Trial Condition(s):

Colorectal Neoplasms

Study to determine safety, pharmacokinetics, pharmacodynamics of BAY73-4506 in combination with mFOLFOX6 or FOLFIRI

Bayer Identifier:

11656

ClinicalTrials.gov Identifier:

NCT00934882

EudraCT Number:

2008-007151-27

Study Completed

Trial Purpose

This multi-center, open-label, non-randomized, non-placebo-controlled, Phase I study will define the safety profile and tumor response profile of the multi-kinase inhibitor BAY73-4506 as oral treatment in combination with the chemotherapy regimen mFOLFOX6 or FOLFIRI in patients with metastatic CRC. It will also determine the impact of the combined administration on the concentration of drugs over time (pharmacokinetics) of BAY73-4506, oxaliplatin, 5 FU, and irinotecan.
This study will be conducted at approximately 5 - 8 study centers in Germany. Up to 60 patients will be enrolled into this study to ensute that at least 12 - 15 patients for each combination regimen can be evaluated for safety and pharmacokinetics. For this reason a minimum of 20 patients will receive mFOLFOX6 in combination with BAY73-4506 and at least 20 patients will receive FOLFIRI in combination with BAY73-4506.

Inclusion Criteria
- Histological or cytological documentation of adenocarcinoma of the colon or rectum.
 - At least 1 measurable lesion as per RECIST
 - ECOG Performance Status of 0 - 1
 - Life expectancy of at least 12 weeks.
 - Adequate bone marrow, liver, and renal function
Exclusion Criteria
- More than 1 previous chemotherapy for Colorectal Cancer. Adjuvant chemotherapy for Colorectal Cancer (Stage I, II, II) is permitted, if the adjuvant therapy ended >6 month before screening.
 - Previous FOLFOX treatment for patients who will be included in the mFOLFOX6 cohort apart from FOLFOX treatment in an adjuvant setting.
 - Previous FOLFIRI treatment for patients who will be included in the FOLFIRI cohort.

Trial Summary

Enrollment Goal
45
Trial Dates
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Phase
1
Could I receive a placebo?
No
Products
Stivarga (Regorafenib, BAY73-4506)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

Klinik für Tumorbiologie Freiburg

Freiburg, Germany, 79106

Status
Completed
 
Locations

Universitätsklinikum Freiburg

Freiburg, Germany, 79106

Status
Completed
 
Locations

Universitätsklinikum Heidelberg

Heidelberg, Germany, 69120

Status
Completed
 
Locations

Marienhospital Herne Universitätsklinik

Herne, Germany, 44625

Status
Completed
 
Locations

Universitätsklinikum Köln

Köln, Germany, 50937

Status
Completed
 
Locations

Medizinische Fakultät Carl Gustav Carus

Dresden, Germany, 01307

Status
Completed
 
Locations

Klinikum Oldenburg gGmbH

Oldenburg, Germany, 26133

Status
Completed
 
Locations

Klinikum Mannheim gGmbH

Mannheim, Germany, 68167

Status
Terminated
 

Trial Design