Trial Condition(s):

Advanced solid tumors

Study to test how well patients with advanced solid tumors respond to treatment with the Elimusertib in combination with pembrolizumab, to find the optimal dose for patients, how the drug is tolerated and the way the body absorbs, distributes and discharges the drug

Bayer Identifier:

19741

ClinicalTrials.gov Identifier:

NCT04095273

EudraCT Number:

2018-003420-36

Recruitment Complete

Trial Purpose

The purpose of the study is to test how well patients with advanced solid tumors respond to treatment with elimusertib (BAY1895344) in combination with pembrolizumab. In addition researchers want to find for patients the optimal dose of elimusertib in combination with pembrolizumab, how the drug is tolerated and the way the body absorbs, distributes and discharges the drug. The study medication, elimusertib, works by blocking a substance (ATR Kinase) which is produced by the body and is important for the growth of tumor cells. Pembrolizumab is an immunologic checkpoint blocker that promotes an immune response against the tumor.

Inclusion Criteria
- Participant must be ≥18 years of age inclusive, at the time of signing the informed consent.
- Presence of the putative biomarkers of DDR deficiency in tumor and/or other tissues (dose escalation only). 
- Participants must have histologically confirmed solid tumors .
- Eastern Cooperative Oncology Group performance status (ECOG-PS) of 0 to 1.
- Adequate bone marrow function as assessed by laboratory tests to be conducted within 7 days before the first dose of study intervention.
- Participants must have adequate kidney function, as assessed by the estimated glomerular filtration rate (eGFR) > 40 mL/min per 1.73 m*2 within 7 days before the first dose of study intervention.
- Participants must have adequate liver function as assessed by laboratory tests to be conducted within 7 days before the first dose of study intervention.
- Participants must have adequate coagulation, as assessed by laboratory tests as applicable, (to be conducted within 7 days before the first dose of study intervention) or be on stable anti-coagulation treatment.
- Adequate cardiac function per institutional normal measured by echocardiography (recommended) or multigated acquisition (MUGA) scan/cardiac MRI per institutional guidelines.
- Participants must have measurable disease (at least one measurable lesion) as per RECIST 1.1, or evaluable disease according to the Prostate Cancer Clinical Trials Working Group 3 (PCWG3) classification as applicable. Lesions situated in a previously irradiated area are considered measurable if progression has been demonstrated in such lesions
Exclusion Criteria
- Ongoing infections of Common terminology criteria for adverse events (CTCAE) grade ≥2 not responding to therapy or active clinically serious infections.
- Participants with
-- Known human immunodeficiency virus (HIV)
-- Active Hepatitis B infection (positive for Hepatitis B surface antigen (HBsAg)/ Hepatitis B virus (HBV) DNA). 
-- Active Hepatitis C infection (positive anti-HCV Antibody and quantitative HCV RNA results greater than the lower limits of detection of the assay).
- Active autoimmune disease (active defined as having autoimmune disease related symptoms and detectable autoantibodies) that has required systemic treatment in the past 2 years (i.e., with use of disease-modifying agents, corticosteroids, or immunosuppressive drugs). Replacement therapy (e.g. thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment
- Diagnosis of immunodeficiency or participant is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to the first dose of study intervention. The use of physiologic doses of corticosteroids may be approved after consultation with the sponsor.
- Pleural effusion or ascites that causes respiratory compromise (CTCAE Grade ≥ 2 dyspnea).
- History of cardiac disease: congestive heart failure New York Heart Association (NYHA) class >II, unstable angina (angina symptoms at rest), new-onset angina (within the past 6 months before study entry), myocardial infarction within the past 6 months before study entry, or cardiac arrhythmias requiring anti-arrhythmic therapy (beta blockers, calcium channel blockers, and digoxin are permitted)
- Uncontrolled arterial hypertension despite optimal medical management (per investigator’s opinion)
- Moderate or severe hepatic impairment, i.e., Child-Pugh class B or C.
- History of organ allograft transplantation
- Evidence or history of bleeding disorder, i.e., any hemorrhage / bleeding event of CTCAE Grade > 2 within 4 weeks before the first dose of study intervention

Trial Summary

Enrollment Goal
56
Trial Dates
black-arrow
Phase
1
Could I receive a placebo?
No
Products
Elimusertib (BAY1895344)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

Johns Hopkins Hospital/Health System

Baltimore, United States, 21287

Status
Completed
 
Locations

University of Texas MD Anderson Cancer Center

Houston, United States, 77030-4000

Status
Active, not recruiting
 
Locations

Stanford University - DCT Dept.

Palo Alto, United States, 94304

Status
Active, not recruiting
 
Locations

Ohio State University

Columbus, United States, 43210

Status
Active, not recruiting
 
Locations

Royal Marsden NHS Trust (Surrey)

Sutton, United Kingdom, SM2 5PT

Status
Completed
 
Locations

Yale Cancer Center

New Haven, United States, 06519

Status
Active, not recruiting
 
Locations

Eberhard-Karls-Universität Tübingen

Tübingen, Germany, 72076

Status
Completed
 
Locations

Universitätsklinikum Heidelberg

Heidelberg, Germany, 69120

Status
Completed
 
Locations

Levine Cancer Institute

Charlotte, United States, 28204-2990

Status
Completed
 
Locations

Weill Cornell Medical College

New York, United States, 10065

Status
Active, not recruiting
 
Locations

Dana-Farber Cancer Institute

Boston, United States, 02115-6084

Status
Completed
 
Locations

Hospital Madrid Norte Sanchinarro

Madrid, Spain, 28050

Status
Active, not recruiting
 
Locations

Fundacion Jimenez Diaz (Clinica de la Concepcion)

Madrid, Spain, 28040

Status
Completed
 
Locations

Freeman Hospital

Newcastle Upon Tyne, United Kingdom, NE7 7DN

Status
Completed
 
Locations

Kantonsspital St. Gallen

St. Gallen, Switzerland, 9007

Status
Completed
 
Locations

Ospedale Regionale di Bellinzona e Valli

Bellinzona, Switzerland, 6500

Status
Completed
 

Trial Design