | Sugar Land, 77478, United States | |
Withdrawn | Monmouth Junction, 08852, United States | |
Withdrawn | Hallandale, 33009, United States | |
Withdrawn | Spring, 77379, United States | |
Completed | Gainesville, 32601, United States | |
Completed | Hialeah, 33016, United States | |
Withdrawn | Miami, 33155, United States | |
Withdrawn | Plantation, 33324, United States | |
Completed | Tampa, 33614, United States | |
Withdrawn | Chicago, 60610, United States | |
Completed | Lockport, 60491, United States | |
Withdrawn | Morton, 61550, United States | |
Completed | Evansville, 47713, United States | |
Completed | Lebanon, 40033, United States | |
Withdrawn | Sterling Heights, 48310, United States | |
Withdrawn | Spring, 77386, United States | |
Completed | Merit Medical Group, Inc. | Richlands, 24641-2067, United States |
Withdrawn | Humble, 77338, United States | |
Withdrawn | Phoenixville, 19460, United States | |
Completed | Phoenix, 85051, United States | |
Completed | Duncansville, 16635, United States | |
Completed | Omaha, 68116-2004, United States | |
Completed | Helping Hands Clinical Trials | Santa Ana, 92704, United States |
Completed | Lawrenceville, 08648, United States | |
Withdrawn | Phoenix, 85016, United States | |
Withdrawn | Williamsville, 14221, United States | |
Withdrawn | West Jordan, 84088, United States | |
Completed | Graysville, 35073, United States | |
Withdrawn | Warwick, 02888, United States | |
Withdrawn | El Cajon, 92019, United States | |
Completed | Hot Springs, 71913-4457, United States | |
Withdrawn | Glendora, 91740, United States | |
Completed | Rockwall, 75032, United States | |
Completed | Perrysburg, 43551, United States | |
Withdrawn | Bensalem, 19020, United States | |
Completed | Marion, 43302, United States | |
Withdrawn | Corpus Christi, 78411, United States | |
Withdrawn | Salt Lake City, 84107, United States | |
Withdrawn | Feasterville Trevose, 19053, United States | |
Withdrawn | Tampa, 33624, United States | |
Completed | Raleigh, 27609, United States | |
Withdrawn | Scarborough, 04074, United States | |
Completed | Los Angeles, 90025, United States | |
Withdrawn | Huntington Beach, 92647, United States | |
Withdrawn | San Francisco, 94117, United States | |
Withdrawn | San Leandro, 94578, United States | |
Withdrawn | Tulare, 93274, United States | |
Withdrawn | Altamonte Springs, 32714, United States | |
Withdrawn | Davie, 33314, United States | |
Completed | Pell City, 35125, United States | |
Completed | Hialeah, 33016, United States | |
Completed | Largo, 33770, United States | |
Withdrawn | Marianna, 32446, United States | |
Withdrawn | Miami, 33101, United States | |
Withdrawn | Port Richey, 34668, United States | |
Withdrawn | Chicago, 60631, United States | |
Completed | Chicago, 60628, United States | |
Withdrawn | Holden, 01520, United States | |
Withdrawn | Torrance, 90503, United States | |
Withdrawn | Bend, 97701, United States | |
Completed | Chicago, 60631-1958, United States | |
Withdrawn | Des Moines, 50316, United States | |
Completed | Newark, 19702, United States | |
Withdrawn | Little Rock, 72202, United States | |
Withdrawn | Houston, 77090, United States | |
Completed | Doylestown, 18901, United States | |
Withdrawn | Phoenix, 85029, United States | |
Withdrawn | Houston, 77088, United States | |
Withdrawn | New York, 10016, United States | |
Withdrawn | Kingwood, 77339, United States | |
Withdrawn | Shreveport, 71106, United States | |
Completed | San Antonio, 78205-1116, United States | |
Withdrawn | Peoria, 61406, United States | |
Completed | Fort Wayne, 46804, United States | |
Withdrawn | Kokomo, 46902, United States | |
Completed | Bridgman, 49106, United States | |
Completed | Interlochen, 49643-9264, United States | |
Completed | Cadillac, 49601, United States | |
Completed | Florissant, 63031, United States | |
Completed | Stephenville, 76401, United States | |
Completed | Honaker, 24260, United States | |
Withdrawn | Philadelphia, 19143, United States | |
Withdrawn | Simpsonville, 29681, United States | |
Withdrawn | Rogersville, 37857, United States | |
Withdrawn | Ashtabula, 44004, United States | |
Withdrawn | Glendora, 08029, United States | |
Withdrawn | Benzonia, 49616, United States | |
Completed | Burlington, 27215, United States | |
Completed | Cherry Hill, 08084, United States | |
Withdrawn | Plantation, 33324, United States | |
Completed | Manati, 00674, United States | |
Completed | Guaynabo, 00968, United States | |
Completed | Trujilo Alto, 00976, United States | |
Completed | Skierniewice, 96-100, Poland | |
Completed | Poznan, 60-539, Poland | |
Completed | Sobotka, Poland | |
Completed | Lublin, 20-258, Poland | |
Completed | Lodz, Poland | |
Completed | Chrzanow, Poland | |
Completed | Wloclawek, Poland | |
Completed | Linia, 84-223, Poland | |
Completed | Katowice, 40-752, Poland | |
Completed | Lublin, Poland | |
Completed | Linden, 07036, United States | |
Completed | PharmaTrials, Inc. | Perth Amboy, 08861, United States |
Withdrawn | Buckingham, 18912, United States | |
Withdrawn | Dauphin, 17018, United States | |
Withdrawn | Arlington, 76012, United States | |
Withdrawn | Dallas, 75224, United States | |
Withdrawn | Greenville, 29601, United States | |
Withdrawn | Lindale, 75771, United States | |
Completed | McKinney, 75069, United States | |
Completed | Panama City, 32401, United States | |
Completed | Columbus, 28722, United States | |
Completed | Troy, 48085, United States | |
Completed | Krakow, 31-567, Poland | |
Completed | Radom, 26-600, Poland | |
Completed | Lancut, Poland | |
Withdrawn | Rzeszow, Poland | |
Completed | Olkusz, Poland | |
Completed | Gdansk, 80-286, Poland | |
Completed | Skierniewice, Poland | |
Completed | Lodz, Poland | |
Withdrawn | Wroclaw, Poland | |
Completed | Katowice, 40-226, Poland | |
Completed | Gliwice, 44-109, Poland | |
Completed | Bialystok, 15-183, Poland | |
Completed | Krakow, 31-637, Poland | |
Completed | Warszawa, 02-796, Poland | |
Completed | Wroclaw, 51-112, Poland | |
Completed | Gdynia, 81-317, Poland | |
Completed | Sellersville, 18960, United States | |
Withdrawn | Delaware, 43105, United States | |
Withdrawn | Voorhees, 08043, United States | |
Withdrawn | Tomball, 77375, United States | |
Withdrawn | Zanesville, 43701, United States | |
Withdrawn | San Diego, 92114, United States | |
Withdrawn | Tomball, 77375, United States | |
Withdrawn | Annapolis, 21401, United States | |
Completed | Omaha, 68114, United States | |
Withdrawn | Tomball, 77375, United States | |
Completed | Fremont, 94536-3702, United States | |
Withdrawn | Boston, 02120, United States | |
Withdrawn | Baltimore, 21237, United States | |
Completed | Hainesport, 08036, United States | |
Withdrawn | Houston, 77090, United States | |
Withdrawn | Chojnice, 89-604, Poland | |
Completed | Krakow, 31-156, Poland | |
Withdrawn | Varese, 21100, Italy | |
Completed | Varese, 21100, Italy | |
Withdrawn | Varese, 21100, Italy | |
Withdrawn | Varese, 21100, Italy | |
Withdrawn | Varese, 21100, Italy | |
Completed | Varese, 21100, Italy | |
Withdrawn | Grosseto, 58100, Italy | |
Completed | Grosseto, 58100, Italy | |
Withdrawn | Grosseto, 58100, Italy | |
Completed | Torino, 10023, Italy | |
Completed | Bergamo, 24128, Italy | |
Completed | Orocovis, 00720, United States | |
Completed | San Juan, 00918, United States | |
Terminated | San Juan, 00918, United States | |
Withdrawn | Olsztyn, Poland | |
Completed | Sopot, 81-746, Poland | |
Completed | Wola, Poland | |
Withdrawn | Warszawa, 01-961, Poland | |
Completed | Skierniewice, Poland | |
Completed | Czechowice-Dziedzice, Poland | |
Completed | Lublin, 20-044, Poland | |
Completed | Malaszewicze, Poland | |
Completed | Bydgoszcz, 85-863, Poland | |
Completed | Lublin, Poland | |
Completed | Naklo nad Notecia, 98-100, Poland | |
Completed | Grodzisk Mazowiecki, 05-825, Poland | |
Completed | Amandola, 63021, Italy | |
Completed | Chiavari, 16043, Italy | |
Completed | Catania, 95124, Italy | |
Completed | Roma, 00161, Italy | |
Completed | Roma, 00157, Italy | |
Completed | Legnano, 20025, Italy | |
Completed | Chieti, 66100, Italy | |
Withdrawn | Benevento, 82037, Italy | |
Withdrawn | Gorizia, 34170, Italy | |
Completed | Asti, 14100, Italy | |
Withdrawn | Monza-Brianza, 20052, Italy | |
Completed | Varese, 21100, Italy | |
Completed | Krakow, Poland | |
Completed | Wejherowo, Poland | |
Completed | Szczyrk, 43-370, Poland | |
Withdrawn | Tarnow, Poland | |
Completed | Warszawa, 02-507, Poland | |
Completed | Bydgoszcz, Poland | |
Withdrawn | Wejherowo, Poland | |
Completed | Elblag, 82-300, Poland | |
Completed | Przeworsk, 37-200, Poland | |
Withdrawn | Wroclaw, 51-215, Poland | |
Completed | Kutno, 99-300, Poland | |
Completed | Ostrow Wielkopolski, 63-400, Poland | |
Completed | Zabrze, Poland | |
Completed | Krakow, 31-011, Poland | |
Completed | Wabrzezno, Poland | |
Completed | Grosseto, 58100, Italy | |
Completed | Barcelona, 08023, Spain | |
Completed | Barcelona, 08023, Spain | |
Completed | Barcelona, 08025, Spain | |
Completed | Murcia, 30008, Spain | |
Completed | Vic (Barcelona), 08500, Spain | |
Completed | Murcia, 30007, Spain | |
Completed | Petrer, 03610, Spain | |
Withdrawn | Orihuela, 03300, Spain | |
Completed | Oviedo, 33013, Spain | |
Withdrawn | Gijón, 33212, Spain | |
Completed | Posada de Llanes, 33594, Spain | |
Completed | Madrid, 28003, Spain | |
Completed | León, 24001, Spain | |
Completed | Zabrze, Poland | |
Completed | Krakow, 30-424, Poland | |
Withdrawn | Gniewkowo, 88-140, Poland | |
Completed | Warszawa, 01-192, Poland | |
Completed | Gdansk, 80-822, Poland | |
Completed | Gdansk, 80-461, Poland | |
Completed | Wroclaw, 50-127, Poland | |
Completed | Malbork, 82-200, Poland | |
Completed | Varese, 21100, Italy | |
Withdrawn | Varese, 21054, Italy | |
Completed | Varese, 21100, Italy | |
Completed | Varese, 21100, Italy | |
Completed | Grosseto, 58100, Italy | |
Completed | Grosseto, 58100, Italy | |
Withdrawn | Grosseto, 58100, Italy | |
Completed | Grosseto, 58100, Italy | |
Withdrawn | Grosseto, 58100, Italy | |
Completed | León, 24001, Spain | |
Withdrawn | León, 24009, Spain | |
Completed | Oviedo, 33009, Spain | |
Completed | Lugo, 27770, Spain | |
Completed | León, Spain | |
Withdrawn | Alatoz, 02152, Spain | |
Completed | Viveiro, 27850, Spain | |
Completed | Madrid, 28032, Spain | |
Completed | Orense, 32003, Spain | |
Withdrawn | Alcobendas, 28100, Spain | |
Completed | Elche, Spain | |
Completed | Novara, 28100, Italy | |
Completed | Reggio Emilia, 42019, Italy | |
Completed | Foggia, 71100, Italy | |
Withdrawn | Milano, 20122, Italy | |
Completed | Chieri, 10023, Italy | |
Completed | Reggio Emilia, 42123, Italy | |
Withdrawn | Reggio Calabria, 89100, Italy | |
Completed | Moncalieri, 10024, Italy | |
Withdrawn | Arezzo, 52100, Italy | |
Completed | Chieri, 10023, Italy | |
Completed | Como, 22066, Italy | |
Completed | Napoli, 80131, Italy | |
Completed | Badajoz, 06140, Spain | |
Completed | La Victoria, 38380, Spain | |
Completed | Gümar, 38591, Spain | |
Withdrawn | Beniganim, 46830, Spain | |
Withdrawn | Manises, 46940, Spain | |
Completed | Benidorm, 03503, Spain | |
Completed | Enniscorthy, Ireland | |
Withdrawn | Limerick, Ireland | |
Withdrawn | Mallow, Ireland | |
Withdrawn | Cork, Ireland | |
Withdrawn | Waterford, Ireland | |
Completed | Cork, Ireland | |
Completed | Grosseto, 58100, Italy | |
Withdrawn | Savona, 17100, Italy | |
Completed | Varese, 21100, Italy | |
Completed | Alcover, 43460, Spain | |
Completed | Begonte, 27373, Spain | |
Completed | Murcia, 300005, Spain | |
Withdrawn | Murcia, 30003, Spain | |
Withdrawn | Zarandona, 30007, Spain | |
Completed | Kilmallock, Ireland | |
Completed | Tallow, Ireland | |
Withdrawn | Galway, Ireland | |
Completed | Dublin, 2, Ireland | |
Completed | Espinardo, 30100, Spain | |
Completed | Xixona, 03100, Spain | |
Withdrawn | Alicante, 03005, Spain | |
Completed | Alicante, 03007, Spain | |
Completed | Madrid, 28003, Spain | |
Completed | Albacete, 2260, Spain | |
Withdrawn | Valencia, 46006, Spain | |
Completed | Huelva, 21003, Spain | |
Completed | Barcelona, 08017, Spain | |
Withdrawn | Oviedo, 33012, Spain | |
Withdrawn | León, 24005, Spain | |
Completed | Salamanca, 27-31, Spain | |
Withdrawn | Albarán, 30550, Spain | |
Completed | Sobrado dos Monxes, 15813, Spain | |
Withdrawn | Chinchilla de Monte Aragón, 02520, Spain | |
Withdrawn | Badajoz, 06011, Spain | |
Withdrawn | Albacete, 02005, Spain | |
Completed | Valladolid, 47007, Spain | |
Completed | Santander, 39009, Spain | |
Withdrawn | Salamanca, 37005, Spain | |
Completed | Madrid, 28030, Spain | |
Completed | La Roda, 06230, Spain | |
Completed | Gorey, Ireland | |
Completed | Bray, Ireland | |
Completed | Rathkeale, Ireland | |
Completed | Bishopstown, Ireland | |
Withdrawn | Rathmines, Ireland | |
Withdrawn | Tramore, Ireland | |
Completed | Gorey, Ireland | |
Withdrawn | Kinvara, Ireland | |
Completed | Meißen, 01662, Germany |
Primary Outcome
- Time to the first occurrence of the composite outcome of MI (myocardial infarction), stroke, cardiovascular death, UA (unstable angina) or TIA (transient ischemic attack)The primary efficacy endpoint was a composite outcome consisting of the first occurrence of confirmed MI, stroke, cardiovascular death, UA, TIA. The time to event was defined as the number of days from the date of randomization to the date of the event confirmed by adjudication. The numbers of days for milestones when 1%, 2%, 3% and 4% of the subjects have reached endpoint events were estimated from Kaplan-Meier-Analyses.date_rangeTime Frame:Until follow-up (approximate 6 years)
Secondary Outcome
- Time to the first occurrence of the composite outcome of cardiovascular death, MI, or stroke (ischemic, hemorrhagic, or unknown)The time to Composite outcome consisting of the first occurrence of cardiovascular death, MI, or stroke (ischemic, hemorrhagic, or unknown) was defined as the number of days from the date of randomization to the date of the event confirmed by adjudication. The numbers of days for milestones when 1%, 2%, 3% and 4% of the subjects have reached endpoint events were estimated from Kaplan-Meier-Analyses.date_rangeTime Frame:Until follow-up (approximate 6 years)
- Time to the first occurrence of the individual components of the primary: non-fatal MI, total MI, non-fatal stroke, total stroke, cardiovascular death, UA and TIAThe time to event was defined as the number of days from the date of randomization to the date of the event confirmed by adjudication. The numbers of days for milestones when 1%, 2%, 3% and 4% of the subjects have reached endpoint events were estimated from Kaplan-Meier-Analyses.date_rangeTime Frame:Until follow-up (approximately 6 years)
- Time to all-cause mortality, the first occurrence of all cancers excluding non-melanoma skin cancer (NMSC) and the first occurrence of colon cancerThe time to event was defined as the number of days from the date of randomization to the date of the event confirmed by adjudication. The numbers of days for milestones when 1%, 2%, 3% and 4% of the subjects have reached endpoint events were estimated from Kaplan-Meier-Analyses.date_rangeTime Frame:Until follow-up (approximately 6 years)
- Incidence of all-cause mortality, all cancers excluding non-melanoma skin cancer and colon cancerdate_rangeTime Frame:Until follow-up (approximately 6 years)
- Incidence of confirmed MI, stroke, cardiovascular death, UA, and TIA separatelyThe percentages of subjects with the efficacy endpoints of confirmed MI, stroke, cardiovascular death, UA and TIA are reported separately.date_rangeTime Frame:Until follow-up (approximately 6 years)
Trial design
Trial Type
InterventionalIntervention Type
DrugTrial Purpose
PreventionAllocation
RandomizedBlinding
Double BlindAssignment
Parallel AssignmentTrial Arms
2Additional Information
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